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The map label for this gene is glxR [H]

Identifier: 161524489

GI number: 161524489

Start: 1445149

End: 1446039

Strand: Direct

Name: glxR [H]

Synonym: Bmul_1316

Alternate gene names: 161524489

Gene position: 1445149-1446039 (Clockwise)

Preceding gene: 161524486

Following gene: 161524494

Centisome position: 41.91

GC content: 72.73

Gene sequence:

>891_bases
GTGGAAGTCGGATTTTGCGGACCGGGATTGATGGGCGCGCCGATGATTCGGCATCTGCTGGCGGCCGGGCATCGCGTCAG
CGTGTGGAACCGGACGCATGCGAAGGCGGAGGCGCTCGCGGCGGAGGGCGCGCAGGTCGTCGATACGCCGCGTGAACTCG
CGGAGCGTGTCGAGACGGTATTCGTCTGCGTGCTCGACACGCGCGCGGTCGGCGACGTCGTATTCGGCGCCGACGGCCTG
CTCGCAGGCGACGCGTCGGCCCGGCGGCTGCAGCGCATCGTCGATCATTCGAGCATTGCGCCGGCCGCGACGCGCGACTA
TGCGGCACGCGCGGCCGCGCTCGGCGTCGGCTGGGTCGACGCGCCGGTGTCGGGCGGCGTGCCGGGCGCGCAGGCCGGCA
CGCTCGCCGTGATGGCGGGCGGCCGTGCGGCCGATCTCGATGCGGTGCGGCCGTTGATCGACACGTACGCGTCGCGCATC
ACGCACATGGGCGACGCCGGCGCCGGGCAGACCGCGAAGCTCTGCAATCAGGCGATCGTGACGGCCACGGTTACGGCAAT
CGCCGAGGCGGTCGGCCTCGCGCAGGCAAGCGGCATCGATGCGGCGCGCCTCGCCGAAGCGCTCGCCGGCGGCTGGGCCG
ACTCGGTGCTGCTGCAGACCTTCGTGCCGCGCATGACGTCGGGCGCGCACGCGCCGATCGGCGCGCTCGGCACCTTTCAG
AAGGATGTGGATGCAATCGCCGACGCCGCGCGCGACACGGGCGCCGTGATGCCCGTATCGGCCACGGTCCAGCAGGTGTT
GCGGCTCGGCGCCGCACAGGGGCTCGCCAGCGCGGACTTCGCGGCGTTCATCGACATCGTGCGCCCGCAGAACGGACGCC
ACGCGCGCTGA

Upstream 100 bases:

>100_bases
GCAAGCCGCGCGCCCGAAGCGGCGTCGCGCGTGTCCGGCTTCTTTGAGTGATAGGTATGATGGGCGGCAAGTGCAACCCT
TATCGGAGACGAGGACAATC

Downstream 100 bases:

>100_bases
CCAAGGCCGCGCGCCGCGCGTTGCGCATGCGGCGCGCGCAGACGGCCGATGGGCCGCGCGGAGGCGGCCCATCGAATCGT
TGGCGGTTCAGCCGAGGGAG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MEVGFCGPGLMGAPMIRHLLAAGHRVSVWNRTHAKAEALAAEGAQVVDTPRELAERVETVFVCVLDTRAVGDVVFGADGL
LAGDASARRLQRIVDHSSIAPAATRDYAARAAALGVGWVDAPVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRI
THMGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGAHAPIGALGTFQ
KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLASADFAAFIDIVRPQNGRHAR

Sequences:

>Translated_296_residues
MEVGFCGPGLMGAPMIRHLLAAGHRVSVWNRTHAKAEALAAEGAQVVDTPRELAERVETVFVCVLDTRAVGDVVFGADGL
LAGDASARRLQRIVDHSSIAPAATRDYAARAAALGVGWVDAPVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRI
THMGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGAHAPIGALGTFQ
KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLASADFAAFIDIVRPQNGRHAR
>Mature_296_residues
MEVGFCGPGLMGAPMIRHLLAAGHRVSVWNRTHAKAEALAAEGAQVVDTPRELAERVETVFVCVLDTRAVGDVVFGADGL
LAGDASARRLQRIVDHSSIAPAATRDYAARAAALGVGWVDAPVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRI
THMGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGAHAPIGALGTFQ
KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLASADFAAFIDIVRPQNGRHAR

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=295, Percent_Identity=28.4745762711864, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI40556376, Length=284, Percent_Identity=28.169014084507, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=36.2676056338028, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI145693186, Length=283, Percent_Identity=34.2756183745583, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1790315, Length=295, Percent_Identity=27.1186440677966, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=26.6211604095563, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17557316, Length=300, Percent_Identity=28, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24655230, Length=301, Percent_Identity=30.8970099667774, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922568, Length=301, Percent_Identity=30.8970099667774, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574115, Length=283, Percent_Identity=28.2685512367491, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30054; Mature: 30054

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVGFCGPGLMGAPMIRHLLAAGHRVSVWNRTHAKAEALAAEGAQVVDTPRELAERVETV
CCCCCCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHH
FVCVLDTRAVGDVVFGADGLLAGDASARRLQRIVDHSSIAPAATRDYAARAAALGVGWVD
HHHEECCHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
APVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRITHMGDAGAGQTAKLCNQAIV
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGAHAPIGALGTFQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLASADFAAFIDIVRPQNGRHAR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEVGFCGPGLMGAPMIRHLLAAGHRVSVWNRTHAKAEALAAEGAQVVDTPRELAERVETV
CCCCCCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHH
FVCVLDTRAVGDVVFGADGLLAGDASARRLQRIVDHSSIAPAATRDYAARAAALGVGWVD
HHHEECCHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
APVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRITHMGDAGAGQTAKLCNQAIV
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGAHAPIGALGTFQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLASADFAAFIDIVRPQNGRHAR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]