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The map label for this gene is adk [H]

Identifier: 160875773

GI number: 160875773

Start: 3155285

End: 3155929

Strand: Reverse

Name: adk [H]

Synonym: Sbal195_2661

Alternate gene names: 160875773

Gene position: 3155929-3155285 (Counterclockwise)

Preceding gene: 160875774

Following gene: 160875772

Centisome position: 59.02

GC content: 48.99

Gene sequence:

>645_bases
ATGCGCATTATCCTATTGGGCGCCCCAGGTGCCGGTAAAGGTACCCAGGCCCAGTTCATTATGGAACAGTATGGTATCCC
ACAAATTTCCACTGGTGATATGTTACGTGCCGCGGTAAAAGCCGGTACTCCACTGGGTTTGGAAGCGAAGAAAGTGATGG
ATGCTGGTCAACTGGTTTCTGATGATCTGATCATCGGTCTGGTTAAAGAGCGTATCGCACAGGAAGACTGTGTTAAAGGT
TTCTTGTTAGACGGTTTCCCACGTACTATCCCACAAGCGGATGCGATGGCGGCAAACGGTATTAGCATTGATCACGTGAT
TGAAATCGACGTGCCAGACGAAGAAATCGTTAAGCGCATGAGCGGTCGCCGTGTTCACCCAGGTTCAGGCCGTGTTTACC
ATGTGGTTTTCAATCCACCTAAAGTGGAAGGTAAAGACGACGTAACTGGCGAAGATTTAGCTATTCGTCCAGATGACGAA
GAAAGCACAGTGCGTAAACGCCTCGCGATTTACCACGAGCAAACTAAGCCGCTGGTTGAATACTACGGTAAAGTGGCTGC
AGCTGGTCAAACTCAATACAACAAGTTTGACGGTACTCAATCGGTTGCGGCTGTGAGTGAGCAGCTTGCCAGCGTGTTGA
AATAA

Upstream 100 bases:

>100_bases
CTGAGGCTAAAGTCGAAGCTAAAAGCCTTCTCAATGGCGGCCAGATGTGCGAAGATCGCCGCCCTAAGAAGAATATCAAT
GCGAAAAGAGGACTCTTGAG

Downstream 100 bases:

>100_bases
CCTAAAAAGCTTAATTTACGAGAACGAGTTCTCATATTAGAAAAAAGCCTGCCGATGCAGGCTTTTTTTATGGGCATCTG
AATGTTAGCCTCCAAGTGAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQEDCVKG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDE
ESTVRKRLAIYHEQTKPLVEYYGKVAAAGQTQYNKFDGTQSVAAVSEQLASVLK

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQEDCVKG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDE
ESTVRKRLAIYHEQTKPLVEYYGKVAAAGQTQYNKFDGTQSVAAVSEQLASVLK
>Mature_214_residues
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQEDCVKG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDE
ESTVRKRLAIYHEQTKPLVEYYGKVAAAGQTQYNKFDGTQSVAAVSEQLASVLK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=50, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=50, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI19923437, Length=184, Percent_Identity=45.6521739130435, Blast_Score=168, Evalue=3e-42,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=39.8009950248756, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=39.8009950248756, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=39.8009950248756, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=39.8009950248756, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI22749187, Length=206, Percent_Identity=27.6699029126214, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4502011, Length=212, Percent_Identity=29.2452830188679, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI28144897, Length=212, Percent_Identity=25.4716981132075, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI28144899, Length=212, Percent_Identity=25.4716981132075, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7706497, Length=221, Percent_Identity=25.7918552036199, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=26.6187050359712, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=26.8115942028986, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=72.3004694835681, Blast_Score=317, Evalue=5e-88,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=46.8085106382979, Blast_Score=183, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=216, Percent_Identity=32.8703703703704, Blast_Score=123, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=33.5164835164835, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=187, Percent_Identity=25.668449197861, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=190, Percent_Identity=50.5263157894737, Blast_Score=204, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=193, Percent_Identity=44.0414507772021, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=185, Percent_Identity=28.6486486486486, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=51.0869565217391, Blast_Score=195, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=45.1086956521739, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=45.1086956521739, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=30.939226519337, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=30.939226519337, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI221459597, Length=194, Percent_Identity=25.7731958762887, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356893, Length=194, Percent_Identity=25.7731958762887, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23157; Mature: 23157

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DDLIIGLVKERIAQEDCVKGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEEEECCHHHHHHHH
SGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDEESTVRKRLAIYHEQTKPLVE
HCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHH
YYGKVAAAGQTQYNKFDGTQSVAAVSEQLASVLK
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DDLIIGLVKERIAQEDCVKGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEEEECCHHHHHHHH
SGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDEESTVRKRLAIYHEQTKPLVE
HCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHH
YYGKVAAAGQTQYNKFDGTQSVAAVSEQLASVLK
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA