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The map label for this gene is nadC [H]

Identifier: 159899899

GI number: 159899899

Start: 4264577

End: 4265470

Strand: Direct

Name: nadC [H]

Synonym: Haur_3382

Alternate gene names: 159899899

Gene position: 4264577-4265470 (Clockwise)

Preceding gene: 159899898

Following gene: 159899900

Centisome position: 67.19

GC content: 53.36

Gene sequence:

>894_bases
ATGATTGACAATCGTAACCCAATGTACAAGGACAATGGTGTTTGTGCAATGTACCTTCCTCAAGCAACTCAACGCCTCAT
CGAATTGGCGTTAGCAGAAGACCTCGATGGTGGCGACTTAACATCACTTGCCACAATTCCGGCTGATTTAGCAGCCAAAG
CCCATGTTTTAGTTAAAGATCAGGGTGTACTCGCAGGCATGGACGTTGCAGCGGCGGTTTGCCGTTTGGTTGACCCGGCC
TTAGAATGGCAACCAGTGTTAGGCGATGGTTCAGCTGTGGAGTATGGCACGATTGTGGCCTACCTCAGCGGGCCAGCTCG
CTCAGTGCTGATGGCTGAACGCACCGTACTTAACTTTTTACAGCGGCTTTCGGGCATTGCCAGCAAAACGGCGCTCTATG
TCGCCAAAATCGCCGATACCCAAGCTAAATTGGTTGATACGCGCAAAACCACCCCAGGCTGGCGGGCTTTGGAAAAAGCC
GCAGTACGGGCAGGGGGTGGCGCAAATCATCGGTTTAATTTGGGCGATGGCGTGCTGATCAAAGACAATCATCTGGCGCT
TGGTGGGCATGATATTGTGGGCGCAATTCAGCGGGCACGGGCTGTTGCGCCGCATACCACCAAAATCGAGGTTGAAGTTG
AAGATTTGGCGGGGGTACAAGCAGCACTTGAGGCGGGAGCCGATATCATTATGCTCGATAATATGTCAATTGAGGCCATG
CACGAGGCTGTACAGTTAATCGCTGGACGGGCCTTAGTCGAGGCTTCGGGCGGCATCACCCTTGAGCGAATTCGGGCGGT
CGCGGAAACGGGAGTCAATGTGATCTCCTGTGGTGCGATTACCCACTCGGCGACGGCGCTCGACATCAGCTTGGACATTG
CAATCAATTCGTAA

Upstream 100 bases:

>100_bases
TGCCAGAGAATCCTGCAGGCGACACCATTAACCATGGATTGCTTGCAGGATTCGTGGTCAGTTGAGGCAAATTGATCACC
GCAACAAGGATTTTTATGCT

Downstream 100 bases:

>100_bases
CGTGCTCATCAGTAGGTTATAAGCAATTTATCAGGTTGGCCATGCTACTATTACGCAGTCAGTACTGAGCAATTGCTTAC
GAACGATTTAGTGCATCGAC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MIDNRNPMYKDNGVCAMYLPQATQRLIELALAEDLDGGDLTSLATIPADLAAKAHVLVKDQGVLAGMDVAAAVCRLVDPA
LEWQPVLGDGSAVEYGTIVAYLSGPARSVLMAERTVLNFLQRLSGIASKTALYVAKIADTQAKLVDTRKTTPGWRALEKA
AVRAGGGANHRFNLGDGVLIKDNHLALGGHDIVGAIQRARAVAPHTTKIEVEVEDLAGVQAALEAGADIIMLDNMSIEAM
HEAVQLIAGRALVEASGGITLERIRAVAETGVNVISCGAITHSATALDISLDIAINS

Sequences:

>Translated_297_residues
MIDNRNPMYKDNGVCAMYLPQATQRLIELALAEDLDGGDLTSLATIPADLAAKAHVLVKDQGVLAGMDVAAAVCRLVDPA
LEWQPVLGDGSAVEYGTIVAYLSGPARSVLMAERTVLNFLQRLSGIASKTALYVAKIADTQAKLVDTRKTTPGWRALEKA
AVRAGGGANHRFNLGDGVLIKDNHLALGGHDIVGAIQRARAVAPHTTKIEVEVEDLAGVQAALEAGADIIMLDNMSIEAM
HEAVQLIAGRALVEASGGITLERIRAVAETGVNVISCGAITHSATALDISLDIAINS
>Mature_297_residues
MIDNRNPMYKDNGVCAMYLPQATQRLIELALAEDLDGGDLTSLATIPADLAAKAHVLVKDQGVLAGMDVAAAVCRLVDPA
LEWQPVLGDGSAVEYGTIVAYLSGPARSVLMAERTVLNFLQRLSGIASKTALYVAKIADTQAKLVDTRKTTPGWRALEKA
AVRAGGGANHRFNLGDGVLIKDNHLALGGHDIVGAIQRARAVAPHTTKIEVEVEDLAGVQAALEAGADIIMLDNMSIEAM
HEAVQLIAGRALVEASGGITLERIRAVAETGVNVISCGAITHSATALDISLDIAINS

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=284, Percent_Identity=36.9718309859155, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=41.1111111111111, Blast_Score=171, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=278, Percent_Identity=34.1726618705036, Blast_Score=143, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31071; Mature: 31071

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDNRNPMYKDNGVCAMYLPQATQRLIELALAEDLDGGDLTSLATIPADLAAKAHVLVKD
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHCCEEEEEEC
QGVLAGMDVAAAVCRLVDPALEWQPVLGDGSAVEYGTIVAYLSGPARSVLMAERTVLNFL
CCCEECHHHHHHHHHHHCCCCCCEEECCCCCCEECCEEEEEECCCHHHHHHHHHHHHHHH
QRLSGIASKTALYVAKIADTQAKLVDTRKTTPGWRALEKAAVRAGGGANHRFNLGDGVLI
HHHHHHHHHHHEEEEECCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEE
KDNHLALGGHDIVGAIQRARAVAPHTTKIEVEVEDLAGVQAALEAGADIIMLDNMSIEAM
ECCEEEECCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCEEEEECCCHHHH
HEAVQLIAGRALVEASGGITLERIRAVAETGVNVISCGAITHSATALDISLDIAINS
HHHHHHHHCHHEEECCCCEEHHHHHHHHHCCCCEEEECCEECCCEEEEEEEEEEECC
>Mature Secondary Structure
MIDNRNPMYKDNGVCAMYLPQATQRLIELALAEDLDGGDLTSLATIPADLAAKAHVLVKD
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHCCEEEEEEC
QGVLAGMDVAAAVCRLVDPALEWQPVLGDGSAVEYGTIVAYLSGPARSVLMAERTVLNFL
CCCEECHHHHHHHHHHHCCCCCCEEECCCCCCEECCEEEEEECCCHHHHHHHHHHHHHHH
QRLSGIASKTALYVAKIADTQAKLVDTRKTTPGWRALEKAAVRAGGGANHRFNLGDGVLI
HHHHHHHHHHHEEEEECCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEE
KDNHLALGGHDIVGAIQRARAVAPHTTKIEVEVEDLAGVQAALEAGADIIMLDNMSIEAM
ECCEEEECCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCEEEEECCCHHHH
HEAVQLIAGRALVEASGGITLERIRAVAETGVNVISCGAITHSATALDISLDIAINS
HHHHHHHHCHHEEECCCCEEHHHHHHHHHCCCCEEEECCEECCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]