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The map label for this gene is hisI [H]

Identifier: 160902485

GI number: 160902485

Start: 1088402

End: 1089058

Strand: Direct

Name: hisI [H]

Synonym: Pmob_1022

Alternate gene names: 160902485

Gene position: 1088402-1089058 (Clockwise)

Preceding gene: 160902484

Following gene: 160902486

Centisome position: 50.17

GC content: 32.72

Gene sequence:

>657_bases
ATGTTAGATTATAAACAAATAATAGACAAATTAGATTGGGAAAAAAACAATGGCCTCATACCTGTAATAGTTCAAGGTCT
CGATGGTGACGTATTAACTTTAGGTTATACAGACAAAGAGGCTCTTAGTAAAACTCTACAAACAGGATATGTTCATTATT
ACTCAAGAAGCAAAGAAAGAATCAGAATGAAAGGAGAAACAAGCGGGAACTATCAAAAATTGAAAGAAGCGTTTGTAGAT
TGTGATAACGACACATTGCTCTTAAAAGTTGATCAAACAGGACCAGCTTGCCACTTAGGAACGAAAAGTTGTTTTAGAAA
AATCGAACAAATTGACAAACTACCTGAATCTAATATAGATTACTCACTAGATTTTCTGAACCAATTAAAGGAAATTATAA
AAGAAAGAAAAAAGAACCCAAAAGAAGGATCTTACACAACTTATCTGTTTAATGAAGGAAAGGAAAAAATCTATAAAAAG
TTTGGAGAAGAAGCAGTTGAAGTTTTAGTTGCTCCAAATAGGGAAAGAACAATATACGAAACCGCTGATATGATTTATCA
TTTGTTGGTGTTATTAACCTACGAAGGAATAGATATAGGAGAAGTTGTTCAAGAATTAAAAAAGAGACACTCGCCAGAGG
GAGGTAAGCAAAGTTGA

Upstream 100 bases:

>100_bases
TTTCAAATAGGTGCAGATGCTGCTCTTGCTGCATCCATATTCCATTATGGTATCTACACTGCAAAAGACCTCAAAATCCA
ATTGAAGAAGGTGGGAATAA

Downstream 100 bases:

>100_bases
AATTCAACCCAATTTTAGAAAGTTTTGAGGAATACAAACCTTCTAATACTTATATCAACGATGGATTCATAGATCTCAGC
AAAAATGAAAATCCATTCGA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MLDYKQIIDKLDWEKNNGLIPVIVQGLDGDVLTLGYTDKEALSKTLQTGYVHYYSRSKERIRMKGETSGNYQKLKEAFVD
CDNDTLLLKVDQTGPACHLGTKSCFRKIEQIDKLPESNIDYSLDFLNQLKEIIKERKKNPKEGSYTTYLFNEGKEKIYKK
FGEEAVEVLVAPNRERTIYETADMIYHLLVLLTYEGIDIGEVVQELKKRHSPEGGKQS

Sequences:

>Translated_218_residues
MLDYKQIIDKLDWEKNNGLIPVIVQGLDGDVLTLGYTDKEALSKTLQTGYVHYYSRSKERIRMKGETSGNYQKLKEAFVD
CDNDTLLLKVDQTGPACHLGTKSCFRKIEQIDKLPESNIDYSLDFLNQLKEIIKERKKNPKEGSYTTYLFNEGKEKIYKK
FGEEAVEVLVAPNRERTIYETADMIYHLLVLLTYEGIDIGEVVQELKKRHSPEGGKQS
>Mature_218_residues
MLDYKQIIDKLDWEKNNGLIPVIVQGLDGDVLTLGYTDKEALSKTLQTGYVHYYSRSKERIRMKGETSGNYQKLKEAFVD
CDNDTLLLKVDQTGPACHLGTKSCFRKIEQIDKLPESNIDYSLDFLNQLKEIIKERKKNPKEGSYTTYLFNEGKEKIYKK
FGEEAVEVLVAPNRERTIYETADMIYHLLVLLTYEGIDIGEVVQELKKRHSPEGGKQS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=205, Percent_Identity=44.8780487804878, Blast_Score=178, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319819, Length=207, Percent_Identity=31.8840579710145, Blast_Score=95, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 25095; Mature: 25095

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYKQIIDKLDWEKNNGLIPVIVQGLDGDVLTLGYTDKEALSKTLQTGYVHYYSRSKER
CCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHH
IRMKGETSGNYQKLKEAFVDCDNDTLLLKVDQTGPACHLGTKSCFRKIEQIDKLPESNID
EEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEECCHHHHHHHHHHHHCCCCCCCC
YSLDFLNQLKEIIKERKKNPKEGSYTTYLFNEGKEKIYKKFGEEAVEVLVAPNRERTIYE
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
TADMIYHLLVLLTYEGIDIGEVVQELKKRHSPEGGKQS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLDYKQIIDKLDWEKNNGLIPVIVQGLDGDVLTLGYTDKEALSKTLQTGYVHYYSRSKER
CCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHH
IRMKGETSGNYQKLKEAFVDCDNDTLLLKVDQTGPACHLGTKSCFRKIEQIDKLPESNID
EEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEECCHHHHHHHHHHHHCCCCCCCC
YSLDFLNQLKEIIKERKKNPKEGSYTTYLFNEGKEKIYKKFGEEAVEVLVAPNRERTIYE
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
TADMIYHLLVLLTYEGIDIGEVVQELKKRHSPEGGKQS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA