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The map label for this gene is map [H]

Identifier: 159897662

GI number: 159897662

Start: 1295626

End: 1296375

Strand: Direct

Name: map [H]

Synonym: Haur_1133

Alternate gene names: 159897662

Gene position: 1295626-1296375 (Clockwise)

Preceding gene: 159897661

Following gene: 159897663

Centisome position: 20.41

GC content: 50.4

Gene sequence:

>750_bases
ATGACACTCGTTTTACGCAACAGCACACAAATCGAAAAAATGCGCAATGCAGGCCGTTTGGTTGCCCAAACCCATGCCAT
GCTGCGCGAATATGTTGTTCCTGGCGCAGTTTTGCTTGATCTCGATCAATTGGTCGAGGAATATCTGCGTGAACATGGCG
CAACCCCATCGTTTAAAAATTATAAAGGCTTTCCAGCGTCAACCTGTATTTCAATTAATGATGTGATTTGCCATGGCATC
CCGGATAAATCGCGCTTAAAAGATGGCGATTTGGTGGCAATCGATATTGGCGCGTTTCTCGATGGCTGGCATGGCGATTC
ATGCGTGACCTATCCGGTTGGCACGATCGACGCGCAAAGCCAAAAATTGATGGATGTCACCAAAGAAGCCATGTGGCGGG
GCATCGCCCAAGCGCGGGCTGGCAATACGCTTGGCGATATCGGCGCGGCCATCCAAGAATATACCGAAAGTCAAGGCTTC
TCCGTTGTGCGTGAATACACAGGCCATGGGATTGGCCGCAACATGCACGAAGCACCAACCGTTTTGCATTATGGCGAGTG
GGGCAAAGGCTTGCGCTTACGCGCTGGCATGACCTTCACAATCGAGCCAATGGTCAATGTTGGTAGCTATGCCACGCGCT
TGCTCAAAGATGGCTGGACGGTTAAAACGGTCGATGGCTCACGCTCAGCTCAATTTGAACATCAACTAGCGGTCACCGAT
GGTGAACCAGATATTTTAACGGTGCTTTAA

Upstream 100 bases:

>100_bases
CCCACAGCACCAACCTGTGCCTGCCGCCAGACCATGCAATCTGCGCGGGATCGTGGCTTGGTTGGCGACGATTGGCGTAC
ATGGATTGGGGAATAAACAC

Downstream 100 bases:

>100_bases
ACAATGGCAATCAGAATCTACAATCAATCGCAAATTAATGAAATGCGCAAAGCTGGCCAATTGGTTGCCAAAGCCCATGC
GATGTTGCGCGAATATGTGG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTLVLRNSTQIEKMRNAGRLVAQTHAMLREYVVPGAVLLDLDQLVEEYLREHGATPSFKNYKGFPASTCISINDVICHGI
PDKSRLKDGDLVAIDIGAFLDGWHGDSCVTYPVGTIDAQSQKLMDVTKEAMWRGIAQARAGNTLGDIGAAIQEYTESQGF
SVVREYTGHGIGRNMHEAPTVLHYGEWGKGLRLRAGMTFTIEPMVNVGSYATRLLKDGWTVKTVDGSRSAQFEHQLAVTD
GEPDILTVL

Sequences:

>Translated_249_residues
MTLVLRNSTQIEKMRNAGRLVAQTHAMLREYVVPGAVLLDLDQLVEEYLREHGATPSFKNYKGFPASTCISINDVICHGI
PDKSRLKDGDLVAIDIGAFLDGWHGDSCVTYPVGTIDAQSQKLMDVTKEAMWRGIAQARAGNTLGDIGAAIQEYTESQGF
SVVREYTGHGIGRNMHEAPTVLHYGEWGKGLRLRAGMTFTIEPMVNVGSYATRLLKDGWTVKTVDGSRSAQFEHQLAVTD
GEPDILTVL
>Mature_248_residues
TLVLRNSTQIEKMRNAGRLVAQTHAMLREYVVPGAVLLDLDQLVEEYLREHGATPSFKNYKGFPASTCISINDVICHGIP
DKSRLKDGDLVAIDIGAFLDGWHGDSCVTYPVGTIDAQSQKLMDVTKEAMWRGIAQARAGNTLGDIGAAIQEYTESQGFS
VVREYTGHGIGRNMHEAPTVLHYGEWGKGLRLRAGMTFTIEPMVNVGSYATRLLKDGWTVKTVDGSRSAQFEHQLAVTDG
EPDILTVL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=245, Percent_Identity=40.4081632653061, Blast_Score=188, Evalue=3e-48,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=37.0967741935484, Blast_Score=182, Evalue=3e-46,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=48, Blast_Score=245, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71996291, Length=215, Percent_Identity=44.6511627906977, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6323273, Length=239, Percent_Identity=38.9121338912134, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319380, Length=251, Percent_Identity=25.4980079681275, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21355531, Length=238, Percent_Identity=44.5378151260504, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24583427, Length=243, Percent_Identity=38.2716049382716, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27309; Mature: 27178

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVLRNSTQIEKMRNAGRLVAQTHAMLREYVVPGAVLLDLDQLVEEYLREHGATPSFKN
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
YKGFPASTCISINDVICHGIPDKSRLKDGDLVAIDIGAFLDGWHGDSCVTYPVGTIDAQS
CCCCCCHHEEEECHHEECCCCCHHHCCCCCEEEEECCCHHCCCCCCCEEEECCCCCCCCH
QKLMDVTKEAMWRGIAQARAGNTLGDIGAAIQEYTESQGFSVVREYTGHGIGRNMHEAPT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCC
VLHYGEWGKGLRLRAGMTFTIEPMVNVGSYATRLLKDGWTVKTVDGSRSAQFEHQLAVTD
EEEECCCCCCEEEECCCEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEC
GEPDILTVL
CCCCEEEEC
>Mature Secondary Structure 
TLVLRNSTQIEKMRNAGRLVAQTHAMLREYVVPGAVLLDLDQLVEEYLREHGATPSFKN
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
YKGFPASTCISINDVICHGIPDKSRLKDGDLVAIDIGAFLDGWHGDSCVTYPVGTIDAQS
CCCCCCHHEEEECHHEECCCCCHHHCCCCCEEEEECCCHHCCCCCCCEEEECCCCCCCCH
QKLMDVTKEAMWRGIAQARAGNTLGDIGAAIQEYTESQGFSVVREYTGHGIGRNMHEAPT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCC
VLHYGEWGKGLRLRAGMTFTIEPMVNVGSYATRLLKDGWTVKTVDGSRSAQFEHQLAVTD
EEEECCCCCCEEEECCCEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEC
GEPDILTVL
CCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]