Click here to switch to the map view.

The map label for this gene is gcvPB [H]

Identifier: 159899390

GI number: 159899390

Start: 3642329

End: 3643798

Strand: Direct

Name: gcvPB [H]

Synonym: Haur_2871

Alternate gene names: 159899390

Gene position: 3642329-3643798 (Clockwise)

Preceding gene: 159899389

Following gene: 159899391

Centisome position: 57.39

GC content: 52.31

Gene sequence:

>1470_bases
ATGCATACCTACGAACCACCAATTTTTGAATTGAGCAGCCCCGGTAAAATTGGCGCAGCCCTGCCCGACGCTGGTGTGCC
CGAAACCGAGTTGCCAGCCCATTTGCTGCGCGACGACGATTTAGCAGGTTTGCCCGAAATTAGCGAAACCGAGGTGGTGC
GCCACTTCACCCGCATCTCACAGCGCAACTTCTGTATCGACACGGGGATGTATCCACTTGGCTCGTGCACGATGAAATAC
AATCCTAAAATTCACGAAGATGCTGCACGGTTGCCTGGCTTTGCCTTTATTCACCCCTTGCAAGCCGAAGAAACCGTCCA
AGGTGCTTTGCAATTGACCTATGAATTGCAAAATATCTTGGCCGAAATTTCGGGCTTTGATCAAGTTTGTTTGCAGCCAG
CCGCTGGCGCTCAAGGCGAATTCGCAGGCATTTTGGTGTTCCGCGCCTATCACCTTGATCGTGGCGATGATCAGCGTGAC
GAAGTGTTGTGCCCCAACTCTGCTCACGGCACGAATCCCGCGACCGCCGCGATGGTCGGTTTCAAAGTCGTCGAAATTGC
TACCGATAGTCGGGGCAATGTTGATTTGGCTGATCTGCGGGCCAAAGTTGGCCCACGTACCGCTGGCTTGATGTTGACCA
ACCCCAATACCTTGGGCTTGTTTGATGAAAACGTGCATGAAGTTGCCAAAATTGTGCATGAAGCTGGTGGCTTGATGTAT
GGCGACGGCGCAAATTTCAACGCGATTTTGGGGATTGTCAAGCCAGGCGATGTAGGCTTTGACTTTATGCACTACAACTT
GCACAAAACCTTTACCACGCCTCACGGTGGTGGTGGCCCTGGTTGTGGTGCGGTTGGCTGTAAAGAATTTTTGGCCGATT
ATCTGCCAGGCCCAATTGTGGCACTCAAAGAAGGCCAATATACCCGCCACACGCCAGTCAAGAGCATTGGCCGCTTGAAA
GCCTTCAAGGGCAATTTTGGCATGTTTGTGCGGGCCTACACCTACATTCGCATGCTCGGCGCGGCTGGCTTGCGCTCGGT
CAGCGAACACGCGGTACTCAACGCCAACTATCTACGGGTCAATTTGGATAAAATTTATCCTGTGGCCTACGACCGCACCT
GTATGCACGAAGTGGTGTTGCAAGGCAAAATCAAGGGTGCGCCAAGTGTCCATACCTTGGATATTGCCAAGCGCTTGATT
GACTTTGGTTTTCACCCACCAACAGTCTATTTCCCGATCAGCGTGGCCGAATCGATTATGATCGAGCCAACTGAAACCGA
ATCGAAGCGCAACATGGATGCCTTTATTGATGCCATGAAGCAAATTGCCCATGAAGCGGTTGAAAACCCAGAGCTGTTGC
ATGCTGCGCCAACCACCGCGCCAGTACGCCGCCTCGATGAAGCCACCGCTGCCCGCCGCCCAATTCTGAAATACGATCAA
GCAGCAATCGCGGCTTTGTTAAGCAAATAA

Upstream 100 bases:

>100_bases
GATTACCCACACTTGGGTAATGCAATGCTGATCTGCGTTACCGAGCAAAATACCAAAAACGATATCGACCAACTTGTCGC
AGTGTTGGGAGGCTAAGCCA

Downstream 100 bases:

>100_bases
TCCATAGATGTTGGATCTAGGCTCTATGTAATGGTTTAGAAGTTGGCAACCGCCATTCAGCCCTCACCCCAACCCCTCTC
CCACTGCGGCGTTTAAGGGC

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MHTYEPPIFELSSPGKIGAALPDAGVPETELPAHLLRDDDLAGLPEISETEVVRHFTRISQRNFCIDTGMYPLGSCTMKY
NPKIHEDAARLPGFAFIHPLQAEETVQGALQLTYELQNILAEISGFDQVCLQPAAGAQGEFAGILVFRAYHLDRGDDQRD
EVLCPNSAHGTNPATAAMVGFKVVEIATDSRGNVDLADLRAKVGPRTAGLMLTNPNTLGLFDENVHEVAKIVHEAGGLMY
GDGANFNAILGIVKPGDVGFDFMHYNLHKTFTTPHGGGGPGCGAVGCKEFLADYLPGPIVALKEGQYTRHTPVKSIGRLK
AFKGNFGMFVRAYTYIRMLGAAGLRSVSEHAVLNANYLRVNLDKIYPVAYDRTCMHEVVLQGKIKGAPSVHTLDIAKRLI
DFGFHPPTVYFPISVAESIMIEPTETESKRNMDAFIDAMKQIAHEAVENPELLHAAPTTAPVRRLDEATAARRPILKYDQ
AAIAALLSK

Sequences:

>Translated_489_residues
MHTYEPPIFELSSPGKIGAALPDAGVPETELPAHLLRDDDLAGLPEISETEVVRHFTRISQRNFCIDTGMYPLGSCTMKY
NPKIHEDAARLPGFAFIHPLQAEETVQGALQLTYELQNILAEISGFDQVCLQPAAGAQGEFAGILVFRAYHLDRGDDQRD
EVLCPNSAHGTNPATAAMVGFKVVEIATDSRGNVDLADLRAKVGPRTAGLMLTNPNTLGLFDENVHEVAKIVHEAGGLMY
GDGANFNAILGIVKPGDVGFDFMHYNLHKTFTTPHGGGGPGCGAVGCKEFLADYLPGPIVALKEGQYTRHTPVKSIGRLK
AFKGNFGMFVRAYTYIRMLGAAGLRSVSEHAVLNANYLRVNLDKIYPVAYDRTCMHEVVLQGKIKGAPSVHTLDIAKRLI
DFGFHPPTVYFPISVAESIMIEPTETESKRNMDAFIDAMKQIAHEAVENPELLHAAPTTAPVRRLDEATAARRPILKYDQ
AAIAALLSK
>Mature_489_residues
MHTYEPPIFELSSPGKIGAALPDAGVPETELPAHLLRDDDLAGLPEISETEVVRHFTRISQRNFCIDTGMYPLGSCTMKY
NPKIHEDAARLPGFAFIHPLQAEETVQGALQLTYELQNILAEISGFDQVCLQPAAGAQGEFAGILVFRAYHLDRGDDQRD
EVLCPNSAHGTNPATAAMVGFKVVEIATDSRGNVDLADLRAKVGPRTAGLMLTNPNTLGLFDENVHEVAKIVHEAGGLMY
GDGANFNAILGIVKPGDVGFDFMHYNLHKTFTTPHGGGGPGCGAVGCKEFLADYLPGPIVALKEGQYTRHTPVKSIGRLK
AFKGNFGMFVRAYTYIRMLGAAGLRSVSEHAVLNANYLRVNLDKIYPVAYDRTCMHEVVLQGKIKGAPSVHTLDIAKRLI
DFGFHPPTVYFPISVAESIMIEPTETESKRNMDAFIDAMKQIAHEAVENPELLHAAPTTAPVRRLDEATAARRPILKYDQ
AAIAALLSK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=412, Percent_Identity=41.747572815534, Blast_Score=295, Evalue=8e-80,
Organism=Escherichia coli, GI1789269, Length=422, Percent_Identity=45.0236966824645, Blast_Score=327, Evalue=8e-91,
Organism=Caenorhabditis elegans, GI17535605, Length=432, Percent_Identity=40.5092592592593, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI32564013, Length=390, Percent_Identity=40.7692307692308, Blast_Score=258, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6323843, Length=408, Percent_Identity=41.421568627451, Blast_Score=287, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24645648, Length=412, Percent_Identity=41.504854368932, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53168; Mature: 53168

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTYEPPIFELSSPGKIGAALPDAGVPETELPAHLLRDDDLAGLPEISETEVVRHFTRIS
CCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHH
QRNFCIDTGMYPLGSCTMKYNPKIHEDAARLPGFAFIHPLQAEETVQGALQLTYELQNIL
CCCEEEECCCCCCCCEEEEECCCCCHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
AEISGFDQVCLQPAAGAQGEFAGILVFRAYHLDRGDDQRDEVLCPNSAHGTNPATAAMVG
HHHCCCHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCCEECCCCCCCCCCHHHHHHC
FKVVEIATDSRGNVDLADLRAKVGPRTAGLMLTNPNTLGLFDENVHEVAKIVHEAGGLMY
EEEEEEECCCCCCEEHHHHHHHCCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHCCEEE
GDGANFNAILGIVKPGDVGFDFMHYNLHKTFTTPHGGGGPGCGAVGCKEFLADYLPGPIV
CCCCCCEEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEE
ALKEGQYTRHTPVKSIGRLKAFKGNFGMFVRAYTYIRMLGAAGLRSVSEHAVLNANYLRV
EEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEE
NLDKIYPVAYDRTCMHEVVLQGKIKGAPSVHTLDIAKRLIDFGFHPPTVYFPISVAESIM
EHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCEE
IEPTETESKRNMDAFIDAMKQIAHEAVENPELLHAAPTTAPVRRLDEATAARRPILKYDQ
ECCCCCCHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHH
AAIAALLSK
HHHHHHHCC
>Mature Secondary Structure
MHTYEPPIFELSSPGKIGAALPDAGVPETELPAHLLRDDDLAGLPEISETEVVRHFTRIS
CCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHH
QRNFCIDTGMYPLGSCTMKYNPKIHEDAARLPGFAFIHPLQAEETVQGALQLTYELQNIL
CCCEEEECCCCCCCCEEEEECCCCCHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
AEISGFDQVCLQPAAGAQGEFAGILVFRAYHLDRGDDQRDEVLCPNSAHGTNPATAAMVG
HHHCCCHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCCEECCCCCCCCCCHHHHHHC
FKVVEIATDSRGNVDLADLRAKVGPRTAGLMLTNPNTLGLFDENVHEVAKIVHEAGGLMY
EEEEEEECCCCCCEEHHHHHHHCCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHCCEEE
GDGANFNAILGIVKPGDVGFDFMHYNLHKTFTTPHGGGGPGCGAVGCKEFLADYLPGPIV
CCCCCCEEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEE
ALKEGQYTRHTPVKSIGRLKAFKGNFGMFVRAYTYIRMLGAAGLRSVSEHAVLNANYLRV
EEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEE
NLDKIYPVAYDRTCMHEVVLQGKIKGAPSVHTLDIAKRLIDFGFHPPTVYFPISVAESIM
EHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCEE
IEPTETESKRNMDAFIDAMKQIAHEAVENPELLHAAPTTAPVRRLDEATAARRPILKYDQ
ECCCCCCHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHH
AAIAALLSK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA