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The map label for this gene is hemH [H]

Identifier: 160875772

GI number: 160875772

Start: 3154154

End: 3155173

Strand: Reverse

Name: hemH [H]

Synonym: Sbal195_2660

Alternate gene names: 160875772

Gene position: 3155173-3154154 (Counterclockwise)

Preceding gene: 160875773

Following gene: 160875771

Centisome position: 59.01

GC content: 50.1

Gene sequence:

>1020_bases
ATGAGCCTAACGTTGAATCCTTGCCCTGCTTTTGGTGTGTTATTGGTTAACCTCGGCACGCCTGATGAACCTAGCCCTAA
AGCCGTAAAACGATTTCTAAGGCAGTTTTTAAGTGATCCCCGTGTCGTCGATTTATCGCCGTGGATTTGGCAACCGCTGC
TGAACGGCATTATCCTCAACACCCGTCCGGCGAAAGTCGCCAAACTCTACCAAAGCGTGTGGACGCCGGAAGGCTCGCCC
TTGATGGTGATAAGTGCACGCCAAGCACAAAAGCTGGCGGTGGACTTAAGCGCCACGTTTAACCAGACCATACCGGTTGA
ACTGGGCATGAGTTACGGCAATCCCTCCATCGATGCGGGATTTGAACGCTTGAAAGACCAAGGGGCAGAGCGCATTATTG
TGCTGCCTTTGTATCCCCAATATTCCTGCTCGACGGTGGCAAGTGTGTTCGATGCCGTTGCCAGTTATCTTAAAACCGTG
CGTGACATACCTCAGGTTCGCTTTAATAAAGACTATTTTGATCATGATGCTTATATAGCGGCGCTGGCGCATTCAGTGAC
ACGTCACTGGAAAACCCATGGGCAGGCCGATAAGTTGCTCTTGTCATTTCACGGTATTCCGCTGCGTTATGTGAAAGAGG
GCGATCCATACCGCGAGCAGTGTTTTGTCACGGCTAAACTGTTAGCGCAAAAACTTGAGCTTAGCGAGTCGCAATGGCAG
GTGTGCTTCCAATCGCGCTTTGGCCGCGAAGAGTGGCTCACGCCCTACGCCGATCAATTATTGGCCGAGTTACCTGCACA
AGGAATCAAAAGTGTCGATGTGATTTGCCCAGCGTTTGCTACTGACTGCCTCGAAACCTTAGAAGAAATCTCCATCGGCG
CTAAGGAAACCTTTTTAGATGCAGGTGGCAGCGACTATCGGTTTATCCCTTGTTTGAACGACGATGAGTTACACATTGAA
TTATTACGGCAATTAATCCAAGAACAAGCGGTATCTTGGGCCCATACCCAAGCCACCTGA

Upstream 100 bases:

>100_bases
TAATTTACGAGAACGAGTTCTCATATTAGAAAAAAGCCTGCCGATGCAGGCTTTTTTTATGGGCATCTGAATGTTAGCCT
CCAAGTGAACTTCATTAACC

Downstream 100 bases:

>100_bases
AGAGTCGAGTTTCAGAGCGCCTAGGGTGATTCAATTCAAGGCGCATCAATGACAGAATGTCGGCCACCTTTTGAATTGAT
GCAACACGGAAGTGAAGTGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSLTLNPCPAFGVLLVNLGTPDEPSPKAVKRFLRQFLSDPRVVDLSPWIWQPLLNGIILNTRPAKVAKLYQSVWTPEGSP
LMVISARQAQKLAVDLSATFNQTIPVELGMSYGNPSIDAGFERLKDQGAERIIVLPLYPQYSCSTVASVFDAVASYLKTV
RDIPQVRFNKDYFDHDAYIAALAHSVTRHWKTHGQADKLLLSFHGIPLRYVKEGDPYREQCFVTAKLLAQKLELSESQWQ
VCFQSRFGREEWLTPYADQLLAELPAQGIKSVDVICPAFATDCLETLEEISIGAKETFLDAGGSDYRFIPCLNDDELHIE
LLRQLIQEQAVSWAHTQAT

Sequences:

>Translated_339_residues
MSLTLNPCPAFGVLLVNLGTPDEPSPKAVKRFLRQFLSDPRVVDLSPWIWQPLLNGIILNTRPAKVAKLYQSVWTPEGSP
LMVISARQAQKLAVDLSATFNQTIPVELGMSYGNPSIDAGFERLKDQGAERIIVLPLYPQYSCSTVASVFDAVASYLKTV
RDIPQVRFNKDYFDHDAYIAALAHSVTRHWKTHGQADKLLLSFHGIPLRYVKEGDPYREQCFVTAKLLAQKLELSESQWQ
VCFQSRFGREEWLTPYADQLLAELPAQGIKSVDVICPAFATDCLETLEEISIGAKETFLDAGGSDYRFIPCLNDDELHIE
LLRQLIQEQAVSWAHTQAT
>Mature_338_residues
SLTLNPCPAFGVLLVNLGTPDEPSPKAVKRFLRQFLSDPRVVDLSPWIWQPLLNGIILNTRPAKVAKLYQSVWTPEGSPL
MVISARQAQKLAVDLSATFNQTIPVELGMSYGNPSIDAGFERLKDQGAERIIVLPLYPQYSCSTVASVFDAVASYLKTVR
DIPQVRFNKDYFDHDAYIAALAHSVTRHWKTHGQADKLLLSFHGIPLRYVKEGDPYREQCFVTAKLLAQKLELSESQWQV
CFQSRFGREEWLTPYADQLLAELPAQGIKSVDVICPAFATDCLETLEEISIGAKETFLDAGGSDYRFIPCLNDDELHIEL
LRQLIQEQAVSWAHTQAT

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=337, Percent_Identity=25.2225519287834, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI60499025, Length=337, Percent_Identity=25.2225519287834, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=51.1111111111111, Blast_Score=318, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6324750, Length=328, Percent_Identity=25, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17864156, Length=339, Percent_Identity=23.598820058997, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24651774, Length=264, Percent_Identity=23.1060606060606, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38040; Mature: 37909

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTLNPCPAFGVLLVNLGTPDEPSPKAVKRFLRQFLSDPRVVDLSPWIWQPLLNGIILN
CCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCEEEC
TRPAKVAKLYQSVWTPEGSPLMVISARQAQKLAVDLSATFNQTIPVELGMSYGNPSIDAG
CCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHEEEHHHCCCCCCCEEECCCCCCCCHHHH
FERLKDQGAERIIVLPLYPQYSCSTVASVFDAVASYLKTVRDIPQVRFNKDYFDHDAYIA
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHH
ALAHSVTRHWKTHGQADKLLLSFHGIPLRYVKEGDPYREQCFVTAKLLAQKLELSESQWQ
HHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHH
VCFQSRFGREEWLTPYADQLLAELPAQGIKSVDVICPAFATDCLETLEEISIGAKETFLD
HHHHHHCCHHHCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHC
AGGSDYRFIPCLNDDELHIELLRQLIQEQAVSWAHTQAT
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLTLNPCPAFGVLLVNLGTPDEPSPKAVKRFLRQFLSDPRVVDLSPWIWQPLLNGIILN
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCEEEC
TRPAKVAKLYQSVWTPEGSPLMVISARQAQKLAVDLSATFNQTIPVELGMSYGNPSIDAG
CCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHEEEHHHCCCCCCCEEECCCCCCCCHHHH
FERLKDQGAERIIVLPLYPQYSCSTVASVFDAVASYLKTVRDIPQVRFNKDYFDHDAYIA
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHH
ALAHSVTRHWKTHGQADKLLLSFHGIPLRYVKEGDPYREQCFVTAKLLAQKLELSESQWQ
HHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHH
VCFQSRFGREEWLTPYADQLLAELPAQGIKSVDVICPAFATDCLETLEEISIGAKETFLD
HHHHHHCCHHHCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHC
AGGSDYRFIPCLNDDELHIELLRQLIQEQAVSWAHTQAT
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]