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The map label for this gene is mtnA1 [H]

Identifier: 160902112

GI number: 160902112

Start: 689338

End: 690456

Strand: Direct

Name: mtnA1 [H]

Synonym: Pmob_0639

Alternate gene names: 160902112

Gene position: 689338-690456 (Clockwise)

Preceding gene: 160902111

Following gene: 160902113

Centisome position: 31.77

GC content: 36.01

Gene sequence:

>1119_bases
GTGTGGTTTAAAGAAGGTTTCAAAGTTGCTAAAGATTGTAAAATCATAATAATTGAGGAGGTTAGAATAATAGTTATGAC
CGTTGTTCCTGTTAAACTTAACGAACTAAAAAACAAATTAGTTATCATTGATCAAACTTTGTTGCCCAATGAGGAAAAAT
TTTTAGAATTAGATAATCCTGAAGAAATTTGGGAAGCAATTAAGAAGCTAAGAGTCAGAGGGGCTCCCGCCATTGGTATT
GCTGCTGCCTTTGGCCTTTACGTCTCTACTTTAAAGTCCAAAGCTGCAAATGTAGCTCAATTTAAAAAAGAATTTGAAGA
AGTCAGGGATTATTTTGCGACCTCAAGACCTACCGCTGTGAACTTGTTTTGGGCCTTAAAAAGAATGACCCGAAGGTTTG
AACAAGAAGAAGATAAGACTGTTGATAAAATTAAACAAGCATTGCTTGATGAAAGTGAAAAAATATTTGCAGAAGATCAG
GAAATGAGCAAAGCCATTGGTAAACACGGCTTGTCGTTATTGAAACCAGGTATGGGGCTTTTAACGCACTGTAATGCTGG
GGGTTTGGCTTCATCAGGTTATGGAACTGCTTTAGCTCCAATATATTTAGGCCATGAAAAGGGTTATAATTTTAAAGTAT
ATGCTGATGAAACAAGACCCTTATTACAAGGGGCCAGACTTACTACATATGAATTATACAAAGCTGGAATAGATGTAACT
TTAATCTGTGATGATATGGCTTCTTTGGTTATGAAAGAAGGTAAGATTGACGCAGTACTTGTTGGTTGTGATCGAGTAGC
AGCTAATGGAGACACAGCCAATAAAATAGGAACTTCTGGACTAGCCGTATTGGCTAAAGAATATGGTATACCAATGTACA
TTCTTGGACCTACTTCTACGATTGACTTAGATGCTTCTACAGGTGAGGATATTAAAATTGAACTCCGTGATGAAGAAGAA
GTTGTTAACGGATTTGGTAGACGAACTGCCCTTAAAGGGGTAAAAGCTTACAATCCTGCTTTTGATGTTACTGATGCTAA
ATATATTACAGCAATCATTACTGAAAAGGGTATTGTTATGCAACCATATAAAGAAAGTTTGAAAAAGTTATTTGAATAA

Upstream 100 bases:

>100_bases
CGCAACCAATACAAACTGGCTGCTGGGTGAAGGGGCTATAAAAAAGATTCTATGTAACTTAGAATGATGTAGGTATTTTA
AAATTTTTTAGATTCTAGAA

Downstream 100 bases:

>100_bases
TACAATAAAAAAGAGAAACAACGGGGAGTGTAAGAAAATTAATGGAGAAACAACTAAAAGTATTAGCTGTTGGTGATCCG
GCTGTCTATGTCTATGTGGA

Product: aIF-2BI family translation initiation factor

Products: NA

Alternate protein names: M1Pi 1; MTR-1-P isomerase 1; S-methyl-5-thioribose-1-phosphate isomerase 1 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MWFKEGFKVAKDCKIIIIEEVRIIVMTVVPVKLNELKNKLVIIDQTLLPNEEKFLELDNPEEIWEAIKKLRVRGAPAIGI
AAAFGLYVSTLKSKAANVAQFKKEFEEVRDYFATSRPTAVNLFWALKRMTRRFEQEEDKTVDKIKQALLDESEKIFAEDQ
EMSKAIGKHGLSLLKPGMGLLTHCNAGGLASSGYGTALAPIYLGHEKGYNFKVYADETRPLLQGARLTTYELYKAGIDVT
LICDDMASLVMKEGKIDAVLVGCDRVAANGDTANKIGTSGLAVLAKEYGIPMYILGPTSTIDLDASTGEDIKIELRDEEE
VVNGFGRRTALKGVKAYNPAFDVTDAKYITAIITEKGIVMQPYKESLKKLFE

Sequences:

>Translated_372_residues
MWFKEGFKVAKDCKIIIIEEVRIIVMTVVPVKLNELKNKLVIIDQTLLPNEEKFLELDNPEEIWEAIKKLRVRGAPAIGI
AAAFGLYVSTLKSKAANVAQFKKEFEEVRDYFATSRPTAVNLFWALKRMTRRFEQEEDKTVDKIKQALLDESEKIFAEDQ
EMSKAIGKHGLSLLKPGMGLLTHCNAGGLASSGYGTALAPIYLGHEKGYNFKVYADETRPLLQGARLTTYELYKAGIDVT
LICDDMASLVMKEGKIDAVLVGCDRVAANGDTANKIGTSGLAVLAKEYGIPMYILGPTSTIDLDASTGEDIKIELRDEEE
VVNGFGRRTALKGVKAYNPAFDVTDAKYITAIITEKGIVMQPYKESLKKLFE
>Mature_372_residues
MWFKEGFKVAKDCKIIIIEEVRIIVMTVVPVKLNELKNKLVIIDQTLLPNEEKFLELDNPEEIWEAIKKLRVRGAPAIGI
AAAFGLYVSTLKSKAANVAQFKKEFEEVRDYFATSRPTAVNLFWALKRMTRRFEQEEDKTVDKIKQALLDESEKIFAEDQ
EMSKAIGKHGLSLLKPGMGLLTHCNAGGLASSGYGTALAPIYLGHEKGYNFKVYADETRPLLQGARLTTYELYKAGIDVT
LICDDMASLVMKEGKIDAVLVGCDRVAANGDTANKIGTSGLAVLAKEYGIPMYILGPTSTIDLDASTGEDIKIELRDEEE
VVNGFGRRTALKGVKAYNPAFDVTDAKYITAIITEKGIVMQPYKESLKKLFE

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=336, Percent_Identity=39.8809523809524, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI23943880, Length=326, Percent_Identity=35.8895705521472, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI78000156, Length=159, Percent_Identity=27.6729559748428, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI78000158, Length=159, Percent_Identity=27.6729559748428, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI187607323, Length=159, Percent_Identity=27.6729559748428, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=338, Percent_Identity=35.207100591716, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17557123, Length=284, Percent_Identity=27.8169014084507, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6325375, Length=380, Percent_Identity=32.8947368421053, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322878, Length=234, Percent_Identity=29.0598290598291, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21357667, Length=355, Percent_Identity=39.4366197183099, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24651647, Length=355, Percent_Identity=39.4366197183099, Blast_Score=241, Evalue=6e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 41261; Mature: 41261

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFKEGFKVAKDCKIIIIEEVRIIVMTVVPVKLNELKNKLVIIDQTLLPNEEKFLELDNP
CCCHHCCCHHCCCEEEEEECCEEEEEEECCHHHHHCCCEEEEEECCCCCCCHHEEECCCH
EEIWEAIKKLRVRGAPAIGIAAAFGLYVSTLKSKAANVAQFKKEFEEVRDYFATSRPTAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
NLFWALKRMTRRFEQEEDKTVDKIKQALLDESEKIFAEDQEMSKAIGKHGLSLLKPGMGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCC
LTHCNAGGLASSGYGTALAPIYLGHEKGYNFKVYADETRPLLQGARLTTYELYKAGIDVT
EEECCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCHHHCCCCCHHHHHHHCCCCEE
LICDDMASLVMKEGKIDAVLVGCDRVAANGDTANKIGTSGLAVLAKEYGIPMYILGPTST
EEHHHHHHHHHHCCCCCEEEEECCCEECCCCCCHHCCCCHHHHHHHHCCCCEEEECCCCE
IDLDASTGEDIKIELRDEEEVVNGFGRRTALKGVKAYNPAFDVTDAKYITAIITEKGIVM
EEECCCCCCCEEEEECCHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHEEEEECCCCCEE
QPYKESLKKLFE
CHHHHHHHHHCC
>Mature Secondary Structure
MWFKEGFKVAKDCKIIIIEEVRIIVMTVVPVKLNELKNKLVIIDQTLLPNEEKFLELDNP
CCCHHCCCHHCCCEEEEEECCEEEEEEECCHHHHHCCCEEEEEECCCCCCCHHEEECCCH
EEIWEAIKKLRVRGAPAIGIAAAFGLYVSTLKSKAANVAQFKKEFEEVRDYFATSRPTAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
NLFWALKRMTRRFEQEEDKTVDKIKQALLDESEKIFAEDQEMSKAIGKHGLSLLKPGMGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCC
LTHCNAGGLASSGYGTALAPIYLGHEKGYNFKVYADETRPLLQGARLTTYELYKAGIDVT
EEECCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCHHHCCCCCHHHHHHHCCCCEE
LICDDMASLVMKEGKIDAVLVGCDRVAANGDTANKIGTSGLAVLAKEYGIPMYILGPTST
EEHHHHHHHHHHCCCCCEEEEECCCEECCCCCCHHCCCCHHHHHHHHCCCCEEEECCCCE
IDLDASTGEDIKIELRDEEEVVNGFGRRTALKGVKAYNPAFDVTDAKYITAIITEKGIVM
EEECCCCCCCEEEEECCHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHEEEEECCCCCEE
QPYKESLKKLFE
CHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA