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The map label for this gene is mutL [H]

Identifier: 160876999

GI number: 160876999

Start: 4588803

End: 4590719

Strand: Reverse

Name: mutL [H]

Synonym: Sbal195_3895

Alternate gene names: 160876999

Gene position: 4590719-4588803 (Counterclockwise)

Preceding gene: 160877000

Following gene: 160876998

Centisome position: 85.85

GC content: 48.2

Gene sequence:

>1917_bases
ATGATGGGCATTCAGATCCTGCCACCGCAATTAGCCAACCAAATTGCGGCGGGGGAAGTGGTTGAGAGACCCGCTTCCGT
AGTCAAAGAATTGGTCGAGAATAGTCTCGACGCAGGAGCGAGCCGAGTCGATATTGAAATCGACAAAGGCGGTAGCAAGC
TGATTAAAATTCGCGATAACGGATCTGGTATACCCAAAGATGAACTCGCGCTGGCCTTATCGCGCCATGCGACCTCAAAG
TTACACACCTTAGACGATCTCGAAGCGATCCTCAGTTTTGGTTTTCGCGGTGAAGCGTTAGCGAGTATCAGCTCAGTCTC
ACGCTTAACCTTAACCTCGCGCACTGCTGATCAAACCGAAGCATGGCAAGCCCATGCTGAAGGTGCCGACATGGCGGTTA
AAGTCATGCCCGCCGCGCATCCTGTTGGTTCTACGATTGAAGTGGTGGATTTATTCTTCAATACGCCAGCTCGCAGACGC
TTTTTAAAGAGCGATAAAACCGAATTTACCCATATCGATGAATGGTTAAAGCGCATTGCATTAGTGCGCGGCGATATCCA
TTTAACGCTGACCCATAACGGTAAGACGGTACGTAATTATCGTCCCGCCATGAATGAAGCCCAGTATTTACAGCGTTTGA
CGCAAGTAAGTGGTCGCCCATTTGCTGAGCAAGCGCTTAAGATTGAATGCCAGCATGATGATTTACGCCTAAGTGGCTAT
TTGCAGTCACCTTGGTCGCCCGTTATCAGCGATACCCATTACTTTTATGTCAACGGACGCTTAATCCGTGACCGCTTAGT
CAATCACGCGGTGCGCCAGGCTTTTGCCCAAAAAGCGGAACTGGAGCAACCCGGCTATGTGTTGATGTTGGATATCGATC
CCCATCAAGTGGATGTTAACGTGCATCCTGCTAAGCATGAGGTGCGATTCCATCAGAGTCGCTATGTGCATGATTATATT
CTGCAAGCATTGCAATCGGCTCTGGAAGAAGCAGGGGAACTCAACTTCGTTCACTCTAGTTCCTTGGATGAAGTTGAAGA
TGTGTTTGTGGATGCCCCGACAAGCGCCACTGAAATCTCAGCCCCTTTTGTACTTGGTGCTGATTCAGCTCAAGTTAATG
TGCCAGCTGATACACTTGAGTCTGCTCAACCGTTAGTTGCCTCTGCCGTTCAAGTAAAATCTGCCGGCGCAGGACGAGAA
GGCGCCAGTTTTGGCACTCAAACGAATGCCTTTGGCAGCATGGCTACGCCAAGGGACAATAGTCGCGGCAATTATTCTGC
TGGTGAATCTCGTCAACGTACTGAATTACCGTCAAAAGCGGCAATTGCAAGTTATGGTGCTTTACTGCAAACACCTTCTT
ACAGTGTAAAAGATCAAGATTATCAGCCATCTCTGCCTATGCCTGCGATTTTAGATGGCCAATATTGGGTAATGGCGACG
GCGGATAAACTGAGTCTATTGCCAATAAAATCAGTAGCATTGGCGACGCGCTGCCAAGAGATTGAGGCTAAGCTAGCGAC
CGGATTAATTGGGCAGCCTTTATTGATGCCAGTGTCTGTCGCGGCCGATGCAGATTGGCAGGCTGTGCTCGATGAACATG
ACACGCTGATCCGCCAGTTAGGTTTAGAACTAACAATTCGTTACCAGCAGTTGATTATTAAAAAAGTGCCCCCATATATC
AGAGAGAGCCAGTTAGCAAAAGTGATCCCTGAGTGGTTACAATCGCTGCGTTTTGAAACACCTGCGCCAAGCGCATTGGC
ATTTTGGTTGGCAAAACACAGTTTAACGGGATTCGTTTCGGCACCAGAAATCTGGGCAGCATTTTCGCAGTTAGCTGAAG
AGAAAAAACAGCTTATTGCCAACAAAGCAATATTACTACCTTGGCAATCGTGGCTAGAAGAGCAAGCAAGTGAATAA

Upstream 100 bases:

>100_bases
CGTGTGCCTATGTCTAGCATCAAACAAGCGAATGGGATGAAGTCCGATGTAGTGCAGTTAGGGCAAACATTAGTCATACC
CCAGAGTTAAATAGGAAAGC

Downstream 100 bases:

>100_bases
AGAATTACAGCCTAAAGTGATATTTTTGATGGGGCCAACGGCCTCAGGCAAAACTGCTTTAGCATTAGAATTGGCCGAAA
AGCATAACTGTGAAATCATT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRVDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSK
LHTLDDLEAILSFGFRGEALASISSVSRLTLTSRTADQTEAWQAHAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRR
FLKSDKTEFTHIDEWLKRIALVRGDIHLTLTHNGKTVRNYRPAMNEAQYLQRLTQVSGRPFAEQALKIECQHDDLRLSGY
LQSPWSPVISDTHYFYVNGRLIRDRLVNHAVRQAFAQKAELEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYI
LQALQSALEEAGELNFVHSSSLDEVEDVFVDAPTSATEISAPFVLGADSAQVNVPADTLESAQPLVASAVQVKSAGAGRE
GASFGTQTNAFGSMATPRDNSRGNYSAGESRQRTELPSKAAIASYGALLQTPSYSVKDQDYQPSLPMPAILDGQYWVMAT
ADKLSLLPIKSVALATRCQEIEAKLATGLIGQPLLMPVSVAADADWQAVLDEHDTLIRQLGLELTIRYQQLIIKKVPPYI
RESQLAKVIPEWLQSLRFETPAPSALAFWLAKHSLTGFVSAPEIWAAFSQLAEEKKQLIANKAILLPWQSWLEEQASE

Sequences:

>Translated_638_residues
MMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRVDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSK
LHTLDDLEAILSFGFRGEALASISSVSRLTLTSRTADQTEAWQAHAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRR
FLKSDKTEFTHIDEWLKRIALVRGDIHLTLTHNGKTVRNYRPAMNEAQYLQRLTQVSGRPFAEQALKIECQHDDLRLSGY
LQSPWSPVISDTHYFYVNGRLIRDRLVNHAVRQAFAQKAELEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYI
LQALQSALEEAGELNFVHSSSLDEVEDVFVDAPTSATEISAPFVLGADSAQVNVPADTLESAQPLVASAVQVKSAGAGRE
GASFGTQTNAFGSMATPRDNSRGNYSAGESRQRTELPSKAAIASYGALLQTPSYSVKDQDYQPSLPMPAILDGQYWVMAT
ADKLSLLPIKSVALATRCQEIEAKLATGLIGQPLLMPVSVAADADWQAVLDEHDTLIRQLGLELTIRYQQLIIKKVPPYI
RESQLAKVIPEWLQSLRFETPAPSALAFWLAKHSLTGFVSAPEIWAAFSQLAEEKKQLIANKAILLPWQSWLEEQASE
>Mature_638_residues
MMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRVDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSK
LHTLDDLEAILSFGFRGEALASISSVSRLTLTSRTADQTEAWQAHAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRR
FLKSDKTEFTHIDEWLKRIALVRGDIHLTLTHNGKTVRNYRPAMNEAQYLQRLTQVSGRPFAEQALKIECQHDDLRLSGY
LQSPWSPVISDTHYFYVNGRLIRDRLVNHAVRQAFAQKAELEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYI
LQALQSALEEAGELNFVHSSSLDEVEDVFVDAPTSATEISAPFVLGADSAQVNVPADTLESAQPLVASAVQVKSAGAGRE
GASFGTQTNAFGSMATPRDNSRGNYSAGESRQRTELPSKAAIASYGALLQTPSYSVKDQDYQPSLPMPAILDGQYWVMAT
ADKLSLLPIKSVALATRCQEIEAKLATGLIGQPLLMPVSVAADADWQAVLDEHDTLIRQLGLELTIRYQQLIIKKVPPYI
RESQLAKVIPEWLQSLRFETPAPSALAFWLAKHSLTGFVSAPEIWAAFSQLAEEKKQLIANKAILLPWQSWLEEQASE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=328, Percent_Identity=35.0609756097561, Blast_Score=210, Evalue=4e-54,
Organism=Homo sapiens, GI4505911, Length=317, Percent_Identity=27.7602523659306, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI189458898, Length=317, Percent_Identity=27.7602523659306, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI189458896, Length=309, Percent_Identity=27.5080906148867, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4505913, Length=340, Percent_Identity=26.7647058823529, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI310128478, Length=340, Percent_Identity=26.7647058823529, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=30.3418803418803, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI91992162, Length=264, Percent_Identity=25.7575757575758, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI91992160, Length=264, Percent_Identity=25.7575757575758, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI310128480, Length=302, Percent_Identity=23.841059602649, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1790612, Length=615, Percent_Identity=47.6422764227642, Blast_Score=487, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=34.472049689441, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=483, Percent_Identity=25.0517598343685, Blast_Score=126, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=341, Percent_Identity=35.1906158357771, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=348, Percent_Identity=27.8735632183908, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6325093, Length=357, Percent_Identity=26.6106442577031, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=361, Percent_Identity=25.207756232687, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136968, Length=334, Percent_Identity=32.3353293413174, Blast_Score=179, Evalue=7e-45,
Organism=Drosophila melanogaster, GI17136970, Length=356, Percent_Identity=26.4044943820225, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 70221; Mature: 70221

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRVDIEIDKGGSKLIKIRDN
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECC
GSGIPKDELALALSRHATSKLHTLDDLEAILSFGFRGEALASISSVSRLTLTSRTADQTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCHHH
AWQAHAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIA
HHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHH
LVRGDIHLTLTHNGKTVRNYRPAMNEAQYLQRLTQVSGRPFAEQALKIECQHDDLRLSGY
HHCCCEEEEEECCCCCHHCCCCCCCHHHHHHHHHHHCCCCCHHHHEEEEECCCCEEEEEE
LQSPWSPVISDTHYFYVNGRLIRDRLVNHAVRQAFAQKAELEQPGYVLMLDIDPHQVDVN
ECCCCCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEE
VHPAKHEVRFHQSRYVHDYILQALQSALEEAGELNFVHSSSLDEVEDVFVDAPTSATEIS
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCCCCC
APFVLGADSAQVNVPADTLESAQPLVASAVQVKSAGAGREGASFGTQTNAFGSMATPRDN
CCEEEECCCCEEECCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
SRGNYSAGESRQRTELPSKAAIASYGALLQTPSYSVKDQDYQPSLPMPAILDGQYWVMAT
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEE
ADKLSLLPIKSVALATRCQEIEAKLATGLIGQPLLMPVSVAADADWQAVLDEHDTLIRQL
CCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEECCCCCHHHHHHHHHHHHHHC
GLELTIRYQQLIIKKVPPYIRESQLAKVIPEWLQSLRFETPAPSALAFWLAKHSLTGFVS
CCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
APEIWAAFSQLAEEKKQLIANKAILLPWQSWLEEQASE
CHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHCCC
>Mature Secondary Structure
MMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRVDIEIDKGGSKLIKIRDN
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECC
GSGIPKDELALALSRHATSKLHTLDDLEAILSFGFRGEALASISSVSRLTLTSRTADQTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCHHH
AWQAHAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIA
HHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHH
LVRGDIHLTLTHNGKTVRNYRPAMNEAQYLQRLTQVSGRPFAEQALKIECQHDDLRLSGY
HHCCCEEEEEECCCCCHHCCCCCCCHHHHHHHHHHHCCCCCHHHHEEEEECCCCEEEEEE
LQSPWSPVISDTHYFYVNGRLIRDRLVNHAVRQAFAQKAELEQPGYVLMLDIDPHQVDVN
ECCCCCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEE
VHPAKHEVRFHQSRYVHDYILQALQSALEEAGELNFVHSSSLDEVEDVFVDAPTSATEIS
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCCCCC
APFVLGADSAQVNVPADTLESAQPLVASAVQVKSAGAGREGASFGTQTNAFGSMATPRDN
CCEEEECCCCEEECCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
SRGNYSAGESRQRTELPSKAAIASYGALLQTPSYSVKDQDYQPSLPMPAILDGQYWVMAT
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEE
ADKLSLLPIKSVALATRCQEIEAKLATGLIGQPLLMPVSVAADADWQAVLDEHDTLIRQL
CCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEECCCCCHHHHHHHHHHHHHHC
GLELTIRYQQLIIKKVPPYIRESQLAKVIPEWLQSLRFETPAPSALAFWLAKHSLTGFVS
CCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
APEIWAAFSQLAEEKKQLIANKAILLPWQSWLEEQASE
CHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA