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The map label for this gene is betA [H]

Identifier: 16119877

GI number: 16119877

Start: 74856

End: 76481

Strand: Direct

Name: betA [H]

Synonym: Atu6063

Alternate gene names: 16119877

Gene position: 74856-76481 (Clockwise)

Preceding gene: 16119876

Following gene: 159161967

Centisome position: 34.94

GC content: 58.98

Gene sequence:

>1626_bases
TTGAAGCAAGTAGAAGCTGATGAATTCGATTTCATCGTCGTCGGAGGAGGATCCGCTGGCGCTGCCGTCGCTGCAAGATT
GGCTGAGCGTGCGGACTTGCGGGTTCTGCTCCTGGAAGCTGGTCGACAGCAGTCCGGCATCCGGTTCCGGCTGCCGATAT
TGACTCCGTTCGCGCTTGCGAAAGAGGATGCAGTCTGGAACTTCACGACATTGCCTGAACCCGGCCTCAATGGCAGGGAA
CTTGTCTGGCCGCGCGGCAGGGGACTTGGGGGTTCCTCTCTCATCAATGGCATGCTCTGGGTACGGGGAGACCCGGTGGA
GTATGACCTCTGGGCTGCCTCAGGCTGTACCGGCTGGTCTTATGGCGATCTGCTGGATTTCTTCAAGCGCAGCGAAACAT
ACATTCCCGGTGATCCGGCGAGCAGAGGGCAGCGCGGGGCTGTGACGGTTACCAGGCACCGTCCAGCAGATCCTCTCTCT
GATGCCTTCCTGAAGGCTTGCGGTAACATGCAGGTATCACAGCAGGATGATTACAATGCGGGTATTTCGGAAGGCGCAGG
CTATCTCCAGTTCAACCAGCGCCGGGGATTGCGTCATGGCACAGACCGTGCCTATCTCTCGCCCGCCAGCAGGTGTGCTA
ACCTGACCATTCGCGAAGGCGCTGTTGCAAACCGCATCCTCTTCGAAGGGAAGAGAGCGATCGGGGTGGAGTATCGCGCG
GCTGATGGCCTGAGATGTGCCATCGCACGGCGGGAGGTCGTTCTATCCTGCGGCACCGTCCAATCCCCGAAGCTGCTTGA
GCTTTCGGGTATAGGGGACGGTGAGGTGCTTGGCCGGGCAGGTATCGTGCCACTGGTGCACCTCCCGGGCGTCGGAGAAA
ATCTGCGCGATCACCTTAATGTGCGCGTCGGATTTCGTACCCGTTTCCGCGGCACCCTGAATGATGTCCAACACAGCTAC
GTCTGGAAGGTACGCGCCATGCTTTGCTGGCTTGCGCGAGGCGGCGGTCCCCTATCTACCATAGGGGCGACAGCCCATGC
ATTTGTGAGAACCCGGTCGGACCTCGAACGGGCGGACGTGAAAATCCAGATGCTGCATTTCAGTGCACCCCACAATACCG
GAAATATCAGCGGACGTCTGGATGAGTTTCCCGGCTTCAGCATCTCGACGTTCGTCCTGAGGCCGAATTCGACGGGTTCC
AGCCACATCCGGTCGGGCGCCGCCGCGGAGCCGCCGGCGATCGTTGCGAACTACCTTTCACACGAGGAGGATCTCCGCTC
GATGCTCGGTGCCTTTCGATTCATCAACAGAATTGCCTCGGATTCGGTCTTTGATGATCTTATGGTCTCACGGGACAACG
ACCTCGCGGGTCTGCAGAGCGATCAGGACATCCTGGAATGGGCAAAAACAACCGGTCTGACGTCCTACCATCCCATCGGA
ACGTGCAAGATGGGTACGGATTCCGCAAGCGTCGTCGATCCGAGACTGAGAGTGATCGGTGTTGACGGACTGAGAGTCGT
TGATGCGTCCGTCATGCCGACAATGCCATCCTCCAACACGCACGGACCCACCGTCATGATTGGGGAGAAGGGGGCGGCAA
TGATCCTGGAGGATAGTTTGTCGTGA

Upstream 100 bases:

>100_bases
ATGAAGTGGTCTCAATCCACGCAGCGCTGGCTCGTTCGAGGCGAAACGGTTCAACAGGAACGCCGGTAAAGTTTCATTCT
CAACACGTGGGAAGAAAATC

Downstream 100 bases:

>100_bases
TAGTCGTTCGACATTGACAGGTTCAGCGTCTGTGGGTGCCGCCCAAATTCAGAAGGAGAATATTTTGATCCGAGACCTGG
ACCTGGTTCGCAATGACTTT

Product: GMC family oxidoreductase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MKQVEADEFDFIVVGGGSAGAAVAARLAERADLRVLLLEAGRQQSGIRFRLPILTPFALAKEDAVWNFTTLPEPGLNGRE
LVWPRGRGLGGSSLINGMLWVRGDPVEYDLWAASGCTGWSYGDLLDFFKRSETYIPGDPASRGQRGAVTVTRHRPADPLS
DAFLKACGNMQVSQQDDYNAGISEGAGYLQFNQRRGLRHGTDRAYLSPASRCANLTIREGAVANRILFEGKRAIGVEYRA
ADGLRCAIARREVVLSCGTVQSPKLLELSGIGDGEVLGRAGIVPLVHLPGVGENLRDHLNVRVGFRTRFRGTLNDVQHSY
VWKVRAMLCWLARGGGPLSTIGATAHAFVRTRSDLERADVKIQMLHFSAPHNTGNISGRLDEFPGFSISTFVLRPNSTGS
SHIRSGAAAEPPAIVANYLSHEEDLRSMLGAFRFINRIASDSVFDDLMVSRDNDLAGLQSDQDILEWAKTTGLTSYHPIG
TCKMGTDSASVVDPRLRVIGVDGLRVVDASVMPTMPSSNTHGPTVMIGEKGAAMILEDSLS

Sequences:

>Translated_541_residues
MKQVEADEFDFIVVGGGSAGAAVAARLAERADLRVLLLEAGRQQSGIRFRLPILTPFALAKEDAVWNFTTLPEPGLNGRE
LVWPRGRGLGGSSLINGMLWVRGDPVEYDLWAASGCTGWSYGDLLDFFKRSETYIPGDPASRGQRGAVTVTRHRPADPLS
DAFLKACGNMQVSQQDDYNAGISEGAGYLQFNQRRGLRHGTDRAYLSPASRCANLTIREGAVANRILFEGKRAIGVEYRA
ADGLRCAIARREVVLSCGTVQSPKLLELSGIGDGEVLGRAGIVPLVHLPGVGENLRDHLNVRVGFRTRFRGTLNDVQHSY
VWKVRAMLCWLARGGGPLSTIGATAHAFVRTRSDLERADVKIQMLHFSAPHNTGNISGRLDEFPGFSISTFVLRPNSTGS
SHIRSGAAAEPPAIVANYLSHEEDLRSMLGAFRFINRIASDSVFDDLMVSRDNDLAGLQSDQDILEWAKTTGLTSYHPIG
TCKMGTDSASVVDPRLRVIGVDGLRVVDASVMPTMPSSNTHGPTVMIGEKGAAMILEDSLS
>Mature_541_residues
MKQVEADEFDFIVVGGGSAGAAVAARLAERADLRVLLLEAGRQQSGIRFRLPILTPFALAKEDAVWNFTTLPEPGLNGRE
LVWPRGRGLGGSSLINGMLWVRGDPVEYDLWAASGCTGWSYGDLLDFFKRSETYIPGDPASRGQRGAVTVTRHRPADPLS
DAFLKACGNMQVSQQDDYNAGISEGAGYLQFNQRRGLRHGTDRAYLSPASRCANLTIREGAVANRILFEGKRAIGVEYRA
ADGLRCAIARREVVLSCGTVQSPKLLELSGIGDGEVLGRAGIVPLVHLPGVGENLRDHLNVRVGFRTRFRGTLNDVQHSY
VWKVRAMLCWLARGGGPLSTIGATAHAFVRTRSDLERADVKIQMLHFSAPHNTGNISGRLDEFPGFSISTFVLRPNSTGS
SHIRSGAAAEPPAIVANYLSHEEDLRSMLGAFRFINRIASDSVFDDLMVSRDNDLAGLQSDQDILEWAKTTGLTSYHPIG
TCKMGTDSASVVDPRLRVIGVDGLRVVDASVMPTMPSSNTHGPTVMIGEKGAAMILEDSLS

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=542, Percent_Identity=35.7933579335793, Blast_Score=308, Evalue=1e-83,
Organism=Escherichia coli, GI1786503, Length=540, Percent_Identity=37.2222222222222, Blast_Score=316, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17532301, Length=560, Percent_Identity=31.6071428571429, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24642048, Length=575, Percent_Identity=36.1739130434783, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI45549471, Length=569, Percent_Identity=34.622144112478, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI45551458, Length=569, Percent_Identity=34.622144112478, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17137792, Length=552, Percent_Identity=36.0507246376812, Blast_Score=272, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24642055, Length=577, Percent_Identity=34.315424610052, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24642042, Length=572, Percent_Identity=34.7902097902098, Blast_Score=267, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24642059, Length=569, Percent_Identity=34.9736379613357, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI18859995, Length=572, Percent_Identity=33.5664335664336, Blast_Score=251, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24642039, Length=584, Percent_Identity=32.5342465753425, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24650267, Length=564, Percent_Identity=35.1063829787234, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24642051, Length=567, Percent_Identity=31.5696649029982, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24642035, Length=573, Percent_Identity=31.9371727748691, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI18859993, Length=578, Percent_Identity=29.9307958477509, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24642037, Length=575, Percent_Identity=31.6521739130435, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24645930, Length=576, Percent_Identity=30.2083333333333, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24642057, Length=583, Percent_Identity=30.5317324185249, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 58515; Mature: 58515

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVEADEFDFIVVGGGSAGAAVAARLAERADLRVLLLEAGRQQSGIRFRLPILTPFALA
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEECCCCCHHHC
KEDAVWNFTTLPEPGLNGRELVWPRGRGLGGSSLINGMLWVRGDPVEYDLWAASGCTGWS
CCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHCCEEEEECCCCEEEEEECCCCCCCC
YGDLLDFFKRSETYIPGDPASRGQRGAVTVTRHRPADPLSDAFLKACGNMQVSQQDDYNA
HHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCC
GISEGAGYLQFNQRRGLRHGTDRAYLSPASRCANLTIREGAVANRILFEGKRAIGVEYRA
CCCCCCCEEEECCCCCCCCCCCCHHCCCHHHHCCCEEECCCHHHHHHCCCCHHEEEEEEC
ADGLRCAIARREVVLSCGTVQSPKLLELSGIGDGEVLGRAGIVPLVHLPGVGENLRDHLN
CCCCEEEEECCEEEEECCCCCCCCEEEEECCCCCHHHCCCCCEEEEECCCCCCCHHHCCE
VRVGFRTRFRGTLNDVQHSYVWKVRAMLCWLARGGGPLSTIGATAHAFVRTRSDLERADV
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCE
KIQMLHFSAPHNTGNISGRLDEFPGFSISTFVLRPNSTGSSHIRSGAAAEPPAIVANYLS
EEEEEEEECCCCCCCCCCCHHCCCCCEEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHC
HEEDLRSMLGAFRFINRIASDSVFDDLMVSRDNDLAGLQSDQDILEWAKTTGLTSYHPIG
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCE
TCKMGTDSASVVDPRLRVIGVDGLRVVDASVMPTMPSSNTHGPTVMIGEKGAAMILEDSL
EEEECCCCCCEECCCEEEEECCCCEEECCCCCCCCCCCCCCCCEEEECCCCCEEEEECCC
S
C
>Mature Secondary Structure
MKQVEADEFDFIVVGGGSAGAAVAARLAERADLRVLLLEAGRQQSGIRFRLPILTPFALA
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEECCCCCHHHC
KEDAVWNFTTLPEPGLNGRELVWPRGRGLGGSSLINGMLWVRGDPVEYDLWAASGCTGWS
CCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHCCEEEEECCCCEEEEEECCCCCCCC
YGDLLDFFKRSETYIPGDPASRGQRGAVTVTRHRPADPLSDAFLKACGNMQVSQQDDYNA
HHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCC
GISEGAGYLQFNQRRGLRHGTDRAYLSPASRCANLTIREGAVANRILFEGKRAIGVEYRA
CCCCCCCEEEECCCCCCCCCCCCHHCCCHHHHCCCEEECCCHHHHHHCCCCHHEEEEEEC
ADGLRCAIARREVVLSCGTVQSPKLLELSGIGDGEVLGRAGIVPLVHLPGVGENLRDHLN
CCCCEEEEECCEEEEECCCCCCCCEEEEECCCCCHHHCCCCCEEEEECCCCCCCHHHCCE
VRVGFRTRFRGTLNDVQHSYVWKVRAMLCWLARGGGPLSTIGATAHAFVRTRSDLERADV
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCE
KIQMLHFSAPHNTGNISGRLDEFPGFSISTFVLRPNSTGSSHIRSGAAAEPPAIVANYLS
EEEEEEEECCCCCCCCCCCHHCCCCCEEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHC
HEEDLRSMLGAFRFINRIASDSVFDDLMVSRDNDLAGLQSDQDILEWAKTTGLTSYHPIG
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCE
TCKMGTDSASVVDPRLRVIGVDGLRVVDASVMPTMPSSNTHGPTVMIGEKGAAMILEDSL
EEEECCCCCCEECCCEEEEECCCCEEECCCCCCCCCCCCCCCCEEEECCCCCEEEEECCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA