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The map label for this gene is lpxB [H]

Identifier: 160874611

GI number: 160874611

Start: 1796646

End: 1797842

Strand: Direct

Name: lpxB [H]

Synonym: Sbal195_1494

Alternate gene names: 160874611

Gene position: 1796646-1797842 (Clockwise)

Preceding gene: 160874610

Following gene: 160874612

Centisome position: 33.6

GC content: 49.87

Gene sequence:

>1197_bases
ATGAGACATGATTGGTTTATGAGCAATAAAACTCCATTAGTGTTTGCCATGGTTGCCGGAGAACTCTCGGGCGATATTTT
AGGCGCAGGTTTAATGGCGGCGCTGCAAAAGAATCACCCCGATGCGCGCTTTGTCGGTATTGGTGGTCCCCGTATGGAAG
CCCTTGGCTTCAGATCCCTGTTTGCGATGGAAGAGCTCGCCGTGATGGGGATTGTAGAAGTGCTATCCCGTTTGCCTCGT
TTATTAACAGTACGTGCCTCCCTGATTAAAGAGATTACCGCGCTTAAGCCCGATTGTTTTATTGGTATCGATGCACCGGA
TTTTAATATTGGCCTCGAGCTTAAACTCAAAGCGCGTGGCATTAAGACGGTTCATTATGTGAGCCCGTCTGTGTGGGCGT
GGCGCCCAAAACGGATATTCAAAATCGCTAAAGCCACTCATATGGTGTTGTCGCTGTTGCCTTTTGAGAAAGCCTTTTAC
GATCAGCATCAGGTGCCTTGTACCTTTGTGGGTCATACCTTGGCCGACGATATTCCCTTCCAAAGCGATAAGGCCGCAGC
CCGTGCCTTGCTCGGACTAGATGCCGATGCTGAATACTTAGCGATTCTGCCCGGTTCCCGCGGCGGTGAGTTAAAGCAAC
TGGCCGAGCCTTTTGTAAAAGCAGCTTTATTGATTAGACAAAATTTCCCAGACATACGTTTTGTGACGCCGCTGGTGAAT
CAAAAACGTCGTGACCAATTTGAGCAAGCGCTGAAGGATTTTGCGCCGGATCTTGAAATCCACATGATTGAAGGTCAGTC
GCGTGAAGTGATGACGGCAGCCGATGGGATTTTATTGGCATCTGGCACAGCGACCTTAGAAGCCATGCTGGTCAAGCGTC
CTATGGTGGTGGCTTATCGGGTGAGCCCGATAACCTATCGCATTGCTAAACGCATGATGCAGGTGGAGCGTTTCTCGTTA
CCGAATTTGCTTGCTGGAAAAGATCTCGTCCCAGAACTCATTCAAGAAGATTGCACCCCTGAGAAAATTGCGGCGGCAGT
CACCCTTGAGCTCAATCGCGATTTTGCGCCGCTCAAAGCCGAGTTTGAAGCCCTGCACCAAGTATTACGCCGTGATGCGA
GTTTAAAAGCCGCCGAGGCCGTGATGGCACTGGTTGATCTCAAACAAAATCATGCTAAATCGCAGGAGGCTAACTAG

Upstream 100 bases:

>100_bases
CATTCAACCATCAATGAGCTTAATCATTAATTTACATCAGTATGGCTTGGAATGATGCGTTTTAGCTGTTGTTCGCCCCG
TCATCCAATGTCATTCATTC

Downstream 100 bases:

>100_bases
TGGCAACCTATAAAAGTTTAACCGAAGCCGATTTACTGGCCTTTTCAACCGGTTTGATTGCCGGTGTGGATGAAGTCGGC
CGCGGCCCCTTAGTCGGCGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRHDWFMSNKTPLVFAMVAGELSGDILGAGLMAALQKNHPDARFVGIGGPRMEALGFRSLFAMEELAVMGIVEVLSRLPR
LLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARGIKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFY
DQHQVPCTFVGHTLADDIPFQSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNFPDIRFVTPLVN
QKRRDQFEQALKDFAPDLEIHMIEGQSREVMTAADGILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKRMMQVERFSL
PNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKAEFEALHQVLRRDASLKAAEAVMALVDLKQNHAKSQEAN

Sequences:

>Translated_398_residues
MRHDWFMSNKTPLVFAMVAGELSGDILGAGLMAALQKNHPDARFVGIGGPRMEALGFRSLFAMEELAVMGIVEVLSRLPR
LLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARGIKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFY
DQHQVPCTFVGHTLADDIPFQSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNFPDIRFVTPLVN
QKRRDQFEQALKDFAPDLEIHMIEGQSREVMTAADGILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKRMMQVERFSL
PNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKAEFEALHQVLRRDASLKAAEAVMALVDLKQNHAKSQEAN
>Mature_398_residues
MRHDWFMSNKTPLVFAMVAGELSGDILGAGLMAALQKNHPDARFVGIGGPRMEALGFRSLFAMEELAVMGIVEVLSRLPR
LLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARGIKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFY
DQHQVPCTFVGHTLADDIPFQSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNFPDIRFVTPLVN
QKRRDQFEQALKDFAPDLEIHMIEGQSREVMTAADGILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKRMMQVERFSL
PNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKAEFEALHQVLRRDASLKAAEAVMALVDLKQNHAKSQEAN

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=380, Percent_Identity=57.3684210526316, Blast_Score=441, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 44130; Mature: 44130

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHDWFMSNKTPLVFAMVAGELSGDILGAGLMAALQKNHPDARFVGIGGPRMEALGFRSL
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHH
FAMEELAVMGIVEVLSRLPRLLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCC
IKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFYDQHQVPCTFVGHTLADDIPF
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHCCCCC
QSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNFPDIRFVTPLVN
CCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHC
QKRRDQFEQALKDFAPDLEIHMIEGQSREVMTAADGILLASGTATLEAMLVKRPMVVAYR
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEECCHHHHHHHHHCCCEEEEEE
VSPITYRIAKRMMQVERFSLPNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKA
ECHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHCCCCHHHHEEEEEEEECCCCCHHHH
EFEALHQVLRRDASLKAAEAVMALVDLKQNHAKSQEAN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRHDWFMSNKTPLVFAMVAGELSGDILGAGLMAALQKNHPDARFVGIGGPRMEALGFRSL
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHH
FAMEELAVMGIVEVLSRLPRLLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCC
IKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFYDQHQVPCTFVGHTLADDIPF
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHCCCCC
QSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNFPDIRFVTPLVN
CCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHC
QKRRDQFEQALKDFAPDLEIHMIEGQSREVMTAADGILLASGTATLEAMLVKRPMVVAYR
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEECCHHHHHHHHHCCCEEEEEE
VSPITYRIAKRMMQVERFSLPNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKA
ECHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHCCCCHHHHEEEEEEEECCCCCHHHH
EFEALHQVLRRDASLKAAEAVMALVDLKQNHAKSQEAN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA