Click here to switch to the map view.

The map label for this gene is dys

Identifier: 15921559

GI number: 15921559

Start: 1292443

End: 1293378

Strand: Direct

Name: dys

Synonym: ST1293

Alternate gene names: 15921559

Gene position: 1292443-1293378 (Clockwise)

Preceding gene: 15921558

Following gene: 15921560

Centisome position: 47.96

GC content: 31.73

Gene sequence:

>936_bases
ATGAAAAGAGAAGAATTACTTGTCGAGGAAATAAAAGATCTAACATTAGAAGAGCTTAAGGGGTATGCAGATTTTTATAA
GATATTAGATAAAGTTTATGGGTTTACCGCAGAATCAGTAGTTAGAGGAGTAAAGATACTAAAAGATATGATAAAAGAAG
CCGATTTACGATTCTTATCTTTTACTGCAAATCTGGTATCTACGGGATTAAGAGGTCTATTTGCTGATCTTATTAAGCAA
GGATATTTTAATGTAATAATTACAACAGGAGGTACTATTGATCATGATATAGCTAGAAGTTTCGGCGGGAAGTACTATAA
AGGTCTTTTCGAATATGATGATTCTATGCTTAGAGAATTAGAAATTCATAGACTAGGCAATATTCTGGTTCCAATGGAAA
GTTATGGTAAAGTAATTGAAGATGTAGTAAGAAAATATATGAATGAGATAGTTAGTATAAAGAAGGAATGGCCTGTATAT
GAGCTTTTATGGGAATTTGGTAAAAGAATAAGTGATGAAAACTCCATACTAAAAGCCGCTTATGAGAAAAAAGTTCCTAT
TATAGTTCCTGGTATTATTGATGGATCATTTGGAACTAACTTGTTTATATACTCACAATTTACTCAATTAAAGTTAAATC
TCTTTGAAGACATGAAACTTATAAAGGATCTAATATTTTCATGTAAAAAGTCCGGTGCTCTTATAATAGGAGGAGGGATA
AGTAAGCATCATACAATTTGGTGGAACCAATTTAAAGACGGATTAGATTATGCGATATACATAACTACAGCTCAAGAATA
TGATGGAAGTCTTAGTGGTGCTAAACCTAGAGAAGCTATATCATGGAATAAGATTAAACCGACAAGCGAAAATGTTGTCA
TCTATGGAGATGCTACAATTATTTTGCCCATTTTGTCAGCATCTTTATTAGGTTAA

Upstream 100 bases:

>100_bases
CTGGAGCTTATAAAGATGTAGATAGAGTAGCTAAAGTAGCTCATGAGGTAAAAATAGCTAAACTAGTTGTAAGATTAAGA
CCAATAGGTGTTACTAAAGG

Downstream 100 bases:

>100_bases
GCGAATAAAATATTTGTATTGTGATGATTTATGTCATCTGAGAAGTTTACTAGTATTTCTCCTGCTGAATTCTTTAAAAG
GAATCCAGAGTTGGCTGGTT

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKREELLVEEIKDLTLEELKGYADFYKILDKVYGFTAESVVRGVKILKDMIKEADLRFLSFTANLVSTGLRGLFADLIKQ
GYFNVIITTGGTIDHDIARSFGGKYYKGLFEYDDSMLRELEIHRLGNILVPMESYGKVIEDVVRKYMNEIVSIKKEWPVY
ELLWEFGKRISDENSILKAAYEKKVPIIVPGIIDGSFGTNLFIYSQFTQLKLNLFEDMKLIKDLIFSCKKSGALIIGGGI
SKHHTIWWNQFKDGLDYAIYITTAQEYDGSLSGAKPREAISWNKIKPTSENVVIYGDATIILPILSASLLG

Sequences:

>Translated_311_residues
MKREELLVEEIKDLTLEELKGYADFYKILDKVYGFTAESVVRGVKILKDMIKEADLRFLSFTANLVSTGLRGLFADLIKQ
GYFNVIITTGGTIDHDIARSFGGKYYKGLFEYDDSMLRELEIHRLGNILVPMESYGKVIEDVVRKYMNEIVSIKKEWPVY
ELLWEFGKRISDENSILKAAYEKKVPIIVPGIIDGSFGTNLFIYSQFTQLKLNLFEDMKLIKDLIFSCKKSGALIIGGGI
SKHHTIWWNQFKDGLDYAIYITTAQEYDGSLSGAKPREAISWNKIKPTSENVVIYGDATIILPILSASLLG
>Mature_311_residues
MKREELLVEEIKDLTLEELKGYADFYKILDKVYGFTAESVVRGVKILKDMIKEADLRFLSFTANLVSTGLRGLFADLIKQ
GYFNVIITTGGTIDHDIARSFGGKYYKGLFEYDDSMLRELEIHRLGNILVPMESYGKVIEDVVRKYMNEIVSIKKEWPVY
ELLWEFGKRISDENSILKAAYEKKVPIIVPGIIDGSFGTNLFIYSQFTQLKLNLFEDMKLIKDLIFSCKKSGALIIGGGI
SKHHTIWWNQFKDGLDYAIYITTAQEYDGSLSGAKPREAISWNKIKPTSENVVIYGDATIILPILSASLLG

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family

Homologues:

Organism=Homo sapiens, GI4503325, Length=326, Percent_Identity=33.4355828220859, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI7108338, Length=325, Percent_Identity=27.0769230769231, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI7108340, Length=325, Percent_Identity=24.9230769230769, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17536927, Length=256, Percent_Identity=35.15625, Blast_Score=181, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321859, Length=273, Percent_Identity=32.2344322344322, Blast_Score=172, Evalue=5e-44,
Organism=Drosophila melanogaster, GI45550569, Length=336, Percent_Identity=31.25, Blast_Score=171, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHYS_SULTO (Q971T3)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377228.1
- ProteinModelPortal:   Q971T3
- SMR:   Q971T3
- GeneID:   1459295
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1293
- NMPDR:   fig|273063.1.peg.1396
- HOGENOM:   HBG716221
- OMA:   RISDENS
- ProtClustDB:   PRK01221
- BioCyc:   STOK273063:ST1293-MONOMER
- BRENDA:   2.5.1.46
- HAMAP:   MF_00153
- InterPro:   IPR002773
- InterPro:   IPR022899
- Gene3D:   G3DSA:3.40.910.10
- PANTHER:   PTHR11703

Pfam domain/function: PF01916 DS

EC number: =2.5.1.46

Molecular weight: Translated: 35303; Mature: 35303

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: ACT_SITE 284-284

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREELLVEEIKDLTLEELKGYADFYKILDKVYGFTAESVVRGVKILKDMIKEADLRFLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
FTANLVSTGLRGLFADLIKQGYFNVIITTGGTIDHDIARSFGGKYYKGLFEYDDSMLREL
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
EIHRLGNILVPMESYGKVIEDVVRKYMNEIVSIKKEWPVYELLWEFGKRISDENSILKAA
HHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHH
YEKKVPIIVPGIIDGSFGTNLFIYSQFTQLKLNLFEDMKLIKDLIFSCKKSGALIIGGGI
HHCCCCEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
SKHHTIWWNQFKDGLDYAIYITTAQEYDGSLSGAKPREAISWNKIKPTSENVVIYGDATI
CCCCEEEHHHHCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHH
ILPILSASLLG
HHHHHHHHHCC
>Mature Secondary Structure
MKREELLVEEIKDLTLEELKGYADFYKILDKVYGFTAESVVRGVKILKDMIKEADLRFLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
FTANLVSTGLRGLFADLIKQGYFNVIITTGGTIDHDIARSFGGKYYKGLFEYDDSMLREL
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
EIHRLGNILVPMESYGKVIEDVVRKYMNEIVSIKKEWPVYELLWEFGKRISDENSILKAA
HHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHH
YEKKVPIIVPGIIDGSFGTNLFIYSQFTQLKLNLFEDMKLIKDLIFSCKKSGALIIGGGI
HHCCCCEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
SKHHTIWWNQFKDGLDYAIYITTAQEYDGSLSGAKPREAISWNKIKPTSENVVIYGDATI
CCCCEEEHHHHCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHH
ILPILSASLLG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479