Click here to switch to the map view.

The map label for this gene is phoQ [H]

Identifier: 160877447

GI number: 160877447

Start: 5134775

End: 5136139

Strand: Direct

Name: phoQ [H]

Synonym: Sbal195_4345

Alternate gene names: 160877447

Gene position: 5134775-5136139 (Clockwise)

Preceding gene: 160877446

Following gene: 160877448

Centisome position: 96.03

GC content: 49.45

Gene sequence:

>1365_bases
ATGAGTAAACGTGCCATTGTGTGGCAAGTATTGAACTCCCTTAAAGCGCGCTTAGTGATTAGCGCGCTATTCTTTATCTT
AGTGTTATTGCCTTTGATCGGCGTCGCCTTAAACGATGCCTTTACCGAGCAAGTTAAAAGCGCGACCAAAAATGAACTTA
GCGCCTATGTCTATTCGATACTCGCGGTGACTGAAGTCGAGAATAAGCAAATCTCTATCCCAGAATTAGTACTCGAAAAT
CGTTTTAACCTCATTCAATCTGGGCTGTATGCCATTGCGACCACTGAAGATGCCAGCGGCAAACAAACGATCGTGTGGCA
CTCGCAATCTTTTATGGGCATGATGCCACCACCGCATTTTACCATCCCAGCAACGGGTCAAAGTGCCTTTGAGCAAATCG
AGCTCGCCGAACAACCCCATTTGATTTATAGCTTTAGCGTCAGTTTTGCCAGCCAAAATCAAAACGTGCCTGTGACGATT
CACATCATCAAGGACGAGCGCGAATTTCAGCAGCAAATCGATCAATTCAACCAACAGCTTTGGACTTGGCTGCTGATCCT
CATGTTCGTCATGCTCGTGTTCCAACTGAGCTGGCTAGTGTGGACGCTGCGGCCATTGGCACGCTTTACCCAAGAATTAC
ATTCCGTCGAGCAAGGTAAGTCGATGCAGCTAAGTAGTCAGTACCCCACTGAACTGCAAGCGGTTGCGCGGCAGCTCAAT
ATTTTGCTCAATACCGAACAAACCCAGCGCAAACGCTATCGTAATGCCTTGGCCGATCTTGCCCACAGCCTCAAAACACC
GCTGGCGGTGATCAAGAGTCAGGCCGACTTAAGCGAAGCCTCCAGCGAACAAGTGTCGGTGATCAGCCGCATTATTGGCC
ACCAGTTGAAACGCGCCCAAACGGCAGCGGCAGCCTCGTGGCATTTAGGGATTCGCGTCGATGACGTCGCCGCTAAGTTA
TTACGCACCTTAGCTAAAATTTATCGCGAGCCGCAAATCAACCTCAGCGGCGAGATGGCAGACGAAGCAGTATTCAAAGG
TGATGAAGCGGATCTCACGGAAATTCTCGGTAACGTGCTCGACAACGCCTGCAAAGCGGCAAAGTCCACGGTTAAATTAA
CCGTGACCGGCGATGCCTATCAATTGCTGATCTGCATCGAAGATGATGGGCCAGGGATCAGTGAAGCGCTGCAAAATCAA
ATCTTTGAACGCGGTATTCGCGCTGATTCCTATCATCAAGGTAATGGTATTGGGCTTGCGATCGTGCGCGATTTAGTCGA
CAGCTATAACGGCAGAATTTCAGTCTCACGTTCAGAAACCTTGGGCGGCGCCAAGTTCAGCATCAGCTTCGTGCACTCTA
TTTAA

Upstream 100 bases:

>100_bases
TTACGCAAAAAACTCGACCCTGATAATCAATACAACCTGATTGAAACCCTGCGCGGCCAAGGTTATCGCCTAAAAGCGTT
AACGCCCGAGCCAACTGCCG

Downstream 100 bases:

>100_bases
CCTTTAATTTCAATAATATAGATTTAAACCCCATCCTAAATTGCGGTTAAAAATAACTTTTTAACCGCAAAATGCTTTCA
GCTTATGTTCATATTCAAAC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSKRAIVWQVLNSLKARLVISALFFILVLLPLIGVALNDAFTEQVKSATKNELSAYVYSILAVTEVENKQISIPELVLEN
RFNLIQSGLYAIATTEDASGKQTIVWHSQSFMGMMPPPHFTIPATGQSAFEQIELAEQPHLIYSFSVSFASQNQNVPVTI
HIIKDEREFQQQIDQFNQQLWTWLLILMFVMLVFQLSWLVWTLRPLARFTQELHSVEQGKSMQLSSQYPTELQAVARQLN
ILLNTEQTQRKRYRNALADLAHSLKTPLAVIKSQADLSEASSEQVSVISRIIGHQLKRAQTAAAASWHLGIRVDDVAAKL
LRTLAKIYREPQINLSGEMADEAVFKGDEADLTEILGNVLDNACKAAKSTVKLTVTGDAYQLLICIEDDGPGISEALQNQ
IFERGIRADSYHQGNGIGLAIVRDLVDSYNGRISVSRSETLGGAKFSISFVHSI

Sequences:

>Translated_454_residues
MSKRAIVWQVLNSLKARLVISALFFILVLLPLIGVALNDAFTEQVKSATKNELSAYVYSILAVTEVENKQISIPELVLEN
RFNLIQSGLYAIATTEDASGKQTIVWHSQSFMGMMPPPHFTIPATGQSAFEQIELAEQPHLIYSFSVSFASQNQNVPVTI
HIIKDEREFQQQIDQFNQQLWTWLLILMFVMLVFQLSWLVWTLRPLARFTQELHSVEQGKSMQLSSQYPTELQAVARQLN
ILLNTEQTQRKRYRNALADLAHSLKTPLAVIKSQADLSEASSEQVSVISRIIGHQLKRAQTAAAASWHLGIRVDDVAAKL
LRTLAKIYREPQINLSGEMADEAVFKGDEADLTEILGNVLDNACKAAKSTVKLTVTGDAYQLLICIEDDGPGISEALQNQ
IFERGIRADSYHQGNGIGLAIVRDLVDSYNGRISVSRSETLGGAKFSISFVHSI
>Mature_453_residues
SKRAIVWQVLNSLKARLVISALFFILVLLPLIGVALNDAFTEQVKSATKNELSAYVYSILAVTEVENKQISIPELVLENR
FNLIQSGLYAIATTEDASGKQTIVWHSQSFMGMMPPPHFTIPATGQSAFEQIELAEQPHLIYSFSVSFASQNQNVPVTIH
IIKDEREFQQQIDQFNQQLWTWLLILMFVMLVFQLSWLVWTLRPLARFTQELHSVEQGKSMQLSSQYPTELQAVARQLNI
LLNTEQTQRKRYRNALADLAHSLKTPLAVIKSQADLSEASSEQVSVISRIIGHQLKRAQTAAAASWHLGIRVDDVAAKLL
RTLAKIYREPQINLSGEMADEAVFKGDEADLTEILGNVLDNACKAAKSTVKLTVTGDAYQLLICIEDDGPGISEALQNQI
FERGIRADSYHQGNGIGLAIVRDLVDSYNGRISVSRSETLGGAKFSISFVHSI

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=289, Percent_Identity=34.9480968858132, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788393, Length=271, Percent_Identity=25.0922509225092, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787894, Length=205, Percent_Identity=28.2926829268293, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=258, Percent_Identity=26.7441860465116, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=29.5652173913043, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50568; Mature: 50436

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRAIVWQVLNSLKARLVISALFFILVLLPLIGVALNDAFTEQVKSATKNELSAYVYSI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAVTEVENKQISIPELVLENRFNLIQSGLYAIATTEDASGKQTIVWHSQSFMGMMPPPHF
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCE
TIPATGQSAFEQIELAEQPHLIYSFSVSFASQNQNVPVTIHIIKDEREFQQQIDQFNQQL
ECCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
WTWLLILMFVMLVFQLSWLVWTLRPLARFTQELHSVEQGKSMQLSSQYPTELQAVARQLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHH
ILLNTEQTQRKRYRNALADLAHSLKTPLAVIKSQADLSEASSEQVSVISRIIGHQLKRAQ
HHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
TAAAASWHLGIRVDDVAAKLLRTLAKIYREPQINLSGEMADEAVFKGDEADLTEILGNVL
HHHHHHEEECEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
DNACKAAKSTVKLTVTGDAYQLLICIEDDGPGISEALQNQIFERGIRADSYHQGNGIGLA
HHHHHHCCCEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHH
IVRDLVDSYNGRISVSRSETLGGAKFSISFVHSI
HHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
SKRAIVWQVLNSLKARLVISALFFILVLLPLIGVALNDAFTEQVKSATKNELSAYVYSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAVTEVENKQISIPELVLENRFNLIQSGLYAIATTEDASGKQTIVWHSQSFMGMMPPPHF
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCE
TIPATGQSAFEQIELAEQPHLIYSFSVSFASQNQNVPVTIHIIKDEREFQQQIDQFNQQL
ECCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
WTWLLILMFVMLVFQLSWLVWTLRPLARFTQELHSVEQGKSMQLSSQYPTELQAVARQLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHH
ILLNTEQTQRKRYRNALADLAHSLKTPLAVIKSQADLSEASSEQVSVISRIIGHQLKRAQ
HHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
TAAAASWHLGIRVDDVAAKLLRTLAKIYREPQINLSGEMADEAVFKGDEADLTEILGNVL
HHHHHHEEECEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
DNACKAAKSTVKLTVTGDAYQLLICIEDDGPGISEALQNQIFERGIRADSYHQGNGIGLA
HHHHHHCCCEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHH
IVRDLVDSYNGRISVSRSETLGGAKFSISFVHSI
HHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA