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The map label for this gene is dnaX [H]

Identifier: 161524619

GI number: 161524619

Start: 1591645

End: 1594110

Strand: Direct

Name: dnaX [H]

Synonym: Bmul_1446

Alternate gene names: 161524619

Gene position: 1591645-1594110 (Clockwise)

Preceding gene: 161524610

Following gene: 161524620

Centisome position: 46.16

GC content: 72.42

Gene sequence:

>2466_bases
ATGACCTATCAAGTTCTCGCACGCAAGTGGCGTCCGAAGGATTTCGCTTCGCTCGTCGGCCAGGAGCACGTCGTCAGGGC
GCTTACGCACGCGCTCGACGGCGGGCGTCTTCATCACGCGTATCTGTTCACCGGCACCCGCGGCGTCGGCAAGACGACGC
TGTCGCGCATCTTCGCGAAGGCGCTCAACTGTGAAACCGGCGTGACGTCGCAACCGTGCGGCGTCTGCCGTGCGTGCCGC
GAGATCGACGAAGGCCGCTTCGTCGACTACGTCGAAATGGATGCCGCGAGCAATCGCGGCGTCGACGAAATGGCCGCGCT
GCTGGAGCGTGCGGTGTACGCGCCGGTCGATGCGCGCTTCAAGGTCTACATGATCGACGAAGTGCACATGCTGACGAACC
ACGCGTTCAACGCGATGCTGAAGACGCTCGAGGAGCCGCCGCCGCATGTGAAGTTCATCCTCGCGACCACCGATCCGCAG
AAGATTCCCGTCACGGTGCTGTCGCGCTGCCTGCAGTTCAACCTGAAGCAGATGCCGGCCGGGCACATCGTGTCGCATCT
CGAGCGCATTCTCGGCGAAGAGCGCATCGCGTTCGAGCCGCAGGCGCTGCGTCTGCTCGCGCGTGCGGCGCAGGGCAGCA
TGCGCGACGCGCTGTCGCTGACCGACCAGGCGATCGCCTATTCGGCCAACGAAGTGACCGAAGCGGCGGTGTCGGGCATG
CTCGGCGCGCTCGACCAGACTTACATGGTGCGGCTGCTCGATGCGCTCGCGGCCGGCAGCGGCCCCGAGATTCTCGCCAT
CGCCGACGAAATGTCGCTGCGCAGCCTGTCGTTCTCGACCGCGCTGCAGGATCTCGCGAGCCTGCTGCACCGGATCGCCT
GGGCGCAGTTCGCGCCGGGCTCGGTGCTCGACGAATGGCCGGAAGCGGCCGATCTGCGTCGCTTCGCCGAGCTGCTGAGC
CCCGAACAGGTGCAGCTGTTCTATCAGATCGCGACGGTCGGCCGCGCGGAACTCGGCCTCGCACCCGACGAATACGCGGG
TTTCACGATGACGCTGCTGCGCATGCTCGCGTTCGAGCCGGCCGTCGGTGCCGGCAGCGCGCCGGGCGGTCAGCCGTCCG
TGCCGCGCGCCGTACCGGCGCCGCGTGCGGCTGCTGCGGCGGCAGCGCCTGCGGCGAAGCCGGTGTCGGCTGCCCGCCCG
CAAGCGGCTGCTCCGGCTCCGCCTGCTGCGCGCCCGGCAGCCGTTGCGCCGGCACCGATCGGCGACGCCGCCACGCGGCC
GGCCACGCAAGCCGCGCCTGCGCCGCAAGCCACGCCGGTTTCGCCCGTCGCGAAGGCGGCGGACGCCGGCGCGACGCCGC
GATCCGACGCGAGCGCTCGATCGGAAGTGTCGACCGCAGCGGCCGACGCGCCGGCGGCCGTTCGCGCCGAACCCGCATCG
TCCGCCGACGCGCAGCGCAGCACCGAAGCCGACGTGTCGGCCGCCGCGCCGCGCAACAGCGCGCCGGAACCGCGCGTCGC
CGCGCAGCCAGCGCGCGAGCCCGAAGCATCGGCGGCCGCGCCGCGCAATGACGAACCCGCACCGCCGGCCGAACCGGCGC
CGCGCGCCGCATCCGCAGGGTCGGCCGCGCGCCCGGCCGCCCGTTCGGGTGGCGCGGCCGCCGCGCTCGACGTGCTGCGC
AATGCCGGGATGCGCGTGTCGTCCGATCGTTCTCGCGCGGGCGCCGCAGCCAAGCCCGCGGCCGAGCCCGCCGCCGCGAA
ACCTGCGCCGGCGCGTCCGGCCGTACAGGTACCGACGCCGCGCGCGACCGCGCGCGCCGCACAGCCGAGCGCCGACACGC
GCCATGCGCCGCCGCCGTGGGAAGACATTCCGCCGGACGACTACGTGCCGCTCAGCGCGGACGAAATGTTCGGCGGCCCG
CCGGACGACGGCTTCGTGCCCGTGTTCGACAGCGGTCCGGACGACGTGCGCGTCGCGCCGTCGCCCGCCGACAGCCGGCC
GTCGGCGCCGGTCGACACGCGTCCGTTGCCGCCCGCGATCGCGCTCGACGCGATCGGCTTCGACGGCGAATGGCCGACGC
TCGCCGCACGATTGCCGCTGAAGGGCGTCGCATATCAGTTGGCGTTCAACAGCGAGCTGACGGCCGTCGACGCGACGTCG
CTGAAGCTGTCGGTGCCCGTCCCGCAGTACGCGGACGCCGCGCAGGTCGCGAAGCTGAAGGCGGCGCTTGCCGATGCGCT
CGGCAAGCCGGTCGAGGTGGCGGTCGAGGTCGGCCCCGCGCGCCGCACCGCAGCGGCGCTCGACGCGGCCGCACGGGCGG
CGCGTCAGCGCGAGGCCGAACAGGAGATTCACGCCGATCCGTTCGTCCAGCAACTCGTGCGCGATTTCGGCGCGCGCATC
GTCGAAGGCTCCGTGCGTCCGCTCGCCGATTCGGCGCCGGACGGCGGCGCGCCGACGCTGCATTGA

Upstream 100 bases:

>100_bases
GCGACGCGTGCGTCGTCAGGCGCCGTCATGCACCGCGATTGCCGCAGCGCGCGGCGTTTCGCGTGTCGGCGCGCGGCAGC
GTTGCTGATACAATTTCCCG

Downstream 100 bases:

>100_bases
ACGGACTGCGCCGCGACAGGCACAATCACGCCCCAACACATTGGCCGGCACGCGCCGCGTGCCGGTTTTCACACGATCGA
GAAGGAGTATTCCCATGTTG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 821; Mature: 820

Protein sequence:

>821_residues
MTYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAKALNCETGVTSQPCGVCRACR
EIDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARFKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQ
KIPVTVLSRCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTEAAVSGM
LGALDQTYMVRLLDALAAGSGPEILAIADEMSLRSLSFSTALQDLASLLHRIAWAQFAPGSVLDEWPEAADLRRFAELLS
PEQVQLFYQIATVGRAELGLAPDEYAGFTMTLLRMLAFEPAVGAGSAPGGQPSVPRAVPAPRAAAAAAAPAAKPVSAARP
QAAAPAPPAARPAAVAPAPIGDAATRPATQAAPAPQATPVSPVAKAADAGATPRSDASARSEVSTAAADAPAAVRAEPAS
SADAQRSTEADVSAAAPRNSAPEPRVAAQPAREPEASAAAPRNDEPAPPAEPAPRAASAGSAARPAARSGGAAAALDVLR
NAGMRVSSDRSRAGAAAKPAAEPAAAKPAPARPAVQVPTPRATARAAQPSADTRHAPPPWEDIPPDDYVPLSADEMFGGP
PDDGFVPVFDSGPDDVRVAPSPADSRPSAPVDTRPLPPAIALDAIGFDGEWPTLAARLPLKGVAYQLAFNSELTAVDATS
LKLSVPVPQYADAAQVAKLKAALADALGKPVEVAVEVGPARRTAAALDAAARAARQREAEQEIHADPFVQQLVRDFGARI
VEGSVRPLADSAPDGGAPTLH

Sequences:

>Translated_821_residues
MTYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAKALNCETGVTSQPCGVCRACR
EIDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARFKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQ
KIPVTVLSRCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTEAAVSGM
LGALDQTYMVRLLDALAAGSGPEILAIADEMSLRSLSFSTALQDLASLLHRIAWAQFAPGSVLDEWPEAADLRRFAELLS
PEQVQLFYQIATVGRAELGLAPDEYAGFTMTLLRMLAFEPAVGAGSAPGGQPSVPRAVPAPRAAAAAAAPAAKPVSAARP
QAAAPAPPAARPAAVAPAPIGDAATRPATQAAPAPQATPVSPVAKAADAGATPRSDASARSEVSTAAADAPAAVRAEPAS
SADAQRSTEADVSAAAPRNSAPEPRVAAQPAREPEASAAAPRNDEPAPPAEPAPRAASAGSAARPAARSGGAAAALDVLR
NAGMRVSSDRSRAGAAAKPAAEPAAAKPAPARPAVQVPTPRATARAAQPSADTRHAPPPWEDIPPDDYVPLSADEMFGGP
PDDGFVPVFDSGPDDVRVAPSPADSRPSAPVDTRPLPPAIALDAIGFDGEWPTLAARLPLKGVAYQLAFNSELTAVDATS
LKLSVPVPQYADAAQVAKLKAALADALGKPVEVAVEVGPARRTAAALDAAARAARQREAEQEIHADPFVQQLVRDFGARI
VEGSVRPLADSAPDGGAPTLH
>Mature_820_residues
TYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAKALNCETGVTSQPCGVCRACRE
IDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARFKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQK
IPVTVLSRCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTEAAVSGML
GALDQTYMVRLLDALAAGSGPEILAIADEMSLRSLSFSTALQDLASLLHRIAWAQFAPGSVLDEWPEAADLRRFAELLSP
EQVQLFYQIATVGRAELGLAPDEYAGFTMTLLRMLAFEPAVGAGSAPGGQPSVPRAVPAPRAAAAAAAPAAKPVSAARPQ
AAAPAPPAARPAAVAPAPIGDAATRPATQAAPAPQATPVSPVAKAADAGATPRSDASARSEVSTAAADAPAAVRAEPASS
ADAQRSTEADVSAAAPRNSAPEPRVAAQPAREPEASAAAPRNDEPAPPAEPAPRAASAGSAARPAARSGGAAAALDVLRN
AGMRVSSDRSRAGAAAKPAAEPAAAKPAPARPAVQVPTPRATARAAQPSADTRHAPPPWEDIPPDDYVPLSADEMFGGPP
DDGFVPVFDSGPDDVRVAPSPADSRPSAPVDTRPLPPAIALDAIGFDGEWPTLAARLPLKGVAYQLAFNSELTAVDATSL
KLSVPVPQYADAAQVAKLKAALADALGKPVEVAVEVGPARRTAAALDAAARAARQREAEQEIHADPFVQQLVRDFGARIV
EGSVRPLADSAPDGGAPTLH

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=322, Percent_Identity=23.6024844720497, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI194306571, Length=325, Percent_Identity=23.3846153846154, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI194306567, Length=325, Percent_Identity=23.3846153846154, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1786676, Length=391, Percent_Identity=54.2199488491049, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1787341, Length=183, Percent_Identity=31.1475409836066, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1787119, Length=303, Percent_Identity=27.7227722772277, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=300, Percent_Identity=24, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=245, Percent_Identity=26.1224489795918, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859927, Length=295, Percent_Identity=22.0338983050847, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921076, Length=305, Percent_Identity=23.9344262295082, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 85300; Mature: 85169

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAK
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHH
ALNCETGVTSQPCGVCRACREIDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARF
HHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCE
KVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQKIPVTVLSRCLQFNLKQMPA
EEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
GHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTEAAVSGM
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LGALDQTYMVRLLDALAAGSGPEILAIADEMSLRSLSFSTALQDLASLLHRIAWAQFAPG
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVLDEWPEAADLRRFAELLSPEQVQLFYQIATVGRAELGLAPDEYAGFTMTLLRMLAFEP
HHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCHHHCCCCCHHHCHHHHHHHHHHHHCC
AVGAGSAPGGQPSVPRAVPAPRAAAAAAAPAAKPVSAARPQAAAPAPPAARPAAVAPAPI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCC
GDAATRPATQAAPAPQATPVSPVAKAADAGATPRSDASARSEVSTAAADAPAAVRAEPAS
CCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEECCCCC
SADAQRSTEADVSAAAPRNSAPEPRVAAQPAREPEASAAAPRNDEPAPPAEPAPRAASAG
CCCHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SAARPAARSGGAAAALDVLRNAGMRVSSDRSRAGAAAKPAAEPAAAKPAPARPAVQVPTP
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCEECCCC
RATARAAQPSADTRHAPPPWEDIPPDDYVPLSADEMFGGPPDDGFVPVFDSGPDDVRVAP
CHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCEEEEECCCCCCCEECC
SPADSRPSAPVDTRPLPPAIALDAIGFDGEWPTLAARLPLKGVAYQLAFNSELTAVDATS
CCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCHHHHCCCCCCEEEEEEECCCCCEEECCC
LKLSVPVPQYADAAQVAKLKAALADALGKPVEVAVEVGPARRTAAALDAAARAARQREAE
EEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
QEIHADPFVQQLVRDFGARIVEGSVRPLADSAPDGGAPTLH
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAK
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHH
ALNCETGVTSQPCGVCRACREIDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARF
HHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCE
KVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQKIPVTVLSRCLQFNLKQMPA
EEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
GHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTEAAVSGM
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LGALDQTYMVRLLDALAAGSGPEILAIADEMSLRSLSFSTALQDLASLLHRIAWAQFAPG
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVLDEWPEAADLRRFAELLSPEQVQLFYQIATVGRAELGLAPDEYAGFTMTLLRMLAFEP
HHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCHHHCCCCCHHHCHHHHHHHHHHHHCC
AVGAGSAPGGQPSVPRAVPAPRAAAAAAAPAAKPVSAARPQAAAPAPPAARPAAVAPAPI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCC
GDAATRPATQAAPAPQATPVSPVAKAADAGATPRSDASARSEVSTAAADAPAAVRAEPAS
CCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEECCCCC
SADAQRSTEADVSAAAPRNSAPEPRVAAQPAREPEASAAAPRNDEPAPPAEPAPRAASAG
CCCHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SAARPAARSGGAAAALDVLRNAGMRVSSDRSRAGAAAKPAAEPAAAKPAPARPAVQVPTP
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCEECCCC
RATARAAQPSADTRHAPPPWEDIPPDDYVPLSADEMFGGPPDDGFVPVFDSGPDDVRVAP
CHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCEEEEECCCCCCCEECC
SPADSRPSAPVDTRPLPPAIALDAIGFDGEWPTLAARLPLKGVAYQLAFNSELTAVDATS
CCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCHHHHCCCCCCEEEEEEECCCCCEEECCC
LKLSVPVPQYADAAQVAKLKAALADALGKPVEVAVEVGPARRTAAALDAAARAARQREAE
EEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
QEIHADPFVQQLVRDFGARIVEGSVRPLADSAPDGGAPTLH
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]