Click here to switch to the map view.

The map label for this gene is rsbRA [H]

Identifier: 159899456

GI number: 159899456

Start: 3712342

End: 3713157

Strand: Direct

Name: rsbRA [H]

Synonym: Haur_2937

Alternate gene names: 159899456

Gene position: 3712342-3713157 (Clockwise)

Preceding gene: 159899454

Following gene: 159899457

Centisome position: 58.49

GC content: 50.37

Gene sequence:

>816_bases
ATGTCCTTCGGAAGCGTTTTTATTGCCATGGAAGAATCCATGAGCGATCAATTGATTGATCAAGCTTTGGTGGAGATTCC
AGGTTACCGCAAATTGCCCCTCACCAAGCAACAATTGGCTCAACGGGTGCTGATTACCGTTCATGCCTTCGGAATGGATT
TGGATGAGGAAGAACCCCATTTTTACCGTACCCACCTCGAAGAAGGGGCTTACCAACGCGCCATGCAAGGCCTGCCTATC
GACGATTTTGAGCAATTGGTGTTGCTCTGGCACCGCCGGGGCATCGAAATGCTTATGGCCAAATTCGAGCACCCAGCTGA
GCATGTCGCCCTTTTACGCCAAACGTTAAAAGTTATTCAATCGGGGCTAGCTGGGTTATATCGTGGCTATGATCGGGCAC
GGATCGGCCAACTCGACCGCCAACAGGCAATTTTGAGCGAATTGGCGCTCCCGATTATTCCAGTCTACAAGCATATTTTG
GCAGTTCCGCTGATTGGGGTCATCGATAGCAGCCGTGCGCAGCAAATGATCGAGCGTTTGCTCGATGAAATTACCACTCT
CAAAGCTCAAATGGTCATCCTCGATCTCACAGGTGTACCATTAATTGATACTGGCGTGGCCCACCATTTGCTTAAAACCG
TGCATTCGGCCCGTTTACTCGGTGCACGGGTGATTATCGTGGGGATTCGTGGCGAAATTGCCCAAACCATGGTCCATTTA
GGCATTGATCTGAGCGAAATTACGACCCGCGCCAATCTCCAAGCAGGCGTAGAATATGCCCTCGCTTGTACTGGCTTTGC
AATTCGCCCATTGTAG

Upstream 100 bases:

>100_bases
CACACTAGCCCAACGTTGTATGGTATCATCGAATGCCACATCCTACTAAAACACTACGCTCATTGCCACCAGCGATCATG
TGGGTTAGGAGCACGCAACT

Downstream 100 bases:

>100_bases
CGTGGGCAGGGAATTTGGATTATGGCTAACCAAACGCCGCAACACGATCATTCACATCAATTAAGTGCTTTAGCCGCCCG
CGAACGCGAGTTGATCAAAC

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSFGSVFIAMEESMSDQLIDQALVEIPGYRKLPLTKQQLAQRVLITVHAFGMDLDEEEPHFYRTHLEEGAYQRAMQGLPI
DDFEQLVLLWHRRGIEMLMAKFEHPAEHVALLRQTLKVIQSGLAGLYRGYDRARIGQLDRQQAILSELALPIIPVYKHIL
AVPLIGVIDSSRAQQMIERLLDEITTLKAQMVILDLTGVPLIDTGVAHHLLKTVHSARLLGARVIIVGIRGEIAQTMVHL
GIDLSEITTRANLQAGVEYALACTGFAIRPL

Sequences:

>Translated_271_residues
MSFGSVFIAMEESMSDQLIDQALVEIPGYRKLPLTKQQLAQRVLITVHAFGMDLDEEEPHFYRTHLEEGAYQRAMQGLPI
DDFEQLVLLWHRRGIEMLMAKFEHPAEHVALLRQTLKVIQSGLAGLYRGYDRARIGQLDRQQAILSELALPIIPVYKHIL
AVPLIGVIDSSRAQQMIERLLDEITTLKAQMVILDLTGVPLIDTGVAHHLLKTVHSARLLGARVIIVGIRGEIAQTMVHL
GIDLSEITTRANLQAGVEYALACTGFAIRPL
>Mature_270_residues
SFGSVFIAMEESMSDQLIDQALVEIPGYRKLPLTKQQLAQRVLITVHAFGMDLDEEEPHFYRTHLEEGAYQRAMQGLPID
DFEQLVLLWHRRGIEMLMAKFEHPAEHVALLRQTLKVIQSGLAGLYRGYDRARIGQLDRQQAILSELALPIIPVYKHILA
VPLIGVIDSSRAQQMIERLLDEITTLKAQMVILDLTGVPLIDTGVAHHLLKTVHSARLLGARVIIVGIRGEIAQTMVHLG
IDLSEITTRANLQAGVEYALACTGFAIRPL

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 30294; Mature: 30163

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50801 STAS ; PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFGSVFIAMEESMSDQLIDQALVEIPGYRKLPLTKQQLAQRVLITVHAFGMDLDEEEPH
CCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCH
FYRTHLEEGAYQRAMQGLPIDDFEQLVLLWHRRGIEMLMAKFEHPAEHVALLRQTLKVIQ
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SGLAGLYRGYDRARIGQLDRQQAILSELALPIIPVYKHILAVPLIGVIDSSRAQQMIERL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LDEITTLKAQMVILDLTGVPLIDTGVAHHLLKTVHSARLLGARVIIVGIRGEIAQTMVHL
HHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHH
GIDLSEITTRANLQAGVEYALACTGFAIRPL
CCCHHHHHHHHHHHHHHHHHHHHCCEEECCC
>Mature Secondary Structure 
SFGSVFIAMEESMSDQLIDQALVEIPGYRKLPLTKQQLAQRVLITVHAFGMDLDEEEPH
CCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCH
FYRTHLEEGAYQRAMQGLPIDDFEQLVLLWHRRGIEMLMAKFEHPAEHVALLRQTLKVIQ
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SGLAGLYRGYDRARIGQLDRQQAILSELALPIIPVYKHILAVPLIGVIDSSRAQQMIERL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LDEITTLKAQMVILDLTGVPLIDTGVAHHLLKTVHSARLLGARVIIVGIRGEIAQTMVHL
HHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHH
GIDLSEITTRANLQAGVEYALACTGFAIRPL
CCCHHHHHHHHHHHHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]