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The map label for this gene is aceA [H]

Identifier: 159897546

GI number: 159897546

Start: 1163272

End: 1164564

Strand: Direct

Name: aceA [H]

Synonym: Haur_1017

Alternate gene names: 159897546

Gene position: 1163272-1164564 (Clockwise)

Preceding gene: 159897545

Following gene: 159897547

Centisome position: 18.33

GC content: 52.9

Gene sequence:

>1293_bases
ATGAACACCACGAACGGTATCTCAACAACAGAACTGGAACGGGGTTGGGCAACGGACGCACGTTGGCAAGGGATTCAGCG
CGATTACACAGCCGAAGATGTTGTGCGCTTGCGCGGTTCAGTGATTATTGAGCAAACTTTAGCTCGGATGGGTGCTGAAC
GCTTGTGGGATCTCCTTCACACCGAAGATTACGTGCATGCGTTGGGTGCGCTGACTGGTAATCAAGCCATGCAGATGGTC
AAAGCAGGCTTGAAGGCGATTTACTTGAGTGGCTGGCAGGTTGCCGCCGATGCCAATATGGCTGGGCAAATGTATCCCGA
TCAAAGCTTGTATCCCGCTAACAGCGTGCCACAAGTTGTCAAACGGATCAACCAAACCTTGCAACGCTGCGACCAAATTT
ATCACTCAGAAGCTAAAGATGGTACCTACTGGTTCGCGCCCATCATCGCCGATGCTGAAGCTGGCTTTGGTGGCCCACTG
AATGCCTTTGAAATGATGAAGGCTATGATCGAAGCTGGCGCGGCTGGGGTGCACTTCGAAGATCAATTATCATCAGAAAA
GAAATGTGGCCACTTGGGCGGCAAGGTCTTGATCCCAACGAGCCACTTTATTCGCACGCTGCAAGCTGCCCGTTTGGCTG
CCGACGTGATGGACGTACCAACCTTGGTCGTCGCTCGTACCGATGCCAACGGTGCATACCTCTTGACCAGCGACGTTGAT
CCACGTGACCGCGAGTTTTGTACAGGCGAACGCACCCCCGAAGGCTTCTTCTGTATTCGCGGTGGGATCGATTCAGCAAT
TGCCCGTGGCTTGGCCTATGCTCCATATGCCGACCTGATTTGGTGTGAAACCTCAACCCCAGATTTGGAAGAAGCACGGA
AATTTGCTGAAGCGATCCATGCTCAATATCCAGGCAAATTGTTGGCCTACAACTGCTCGCCATCATTCAACTGGAAGCGC
AACTTGGATGATGCCACGATTGCCAAGTTCCAAAGCGAACTCGGCGCGATGGGTTACAAGTTCCAATTCATCACCTTGGC
GGGCTTCCACGCCTTGAACTACAGCATGTTCGATTTGGCAACCGGCTATCGCGACCAAGGCATGAGCGCCTATGTGCAAT
TGCAACAAGCTGAATTCAACCGCGAAAGCGAAGGCTATACCGCCGTCAAGCACCAACGCGAAGTTGGCACTGGCTACTTC
GATTTGGTTGCGCAAGCAGTTTCAGGTGGCATGTCATCGACCACCGCCTTGAGCGGCTCGACCGAGCACGAACAATTTGT
TGGAGCCCATTAG

Upstream 100 bases:

>100_bases
GGGATAGATTCTTGATTTTCATTACCTTGGCGACGTTGCCCAAGCGCTTTGAGCGATTGTAATGAATAGCCACCATTGTA
ATTTGACAAAGGAGTCAGCC

Downstream 100 bases:

>100_bases
TAAAGTCAAAAGGCAGAAATCAAAAGGCAAAAGTAGGATTTAGGAGTCATCAGGGATTAGATAACTGTTAATGCAGAGGC
GCAGAGCATCTATTGTGCTG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNTTNGISTTELERGWATDARWQGIQRDYTAEDVVRLRGSVIIEQTLARMGAERLWDLLHTEDYVHALGALTGNQAMQMV
KAGLKAIYLSGWQVAADANMAGQMYPDQSLYPANSVPQVVKRINQTLQRCDQIYHSEAKDGTYWFAPIIADAEAGFGGPL
NAFEMMKAMIEAGAAGVHFEDQLSSEKKCGHLGGKVLIPTSHFIRTLQAARLAADVMDVPTLVVARTDANGAYLLTSDVD
PRDREFCTGERTPEGFFCIRGGIDSAIARGLAYAPYADLIWCETSTPDLEEARKFAEAIHAQYPGKLLAYNCSPSFNWKR
NLDDATIAKFQSELGAMGYKFQFITLAGFHALNYSMFDLATGYRDQGMSAYVQLQQAEFNRESEGYTAVKHQREVGTGYF
DLVAQAVSGGMSSTTALSGSTEHEQFVGAH

Sequences:

>Translated_430_residues
MNTTNGISTTELERGWATDARWQGIQRDYTAEDVVRLRGSVIIEQTLARMGAERLWDLLHTEDYVHALGALTGNQAMQMV
KAGLKAIYLSGWQVAADANMAGQMYPDQSLYPANSVPQVVKRINQTLQRCDQIYHSEAKDGTYWFAPIIADAEAGFGGPL
NAFEMMKAMIEAGAAGVHFEDQLSSEKKCGHLGGKVLIPTSHFIRTLQAARLAADVMDVPTLVVARTDANGAYLLTSDVD
PRDREFCTGERTPEGFFCIRGGIDSAIARGLAYAPYADLIWCETSTPDLEEARKFAEAIHAQYPGKLLAYNCSPSFNWKR
NLDDATIAKFQSELGAMGYKFQFITLAGFHALNYSMFDLATGYRDQGMSAYVQLQQAEFNRESEGYTAVKHQREVGTGYF
DLVAQAVSGGMSSTTALSGSTEHEQFVGAH
>Mature_430_residues
MNTTNGISTTELERGWATDARWQGIQRDYTAEDVVRLRGSVIIEQTLARMGAERLWDLLHTEDYVHALGALTGNQAMQMV
KAGLKAIYLSGWQVAADANMAGQMYPDQSLYPANSVPQVVKRINQTLQRCDQIYHSEAKDGTYWFAPIIADAEAGFGGPL
NAFEMMKAMIEAGAAGVHFEDQLSSEKKCGHLGGKVLIPTSHFIRTLQAARLAADVMDVPTLVVARTDANGAYLLTSDVD
PRDREFCTGERTPEGFFCIRGGIDSAIARGLAYAPYADLIWCETSTPDLEEARKFAEAIHAQYPGKLLAYNCSPSFNWKR
NLDDATIAKFQSELGAMGYKFQFITLAGFHALNYSMFDLATGYRDQGMSAYVQLQQAEFNRESEGYTAVKHQREVGTGYF
DLVAQAVSGGMSSTTALSGSTEHEQFVGAH

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=426, Percent_Identity=67.1361502347418, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1786525, Length=262, Percent_Identity=28.2442748091603, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17561814, Length=417, Percent_Identity=66.1870503597122, Blast_Score=565, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71982926, Length=417, Percent_Identity=66.1870503597122, Blast_Score=565, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6320908, Length=297, Percent_Identity=35.016835016835, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6325263, Length=249, Percent_Identity=38.1526104417671, Blast_Score=155, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 47248; Mature: 47248

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTNGISTTELERGWATDARWQGIQRDYTAEDVVRLRGSVIIEQTLARMGAERLWDLLH
CCCCCCCCHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEDYVHALGALTGNQAMQMVKAGLKAIYLSGWQVAADANMAGQMYPDQSLYPANSVPQVV
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHH
KRINQTLQRCDQIYHSEAKDGTYWFAPIIADAEAGFGGPLNAFEMMKAMIEAGAAGVHFE
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCH
DQLSSEKKCGHLGGKVLIPTSHFIRTLQAARLAADVMDVPTLVVARTDANGAYLLTSDVD
HHHCCHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCC
PRDREFCTGERTPEGFFCIRGGIDSAIARGLAYAPYADLIWCETSTPDLEEARKFAEAIH
CCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
AQYPGKLLAYNCSPSFNWKRNLDDATIAKFQSELGAMGYKFQFITLAGFHALNYSMFDLA
HCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEHHHHHCCHHHHHH
TGYRDQGMSAYVQLQQAEFNRESEGYTAVKHQREVGTGYFDLVAQAVSGGMSSTTALSGS
CCCCCCCCHHHHEEHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECCCC
TEHEQFVGAH
CCHHHHCCCC
>Mature Secondary Structure
MNTTNGISTTELERGWATDARWQGIQRDYTAEDVVRLRGSVIIEQTLARMGAERLWDLLH
CCCCCCCCHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEDYVHALGALTGNQAMQMVKAGLKAIYLSGWQVAADANMAGQMYPDQSLYPANSVPQVV
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHH
KRINQTLQRCDQIYHSEAKDGTYWFAPIIADAEAGFGGPLNAFEMMKAMIEAGAAGVHFE
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCH
DQLSSEKKCGHLGGKVLIPTSHFIRTLQAARLAADVMDVPTLVVARTDANGAYLLTSDVD
HHHCCHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCC
PRDREFCTGERTPEGFFCIRGGIDSAIARGLAYAPYADLIWCETSTPDLEEARKFAEAIH
CCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
AQYPGKLLAYNCSPSFNWKRNLDDATIAKFQSELGAMGYKFQFITLAGFHALNYSMFDLA
HCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEHHHHHCCHHHHHH
TGYRDQGMSAYVQLQQAEFNRESEGYTAVKHQREVGTGYFDLVAQAVSGGMSSTTALSGS
CCCCCCCCHHHHEEHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECCCC
TEHEQFVGAH
CCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]