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The map label for this gene is lytS

Identifier: 16079945

GI number: 16079945

Start: 2956486

End: 2958267

Strand: Reverse

Name: lytS

Synonym: BSU28930

Alternate gene names: 16079945

Gene position: 2958267-2956486 (Counterclockwise)

Preceding gene: 16079947

Following gene: 16079944

Centisome position: 70.17

GC content: 46.46

Gene sequence:

>1782_bases
ATGATTCATTTAATGATTATGATGCTGGAGAGAGTGGGGATTATTGTTATATTAGGGTTCATTCTCGCCCATACGAAACT
TTTCAGACAAGCTCTTCAGAATCAGGACGGCTATAAAGGAAAAGCGATTTTAATTTCTATTTTTTCTCTTTTCAGCATCA
TCAGCAATTATACAGGCATCGAAATTCAAAGAAATATGATTGTAAACAATGACTGGGTGTTTACGATAGATCCATCGGGC
TCTATCGCGAATACCCGTATTTTGGGCGTGGAAATCGGGGGCCTTCTCGGAGGTCCTTTTGTAGGGGCTGGGATCGGCAT
ACTTGCGGGCCTGCATCGTTTTTCACTCGGTGGCAGCACGGCCTTAAGCTGTGCCGTCTCATCTATTTTAGCGGGTGTTC
TTGCAGGCTTGATCGGCAGGTATTTTACGAAGCGATATCGAATGCCGACACCGCGCATCGCCGCTCTTGTGGGAATCGGC
ATGGAGTCACTGCAAATGATCATTATTTTGCTGATGGCAAAGCCGTTCAGTGACGCTTGGGAGCTTGTCAGCATGATCGG
AATTCCGATGATACTCATCAATGGAACAGGCAGTTTTATTTTTCTGTCTATTATTCAAGCGATCATTCGCAAGGAAGAAC
AGGCAAGGGCTCTCGAAACGCATCGAGTGCTTACGATTGCTGATCAGACACTTCCATTTTTCCGCCAAGGATTAAATGAA
AACTCCTGTAAAAGTGTAGCGGCTATTATCCATAAGCTGACAGGAACAGATGCGGTGTCTCTCACTGACAAAGAAAAGAT
CCTTGCGCATGTCGGTGCGGGAATGGATCACCACATCCCATCGAAAAGCTTGATCACCGGCCTGTCCAAAAAGGTGATTA
AAACAGGGCATATTATGAAGGCGATTTCGCAGGAAGAGATTGAATGCACGCATGCTGAATGCCCTTTGCACGCTGCAATT
GTCCTACCGCTGACATCGAACGGCAATACAATCGGCACCTTAAAAATGTACTTTAAAAGCCCGGCAGGCCTGAGTCAGGT
AGAGGAGGAACTTGCCGAGGGGCTGGCCATGCTGTTTTCGACACAGCTTGAGCTTGGGGAAGCAGAGCTGCAAAGCAAAC
TTCTCAAGGATGCTGAAATTAAAGCGCTTCAAGCACAGGTGAATCCGCATTTTTTATTTAATGCGATCAACACGATTTCT
GCGTTATGCCGTACAGATGTTGAAAAAACCCGTAAGCTCCTATTGCAGCTCAGTGTTTATTTTCGTTCAAACCTTCAAGG
AGCGAGACAGCTGCTGATTCCGCTCTCAAAGGAGCTGAACCATCTTAACGCCTATTTGTCATTAGAACAGGCGCGTTTTC
CCGGGAAATATAAAATTGAGCTTAATATCGACAGCAGACTGGAGCAGATTGAAATCCCTCCGTTTGTTTTGCAGGTGCTT
GTCGAGAACGCGCTTCGGCACGCGTTTCCGAAAAAACAAGACATATGCAAGGTTACAGTCTGTGTCTTATCTGATGATGC
ATCCGTCTATATGAAGGTGGCGGATAACGGACGCGGAATTCCGCCGGACGTCTTGCCGGAACTGGGGAAGAAACCGTTTC
CGTCTAAGGAGGGAACCGGTACAGCGCTTTATAACCTAAATCAGCGGCTGATCGGTTTATTCGGACAGCAGGCTGCACTG
CATATCAGCAGTGAGGTTCATAAAGGGACAGAGGTTTCCTTTCAAGTGCCAATGCAACAGATGAAAGAGGGAGAAGAACA
TGCTCAGGGTGTTAATAGTTGA

Upstream 100 bases:

>100_bases
TAAAAGCCTTGTGAAATATGTTTTCAGACGATTTTAAAAAAACAGTCAGCCGCAAAACGAAAACATGCTAGAATGAAAAC
GGAAAGAACAGGTGACATGA

Downstream 100 bases:

>100_bases
TGATGAGATGCTGGCAAGGGATGAACTGGCTTACTTGCTTAAGCGGACCAATGATGAAATGGAAATCAATGAAGCGGAAA
ATATCGAATCCGCTTTTGAC

Product: two-component sensor histidine kinase LytT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAILISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSG
SIANTRILGVEIGGLLGGPFVGAGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG
MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARALETHRVLTIADQTLPFFRQGLNE
NSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMDHHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAI
VLPLTSNGNTIGTLKMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFLFNAINTIS
ALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQARFPGKYKIELNIDSRLEQIEIPPFVLQVL
VENALRHAFPKKQDICKVTVCVLSDDASVYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAAL
HISSEVHKGTEVSFQVPMQQMKEGEEHAQGVNS

Sequences:

>Translated_593_residues
MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAILISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSG
SIANTRILGVEIGGLLGGPFVGAGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG
MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARALETHRVLTIADQTLPFFRQGLNE
NSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMDHHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAI
VLPLTSNGNTIGTLKMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFLFNAINTIS
ALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQARFPGKYKIELNIDSRLEQIEIPPFVLQVL
VENALRHAFPKKQDICKVTVCVLSDDASVYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAAL
HISSEVHKGTEVSFQVPMQQMKEGEEHAQGVNS
>Mature_593_residues
MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAILISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSG
SIANTRILGVEIGGLLGGPFVGAGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG
MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARALETHRVLTIADQTLPFFRQGLNE
NSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMDHHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAI
VLPLTSNGNTIGTLKMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFLFNAINTIS
ALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQARFPGKYKIELNIDSRLEQIEIPPFVLQVL
VENALRHAFPKKQDICKVTVCVLSDDASVYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAAL
HISSEVHKGTEVSFQVPMQQMKEGEEHAQGVNS

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1788723, Length=584, Percent_Identity=33.0479452054795, Blast_Score=305, Evalue=7e-84,
Organism=Escherichia coli, GI1788446, Length=583, Percent_Identity=33.7907375643225, Blast_Score=302, Evalue=4e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LYTS_BACSU (P94513)

Other databases:

- EMBL:   Z75208
- EMBL:   AL009126
- PIR:   A69655
- RefSeq:   NP_390771.1
- ProteinModelPortal:   P94513
- SMR:   P94513
- EnsemblBacteria:   EBBACT00000000586
- GeneID:   937404
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU28930
- NMPDR:   fig|224308.1.peg.2896
- GenoList:   BSU28930
- GeneTree:   EBGT00070000032087
- HOGENOM:   HBG724694
- OMA:   IGIGDDH
- PhylomeDB:   P94513
- ProtClustDB:   CLSK887701
- BioCyc:   BSUB:BSU28930-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620
- Gene3D:   G3DSA:3.30.565.10
- SMART:   SM00065
- SMART:   SM00387

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase; SSF55874 ATP_bd_ATPase

EC number: =2.7.13.3

Molecular weight: Translated: 64856; Mature: 64856

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10c0a7b8)-; HASH(0xe51fb44)-; HASH(0x10f82028)-; HASH(0x119c507c)-; HASH(0x11819848)-; HASH(0xd6d189c)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAILISIFSLFSIISNYTGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCC
EIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVGAGIGILAGLHRFSLGGST
EEEECEEECCCEEEEECCCCCCCCEEEEEEEECCHHCCCHHHHHHHHHHHHHHHCCCCHH
ALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIGMESLQMIIILLMAKPFSDAW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHH
ELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARALETHRVLTIADQTLPFFRQGLNE
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHEEEEEEHHHHHHHHCCCCC
NSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMDHHIPSKSLITGLSKKVIKTGHIMK
CHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AISQEEIECTHAECPLHAAIVLPLTSNGNTIGTLKMYFKSPAGLSQVEEELAEGLAMLFS
HHHHHHHHHCCCCCCEEEEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
TQLELGEAELQSKLLKDAEIKALQAQVNPHFLFNAINTISALCRTDVEKTRKLLLQLSVY
HHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRSNLQGARQLLIPLSKELNHLNAYLSLEQARFPGKYKIELNIDSRLEQIEIPPFVLQVL
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCCCHHHHHHH
VENALRHAFPKKQDICKVTVCVLSDDASVYMKVADNGRGIPPDVLPELGKKPFPSKEGTG
HHHHHHHCCCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCC
TALYNLNQRLIGLFGQQAALHISSEVHKGTEVSFQVPMQQMKEGEEHAQGVNS
CEEEHHHHHHHHHHCCHHHEEEHHHHCCCCCEEEECCHHHHHCCHHHCCCCCH
>Mature Secondary Structure
MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAILISIFSLFSIISNYTGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCC
EIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVGAGIGILAGLHRFSLGGST
EEEECEEECCCEEEEECCCCCCCCEEEEEEEECCHHCCCHHHHHHHHHHHHHHHCCCCHH
ALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIGMESLQMIIILLMAKPFSDAW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHH
ELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARALETHRVLTIADQTLPFFRQGLNE
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHEEEEEEHHHHHHHHCCCCC
NSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMDHHIPSKSLITGLSKKVIKTGHIMK
CHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AISQEEIECTHAECPLHAAIVLPLTSNGNTIGTLKMYFKSPAGLSQVEEELAEGLAMLFS
HHHHHHHHHCCCCCCEEEEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
TQLELGEAELQSKLLKDAEIKALQAQVNPHFLFNAINTISALCRTDVEKTRKLLLQLSVY
HHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRSNLQGARQLLIPLSKELNHLNAYLSLEQARFPGKYKIELNIDSRLEQIEIPPFVLQVL
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCCCHHHHHHH
VENALRHAFPKKQDICKVTVCVLSDDASVYMKVADNGRGIPPDVLPELGKKPFPSKEGTG
HHHHHHHCCCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCC
TALYNLNQRLIGLFGQQAALHISSEVHKGTEVSFQVPMQQMKEGEEHAQGVNS
CEEEHHHHHHHHHHCCHHHEEEHHHHCCCCCEEEECCHHHHHCCHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377