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The map label for this gene is dxr [H]

Identifier: 161485632

GI number: 161485632

Start: 652941

End: 654566

Strand: Direct

Name: dxr [H]

Synonym: Tery_0416

Alternate gene names: 161485632

Gene position: 652941-654566 (Clockwise)

Preceding gene: 113474288

Following gene: 113474292

Centisome position: 8.42

GC content: 34.93

Gene sequence:

>1626_bases
ATGAAACCAATTACAATCTTAGGATCTACAGGGTCTATTGGTACTCAAACTTTGAACATTGTGGCTCACAACCCAAACAA
ATTTCGAGTTATTGGGTTAGCTGCTGGAAGTAATGTAGAAATATTAGCCCAACAGGTCAGACAATTTTGCCCTCAAATTG
TTGCTATTAATGATAAGTCCAAATTTAGGGAACTACAAGAGGCCATTGCTGACTTGCAGCCTCAGCCTATATTGGTTGCT
GACCAAGATGGTGTTATACAAGTAGCTAGATATGGGGAATCAGAAGTAGTCGTAACTGGTATTGTTGGTTGTGCTGGTTT
ATTGCCTACTATTGCTGCTATTGAAGCAGGCAAAGATATTGCTTTAGCAAATAAAGAAACACTTATTGCAGCAGGTCCAG
TTGTTAATCCTTTAATTGAAAAATATAGAGTCAAATTATTACCAGCAGACTCAGAACATTCAGCAATTTTTCAATGTCTT
CAAGGTTTACCATTAGAGGGTTTGCGCAGAATTATTTTAACTGCTTCTGGTGGTGCTTTTCGAGATTGGCCGATTGAGAA
ATTATCAAAAGTAAAAGTGGCAGATGCTATTAAACATCCTAACTGGTCAATGGGTAAGAAAATTACCGTTGATTCTGCTA
CAATGATGAATAAAGGTTTGGAAGTTATTGAAGCTCATTATTTGTTTGGATTGAATTATGATAATATTGATATAGTAATT
CATCCTCAAAGCATAATTCACTCTTTAATTGAGTTACAAGATACTTCTGTTTTAGCTCAACTAGGTTGGCCGGATATGCG
TTTGCCTTTGCTTTACGCTTTATCTTGGCCGGAAAGAATTTATACTGATTGGAAACAGTTAGATTTAGTTAAAGCTGGAA
GTTTGACTTTCAAGGAACCTGATAATTTGAAATATCCTTGCATTCAGTTAGCTTATACAGCTGGTCGTATGGGTGGTTCT
ATGCCTGGAGTTTTGAATGCTGCAAATGAACAGGCTGTAGCATTGTTTTTAGAAGAAAAAATAGCATTTTTGGATATTCC
AAAATTGATTGAATATGTCTGTGAAAAGCATAATTCAAATTATCAAGAAAATCCTAGTCTAGATGATATTTTGGCAGCAG
ATAAATGGGCAAGAAAAGAGGTTTTAGCAGCAAGTAGTATAGTAAATAATTCTCTAATAAATTTAAGTTTGGTTAATCTT
GAGGAAAATCCCACAGAAATATTTACAAAAATCGAAAATGAGCAGATAGAATTTAATGATTTTTATCAGCGGGGATTAGC
TAAATATGAACAACAAGATTATCAATCAGCTTTAGCAGAGTTTGATCGAGCAATAGATATAGACTCCAGTCATATAGATG
CTTATATTTATAGGGGTGATGCTAAAGATAAATTAGAAGACTATGAGGGAGCAATTGCTGATTATAATGAGGCAATTAAA
ATAGATTCAAGTCATCCAAAAGCTTATTATAGTCGGGAAAATGTACTGCGAAAAGCTGGAGATAGTAGGGAAGCGATCGC
TGATTATGATCAAGCAATTAAACTAGATCCAAATTATACACCTACCAAGAATTGGAGTCATGTTCATGTTAACTCAGAAA
CTACGGAAAAGTTACGACAGGAGTAA

Upstream 100 bases:

>100_bases
GAATGGCTAAAATTTATGACTCTAGCAAACTAGCTCTTAACACAAAATGACCAATGAATCGTATAGTGGAATTGTGGACA
ATTTCCTAAAAACAAACAAT

Downstream 100 bases:

>100_bases
GTTGATATAATCATTTTTCTAGAAAGATAAAATAATGATTCACTTAATTATTATCAGCAATATCTGAAGTTAAAAATAAA
TTAATTAAGAAGATTTTATT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MKPITILGSTGSIGTQTLNIVAHNPNKFRVIGLAAGSNVEILAQQVRQFCPQIVAINDKSKFRELQEAIADLQPQPILVA
DQDGVIQVARYGESEVVVTGIVGCAGLLPTIAAIEAGKDIALANKETLIAAGPVVNPLIEKYRVKLLPADSEHSAIFQCL
QGLPLEGLRRIILTASGGAFRDWPIEKLSKVKVADAIKHPNWSMGKKITVDSATMMNKGLEVIEAHYLFGLNYDNIDIVI
HPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWKQLDLVKAGSLTFKEPDNLKYPCIQLAYTAGRMGGS
MPGVLNAANEQAVALFLEEKIAFLDIPKLIEYVCEKHNSNYQENPSLDDILAADKWARKEVLAASSIVNNSLINLSLVNL
EENPTEIFTKIENEQIEFNDFYQRGLAKYEQQDYQSALAEFDRAIDIDSSHIDAYIYRGDAKDKLEDYEGAIADYNEAIK
IDSSHPKAYYSRENVLRKAGDSREAIADYDQAIKLDPNYTPTKNWSHVHVNSETTEKLRQE

Sequences:

>Translated_541_residues
MKPITILGSTGSIGTQTLNIVAHNPNKFRVIGLAAGSNVEILAQQVRQFCPQIVAINDKSKFRELQEAIADLQPQPILVA
DQDGVIQVARYGESEVVVTGIVGCAGLLPTIAAIEAGKDIALANKETLIAAGPVVNPLIEKYRVKLLPADSEHSAIFQCL
QGLPLEGLRRIILTASGGAFRDWPIEKLSKVKVADAIKHPNWSMGKKITVDSATMMNKGLEVIEAHYLFGLNYDNIDIVI
HPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWKQLDLVKAGSLTFKEPDNLKYPCIQLAYTAGRMGGS
MPGVLNAANEQAVALFLEEKIAFLDIPKLIEYVCEKHNSNYQENPSLDDILAADKWARKEVLAASSIVNNSLINLSLVNL
EENPTEIFTKIENEQIEFNDFYQRGLAKYEQQDYQSALAEFDRAIDIDSSHIDAYIYRGDAKDKLEDYEGAIADYNEAIK
IDSSHPKAYYSRENVLRKAGDSREAIADYDQAIKLDPNYTPTKNWSHVHVNSETTEKLRQE
>Mature_541_residues
MKPITILGSTGSIGTQTLNIVAHNPNKFRVIGLAAGSNVEILAQQVRQFCPQIVAINDKSKFRELQEAIADLQPQPILVA
DQDGVIQVARYGESEVVVTGIVGCAGLLPTIAAIEAGKDIALANKETLIAAGPVVNPLIEKYRVKLLPADSEHSAIFQCL
QGLPLEGLRRIILTASGGAFRDWPIEKLSKVKVADAIKHPNWSMGKKITVDSATMMNKGLEVIEAHYLFGLNYDNIDIVI
HPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWKQLDLVKAGSLTFKEPDNLKYPCIQLAYTAGRMGGS
MPGVLNAANEQAVALFLEEKIAFLDIPKLIEYVCEKHNSNYQENPSLDDILAADKWARKEVLAASSIVNNSLINLSLVNL
EENPTEIFTKIENEQIEFNDFYQRGLAKYEQQDYQSALAEFDRAIDIDSSHIDAYIYRGDAKDKLEDYEGAIADYNEAIK
IDSSHPKAYYSRENVLRKAGDSREAIADYDQAIKLDPNYTPTKNWSHVHVNSETTEKLRQE

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=400, Percent_Identity=44.5, Blast_Score=327, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 60205; Mature: 60205

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPITILGSTGSIGTQTLNIVAHNPNKFRVIGLAAGSNVEILAQQVRQFCPQIVAINDKS
CCCEEEEECCCCCCCEEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHCCCEEEECCHH
KFRELQEAIADLQPQPILVADQDGVIQVARYGESEVVVTGIVGCAGLLPTIAAIEAGKDI
HHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCE
ALANKETLIAAGPVVNPLIEKYRVKLLPADSEHSAIFQCLQGLPLEGLRRIILTASGGAF
EEECCCEEEEECCHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCHHHHEEEEEEECCCCC
RDWPIEKLSKVKVADAIKHPNWSMGKKITVDSATMMNKGLEVIEAHYLFGLNYDNIDIVI
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHCCHHHEEEEEEEEECCCCEEEEE
HPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWKQLDLVKAGSLTFKEP
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCCHHHHCCHHHHHEEEECCEEECCC
DNLKYPCIQLAYTAGRMGGSMPGVLNAANEQAVALFLEEKIAFLDIPKLIEYVCEKHNSN
CCCCCCHHHEEEHHHHCCCCCCCCEECCCCCEEEEHHHHHHHHCCHHHHHHHHHHHCCCC
YQENPSLDDILAADKWARKEVLAASSIVNNSLINLSLVNLEENPTEIFTKIENEQIEFND
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCCCHHH
FYQRGLAKYEQQDYQSALAEFDRAIDIDSSHIDAYIYRGDAKDKLEDYEGAIADYNEAIK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCHHCCCCEEE
IDSSHPKAYYSRENVLRKAGDSREAIADYDQAIKLDPNYTPTKNWSHVHVNSETTEKLRQ
ECCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCCCCCCCCEEEECCHHHHHHHC
E
C
>Mature Secondary Structure
MKPITILGSTGSIGTQTLNIVAHNPNKFRVIGLAAGSNVEILAQQVRQFCPQIVAINDKS
CCCEEEEECCCCCCCEEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHCCCEEEECCHH
KFRELQEAIADLQPQPILVADQDGVIQVARYGESEVVVTGIVGCAGLLPTIAAIEAGKDI
HHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCE
ALANKETLIAAGPVVNPLIEKYRVKLLPADSEHSAIFQCLQGLPLEGLRRIILTASGGAF
EEECCCEEEEECCHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCHHHHEEEEEEECCCCC
RDWPIEKLSKVKVADAIKHPNWSMGKKITVDSATMMNKGLEVIEAHYLFGLNYDNIDIVI
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHCCHHHEEEEEEEEECCCCEEEEE
HPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWKQLDLVKAGSLTFKEP
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCCHHHHCCHHHHHEEEECCEEECCC
DNLKYPCIQLAYTAGRMGGSMPGVLNAANEQAVALFLEEKIAFLDIPKLIEYVCEKHNSN
CCCCCCHHHEEEHHHHCCCCCCCCEECCCCCEEEEHHHHHHHHCCHHHHHHHHHHHCCCC
YQENPSLDDILAADKWARKEVLAASSIVNNSLINLSLVNLEENPTEIFTKIENEQIEFND
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCCCHHH
FYQRGLAKYEQQDYQSALAEFDRAIDIDSSHIDAYIYRGDAKDKLEDYEGAIADYNEAIK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCHHCCCCEEE
IDSSHPKAYYSRENVLRKAGDSREAIADYDQAIKLDPNYTPTKNWSHVHVNSETTEKLRQ
ECCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCCCCCCCCEEEECCHHHHHHHC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA