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The map label for this gene is nucA [H]

Identifier: 159897667

GI number: 159897667

Start: 1300871

End: 1301941

Strand: Reverse

Name: nucA [H]

Synonym: Haur_1138

Alternate gene names: 159897667

Gene position: 1301941-1300871 (Counterclockwise)

Preceding gene: 159897670

Following gene: 159897665

Centisome position: 20.51

GC content: 51.91

Gene sequence:

>1071_bases
ATGACTGGTCTGCGTCGGCTTCTTGGTTTACTCGTTTTAGGATTGTTGGCGCTAGGCCTGCGTCAACCGACTACTCAAGC
GGCTCCCAACGATAGTTTACACCTCACGCTGGGCAACCCTAGCAATGCTGTAGCTGATCCTTTAGTGCCAAATAATTATT
TAATTGAACGTACCCAGTATGCCTTGGCCTATCAGCGCGATGCGGGAATTCCAGCATGGGTCAGTTGGCATTTGGAAGTG
CAAGATTTGGGCAGCACTTCGCGCGGCGATTTTGCGGTTGATACCAGCTTGCCCAGTGGTTGGTATCGTGTCGCGACCAG
CGACTATAGCGGTAGCGGCTATGATCGTGGTCATATGACCCCATCGGGCGATCGCACCAGTTCGCGGGCAGCCAACGATC
AAACCTTCATTATGTCGAATATTATTCCTCAAGCGCCCGACAACAACCAAGGCCCATGGAACGATTTGGAAAACGATAGT
CGTACCTGGGCACGCGCTGGCAATGAGTTATACATTATTAGTGGTGGCTATGGTACGAAAGGCACGATTGCTAGTGGTCG
GGTGTTAATTCCTGCGGTAACGTGGAAGGTGATTGTGGTGCTGCCAGTGGGGAATGATGATGCCAATCGTGTGGCCGCCA
ATACCCGCGTGATCGGGATTTGGATGCCAAATGATCAAGGAATTCGGAGTAATGCTTGGGAGCAATATCGGGTCAGCGTC
GATTATATTGAAAGTATGACTGGCTACGATTTTCTCTCGAATGTACCAACTGCGATTCAAGCGATTGTCGAGGCGCAGGT
TGATGGTTCGCCGGTAGTAACCGTCACGCCTGGAACGGTTTCGCCAACTGCGACGCGCACGCCAACCGCGACTCCAACTG
CTACCCGTACCGCTACCCCTACAGCAACGACTAGCGCAACCGCTACGCCAAGCAATACGCTTACCCCAACTGCGACAGTA
ACCACAATTCCTAGCGTAACCCCATCGATCACGGCCAGTGCTACGCCTTCAGTCAGCGCAACTGTGGTTATTCCTCAATA
TTATTCGTTTTTGCCCTACGTCACTCAATAA

Upstream 100 bases:

>100_bases
CGGGATTTTGCTGAGGCCGCATTGTTGATTAACGCCTAGACAGCTATGGTACAGTATGCAAGCTATCATCATACTTTCAT
TGCGAAAGGACATTGCTGTC

Downstream 100 bases:

>100_bases
CTAAAAAAATGCCGCATCCTGCTAGCGATACTCCTAGCAGGATGCGCTTGTCGAGCGGTTCATCAGGCAGCCAATAACTC
AGTTAAAGGCTGCTCGATTT

Product: DNA/RNA non-specific endonuclease

Products: NA

Alternate protein names: Endonuclease [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTGLRRLLGLLVLGLLALGLRQPTTQAAPNDSLHLTLGNPSNAVADPLVPNNYLIERTQYALAYQRDAGIPAWVSWHLEV
QDLGSTSRGDFAVDTSLPSGWYRVATSDYSGSGYDRGHMTPSGDRTSSRAANDQTFIMSNIIPQAPDNNQGPWNDLENDS
RTWARAGNELYIISGGYGTKGTIASGRVLIPAVTWKVIVVLPVGNDDANRVAANTRVIGIWMPNDQGIRSNAWEQYRVSV
DYIESMTGYDFLSNVPTAIQAIVEAQVDGSPVVTVTPGTVSPTATRTPTATPTATRTATPTATTSATATPSNTLTPTATV
TTIPSVTPSITASATPSVSATVVIPQYYSFLPYVTQ

Sequences:

>Translated_356_residues
MTGLRRLLGLLVLGLLALGLRQPTTQAAPNDSLHLTLGNPSNAVADPLVPNNYLIERTQYALAYQRDAGIPAWVSWHLEV
QDLGSTSRGDFAVDTSLPSGWYRVATSDYSGSGYDRGHMTPSGDRTSSRAANDQTFIMSNIIPQAPDNNQGPWNDLENDS
RTWARAGNELYIISGGYGTKGTIASGRVLIPAVTWKVIVVLPVGNDDANRVAANTRVIGIWMPNDQGIRSNAWEQYRVSV
DYIESMTGYDFLSNVPTAIQAIVEAQVDGSPVVTVTPGTVSPTATRTPTATPTATRTATPTATTSATATPSNTLTPTATV
TTIPSVTPSITASATPSVSATVVIPQYYSFLPYVTQ
>Mature_355_residues
TGLRRLLGLLVLGLLALGLRQPTTQAAPNDSLHLTLGNPSNAVADPLVPNNYLIERTQYALAYQRDAGIPAWVSWHLEVQ
DLGSTSRGDFAVDTSLPSGWYRVATSDYSGSGYDRGHMTPSGDRTSSRAANDQTFIMSNIIPQAPDNNQGPWNDLENDSR
TWARAGNELYIISGGYGTKGTIASGRVLIPAVTWKVIVVLPVGNDDANRVAANTRVIGIWMPNDQGIRSNAWEQYRVSVD
YIESMTGYDFLSNVPTAIQAIVEAQVDGSPVVTVTPGTVSPTATRTPTATPTATRTATPTATTSATATPSNTLTPTATVT
TIPSVTPSITASATPSVSATVVIPQYYSFLPYVTQ

Specific function: Catalyzes the degradation of both RNA and DNA; has the potential to act as an endonuclease [H]

COG id: COG1864

COG function: function code F; DNA/RNA endonuclease G, NUC1

Gene ontology:

Cell location: Periplasm. Note=Periplasmic or loosely attached to the cytoplasmic or the outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA/RNA non-specific endonuclease family [H]

Homologues:

Organism=Homo sapiens, GI53759134, Length=217, Percent_Identity=29.4930875576037, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI224451073, Length=216, Percent_Identity=28.7037037037037, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI224451075, Length=169, Percent_Identity=28.9940828402367, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17505967, Length=156, Percent_Identity=32.6923076923077, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322253, Length=242, Percent_Identity=26.4462809917355, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI20129899, Length=166, Percent_Identity=29.5180722891566, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24581065, Length=123, Percent_Identity=30.0813008130081, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018524
- InterPro:   IPR001604
- InterPro:   IPR020821 [H]

Pfam domain/function: PF01223 Endonuclease_NS [H]

EC number: NA

Molecular weight: Translated: 37903; Mature: 37771

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS01070 NUCLEASE_NON_SPEC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLRRLLGLLVLGLLALGLRQPTTQAAPNDSLHLTLGNPSNAVADPLVPNNYLIERTQY
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEHHHE
ALAYQRDAGIPAWVSWHLEVQDLGSTSRGDFAVDTSLPSGWYRVATSDYSGSGYDRGHMT
EEEEECCCCCCEEEEEEEEEEECCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCC
PSGDRTSSRAANDQTFIMSNIIPQAPDNNQGPWNDLENDSRTWARAGNELYIISGGYGTK
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCCCCC
GTIASGRVLIPAVTWKVIVVLPVGNDDANRVAANTRVIGIWMPNDQGIRSNAWEQYRVSV
CEECCCCEEEEEEEEEEEEEEECCCCCCCEEEECEEEEEEECCCCCCCCCCCCHHEEEEH
DYIESMTGYDFLSNVPTAIQAIVEAQVDGSPVVTVTPGTVSPTATRTPTATPTATRTATP
HHHHHHCCHHHHHCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCC
TATTSATATPSNTLTPTATVTTIPSVTPSITASATPSVSATVVIPQYYSFLPYVTQ
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCHHCCCCCCCC
>Mature Secondary Structure 
TGLRRLLGLLVLGLLALGLRQPTTQAAPNDSLHLTLGNPSNAVADPLVPNNYLIERTQY
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEHHHE
ALAYQRDAGIPAWVSWHLEVQDLGSTSRGDFAVDTSLPSGWYRVATSDYSGSGYDRGHMT
EEEEECCCCCCEEEEEEEEEEECCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCC
PSGDRTSSRAANDQTFIMSNIIPQAPDNNQGPWNDLENDSRTWARAGNELYIISGGYGTK
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCCCCC
GTIASGRVLIPAVTWKVIVVLPVGNDDANRVAANTRVIGIWMPNDQGIRSNAWEQYRVSV
CEECCCCEEEEEEEEEEEEEEECCCCCCCEEEECEEEEEEECCCCCCCCCCCCHHEEEEH
DYIESMTGYDFLSNVPTAIQAIVEAQVDGSPVVTVTPGTVSPTATRTPTATPTATRTATP
HHHHHHCCHHHHHCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCC
TATTSATATPSNTLTPTATVTTIPSVTPSITASATPSVSATVVIPQYYSFLPYVTQ
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1343821; 11759840 [H]