Click here to switch to the map view.

The map label for this gene is pccB [H]

Identifier: 159897473

GI number: 159897473

Start: 1080165

End: 1081715

Strand: Reverse

Name: pccB [H]

Synonym: Haur_0944

Alternate gene names: 159897473

Gene position: 1081715-1080165 (Counterclockwise)

Preceding gene: 159897474

Following gene: 159897472

Centisome position: 17.04

GC content: 53.06

Gene sequence:

>1551_bases
ATGACGACAACAGCAGAAAAAATCGCTGAGTTGCGGCGACGGCGTGAACAAGCAGCAACCACCGATCCCAAGGCCGCCGA
AAAGCAACATGCCCGTGGCAAATTGACCGCGCGTGAGCGGATCGAACGCTTGCTTGACCCCGATTCGTTTGTCGAACTCG
ATGCCTTGGCCGTTCACCGCTCAACCGCTTTTGGCTTAGAGCACAAACGGATTCTTGGCGACGGCGTGATCACGGGCCAT
GGCACGATTGATGGTCGCCAAGTTTGTGTGTTTTCGCAAGATTTCACCGTGCTTGGTGGTTCGTTGGGTGAAGTATTCGC
CGAAAAAATCGTCAAAGTGATGGATTTGGCGATGCGCATGGGCGTGCCGCTGATTGGCATCAACGATAGCGGCGGCGCAC
GCATTCAAGAGGGCGTGGTCGCGCTAGGTGGTTACGCCGAAATTTTCTATCGCAACGTTGTGGCTTCGGGCGTAATTCCC
CAGCTTTCGATTATCGCCGGACCATGTGCTGGCGGTGCGGTCTACTCACCTGCCATGACCGACTTCATTCTGATGGTCAA
GGGCACATCGCAAATGTTCATCACCGGACCAGATGTGATTAAAACCGTGACTGGCGAGGAAGTGACCCAAGAACAATTGG
GCGGTGCGATGACCCACAACAGCAAATCGGGCGTGGCGCATTTTGCTGCCGATGATGAGGATGAATGTTTCGAGCAATTG
CGCACGCTACTTTCGTTCCTGCCGCTGAATAATATGGATGATGCACCGATCATCGAGCCAACCGACGATCCCAACCGCAT
GGATGATGCCTTGCAAAGCATTATTCCCGATCAGCCTAAAAAACCCTACGATATGAAAGCCGTGATCGAATTGATCGTTG
ATGATGGCTTTTTCTTCGAAGTTCAGCCGCATTATGCGCCCAACTTGGTAATTGGTTTTGCGCGGCTTGATGGCATGCCC
GTGGGTATTGTGGGCAATCAGCCTGCCGCCTTGGCCGGAACCTTGGATATTGATTCATCGGTTAAGGGTGCACGCTTTGT
GCGCTTCTGCGATGCCTTCAATATTCCGTTGATCACCTTTGTTGATGTCCCAGGCTTCTTGCCGGGCACGCATCAGGAGT
ATGGTGGCATTATTCGCCACGGCGCAAAACTGCTGTATGCCTATTGTGAAGCGACTGTACCAAAACTGACCGTGATCACG
CGCAAGGCCTATGGTGGAGCCTACGATGTGATGGCCTCGAAGCATATTCGCGCTGATTTCAACTTTGCATGGCCTACCGC
CGAAATCGCCGTGATGGGGGCAAGCGGCGCAGTATCGATCATCTTCCGCAAAGAAATTGCTGAATCGACCGATCCTGTGG
CAACCAACGCTGAGTTGATTCACAATTACGAAGAGCGGTTTGCCAATCCCTATATTGCTGCCGAACGCGGCTATATCGAT
TCGGTGATCGAGCCACGCGAAACCCGCCCAGCCTTAATCAAAGCGCTGCATTTATCGCGTACCAAACGCCAAAGCCTGCC
ACCACGCAAACATGGCAATATGCCGTTGTAA

Upstream 100 bases:

>100_bases
ATTTAGCCCAAACAGTTGCCTAAATTCCGCCCTAGCCGTAGTAATTTCCGCTGGCACTCTTGCCTGCTACGGCTAGCGCT
ATTCTGTGGGAGATATGTCA

Downstream 100 bases:

>100_bases
TCGAGGGGTCAGGGGCTAGGGATCAGGGGTCAGAGTTTTTTGACTATTGGCTATTGGCTCTAGGCTTTTGGGATTGGGAT
CAGTAAATTGACCACGAAGA

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MTTTAEKIAELRRRREQAATTDPKAAEKQHARGKLTARERIERLLDPDSFVELDALAVHRSTAFGLEHKRILGDGVITGH
GTIDGRQVCVFSQDFTVLGGSLGEVFAEKIVKVMDLAMRMGVPLIGINDSGGARIQEGVVALGGYAEIFYRNVVASGVIP
QLSIIAGPCAGGAVYSPAMTDFILMVKGTSQMFITGPDVIKTVTGEEVTQEQLGGAMTHNSKSGVAHFAADDEDECFEQL
RTLLSFLPLNNMDDAPIIEPTDDPNRMDDALQSIIPDQPKKPYDMKAVIELIVDDGFFFEVQPHYAPNLVIGFARLDGMP
VGIVGNQPAALAGTLDIDSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTHQEYGGIIRHGAKLLYAYCEATVPKLTVIT
RKAYGGAYDVMASKHIRADFNFAWPTAEIAVMGASGAVSIIFRKEIAESTDPVATNAELIHNYEERFANPYIAAERGYID
SVIEPRETRPALIKALHLSRTKRQSLPPRKHGNMPL

Sequences:

>Translated_516_residues
MTTTAEKIAELRRRREQAATTDPKAAEKQHARGKLTARERIERLLDPDSFVELDALAVHRSTAFGLEHKRILGDGVITGH
GTIDGRQVCVFSQDFTVLGGSLGEVFAEKIVKVMDLAMRMGVPLIGINDSGGARIQEGVVALGGYAEIFYRNVVASGVIP
QLSIIAGPCAGGAVYSPAMTDFILMVKGTSQMFITGPDVIKTVTGEEVTQEQLGGAMTHNSKSGVAHFAADDEDECFEQL
RTLLSFLPLNNMDDAPIIEPTDDPNRMDDALQSIIPDQPKKPYDMKAVIELIVDDGFFFEVQPHYAPNLVIGFARLDGMP
VGIVGNQPAALAGTLDIDSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTHQEYGGIIRHGAKLLYAYCEATVPKLTVIT
RKAYGGAYDVMASKHIRADFNFAWPTAEIAVMGASGAVSIIFRKEIAESTDPVATNAELIHNYEERFANPYIAAERGYID
SVIEPRETRPALIKALHLSRTKRQSLPPRKHGNMPL
>Mature_515_residues
TTTAEKIAELRRRREQAATTDPKAAEKQHARGKLTARERIERLLDPDSFVELDALAVHRSTAFGLEHKRILGDGVITGHG
TIDGRQVCVFSQDFTVLGGSLGEVFAEKIVKVMDLAMRMGVPLIGINDSGGARIQEGVVALGGYAEIFYRNVVASGVIPQ
LSIIAGPCAGGAVYSPAMTDFILMVKGTSQMFITGPDVIKTVTGEEVTQEQLGGAMTHNSKSGVAHFAADDEDECFEQLR
TLLSFLPLNNMDDAPIIEPTDDPNRMDDALQSIIPDQPKKPYDMKAVIELIVDDGFFFEVQPHYAPNLVIGFARLDGMPV
GIVGNQPAALAGTLDIDSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTHQEYGGIIRHGAKLLYAYCEATVPKLTVITR
KAYGGAYDVMASKHIRADFNFAWPTAEIAVMGASGAVSIIFRKEIAESTDPVATNAELIHNYEERFANPYIAAERGYIDS
VIEPRETRPALIKALHLSRTKRQSLPPRKHGNMPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=517, Percent_Identity=58.8007736943907, Blast_Score=602, Evalue=1e-172,
Organism=Homo sapiens, GI295821216, Length=537, Percent_Identity=56.610800744879, Blast_Score=590, Evalue=1e-168,
Organism=Homo sapiens, GI11545863, Length=500, Percent_Identity=34.2, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI134142062, Length=393, Percent_Identity=26.7175572519084, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI38679971, Length=406, Percent_Identity=24.1379310344828, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI38679974, Length=406, Percent_Identity=24.1379310344828, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI38679977, Length=406, Percent_Identity=24.1379310344828, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI38679967, Length=406, Percent_Identity=24.1379310344828, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI38679960, Length=406, Percent_Identity=24.1379310344828, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788655, Length=214, Percent_Identity=28.5046728971963, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=512, Percent_Identity=58.7890625, Blast_Score=608, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI25147359, Length=512, Percent_Identity=58.7890625, Blast_Score=607, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI17552936, Length=505, Percent_Identity=34.0594059405941, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI71997163, Length=376, Percent_Identity=25.531914893617, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324343, Length=360, Percent_Identity=23.3333333333333, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323863, Length=299, Percent_Identity=25.752508361204, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24586065, Length=500, Percent_Identity=34.4, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56140; Mature: 56009

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00589 PTS_HPR_SER ; PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTAEKIAELRRRREQAATTDPKAAEKQHARGKLTARERIERLLDPDSFVELDALAVHR
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHEEHHHHHHHH
STAFGLEHKRILGDGVITGHGTIDGRQVCVFSQDFTVLGGSLGEVFAEKIVKVMDLAMRM
HHHCCCCHHHEECCCEEECCCCCCCCEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHC
GVPLIGINDSGGARIQEGVVALGGYAEIFYRNVVASGVIPQLSIIAGPCAGGAVYSPAMT
CCCEEEECCCCCCCHHCCEEEECCHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCCCHHH
DFILMVKGTSQMFITGPDVIKTVTGEEVTQEQLGGAMTHNSKSGVAHFAADDEDECFEQL
EEEEEEECCCEEEEECCHHHHCCCCCHHHHHHHCCEECCCCCCCEEEECCCCHHHHHHHH
RTLLSFLPLNNMDDAPIIEPTDDPNRMDDALQSIIPDQPKKPYDMKAVIELIVDDGFFFE
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEE
VQPHYAPNLVIGFARLDGMPVGIVGNQPAALAGTLDIDSSVKGARFVRFCDAFNIPLITF
ECCCCCCCEEEEEEHHCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEE
VDVPGFLPGTHQEYGGIIRHGAKLLYAYCEATVPKLTVITRKAYGGAYDVMASKHIRADF
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCEECCC
NFAWPTAEIAVMGASGAVSIIFRKEIAESTDPVATNAELIHNYEERFANPYIAAERGYID
CEECCCEEEEEEECCCCEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHH
SVIEPRETRPALIKALHLSRTKRQSLPPRKHGNMPL
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTTAEKIAELRRRREQAATTDPKAAEKQHARGKLTARERIERLLDPDSFVELDALAVHR
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHEEHHHHHHHH
STAFGLEHKRILGDGVITGHGTIDGRQVCVFSQDFTVLGGSLGEVFAEKIVKVMDLAMRM
HHHCCCCHHHEECCCEEECCCCCCCCEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHC
GVPLIGINDSGGARIQEGVVALGGYAEIFYRNVVASGVIPQLSIIAGPCAGGAVYSPAMT
CCCEEEECCCCCCCHHCCEEEECCHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCCCHHH
DFILMVKGTSQMFITGPDVIKTVTGEEVTQEQLGGAMTHNSKSGVAHFAADDEDECFEQL
EEEEEEECCCEEEEECCHHHHCCCCCHHHHHHHCCEECCCCCCCEEEECCCCHHHHHHHH
RTLLSFLPLNNMDDAPIIEPTDDPNRMDDALQSIIPDQPKKPYDMKAVIELIVDDGFFFE
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEE
VQPHYAPNLVIGFARLDGMPVGIVGNQPAALAGTLDIDSSVKGARFVRFCDAFNIPLITF
ECCCCCCCEEEEEEHHCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEE
VDVPGFLPGTHQEYGGIIRHGAKLLYAYCEATVPKLTVITRKAYGGAYDVMASKHIRADF
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCEECCC
NFAWPTAEIAVMGASGAVSIIFRKEIAESTDPVATNAELIHNYEERFANPYIAAERGYID
CEECCCEEEEEEECCCCEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHH
SVIEPRETRPALIKALHLSRTKRQSLPPRKHGNMPL
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]