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The map label for this gene is menH [H]

Identifier: 160877391

GI number: 160877391

Start: 5069487

End: 5070281

Strand: Direct

Name: menH [H]

Synonym: Sbal195_4289

Alternate gene names: 160877391

Gene position: 5069487-5070281 (Clockwise)

Preceding gene: 160877390

Following gene: 160877392

Centisome position: 94.8

GC content: 50.31

Gene sequence:

>795_bases
ATGCCAACCATGGCCCGTTACGGCGATCCTTCACTACCGACCTTAGTGCTACTACATGGCTTTTTAGGCACTAAGGCCGA
CTGGTTGCCGTTAATGCCTGCGCTAAGCCAGCACTTTCATTGTATTTGTTTGGATCTGCCGGGCCATGGAGATAATCAAG
CTGAAGGGTCGACTGAGGCTAAGCTCGATTTTGATTTTTGCGTCGAAAACATAGTGACGCGGCTCGATAGCCTTAATCCA
AGTCCCGAACCGTTTCATCTCTACGGTTATTCCTTAGGCGGGCGTATTGCCTTGCACCTTGCAAAAGCCTATCCGCAGCG
CTTGTTAAGTCTGAACCTCGAATCCTGCCATCCAGGACTGGTAGACCCGCAAGAAAAAACGGCCAGAACCAAGAATGATG
CCCAATGGGCCGAGCGTTTATTGCACCTGGCTAGCAAAGATTTTTTAAGCCTGTGGTATCAGCAGCCCGTGTTTGCTGAC
ATGACTGTGGCCAAACGTAAAGCCTTAATCGAGCATCGTTCTGCAGCATTAGATCTGCATCCTAAACAGCTGCTTAAAGA
GGTATTCTTAGCCACTTCACTTGCGCGCCAAGCATCGATGTGGGATGTGCCTTCGCAACTTGCCTGTGAGTGCCATTTCT
TTGTGGGCAGCCAAGATACCAAGTTCCACGCCCTCGCCCAAGAATGGCAATTACACGCGCCTATTCTCGTCCACAGTATT
AGCGGCGCCGGACACAACATACACCAAGCAGCTCCCGAGGCATTAATCGCAACAATAGTTAAGCTGCTAGGGTAA

Upstream 100 bases:

>100_bases
CGCTGGATTTTCAGGGGGCTTCGATCATTGAAGTCAATGTGAGCCAAAACCAAGCCAGCGACCAAATCGCCGCGCTCAAC
CTTTGGGTGAAACAAAGCTA

Downstream 100 bases:

>100_bases
ACAACACAATTAAAATGTAGGAAATATATGATCTTAACTTCGCTTAACCTGTATCAATATCGACTACCGCTCGATGTATT
ATTGCCCGTAGGCAAGCAAC

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: SHCHC synthase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MPTMARYGDPSLPTLVLLHGFLGTKADWLPLMPALSQHFHCICLDLPGHGDNQAEGSTEAKLDFDFCVENIVTRLDSLNP
SPEPFHLYGYSLGGRIALHLAKAYPQRLLSLNLESCHPGLVDPQEKTARTKNDAQWAERLLHLASKDFLSLWYQQPVFAD
MTVAKRKALIEHRSAALDLHPKQLLKEVFLATSLARQASMWDVPSQLACECHFFVGSQDTKFHALAQEWQLHAPILVHSI
SGAGHNIHQAAPEALIATIVKLLG

Sequences:

>Translated_264_residues
MPTMARYGDPSLPTLVLLHGFLGTKADWLPLMPALSQHFHCICLDLPGHGDNQAEGSTEAKLDFDFCVENIVTRLDSLNP
SPEPFHLYGYSLGGRIALHLAKAYPQRLLSLNLESCHPGLVDPQEKTARTKNDAQWAERLLHLASKDFLSLWYQQPVFAD
MTVAKRKALIEHRSAALDLHPKQLLKEVFLATSLARQASMWDVPSQLACECHFFVGSQDTKFHALAQEWQLHAPILVHSI
SGAGHNIHQAAPEALIATIVKLLG
>Mature_263_residues
PTMARYGDPSLPTLVLLHGFLGTKADWLPLMPALSQHFHCICLDLPGHGDNQAEGSTEAKLDFDFCVENIVTRLDSLNPS
PEPFHLYGYSLGGRIALHLAKAYPQRLLSLNLESCHPGLVDPQEKTARTKNDAQWAERLLHLASKDFLSLWYQQPVFADM
TVAKRKALIEHRSAALDLHPKQLLKEVFLATSLARQASMWDVPSQLACECHFFVGSQDTKFHALAQEWQLHAPILVHSIS
GAGHNIHQAAPEALIATIVKLLG

Specific function: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. MenH family [H]

Homologues:

Organism=Homo sapiens, GI189027141, Length=135, Percent_Identity=34.8148148148148, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1788598, Length=260, Percent_Identity=34.6153846153846, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022485 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =4.2.99.20 [H]

Molecular weight: Translated: 29288; Mature: 29157

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTMARYGDPSLPTLVLLHGFLGTKADWLPLMPALSQHFHCICLDLPGHGDNQAEGSTEA
CCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCC
KLDFDFCVENIVTRLDSLNPSPEPFHLYGYSLGGRIALHLAKAYPQRLLSLNLESCHPGL
CCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHCCCCC
VDPQEKTARTKNDAQWAERLLHLASKDFLSLWYQQPVFADMTVAKRKALIEHRSAALDLH
CCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
PKQLLKEVFLATSLARQASMWDVPSQLACECHFFVGSQDTKFHALAQEWQLHAPILVHSI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEC
SGAGHNIHQAAPEALIATIVKLLG
CCCCCCHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
PTMARYGDPSLPTLVLLHGFLGTKADWLPLMPALSQHFHCICLDLPGHGDNQAEGSTEA
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCC
KLDFDFCVENIVTRLDSLNPSPEPFHLYGYSLGGRIALHLAKAYPQRLLSLNLESCHPGL
CCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHCCCCC
VDPQEKTARTKNDAQWAERLLHLASKDFLSLWYQQPVFADMTVAKRKALIEHRSAALDLH
CCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
PKQLLKEVFLATSLARQASMWDVPSQLACECHFFVGSQDTKFHALAQEWQLHAPILVHSI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEC
SGAGHNIHQAAPEALIATIVKLLG
CCCCCCHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA