Click here to switch to the map view.

The map label for this gene is gcvPA [H]

Identifier: 159899389

GI number: 159899389

Start: 3640993

End: 3642324

Strand: Direct

Name: gcvPA [H]

Synonym: Haur_2870

Alternate gene names: 159899389

Gene position: 3640993-3642324 (Clockwise)

Preceding gene: 159899388

Following gene: 159899390

Centisome position: 57.37

GC content: 52.78

Gene sequence:

>1332_bases
ATGAGCCACTACATTTCGATTACCGAGAGCGAACGCGCAGAGATGCTCAAGGCGATTGGCGTTGCCGATGTTGCCGAGCT
TTTCCACGATGTTCCTGCTGATCTTCGGTTTCCAACGCTCGATCTGCCCGCCGCACTTGCTGAAGGTGAAATGGCCCGCG
AATTACGCCGCTTGAGCAGCAAAAATAGCGATGTGCTGAACTATAGCTGTTTCTTGGGCGCGGGAGCCTACAACCACTTT
ATCCCTGCCGCAGTCGATTCGTTGTTGCGCCGCTCGGAGTTCTACACCGCCTACACGCCCTATCAGCCCGAAATTTCTCA
AGGTACGTTGCAAGCAATTTTTGAATACCAATCGTTGATGTGTGGTTTGTTGCAGATGGATGCAGCCAATGCTTCGCACT
ACGATGGCGCAACGGCCATGGCTGAAGGCGCAATTATGGCGATCAGCGCAACTCGTAATCGGCGCAAAATTGTCGTGGCT
CCTTCGGTGCATCCGCAATATCGCGGCGTGCTACGCAGTTATACCCAAGGTTTGGGCGTAACAATCACTGGCGACGAAAA
TCCAGCTGCCAGCGTGGCCGATGCAGCGGCTTTGGTCGATAACGAAACTGCGGTGTTTATTGTGCAATCGCCTGATTTCT
TGGGTGTGCTGCACGATTTGAAGCCTGTCGCCGAACAGATTCACGCGGCTGGCGCACTGCTGTTGATGGTCACCAATCCG
ATCGCCTTGGGCTTGTTCCAAACACCAGGTATGGTTGGCGCTGATATTGCGGTGATGGAAGGCCAGCCCTTGGGGATTCC
GCTGAGCTTTGGCGGGCCATATGTTGGCGTATTTAGCTGTACCGAAAAACTCTTGCGGCGCATGGCTGGGCGTTTGGTGG
GCGTAACGACCGACCTCAATGGCCAATTGGGCTATGTGTTAACCCTACAAACCCGTGAGCAACATATTCGCCGCGAAAAA
GCTACCTCGAATATTTGTACCAACCAAGGCTTGATGGCCTTGGCTGCGACGATTTATACCTCGCTGATGGGCAAAACTGG
CTTGCGTAAAGTGGCTGAACTTTGCTACCAACGCGCCCATTATGCTGCCAAAGCGATTGGCAATTTGGCTGGTTACGAGG
TGCTTGAGCAAGGCGCTTTCTTCCATGAATTTGTGGTGCGCTGCCCACGACCTGTAGCTGAAATTACCCAAGCCTTGCAT
GCTCAAGGCATTATCGGCGGCTACGATTTGAGCAAGGATTACCCACACTTGGGTAATGCAATGCTGATCTGCGTTACCGA
GCAAAATACCAAAAACGATATCGACCAACTTGTCGCAGTGTTGGGAGGCTAA

Upstream 100 bases:

>100_bases
CTAAAGTATTTAACGCTGAGAAATCAAAAGGTGATTGGAATAATCCTAAGGCATTTCTGCCTTTTGCCTTTTGCCTTTTG
ATTTCACCATAAGGTGAAAC

Downstream 100 bases:

>100_bases
GCCAATGCATACCTACGAACCACCAATTTTTGAATTGAGCAGCCCCGGTAAAATTGGCGCAGCCCTGCCCGACGCTGGTG
TGCCCGAAACCGAGTTGCCA

Product: glycine dehydrogenase

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSHYISITESERAEMLKAIGVADVAELFHDVPADLRFPTLDLPAALAEGEMARELRRLSSKNSDVLNYSCFLGAGAYNHF
IPAAVDSLLRRSEFYTAYTPYQPEISQGTLQAIFEYQSLMCGLLQMDAANASHYDGATAMAEGAIMAISATRNRRKIVVA
PSVHPQYRGVLRSYTQGLGVTITGDENPAASVADAAALVDNETAVFIVQSPDFLGVLHDLKPVAEQIHAAGALLLMVTNP
IALGLFQTPGMVGADIAVMEGQPLGIPLSFGGPYVGVFSCTEKLLRRMAGRLVGVTTDLNGQLGYVLTLQTREQHIRREK
ATSNICTNQGLMALAATIYTSLMGKTGLRKVAELCYQRAHYAAKAIGNLAGYEVLEQGAFFHEFVVRCPRPVAEITQALH
AQGIIGGYDLSKDYPHLGNAMLICVTEQNTKNDIDQLVAVLGG

Sequences:

>Translated_443_residues
MSHYISITESERAEMLKAIGVADVAELFHDVPADLRFPTLDLPAALAEGEMARELRRLSSKNSDVLNYSCFLGAGAYNHF
IPAAVDSLLRRSEFYTAYTPYQPEISQGTLQAIFEYQSLMCGLLQMDAANASHYDGATAMAEGAIMAISATRNRRKIVVA
PSVHPQYRGVLRSYTQGLGVTITGDENPAASVADAAALVDNETAVFIVQSPDFLGVLHDLKPVAEQIHAAGALLLMVTNP
IALGLFQTPGMVGADIAVMEGQPLGIPLSFGGPYVGVFSCTEKLLRRMAGRLVGVTTDLNGQLGYVLTLQTREQHIRREK
ATSNICTNQGLMALAATIYTSLMGKTGLRKVAELCYQRAHYAAKAIGNLAGYEVLEQGAFFHEFVVRCPRPVAEITQALH
AQGIIGGYDLSKDYPHLGNAMLICVTEQNTKNDIDQLVAVLGG
>Mature_442_residues
SHYISITESERAEMLKAIGVADVAELFHDVPADLRFPTLDLPAALAEGEMARELRRLSSKNSDVLNYSCFLGAGAYNHFI
PAAVDSLLRRSEFYTAYTPYQPEISQGTLQAIFEYQSLMCGLLQMDAANASHYDGATAMAEGAIMAISATRNRRKIVVAP
SVHPQYRGVLRSYTQGLGVTITGDENPAASVADAAALVDNETAVFIVQSPDFLGVLHDLKPVAEQIHAAGALLLMVTNPI
ALGLFQTPGMVGADIAVMEGQPLGIPLSFGGPYVGVFSCTEKLLRRMAGRLVGVTTDLNGQLGYVLTLQTREQHIRREKA
TSNICTNQGLMALAATIYTSLMGKTGLRKVAELCYQRAHYAAKAIGNLAGYEVLEQGAFFHEFVVRCPRPVAEITQALHA
QGIIGGYDLSKDYPHLGNAMLICVTEQNTKNDIDQLVAVLGG

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=445, Percent_Identity=34.3820224719101, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1789269, Length=451, Percent_Identity=31.0421286031042, Blast_Score=189, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17535605, Length=380, Percent_Identity=35.7894736842105, Blast_Score=213, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323843, Length=391, Percent_Identity=32.2250639386189, Blast_Score=209, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24645648, Length=392, Percent_Identity=36.734693877551, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 47725; Mature: 47594

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHYISITESERAEMLKAIGVADVAELFHDVPADLRFPTLDLPAALAEGEMARELRRLSS
CCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHC
KNSDVLNYSCFLGAGAYNHFIPAAVDSLLRRSEFYTAYTPYQPEISQGTLQAIFEYQSLM
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHHH
CGLLQMDAANASHYDGATAMAEGAIMAISATRNRRKIVVAPSVHPQYRGVLRSYTQGLGV
HHHHHHCCCCCCCCCCHHHHHCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCE
TITGDENPAASVADAAALVDNETAVFIVQSPDFLGVLHDLKPVAEQIHAAGALLLMVTNP
EEECCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEECCC
IALGLFQTPGMVGADIAVMEGQPLGIPLSFGGPYVGVFSCTEKLLRRMAGRLVGVTTDLN
HHEEEECCCCCCCCCEEEECCCCCEEEEECCCCEEHHHHHHHHHHHHHHCCEEEEEECCC
GQLGYVLTLQTREQHIRREKATSNICTNQGLMALAATIYTSLMGKTGLRKVAELCYQRAH
CCEEEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YAAKAIGNLAGYEVLEQGAFFHEFVVRCPRPVAEITQALHAQGIIGGYDLSKDYPHLGNA
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
MLICVTEQNTKNDIDQLVAVLGG
EEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SHYISITESERAEMLKAIGVADVAELFHDVPADLRFPTLDLPAALAEGEMARELRRLSS
CCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHC
KNSDVLNYSCFLGAGAYNHFIPAAVDSLLRRSEFYTAYTPYQPEISQGTLQAIFEYQSLM
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHHH
CGLLQMDAANASHYDGATAMAEGAIMAISATRNRRKIVVAPSVHPQYRGVLRSYTQGLGV
HHHHHHCCCCCCCCCCHHHHHCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCE
TITGDENPAASVADAAALVDNETAVFIVQSPDFLGVLHDLKPVAEQIHAAGALLLMVTNP
EEECCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEECCC
IALGLFQTPGMVGADIAVMEGQPLGIPLSFGGPYVGVFSCTEKLLRRMAGRLVGVTTDLN
HHEEEECCCCCCCCCEEEECCCCCEEEEECCCCEEHHHHHHHHHHHHHHCCEEEEEECCC
GQLGYVLTLQTREQHIRREKATSNICTNQGLMALAATIYTSLMGKTGLRKVAELCYQRAH
CCEEEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YAAKAIGNLAGYEVLEQGAFFHEFVVRCPRPVAEITQALHAQGIIGGYDLSKDYPHLGNA
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
MLICVTEQNTKNDIDQLVAVLGG
EEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA