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The map label for this gene is lexA

Identifier: 15926920

GI number: 15926920

Start: 1337131

End: 1337754

Strand: Reverse

Name: lexA

Synonym: SA1174

Alternate gene names: 15926920

Gene position: 1337754-1337131 (Counterclockwise)

Preceding gene: 15926928

Following gene: 15926914

Centisome position: 47.53

GC content: 35.9

Gene sequence:

>624_bases
ATGAGAGAATTAACAAAACGACAAAGCGAAATATATAACTATATTAAACAAGTTGTTCAAATGAAAGGTTATCCGCCTAG
TGTTCGCGAAATTGGTGAAGCAGTTGGCTTAGCATCCAGTTCAACTGTTCATGGTCATCTTTCACGTCTTGAAGAAAAAG
GATATATAAGAAGAGATCCAACGAAACCACGTGCTATAGAAATTGTAAGTGATCAAACAAATGATAATATTAATATGGAA
GAAACGATTCATGTGCCAGTTATTGGTAAAGTCACAGCAGGTGTTCCTATTACCGCTGTAGAAAATATTGAAGAGTATTT
TCCATTACCTGAACACTTAACATCGACACATAATAGCGACATATTCATATTAAACGTCGTAGGCGACAGTATGATTGAGG
CTGGTATATTAGACGGAGACAAAGTAATTGTTCGCAGTCAAACCATAGCAGAAAATGGAGACATTATTGTTGCTATGACT
GAGGAAGATGAAGCAACTGTCAAACGCTTCTATAAAGAAAAAAATCGTTATCGATTACAACCTGAAAATAGTACAATGGA
GCCAATTTACCTCGACAATGTTGCTGTAATTGGGAAAGTAATTGGTTTGTACCGCGAAATGTAA

Upstream 100 bases:

>100_bases
AGAACTTATGTTCTGTGTCAATATTTTAACGAACAAATGTTTGTTTTGGTTGTGAATTAATGATATACTGTATTTAAATT
AATTTAGGGAGTGCCTATAT

Downstream 100 bases:

>100_bases
TATTTTAAACCGTTATATATTATCGTAATTGTTAAACCCTCATTTTTATAAATTTTGGACCTCTTGAAAAAGTTTCGTTT
TCAAGAGGTTTTATTTATTC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MRELTKRQSEIYNYIKQVVQMKGYPPSVREIGEAVGLASSSTVHGHLSRLEEKGYIRRDPTKPRAIEIVSDQTNDNINME
ETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSDIFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMT
EEDEATVKRFYKEKNRYRLQPENSTMEPIYLDNVAVIGKVIGLYREM

Sequences:

>Translated_207_residues
MRELTKRQSEIYNYIKQVVQMKGYPPSVREIGEAVGLASSSTVHGHLSRLEEKGYIRRDPTKPRAIEIVSDQTNDNINME
ETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSDIFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMT
EEDEATVKRFYKEKNRYRLQPENSTMEPIYLDNVAVIGKVIGLYREM
>Mature_207_residues
MRELTKRQSEIYNYIKQVVQMKGYPPSVREIGEAVGLASSSTVHGHLSRLEEKGYIRRDPTKPRAIEIVSDQTNDNINME
ETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSDIFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMT
EEDEATVKRFYKEKNRYRLQPENSTMEPIYLDNVAVIGKVIGLYREM

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=210, Percent_Identity=34.7619047619048, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1787431, Length=134, Percent_Identity=33.5820895522388, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_STAA1 (A7X1Z4)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441918.1
- ProteinModelPortal:   A7X1Z4
- SMR:   A7X1Z4
- STRING:   A7X1Z4
- EnsemblBacteria:   EBSTAT00000004722
- GeneID:   5560962
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1328
- eggNOG:   COG1974
- GeneTree:   EBGT00050000023993
- HOGENOM:   HBG679610
- OMA:   IAENPDF
- ProtClustDB:   PRK00215
- BioCyc:   SAUR418127:SAHV_1328-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 23332; Mature: 23332

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: ACT_SITE 130-130 ACT_SITE 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELTKRQSEIYNYIKQVVQMKGYPPSVREIGEAVGLASSSTVHGHLSRLEEKGYIRRDP
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEECCC
TKPRAIEIVSDQTNDNINMEETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSD
CCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHCCCCCC
IFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMTEEDEATVKRFYKEKNRYRLQ
EEEEEECCCHHHHHCCCCCCEEEEEECEECCCCCEEEEEECCCHHHHHHHHHHCCCEEEC
PENSTMEPIYLDNVAVIGKVIGLYREM
CCCCCCCCEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRELTKRQSEIYNYIKQVVQMKGYPPSVREIGEAVGLASSSTVHGHLSRLEEKGYIRRDP
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEECCC
TKPRAIEIVSDQTNDNINMEETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSD
CCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHCCCCCC
IFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMTEEDEATVKRFYKEKNRYRLQ
EEEEEECCCHHHHHCCCCCCEEEEEECEECCCCCEEEEEECCCHHHHHHHHHHCCCEEEC
PENSTMEPIYLDNVAVIGKVIGLYREM
CCCCCCCCEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA