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The map label for this gene is pncB [H]

Identifier: 159899898

GI number: 159899898

Start: 4262832

End: 4264367

Strand: Direct

Name: pncB [H]

Synonym: Haur_3381

Alternate gene names: 159899898

Gene position: 4262832-4264367 (Clockwise)

Preceding gene: 159899892

Following gene: 159899899

Centisome position: 67.17

GC content: 55.27

Gene sequence:

>1536_bases
ATGACAACCCGCTTTCAACATGGCATTCTCTTCACCGATCAATATCAATTAACCATGTCGCAGGTGTATTATCGCTTGGG
GCTGCATGAACGCCCAGCCTTGTTCGACCACTACTTCCGTTCGTATCCCAATTATGGAGCGCATGCGGCGGGCTATGCGG
TGGCCGCTGGCATGCAACCCTTGCTCGAATGGATGGATACCGCCCGCTTTGGCGAAGGCGAAATCGCTGCGCTCTCGGCG
ATGAAAGGCCGCACTGGCCAAGCGTTGTTTAGCAGCGATTTTTTGGGCTGGCTGCGCAAATATGGCGATCTGCGCAATGT
TACGATTCGGGCGATTCCCGAGGGGCGTGTGGTGCATCACACCGTGCCAATGACGATTGTCGAAGGCCCATTGGTGTTGG
CGCAAATTCTCGAAACGCCCTTGTTGAATATGCTCAACTTCAGCACACTTATCGCTACCAAAGCGGCACGGGTGCGCGAG
AGCGCTGGCGATGGCTTATTTTTGGAATTTGGCATGCGCCGCGCTCAAGGCTGGGGAGCCAATTTGGCCACTCGGGCAGC
CCTCATCGGCGGGGCTGATAGCTCATCGAACGTTGGCGCAGCGCTGGATATGGGTGTGCAGCCAAGTGGCACCCATGCCC
ATAGTTTGGTCCAAACCGCCATGGCGTTGGGCATGGGCGAATTAGGCGCATTCGAGGCCTACGCTGAAGCCTACCCCGAC
GACACGCTGCTGCTGGTCGATACGATCAACACCTTGGAAAGCGGCGTGCCCAATGCGATCAAGGTATTTGAAAAGTTGCG
TCGCCAAGGCCATAAACCCGTTGGCATTCGGCTCGATTCAGGCGACTTGGCCTATTTGAGCATTCAGGCCGCCAAAATGC
TCAATACTGCCGGATTCCCCGATGTTTCGATTGTGCTTTCCAACAATCTCGATGAATTAGTGATTTGGCAAATTTTGACC
CAAATTCGCGCCGAAGCGCCGCGCTATGGCCTTGAAGCCGATGCCGTAATCAAGCGCTTGGTGTTTGGGGTCGGCACGCA
TTTGGTCACATCGTGGGGCGAACCAGCCTTAGGCGGCGTGTATAAATTGGTTTCATTGTTTGATCGCGATACATGGAAAC
CAGCGATCAAGCTCTCAGAGAACCCGCAGAAAACTCCAACTCCTGGGCGCAAAGCAGCATGGCGGGTCTATGATAGCCGT
GGGCGAGCTAGCGCCGATGTTTTGACCTTGGATGACGAACATCCACAGCAAAGCGAAGCCTTGAGCCTGTATCACCCAAC
TGATTCGAGCAAACAACGCACCCTGACTCCTGCCGACCACACCATTGAGGCCTTGTATGCGACGGTGCTCGATTCTGGCC
GACGGGTCGTTGATGTGCCCGATTTGGCCGAGTTGCGCGAACGGCGGGTGCGCGATTTGGCGCGGCTTGATCCTGGGGTT
TTGCGCTTGGTCAATCCCCACATCTACCACGTTTCGCTCAGCCAACGCTTATGGGAATTGAAACAGAACCTGATTAAAGA
GATGCGCAAGGGCTAA

Upstream 100 bases:

>100_bases
TCCTTCGTGTCCTTCGTGTCCTTCGTGGATCATTAGTGCTTGACAATTAGTGTATTATAGACACTAAGTCAGTTTTTCGA
TTTACAAAGGATAGCAATAT

Downstream 100 bases:

>100_bases
GCGCGATCAAACGCCTTGAGATTGGCCACGTTAATAATCAACTGGCAAATTTAAGGCTTATTTATAAAGATTTTTAATAA
ATTTATTATTCGATCAGCCC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTTRFQHGILFTDQYQLTMSQVYYRLGLHERPALFDHYFRSYPNYGAHAAGYAVAAGMQPLLEWMDTARFGEGEIAALSA
MKGRTGQALFSSDFLGWLRKYGDLRNVTIRAIPEGRVVHHTVPMTIVEGPLVLAQILETPLLNMLNFSTLIATKAARVRE
SAGDGLFLEFGMRRAQGWGANLATRAALIGGADSSSNVGAALDMGVQPSGTHAHSLVQTAMALGMGELGAFEAYAEAYPD
DTLLLVDTINTLESGVPNAIKVFEKLRRQGHKPVGIRLDSGDLAYLSIQAAKMLNTAGFPDVSIVLSNNLDELVIWQILT
QIRAEAPRYGLEADAVIKRLVFGVGTHLVTSWGEPALGGVYKLVSLFDRDTWKPAIKLSENPQKTPTPGRKAAWRVYDSR
GRASADVLTLDDEHPQQSEALSLYHPTDSSKQRTLTPADHTIEALYATVLDSGRRVVDVPDLAELRERRVRDLARLDPGV
LRLVNPHIYHVSLSQRLWELKQNLIKEMRKG

Sequences:

>Translated_511_residues
MTTRFQHGILFTDQYQLTMSQVYYRLGLHERPALFDHYFRSYPNYGAHAAGYAVAAGMQPLLEWMDTARFGEGEIAALSA
MKGRTGQALFSSDFLGWLRKYGDLRNVTIRAIPEGRVVHHTVPMTIVEGPLVLAQILETPLLNMLNFSTLIATKAARVRE
SAGDGLFLEFGMRRAQGWGANLATRAALIGGADSSSNVGAALDMGVQPSGTHAHSLVQTAMALGMGELGAFEAYAEAYPD
DTLLLVDTINTLESGVPNAIKVFEKLRRQGHKPVGIRLDSGDLAYLSIQAAKMLNTAGFPDVSIVLSNNLDELVIWQILT
QIRAEAPRYGLEADAVIKRLVFGVGTHLVTSWGEPALGGVYKLVSLFDRDTWKPAIKLSENPQKTPTPGRKAAWRVYDSR
GRASADVLTLDDEHPQQSEALSLYHPTDSSKQRTLTPADHTIEALYATVLDSGRRVVDVPDLAELRERRVRDLARLDPGV
LRLVNPHIYHVSLSQRLWELKQNLIKEMRKG
>Mature_510_residues
TTRFQHGILFTDQYQLTMSQVYYRLGLHERPALFDHYFRSYPNYGAHAAGYAVAAGMQPLLEWMDTARFGEGEIAALSAM
KGRTGQALFSSDFLGWLRKYGDLRNVTIRAIPEGRVVHHTVPMTIVEGPLVLAQILETPLLNMLNFSTLIATKAARVRES
AGDGLFLEFGMRRAQGWGANLATRAALIGGADSSSNVGAALDMGVQPSGTHAHSLVQTAMALGMGELGAFEAYAEAYPDD
TLLLVDTINTLESGVPNAIKVFEKLRRQGHKPVGIRLDSGDLAYLSIQAAKMLNTAGFPDVSIVLSNNLDELVIWQILTQ
IRAEAPRYGLEADAVIKRLVFGVGTHLVTSWGEPALGGVYKLVSLFDRDTWKPAIKLSENPQKTPTPGRKAAWRVYDSRG
RASADVLTLDDEHPQQSEALSLYHPTDSSKQRTLTPADHTIEALYATVLDSGRRVVDVPDLAELRERRVRDLARLDPGVL
RLVNPHIYHVSLSQRLWELKQNLIKEMRKG

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=549, Percent_Identity=35.1548269581056, Blast_Score=243, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71997947, Length=552, Percent_Identity=33.1521739130435, Blast_Score=274, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI71997952, Length=552, Percent_Identity=33.1521739130435, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71997955, Length=212, Percent_Identity=36.3207547169811, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24581587, Length=555, Percent_Identity=32.972972972973, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI161076680, Length=262, Percent_Identity=33.587786259542, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24581595, Length=262, Percent_Identity=33.587786259542, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28574709, Length=262, Percent_Identity=33.587786259542, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24581593, Length=262, Percent_Identity=33.587786259542, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24581591, Length=262, Percent_Identity=33.587786259542, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 56378; Mature: 56247

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRFQHGILFTDQYQLTMSQVYYRLGLHERPALFDHYFRSYPNYGAHAAGYAVAAGMQP
CCCCCCCCCEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LLEWMDTARFGEGEIAALSAMKGRTGQALFSSDFLGWLRKYGDLRNVTIRAIPEGRVVHH
HHHHHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEE
TVPMTIVEGPLVLAQILETPLLNMLNFSTLIATKAARVRESAGDGLFLEFGMRRAQGWGA
ECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCC
NLATRAALIGGADSSSNVGAALDMGVQPSGTHAHSLVQTAMALGMGELGAFEAYAEAYPD
CHHHHHHHEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
DTLLLVDTINTLESGVPNAIKVFEKLRRQGHKPVGIRLDSGDLAYLSIQAAKMLNTAGFP
CCEEEEECHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEEEHHHHHHHHCCCCC
DVSIVLSNNLDELVIWQILTQIRAEAPRYGLEADAVIKRLVFGVGTHLVTSWGEPALGGV
CEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
YKLVSLFDRDTWKPAIKLSENPQKTPTPGRKAAWRVYDSRGRASADVLTLDDEHPQQSEA
HHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHEEEEECCCCCCCCEEEEECCCCCCCCCC
LSLYHPTDSSKQRTLTPADHTIEALYATVLDSGRRVVDVPDLAELRERRVRDLARLDPGV
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHH
LRLVNPHIYHVSLSQRLWELKQNLIKEMRKG
EEECCCEEEEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTRFQHGILFTDQYQLTMSQVYYRLGLHERPALFDHYFRSYPNYGAHAAGYAVAAGMQP
CCCCCCCCEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LLEWMDTARFGEGEIAALSAMKGRTGQALFSSDFLGWLRKYGDLRNVTIRAIPEGRVVHH
HHHHHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEE
TVPMTIVEGPLVLAQILETPLLNMLNFSTLIATKAARVRESAGDGLFLEFGMRRAQGWGA
ECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCC
NLATRAALIGGADSSSNVGAALDMGVQPSGTHAHSLVQTAMALGMGELGAFEAYAEAYPD
CHHHHHHHEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
DTLLLVDTINTLESGVPNAIKVFEKLRRQGHKPVGIRLDSGDLAYLSIQAAKMLNTAGFP
CCEEEEECHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEEEHHHHHHHHCCCCC
DVSIVLSNNLDELVIWQILTQIRAEAPRYGLEADAVIKRLVFGVGTHLVTSWGEPALGGV
CEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
YKLVSLFDRDTWKPAIKLSENPQKTPTPGRKAAWRVYDSRGRASADVLTLDDEHPQQSEA
HHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHEEEEECCCCCCCCEEEEECCCCCCCCCC
LSLYHPTDSSKQRTLTPADHTIEALYATVLDSGRRVVDVPDLAELRERRVRDLARLDPGV
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHH
LRLVNPHIYHVSLSQRLWELKQNLIKEMRKG
EEECCCEEEEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]