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The map label for this gene is mcl1 [H]

Identifier: 159899707

GI number: 159899707

Start: 4034303

End: 4035208

Strand: Direct

Name: mcl1 [H]

Synonym: Haur_3189

Alternate gene names: 159899707

Gene position: 4034303-4035208 (Clockwise)

Preceding gene: 159899706

Following gene: 159899708

Centisome position: 63.57

GC content: 51.88

Gene sequence:

>906_bases
ATGTCGTCAAGGATTCGCCGCAGTGAAATGACCTGCCCCGCCCATAGCCTAGCCATGATCACCAAAGCCGCCGCCTCTGA
GGCCGACGAAGTGATTATCGATTTAGAAGATGCTTGCGCCGTTTCACAGAAAATTGCCGCCCGTGCCACAGTCATTCAAG
CCTTGCAAAGCTTAGATTTTGGCCAGAAAATTGTAGCAGTGCGCCCAAATGCGGTGCAAACTCATTATCACTATCGCGAT
GTCGTTGAAATTGTCGAGGCGGCTGGCGCTAAAATTGATGTTTTGGTGATTCCCAAAATTGAAAGCGCTGACGATGTGCG
CTTCGTTGATCGGTTGCTCAGTCAAATCGAGGCCAATATTGGCTTGCAGGTTGGCACAATTAAGCTCGAAGTATTAATTG
AAGGCACTCGCGCCTTGCAAGCGGTTGAGCAGATTGCCAACGCCTCGCCTCGTTTGGAAAGCTTAATTTTTGGTTTGGCG
GATTATGCAGGCGATTTGGGAGCACGCTCGGCAGATGATCAATGGGGCATGTTTGCTTACCCCAAGCACAAAATGTTGGT
AGCGGCCAAAGCGGCGGGCCTAGAGGCGATCGATAATGTGACCTTTGCCTTTCGCGATGCCGAGGCCTGCCAACGCGATG
CAGAACGCGCTGCCGCGATGGGTTTCGATGGCAAATGGGCAATTCATCCGGTACAAGTGCCAATCATCAACCAAGCCTTT
TTGCCCAGCGCTGCCGAAATTGCCGAAGCTCAACGCCTGATCAAGGCCTACCAAGCTGCCGATCAACAGGCAGGCTTAGG
GGCAATTGCGATTGATGATCAGATGATCGATGCAGCAAGCTTGCGGGTTCATGCCAAAAAATTAGCTATGGCGCAACGGG
CAGGGTTAATCGCCATTCAGCCTTAG

Upstream 100 bases:

>100_bases
CAAGCCTAATTTTAGCATCAAGCCGCTCAGTTCCAAAGTCTCCTGACAATGCGCCTTTGGGTCTTGGCGGCTTGCCGTTT
TTAGCACAAAGGATGCCTGC

Downstream 100 bases:

>100_bases
CTCAATCAATTTCGTGCCTCATGATATACTGTCAACAGATTGACATTGCAAGCCCTCACACAATAGGACATAAAGGACAC
AATGGCTGAACAGACGCACA

Product: citrate (pro-3S)-lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSSRIRRSEMTCPAHSLAMITKAAASEADEVIIDLEDACAVSQKIAARATVIQALQSLDFGQKIVAVRPNAVQTHYHYRD
VVEIVEAAGAKIDVLVIPKIESADDVRFVDRLLSQIEANIGLQVGTIKLEVLIEGTRALQAVEQIANASPRLESLIFGLA
DYAGDLGARSADDQWGMFAYPKHKMLVAAKAAGLEAIDNVTFAFRDAEACQRDAERAAAMGFDGKWAIHPVQVPIINQAF
LPSAAEIAEAQRLIKAYQAADQQAGLGAIAIDDQMIDAASLRVHAKKLAMAQRAGLIAIQP

Sequences:

>Translated_301_residues
MSSRIRRSEMTCPAHSLAMITKAAASEADEVIIDLEDACAVSQKIAARATVIQALQSLDFGQKIVAVRPNAVQTHYHYRD
VVEIVEAAGAKIDVLVIPKIESADDVRFVDRLLSQIEANIGLQVGTIKLEVLIEGTRALQAVEQIANASPRLESLIFGLA
DYAGDLGARSADDQWGMFAYPKHKMLVAAKAAGLEAIDNVTFAFRDAEACQRDAERAAAMGFDGKWAIHPVQVPIINQAF
LPSAAEIAEAQRLIKAYQAADQQAGLGAIAIDDQMIDAASLRVHAKKLAMAQRAGLIAIQP
>Mature_300_residues
SSRIRRSEMTCPAHSLAMITKAAASEADEVIIDLEDACAVSQKIAARATVIQALQSLDFGQKIVAVRPNAVQTHYHYRDV
VEIVEAAGAKIDVLVIPKIESADDVRFVDRLLSQIEANIGLQVGTIKLEVLIEGTRALQAVEQIANASPRLESLIFGLAD
YAGDLGARSADDQWGMFAYPKHKMLVAAKAAGLEAIDNVTFAFRDAEACQRDAERAAAMGFDGKWAIHPVQVPIINQAFL
PSAAEIAEAQRLIKAYQAADQQAGLGAIAIDDQMIDAASLRVHAKKLAMAQRAGLIAIQP

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=286, Percent_Identity=30.4195804195804, Blast_Score=124, Evalue=8e-29,
Organism=Escherichia coli, GI87081764, Length=277, Percent_Identity=29.2418772563177, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17557458, Length=285, Percent_Identity=28.4210526315789, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 32335; Mature: 32204

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRIRRSEMTCPAHSLAMITKAAASEADEVIIDLEDACAVSQKIAARATVIQALQSLDF
CCCCCCHHHCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCC
GQKIVAVRPNAVQTHYHYRDVVEIVEAAGAKIDVLVIPKIESADDVRFVDRLLSQIEANI
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHC
GLQVGTIKLEVLIEGTRALQAVEQIANASPRLESLIFGLADYAGDLGARSADDQWGMFAY
CEEEEEEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEC
PKHKMLVAAKAAGLEAIDNVTFAFRDAEACQRDAERAAAMGFDGKWAIHPVQVPIINQAF
CCCCEEEEEHHCCHHHHHCCCEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
LPSAAEIAEAQRLIKAYQAADQQAGLGAIAIDDQMIDAASLRVHAKKLAMAQRAGLIAIQ
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEEC
P
C
>Mature Secondary Structure 
SSRIRRSEMTCPAHSLAMITKAAASEADEVIIDLEDACAVSQKIAARATVIQALQSLDF
CCCCCHHHCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCC
GQKIVAVRPNAVQTHYHYRDVVEIVEAAGAKIDVLVIPKIESADDVRFVDRLLSQIEANI
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHC
GLQVGTIKLEVLIEGTRALQAVEQIANASPRLESLIFGLADYAGDLGARSADDQWGMFAY
CEEEEEEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEC
PKHKMLVAAKAAGLEAIDNVTFAFRDAEACQRDAERAAAMGFDGKWAIHPVQVPIINQAF
CCCCEEEEEHHCCHHHHHCCCEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
LPSAAEIAEAQRLIKAYQAADQQAGLGAIAIDDQMIDAASLRVHAKKLAMAQRAGLIAIQ
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEEC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA