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The map label for this gene is mdtL [H]

Identifier: 160877373

GI number: 160877373

Start: 5051196

End: 5052404

Strand: Reverse

Name: mdtL [H]

Synonym: Sbal195_4271

Alternate gene names: 160877373

Gene position: 5052404-5051196 (Counterclockwise)

Preceding gene: 160877376

Following gene: 160877372

Centisome position: 94.49

GC content: 49.79

Gene sequence:

>1209_bases
ATGCGGCGCAATCTATTACCTATCCTGATGTCTATGGTGCTTCTCAGCCCATTGGCAATCGATATTTACTTACCTTCAAT
GCCAACTATGGCGGCAGAATTCGCCGTATCTGCCAGTGATGTGCAATCTACGATCGTATTATTTTTATTCGCCATGGGCT
TAGGCCAAGTGTTGATCGGGCCATTAGCCGACCGTTATGGCCGCCGTCCTGTGGCAATCTTTGGGGTCTTACTCTACGGT
GCGAGCAGCCTTTTAGCCGCTGCGGCTATCGAGTTTCATTGGTTACAGATTGCCCGTTTGCTGCAAGGTTTAGCCGCCTG
TTCGACTTCTATCGTGGTGTTTAGCGCGGTGCGTGACTGCTACGATCAAAAAGAAGGCGCTAAGATTTACAGTTACTTAA
ATGGTGCCATTTGCGTTATTCCTGCATTAGCACCGACTTTAGGTGGTTTATTGGCAATGCAATTTGGGTGGCGCTCAACC
TTCGTTTTCATGACGTTATATGCCATGTTGATGTTGCTCGTTGTCGGTTATCGCTTACCCGAGACTCGACCTGCTAATAC
GGTTACCACTGGCCCACTTTACCGTTGGGGTCGATACAAGCCTGTACTGGGTAACACTCACTTTTTGTTTTATGCCTTTG
CTTGTATGTCGGCGATGGCGGCGATTTTGTGTTACGTGTCGTATGCGCCTGTGTGGCTGATTGGGCATTTAGGGCTTTCT
GAGCTCATGTTTAGTGGTCTATTCGGTTTTAATGCTGTGTTTAATATCGTGGCCTGTTTTACGGCGCCGCTGGTCATTCG
CAAACTCGGCAATCGTCCGACAACGATTTTGGCGCTGTCCATACTCGTTCTGTCTGCCGCTATCACTGTGGCGGGTCAGC
AATTCGGTCCGAGCACTGGGATGATGGCAGCGTTTGCCTTTATGTTGCCTATGTTGATGTTAGGCGTGGGATTTTCCTTC
TTACTTGGCCCTGCGACCAGTATGGCCCTGTCGGCCTTCGGTGAACGAGCTGGAACGGCGGCGGCTATGTTAGGTTTTAT
TCAGATGAGCGGCGCATCCGTGCTTGCTGGACTCGTACAACAAACGAGTTTAACCGCACCTTATGCAGTGGCCTTAGTGA
TGGGCGTATTTCCTATCGGTTTATTGTTGATGATGGCGCTGAGTCGATTTGACCACTGGCATCAAGAGCAGTTAGCTGGC
GAGCATTAG

Upstream 100 bases:

>100_bases
AGGAAATTTACTTTGGAAATTATACCATTTCTGTTCATACCTTGAGTTAATTAAAATAGCGCCCACTGAAATACCTTTTT
CTGATCAACTGAGATTATTT

Downstream 100 bases:

>100_bases
TTCGCGGCACAGGTTAATTACAAAGTCGTTAATTACAGAGTACACCCTTTACCCACAGTTTGTTTGACCGCGAACTGTGG
GTATTTTTTATTGTGCCTAA

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MRRNLLPILMSMVLLSPLAIDIYLPSMPTMAAEFAVSASDVQSTIVLFLFAMGLGQVLIGPLADRYGRRPVAIFGVLLYG
ASSLLAAAAIEFHWLQIARLLQGLAACSTSIVVFSAVRDCYDQKEGAKIYSYLNGAICVIPALAPTLGGLLAMQFGWRST
FVFMTLYAMLMLLVVGYRLPETRPANTVTTGPLYRWGRYKPVLGNTHFLFYAFACMSAMAAILCYVSYAPVWLIGHLGLS
ELMFSGLFGFNAVFNIVACFTAPLVIRKLGNRPTTILALSILVLSAAITVAGQQFGPSTGMMAAFAFMLPMLMLGVGFSF
LLGPATSMALSAFGERAGTAAAMLGFIQMSGASVLAGLVQQTSLTAPYAVALVMGVFPIGLLLMMALSRFDHWHQEQLAG
EH

Sequences:

>Translated_402_residues
MRRNLLPILMSMVLLSPLAIDIYLPSMPTMAAEFAVSASDVQSTIVLFLFAMGLGQVLIGPLADRYGRRPVAIFGVLLYG
ASSLLAAAAIEFHWLQIARLLQGLAACSTSIVVFSAVRDCYDQKEGAKIYSYLNGAICVIPALAPTLGGLLAMQFGWRST
FVFMTLYAMLMLLVVGYRLPETRPANTVTTGPLYRWGRYKPVLGNTHFLFYAFACMSAMAAILCYVSYAPVWLIGHLGLS
ELMFSGLFGFNAVFNIVACFTAPLVIRKLGNRPTTILALSILVLSAAITVAGQQFGPSTGMMAAFAFMLPMLMLGVGFSF
LLGPATSMALSAFGERAGTAAAMLGFIQMSGASVLAGLVQQTSLTAPYAVALVMGVFPIGLLLMMALSRFDHWHQEQLAG
EH
>Mature_402_residues
MRRNLLPILMSMVLLSPLAIDIYLPSMPTMAAEFAVSASDVQSTIVLFLFAMGLGQVLIGPLADRYGRRPVAIFGVLLYG
ASSLLAAAAIEFHWLQIARLLQGLAACSTSIVVFSAVRDCYDQKEGAKIYSYLNGAICVIPALAPTLGGLLAMQFGWRST
FVFMTLYAMLMLLVVGYRLPETRPANTVTTGPLYRWGRYKPVLGNTHFLFYAFACMSAMAAILCYVSYAPVWLIGHLGLS
ELMFSGLFGFNAVFNIVACFTAPLVIRKLGNRPTTILALSILVLSAAITVAGQQFGPSTGMMAAFAFMLPMLMLGVGFSF
LLGPATSMALSAFGERAGTAAAMLGFIQMSGASVLAGLVQQTSLTAPYAVALVMGVFPIGLLLMMALSRFDHWHQEQLAG
EH

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790146, Length=344, Percent_Identity=31.3953488372093, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI87082312, Length=343, Percent_Identity=29.4460641399417, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788509, Length=270, Percent_Identity=29.2592592592593, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI48994889, Length=237, Percent_Identity=29.957805907173, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790794, Length=280, Percent_Identity=26.7857142857143, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787065, Length=341, Percent_Identity=25.5131964809384, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319657, Length=198, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324264, Length=168, Percent_Identity=26.7857142857143, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43155; Mature: 43155

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA