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The map label for this gene is panB1 [H]

Identifier: 160876113

GI number: 160876113

Start: 3572287

End: 3573129

Strand: Direct

Name: panB1 [H]

Synonym: Sbal195_3004

Alternate gene names: 160876113

Gene position: 3572287-3573129 (Clockwise)

Preceding gene: 160876111

Following gene: 160876114

Centisome position: 66.81

GC content: 50.18

Gene sequence:

>843_bases
ATGAGCATCCACATGAATAAAAATCGGGTTACGCCCGTCACCTTACAGAAAATGAAAGGTAAAACGCCAATAGTCGCCCT
CACCGCCTATGAAAAACCGATGGCGGAACTTATCGATCCCCATGCGGATATGATTATCGTCGGCGACTCCGTCGGTATGG
TGGTTTATGGGCAAGACTCTACGCTAGGGGTTACCTTAGAAATGATGATTAACCATGGTCTTGCTGTCACTCGCGGCGCA
GCACATGCCTGCGTGATTATCGATATGCCCTTTGGGAGTTATCAAGAATCGCCTCAGCAAGCCTTTAGACATGCCAGCCA
AGTATTAATACGTACAGGCGCGCAGGCGGTAAAACTTGAGGGTGGCGCAGAAATGCTCGACACGACTCGCTTTTTAACCC
AGCGAGGGATCCCTGTGATGCCACACATAGGATTGATGCCGCAACACGTCAATCAATTGGGTGGATTTAAAACCCAAGCT
AGGGATGCTGCCGCCATCGAAGCCCTCGTTCGTTTAGCGAAAGACTTTGAGCAAGCAGGCGCTTTTAGCATACTGATTGA
AGGAACGTCCGAACTCGCGGCGCGCACAGTAACGGCAGAAGTCTCAATCCCCGTAATCGGCATTGGCGCCTCACCCGCCT
GCGATGGTCAAGTGCTCGTGACTGAGGACATTTTAGGCTTATTTTCTGACTACACGCCTAAATTTGCCAAACGCTATATC
GACCTAAGCCCCTTAATCACTCACGCCTGCGCCGAATATGCCAGAGAAGTAAGAACCGCTGAGTTTCCAACAGCAGAGCA
TTGCTTTGGCCTCAGCCAAACAATCAAGATTACAGCGGATTAA

Upstream 100 bases:

>100_bases
AGAAGTGTCTTTTTATCTAGACATTAAGTCAACCTATCGAGCTAACGCCAAAGCGGCAAGCGCTAACATGCCCTCTCAGA
TTTAACAAATTGGAGATGAC

Downstream 100 bases:

>100_bases
TTGTCTAAAGCGAAATATTGCAGTAATCGAATAAACGATAAATCGAAATTTACAACTAATTGACTCTACCGACTTGCTTT
TTATAGGGGGGCGTTGCTTT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase 1; KPHMT 1 [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSIHMNKNRVTPVTLQKMKGKTPIVALTAYEKPMAELIDPHADMIIVGDSVGMVVYGQDSTLGVTLEMMINHGLAVTRGA
AHACVIIDMPFGSYQESPQQAFRHASQVLIRTGAQAVKLEGGAEMLDTTRFLTQRGIPVMPHIGLMPQHVNQLGGFKTQA
RDAAAIEALVRLAKDFEQAGAFSILIEGTSELAARTVTAEVSIPVIGIGASPACDGQVLVTEDILGLFSDYTPKFAKRYI
DLSPLITHACAEYAREVRTAEFPTAEHCFGLSQTIKITAD

Sequences:

>Translated_280_residues
MSIHMNKNRVTPVTLQKMKGKTPIVALTAYEKPMAELIDPHADMIIVGDSVGMVVYGQDSTLGVTLEMMINHGLAVTRGA
AHACVIIDMPFGSYQESPQQAFRHASQVLIRTGAQAVKLEGGAEMLDTTRFLTQRGIPVMPHIGLMPQHVNQLGGFKTQA
RDAAAIEALVRLAKDFEQAGAFSILIEGTSELAARTVTAEVSIPVIGIGASPACDGQVLVTEDILGLFSDYTPKFAKRYI
DLSPLITHACAEYAREVRTAEFPTAEHCFGLSQTIKITAD
>Mature_279_residues
SIHMNKNRVTPVTLQKMKGKTPIVALTAYEKPMAELIDPHADMIIVGDSVGMVVYGQDSTLGVTLEMMINHGLAVTRGAA
HACVIIDMPFGSYQESPQQAFRHASQVLIRTGAQAVKLEGGAEMLDTTRFLTQRGIPVMPHIGLMPQHVNQLGGFKTQAR
DAAAIEALVRLAKDFEQAGAFSILIEGTSELAARTVTAEVSIPVIGIGASPACDGQVLVTEDILGLFSDYTPKFAKRYID
LSPLITHACAEYAREVRTAEFPTAEHCFGLSQTIKITAD

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=257, Percent_Identity=41.2451361867704, Blast_Score=182, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319653, Length=282, Percent_Identity=34.0425531914894, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 30164; Mature: 30033

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIHMNKNRVTPVTLQKMKGKTPIVALTAYEKPMAELIDPHADMIIVGDSVGMVVYGQDS
CEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCEEEEECCCCEEEECCCC
TLGVTLEMMINHGLAVTRGAAHACVIIDMPFGSYQESPQQAFRHASQVLIRTGAQAVKLE
CCEEEEEHHHHCCEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEC
GGAEMLDTTRFLTQRGIPVMPHIGLMPQHVNQLGGFKTQARDAAAIEALVRLAKDFEQAG
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
AFSILIEGTSELAARTVTAEVSIPVIGIGASPACDGQVLVTEDILGLFSDYTPKFAKRYI
CEEEEEECCHHHHHEEEEEEEEEEEEEECCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHC
DLSPLITHACAEYAREVRTAEFPTAEHCFGLSQTIKITAD
CHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEEC
>Mature Secondary Structure 
SIHMNKNRVTPVTLQKMKGKTPIVALTAYEKPMAELIDPHADMIIVGDSVGMVVYGQDS
EEECCCCCCCHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCEEEEECCCCEEEECCCC
TLGVTLEMMINHGLAVTRGAAHACVIIDMPFGSYQESPQQAFRHASQVLIRTGAQAVKLE
CCEEEEEHHHHCCEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEC
GGAEMLDTTRFLTQRGIPVMPHIGLMPQHVNQLGGFKTQARDAAAIEALVRLAKDFEQAG
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
AFSILIEGTSELAARTVTAEVSIPVIGIGASPACDGQVLVTEDILGLFSDYTPKFAKRYI
CEEEEEECCHHHHHEEEEEEEEEEEEEECCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHC
DLSPLITHACAEYAREVRTAEFPTAEHCFGLSQTIKITAD
CHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA