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The map label for this gene is lysP [H]

Identifier: 15926914

GI number: 15926914

Start: 1330441

End: 1331895

Strand: Reverse

Name: lysP [H]

Synonym: SA1169

Alternate gene names: 15926914

Gene position: 1331895-1330441 (Counterclockwise)

Preceding gene: 15926920

Following gene: 15926913

Centisome position: 47.32

GC content: 33.2

Gene sequence:

>1455_bases
ATGGAAGATAATAAAATGAACCGTAGTCTTAACTCAAGACACATTTCCATGATTGCTATAGGTGGTGCAATTGGGACTGG
TCTATTTGTAGCTACTGGTAATATCATTTCTCAAGCTGGTCCTGGAGGCGCTATACTCGCTTATCTTGTTATTGGTGTCA
TGCTATATTTCTTAATGTCATCAATTGGAGAGTTGGCAACATTTTATCCAGTATCAGGTTCATTCAGCTCTTATTCAACA
CGCTTTATTGACTCATCTCTTGGCTTTACCATGGGATGGTTGTATTGGGCATTGTGGTCATTAGTTACAAGTGTTGATGT
CATAGTAGCGTCAAATGTGCTTTATTTCTGGGACACATTTAAATTTTTCCACCCCATTACTTGGAGCTTAATCTTTATTA
CAATTTTACTATTATTAAACATTTTTTCTGTAAAATCATTTGGAGAAACTGAGTTTTGGTTATCATTGATTAAAGTGTTA
ACAATTATCGTATTCGTTATTTTTGGCTTTTTAATGATTTTCGGTATCTTAGGTGGTCATACATATGGATTTGAAAACTA
TACAAAAGGCCAAGCACCGTTTGTTGGTGGTATCTCTGGTTTCTTAGGCGTATTATTAGTCGCCGGATTTTCGGTTGGTG
GTACAGAAGTAGTAGCAGTAACTGCTGGTGAATCAGATGACCCTAAAAAGTCTATGCCTAAGGCAATTAAACAAGTATTT
TGGCGTATTCTTTTATTCTATGTCTTATCAATTGCAGTAATTGGTGCAATTATTCCGTACACAGATCCATCATTATTAAG
AGCAAGTAGTTCAATAAGTCAAAGCCCATTTACAATTGTATTCGATAGAGTAGGCATAGCCTTTGCAGCATCAGTAATCA
ACGCGGTTATTTTAACTTCATTATTATCCGCTGCAAATTCAGGTGTTTATACAACAGGCAGAATGTTGTATTCCTTAAGT
TCAGACAAAAAAGCACCCCAATTTTTAAGTAAATTAAACAAGACAACTAAGTTACCTTTAAGAGCATTATTAACTACTTA
TGCAGTCGTTGTTATTGTTATTATTTATGCAAACTTTAATTCAAATGCCGTTTTTAATTTACTTGAAATTATTGGTTCAA
TGATTATAGTTGTTTGGGGATCAAGCATTTGGTCACAAATACGATTGCGACAAGCTATTAAAAAACAAGGTCAAGACCCT
AATAAGGTCCTACCATATAAAGCACCTTTTTATCCATTAGGACCAATCATTGTCATCACTACACTATTATTCTTGCTATT
TGGTGGCTCAGTTGAATATATTTTAAAAGATCAATGGTTAAATGCTTTTAAAAACTTTTTACCTTTAATCATTCTAGCGT
TGATTTACTTTATTCATAAAATCATTCACAAAACAAAATTTGTAAAGCTAGAAACAATTAATTTAAAACCACACGATTAT
GACAATCAAAAATAA

Upstream 100 bases:

>100_bases
AAATTTTAATTTTTTCGCTTTACAGTACTAAATAGTTATTGAATAGTACACTTAAAAAGCTTACAATAATGGGTATATTT
AAATAGATGGGAGACTAAAT

Downstream 100 bases:

>100_bases
ATAAATTCTTACACGGCAGATGCTTTAGATTATCTATAGCATTTGCCGCTTTTTAATGGTGTAAAGCAGATATACTTTAA
TATCTTTTTCTAGTATAAAG

Product: gamma-aminobutyrate permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MEDNKMNRSLNSRHISMIAIGGAIGTGLFVATGNIISQAGPGGAILAYLVIGVMLYFLMSSIGELATFYPVSGSFSSYST
RFIDSSLGFTMGWLYWALWSLVTSVDVIVASNVLYFWDTFKFFHPITWSLIFITILLLLNIFSVKSFGETEFWLSLIKVL
TIIVFVIFGFLMIFGILGGHTYGFENYTKGQAPFVGGISGFLGVLLVAGFSVGGTEVVAVTAGESDDPKKSMPKAIKQVF
WRILLFYVLSIAVIGAIIPYTDPSLLRASSSISQSPFTIVFDRVGIAFAASVINAVILTSLLSAANSGVYTTGRMLYSLS
SDKKAPQFLSKLNKTTKLPLRALLTTYAVVVIVIIYANFNSNAVFNLLEIIGSMIIVVWGSSIWSQIRLRQAIKKQGQDP
NKVLPYKAPFYPLGPIIVITTLLFLLFGGSVEYILKDQWLNAFKNFLPLIILALIYFIHKIIHKTKFVKLETINLKPHDY
DNQK

Sequences:

>Translated_484_residues
MEDNKMNRSLNSRHISMIAIGGAIGTGLFVATGNIISQAGPGGAILAYLVIGVMLYFLMSSIGELATFYPVSGSFSSYST
RFIDSSLGFTMGWLYWALWSLVTSVDVIVASNVLYFWDTFKFFHPITWSLIFITILLLLNIFSVKSFGETEFWLSLIKVL
TIIVFVIFGFLMIFGILGGHTYGFENYTKGQAPFVGGISGFLGVLLVAGFSVGGTEVVAVTAGESDDPKKSMPKAIKQVF
WRILLFYVLSIAVIGAIIPYTDPSLLRASSSISQSPFTIVFDRVGIAFAASVINAVILTSLLSAANSGVYTTGRMLYSLS
SDKKAPQFLSKLNKTTKLPLRALLTTYAVVVIVIIYANFNSNAVFNLLEIIGSMIIVVWGSSIWSQIRLRQAIKKQGQDP
NKVLPYKAPFYPLGPIIVITTLLFLLFGGSVEYILKDQWLNAFKNFLPLIILALIYFIHKIIHKTKFVKLETINLKPHDY
DNQK
>Mature_484_residues
MEDNKMNRSLNSRHISMIAIGGAIGTGLFVATGNIISQAGPGGAILAYLVIGVMLYFLMSSIGELATFYPVSGSFSSYST
RFIDSSLGFTMGWLYWALWSLVTSVDVIVASNVLYFWDTFKFFHPITWSLIFITILLLLNIFSVKSFGETEFWLSLIKVL
TIIVFVIFGFLMIFGILGGHTYGFENYTKGQAPFVGGISGFLGVLLVAGFSVGGTEVVAVTAGESDDPKKSMPKAIKQVF
WRILLFYVLSIAVIGAIIPYTDPSLLRASSSISQSPFTIVFDRVGIAFAASVINAVILTSLLSAANSGVYTTGRMLYSLS
SDKKAPQFLSKLNKTTKLPLRALLTTYAVVVIVIIYANFNSNAVFNLLEIIGSMIIVVWGSSIWSQIRLRQAIKKQGQDP
NKVLPYKAPFYPLGPIIVITTLLFLLFGGSVEYILKDQWLNAFKNFLPLIILALIYFIHKIIHKTKFVKLETINLKPHDY
DNQK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=392, Percent_Identity=25, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614003, Length=405, Percent_Identity=22.4691358024691, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258614005, Length=405, Percent_Identity=22.4691358024691, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788480, Length=485, Percent_Identity=45.5670103092784, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI87081708, Length=422, Percent_Identity=35.5450236966825, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI1786789, Length=422, Percent_Identity=35.0710900473934, Blast_Score=252, Evalue=5e-68,
Organism=Escherichia coli, GI1786302, Length=427, Percent_Identity=33.9578454332553, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI87081915, Length=413, Percent_Identity=35.3510895883777, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI48994972, Length=482, Percent_Identity=32.9875518672199, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1790653, Length=433, Percent_Identity=34.6420323325635, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1789017, Length=401, Percent_Identity=33.6658354114713, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786602, Length=428, Percent_Identity=34.3457943925234, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17532491, Length=364, Percent_Identity=22.5274725274725, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=423, Percent_Identity=39.2434988179669, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6324061, Length=497, Percent_Identity=35.2112676056338, Blast_Score=277, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6324553, Length=496, Percent_Identity=32.4596774193548, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6322892, Length=411, Percent_Identity=37.712895377129, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6321629, Length=499, Percent_Identity=33.2665330661323, Blast_Score=246, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6324059, Length=428, Percent_Identity=37.1495327102804, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6319542, Length=414, Percent_Identity=34.7826086956522, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6324990, Length=496, Percent_Identity=30.4435483870968, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320717, Length=494, Percent_Identity=30.3643724696356, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6319543, Length=490, Percent_Identity=31.6326530612245, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6319824, Length=493, Percent_Identity=30.2231237322515, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6324924, Length=489, Percent_Identity=30.6748466257669, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320251, Length=414, Percent_Identity=32.1256038647343, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321053, Length=475, Percent_Identity=30.7368421052632, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322967, Length=476, Percent_Identity=28.3613445378151, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319608, Length=433, Percent_Identity=28.6374133949192, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324981, Length=485, Percent_Identity=31.340206185567, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320364, Length=551, Percent_Identity=25.2268602540835, Blast_Score=139, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53414; Mature: 53414

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDNKMNRSLNSRHISMIAIGGAIGTGLFVATGNIISQAGPGGAILAYLVIGVMLYFLMS
CCCCHHCCCCCCCEEEEEEECCHHHCCHHHEECHHHHCCCCCHHHHHHHHHHHHHHHHHH
SIGELATFYPVSGSFSSYSTRFIDSSLGFTMGWLYWALWSLVTSVDVIVASNVLYFWDTF
HHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KFFHPITWSLIFITILLLLNIFSVKSFGETEFWLSLIKVLTIIVFVIFGFLMIFGILGGH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TYGFENYTKGQAPFVGGISGFLGVLLVAGFSVGGTEVVAVTAGESDDPKKSMPKAIKQVF
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
WRILLFYVLSIAVIGAIIPYTDPSLLRASSSISQSPFTIVFDRVGIAFAASVINAVILTS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
LLSAANSGVYTTGRMLYSLSSDKKAPQFLSKLNKTTKLPLRALLTTYAVVVIVIIYANFN
HHHHHCCCCEEHHHHHEECCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SNAVFNLLEIIGSMIIVVWGSSIWSQIRLRQAIKKQGQDPNKVLPYKAPFYPLGPIIVIT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
TLLFLLFGGSVEYILKDQWLNAFKNFLPLIILALIYFIHKIIHKTKFVKLETINLKPHDY
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCC
DNQK
CCCC
>Mature Secondary Structure
MEDNKMNRSLNSRHISMIAIGGAIGTGLFVATGNIISQAGPGGAILAYLVIGVMLYFLMS
CCCCHHCCCCCCCEEEEEEECCHHHCCHHHEECHHHHCCCCCHHHHHHHHHHHHHHHHHH
SIGELATFYPVSGSFSSYSTRFIDSSLGFTMGWLYWALWSLVTSVDVIVASNVLYFWDTF
HHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KFFHPITWSLIFITILLLLNIFSVKSFGETEFWLSLIKVLTIIVFVIFGFLMIFGILGGH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TYGFENYTKGQAPFVGGISGFLGVLLVAGFSVGGTEVVAVTAGESDDPKKSMPKAIKQVF
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
WRILLFYVLSIAVIGAIIPYTDPSLLRASSSISQSPFTIVFDRVGIAFAASVINAVILTS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
LLSAANSGVYTTGRMLYSLSSDKKAPQFLSKLNKTTKLPLRALLTTYAVVVIVIIYANFN
HHHHHCCCCEEHHHHHEECCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SNAVFNLLEIIGSMIIVVWGSSIWSQIRLRQAIKKQGQDPNKVLPYKAPFYPLGPIIVIT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
TLLFLLFGGSVEYILKDQWLNAFKNFLPLIILALIYFIHKIIHKTKFVKLETINLKPHDY
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCC
DNQK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]