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The map label for this gene is lpxA [H]

Identifier: 160874610

GI number: 160874610

Start: 1795673

End: 1796443

Strand: Direct

Name: lpxA [H]

Synonym: Sbal195_1493

Alternate gene names: 160874610

Gene position: 1795673-1796443 (Clockwise)

Preceding gene: 160874609

Following gene: 160874611

Centisome position: 33.58

GC content: 47.6

Gene sequence:

>771_bases
GTGATAGATACATTAGCGTTTGTGCATCCCGATGCAAAAATTGGCAATAACGTCACTATTGGCCCTTGGACCTATATCGG
TGCAGGCGTTGAAATTGGCGATGATTGTTGGTTGAGTTCCCATGTGGTTGTTAAAGGCCCAACGATTATCGGCAAAGGTA
ATCGTATTTTTCAGTTCGCCTCAGTAGGCGAAGAGTGCCAAGACAAAAAGTATGCTGGCGAACCCACACGACTGATCATT
GGTGACAATAACGTCATCCGTGAAAACGTGACTATCCACCGCGGTACAGTCCAAGATAACAGTGAGACGCGTATTGGGTC
GAACAACCTGTTTATGAACTATGTACATATCGCCCATGACTGTGTGGTCGGCGACAATGTGATCATGGCCAATAACGCTT
CTATCGCGGGTCACGTACATGTGGGTGATTGGGCGATTTTAGGCGGCATGACAGGTGTTCACCAGTTTGTGCATATCGGT
GCCCATGCGTTTACTGCAGGTTGTTCTTTAGTGCTGCAGGATGTACCTCCCTTTGTGATGGCGGCGGGTCAACCGACGAT
TCCACGCGGTTTAAACAGCGAAGGCATGAAGCGTCGTGGTTTTTCTAAAGAAAGCCAATTGGCAGTGCGCCGTGCTTATA
AAACCTTATATCGCAGCAGCTTGACAGTTGAAGAAGCGATTGAAGCGTTGGCTGAAGATGCGCAGAACGATGAGCAAGTG
AAATTGTTCCTTGAATTTGTAAAGTCATCGAGTCGCGGCATTATTCGCTAA

Upstream 100 bases:

>100_bases
AAGAGCGCCGCGGGATTGGCGTCTTCTACGGTGAGGCCAAAGTGGATGGTGAAGTGGTTTGTTCCGCTGAAATCATGTGT
GCCCGCAGAGAGATTAGTCA

Downstream 100 bases:

>100_bases
CTTGATGACCACACGACAACAAAAGGGCATTTTTATGCCCTTTTGTATTATTGGCTTAAGCCTACTAGGTGGTTAGACGT
TTTTGTTAGCAATGTCCTTG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MIDTLAFVHPDAKIGNNVTIGPWTYIGAGVEIGDDCWLSSHVVVKGPTIIGKGNRIFQFASVGEECQDKKYAGEPTRLII
GDNNVIRENVTIHRGTVQDNSETRIGSNNLFMNYVHIAHDCVVGDNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIG
AHAFTAGCSLVLQDVPPFVMAAGQPTIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVEEAIEALAEDAQNDEQV
KLFLEFVKSSSRGIIR

Sequences:

>Translated_256_residues
MIDTLAFVHPDAKIGNNVTIGPWTYIGAGVEIGDDCWLSSHVVVKGPTIIGKGNRIFQFASVGEECQDKKYAGEPTRLII
GDNNVIRENVTIHRGTVQDNSETRIGSNNLFMNYVHIAHDCVVGDNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIG
AHAFTAGCSLVLQDVPPFVMAAGQPTIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVEEAIEALAEDAQNDEQV
KLFLEFVKSSSRGIIR
>Mature_256_residues
MIDTLAFVHPDAKIGNNVTIGPWTYIGAGVEIGDDCWLSSHVVVKGPTIIGKGNRIFQFASVGEECQDKKYAGEPTRLII
GDNNVIRENVTIHRGTVQDNSETRIGSNNLFMNYVHIAHDCVVGDNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIG
AHAFTAGCSLVLQDVPPFVMAAGQPTIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVEEAIEALAEDAQNDEQV
KLFLEFVKSSSRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=56.8702290076336, Blast_Score=291, Evalue=3e-80,
Organism=Escherichia coli, GI1786376, Length=237, Percent_Identity=28.2700421940928, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27842; Mature: 27842

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTLAFVHPDAKIGNNVTIGPWTYIGAGVEIGDDCWLSSHVVVKGPTIIGKGNRIFQFA
CCCCEEEECCCCCCCCEEEECCHHEEECCEEECCCCEECCEEEEECCEEEECCCEEEEEH
SVGEECQDKKYAGEPTRLIIGDNNVIRENVTIHRGTVQDNSETRIGSNNLFMNYVHIAHD
HCCHHHHCCCCCCCCCEEEECCCCEEECCEEEEECCCCCCCCCEECCCCEEEEEEEEHHH
CVVGDNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIGAHAFTAGCSLVLQDVPPFVM
EEECCCEEEECCCCEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
AAGQPTIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVEEAIEALAEDAQNDEQV
ECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHH
KLFLEFVKSSSRGIIR
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIDTLAFVHPDAKIGNNVTIGPWTYIGAGVEIGDDCWLSSHVVVKGPTIIGKGNRIFQFA
CCCCEEEECCCCCCCCEEEECCHHEEECCEEECCCCEECCEEEEECCEEEECCCEEEEEH
SVGEECQDKKYAGEPTRLIIGDNNVIRENVTIHRGTVQDNSETRIGSNNLFMNYVHIAHD
HCCHHHHCCCCCCCCCEEEECCCCEEECCEEEEECCCCCCCCCEECCCCEEEEEEEEHHH
CVVGDNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIGAHAFTAGCSLVLQDVPPFVM
EEECCCEEEECCCCEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
AAGQPTIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVEEAIEALAEDAQNDEQV
ECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHH
KLFLEFVKSSSRGIIR
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA