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The map label for this gene is arlS [H]

Identifier: 160901587

GI number: 160901587

Start: 94006

End: 95283

Strand: Direct

Name: arlS [H]

Synonym: Pmob_0096

Alternate gene names: 160901587

Gene position: 94006-95283 (Clockwise)

Preceding gene: 160901586

Following gene: 160901588

Centisome position: 4.33

GC content: 32.16

Gene sequence:

>1278_bases
ATGAGTATAGTATTGACAATTGTTGGCATAGTGAGGATCGTTTTTGTACAATTCACACTTCAAAGTTACAACGACATGTA
TATTGCACAATTGAATGTAAGTGGACTGAATAGGGGAAATGCTAACAATCCTCAGGAACCTCTAGATTTGCTTTACCAAA
TTATGCAAGATTCAAGTGTATTGAGAAGAAGTTTATTATCAAACAGGATCGTCATTCTAGACGGACAGTTGATTTCAGAC
CCTTATGGTTTGATAAAGGAGAATTTCAAAATTCCTAGGTTACCGTATCTTTATGAATCTGATGGAATGTACTACATCTT
TGCAGGTGTTCCTATATTTGGTTCATCTCTTTTAATAGTCGGCGGACCATCTCTTGAGCTAACAGCTCTTTTGAGAAACT
TTGAAAAAGCCGTTTTTGTCATAATAACGACTGGTCTTTTTATATCACTATTGGTATCTTATTTTTTAGCAAAAAGCACA
CTAAAACCAGTAGTCAAAATGGCAGAACAAATATCTGAAATAGATGCCAATACCATAGATAAGAGGATATCAGAACAAAA
ATCACAAGAATTCGATATCTTCGCACAAAAATTAAATTCTATGTTGGATAGAATTGAAAATGCTTTTGAAATACAAAATC
AATTCGTTTCCGATGTTTCTCATGAGCTGAGAACACCTTTAACTTCTATAAATGGTTACATTAAAATGCTGAAAAGATGG
GGGAAAAACGATCCCAAAATTATGGAAGAATCACTGAACAGTATAGAAGCATCCAGCGAATATTTAAGGGATCTAGTTGA
ACAGCTCTTGCTTCTGACTAAAAACGATTACCAAATCAAAAAAGAAAATATTGATATTAAAAACGTAGTAAAAGAAACTT
TGAACCTTTTTAAATTAGAATTGAACGAATTCAATATAGATATACAAGGAAAAAGTTTTACAGTGAACAGCTCTAACGAA
TATCTCTCTTTAATCCTCAAAATTTTCATTGAAAACGCAATAAAATACTCATCAAATCAAAAAGAGATAACAATAAAATT
AGACCCAGATCAAAAGAGCATAAGTATACAAGACCATGGTATCGGTATTGAACAAACTAAATTAAAAAATATCTTTGAAA
GGTTCTACAAAGTGGACTCTTCTCGAAGCGATAAAGGCCATGGATTAGGATTATCAATAGCAAAAAAACTAGCTGATGCG
TTAGATATTGAATTAAAAGCCTATTCTGAATTAGGTAAAGGTAGTACTTTTACCTTGATCTTTTTGAATCAACTGTGA

Upstream 100 bases:

>100_bases
AATATAGAAACTGTGCGAGGTGTTGGTTACGTTATTAGGGAGAAAGAAAGTAAAACATAGTGCAATTTTTAGACAAACAA
TAGTTTTTACAGCCATTACT

Downstream 100 bases:

>100_bases
GGAGGAAGCTAACGTGGTTTATTTCGACAACAACGCAACTACCCAAGTTGATAGAGAGGTTGCTGATTTGATTTTGAAAT
ATATGACAGAATACTATGCA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSIVLTIVGIVRIVFVQFTLQSYNDMYIAQLNVSGLNRGNANNPQEPLDLLYQIMQDSSVLRRSLLSNRIVILDGQLISD
PYGLIKENFKIPRLPYLYESDGMYYIFAGVPIFGSSLLIVGGPSLELTALLRNFEKAVFVIITTGLFISLLVSYFLAKST
LKPVVKMAEQISEIDANTIDKRISEQKSQEFDIFAQKLNSMLDRIENAFEIQNQFVSDVSHELRTPLTSINGYIKMLKRW
GKNDPKIMEESLNSIEASSEYLRDLVEQLLLLTKNDYQIKKENIDIKNVVKETLNLFKLELNEFNIDIQGKSFTVNSSNE
YLSLILKIFIENAIKYSSNQKEITIKLDPDQKSISIQDHGIGIEQTKLKNIFERFYKVDSSRSDKGHGLGLSIAKKLADA
LDIELKAYSELGKGSTFTLIFLNQL

Sequences:

>Translated_425_residues
MSIVLTIVGIVRIVFVQFTLQSYNDMYIAQLNVSGLNRGNANNPQEPLDLLYQIMQDSSVLRRSLLSNRIVILDGQLISD
PYGLIKENFKIPRLPYLYESDGMYYIFAGVPIFGSSLLIVGGPSLELTALLRNFEKAVFVIITTGLFISLLVSYFLAKST
LKPVVKMAEQISEIDANTIDKRISEQKSQEFDIFAQKLNSMLDRIENAFEIQNQFVSDVSHELRTPLTSINGYIKMLKRW
GKNDPKIMEESLNSIEASSEYLRDLVEQLLLLTKNDYQIKKENIDIKNVVKETLNLFKLELNEFNIDIQGKSFTVNSSNE
YLSLILKIFIENAIKYSSNQKEITIKLDPDQKSISIQDHGIGIEQTKLKNIFERFYKVDSSRSDKGHGLGLSIAKKLADA
LDIELKAYSELGKGSTFTLIFLNQL
>Mature_424_residues
SIVLTIVGIVRIVFVQFTLQSYNDMYIAQLNVSGLNRGNANNPQEPLDLLYQIMQDSSVLRRSLLSNRIVILDGQLISDP
YGLIKENFKIPRLPYLYESDGMYYIFAGVPIFGSSLLIVGGPSLELTALLRNFEKAVFVIITTGLFISLLVSYFLAKSTL
KPVVKMAEQISEIDANTIDKRISEQKSQEFDIFAQKLNSMLDRIENAFEIQNQFVSDVSHELRTPLTSINGYIKMLKRWG
KNDPKIMEESLNSIEASSEYLRDLVEQLLLLTKNDYQIKKENIDIKNVVKETLNLFKLELNEFNIDIQGKSFTVNSSNEY
LSLILKIFIENAIKYSSNQKEITIKLDPDQKSISIQDHGIGIEQTKLKNIFERFYKVDSSRSDKGHGLGLSIAKKLADAL
DIELKAYSELGKGSTFTLIFLNQL

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=27.5423728813559, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790346, Length=246, Percent_Identity=27.2357723577236, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788393, Length=268, Percent_Identity=24.6268656716418, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788549, Length=215, Percent_Identity=28.8372093023256, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790861, Length=314, Percent_Identity=24.8407643312102, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1790551, Length=280, Percent_Identity=23.2142857142857, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=291, Percent_Identity=22.680412371134, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=29.9145299145299, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=235, Percent_Identity=27.6595744680851, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788713, Length=222, Percent_Identity=27.4774774774775, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=346, Percent_Identity=23.6994219653179, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789808, Length=238, Percent_Identity=22.2689075630252, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789149, Length=345, Percent_Identity=23.1884057971014, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=334, Percent_Identity=21.8562874251497, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788279, Length=320, Percent_Identity=26.25, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=23.5807860262009, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=25.8620689655172, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=284, Percent_Identity=23.943661971831, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=289, Percent_Identity=20.0692041522491, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48272; Mature: 48141

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVLTIVGIVRIVFVQFTLQSYNDMYIAQLNVSGLNRGNANNPQEPLDLLYQIMQDSSV
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
LRRSLLSNRIVILDGQLISDPYGLIKENFKIPRLPYLYESDGMYYIFAGVPIFGSSLLIV
HHHHHHHCCEEEEECCCCCCCHHHHHCCCCCCCCCCEEECCCEEEEEECCCCCCCCEEEE
GGPSLELTALLRNFEKAVFVIITTGLFISLLVSYFLAKSTLKPVVKMAEQISEIDANTID
ECCCHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
KRISEQKSQEFDIFAQKLNSMLDRIENAFEIQNQFVSDVSHELRTPLTSINGYIKMLKRW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GKNDPKIMEESLNSIEASSEYLRDLVEQLLLLTKNDYQIKKENIDIKNVVKETLNLFKLE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHEEE
LNEFNIDIQGKSFTVNSSNEYLSLILKIFIENAIKYSSNQKEITIKLDPDQKSISIQDHG
ECCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCC
IGIEQTKLKNIFERFYKVDSSRSDKGHGLGLSIAKKLADALDIELKAYSELGKGSTFTLI
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
FLNQL
EEECC
>Mature Secondary Structure 
SIVLTIVGIVRIVFVQFTLQSYNDMYIAQLNVSGLNRGNANNPQEPLDLLYQIMQDSSV
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
LRRSLLSNRIVILDGQLISDPYGLIKENFKIPRLPYLYESDGMYYIFAGVPIFGSSLLIV
HHHHHHHCCEEEEECCCCCCCHHHHHCCCCCCCCCCEEECCCEEEEEECCCCCCCCEEEE
GGPSLELTALLRNFEKAVFVIITTGLFISLLVSYFLAKSTLKPVVKMAEQISEIDANTID
ECCCHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
KRISEQKSQEFDIFAQKLNSMLDRIENAFEIQNQFVSDVSHELRTPLTSINGYIKMLKRW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GKNDPKIMEESLNSIEASSEYLRDLVEQLLLLTKNDYQIKKENIDIKNVVKETLNLFKLE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHEEE
LNEFNIDIQGKSFTVNSSNEYLSLILKIFIENAIKYSSNQKEITIKLDPDQKSISIQDHG
ECCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCC
IGIEQTKLKNIFERFYKVDSSRSDKGHGLGLSIAKKLADALDIELKAYSELGKGSTFTLI
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
FLNQL
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA