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The map label for this gene is gcvPB

Identifier: 15921471

GI number: 15921471

Start: 1210296

End: 1211813

Strand: Direct

Name: gcvPB

Synonym: ST1208

Alternate gene names: 15921471

Gene position: 1210296-1211813 (Clockwise)

Preceding gene: 15921470

Following gene: 15921475

Centisome position: 44.91

GC content: 35.05

Gene sequence:

>1518_bases
ATGAGCTGGCATCAAGCTGTATGGAACGAGCCTCTAATTTTTGAGTATAAAGGAAAGGGAAGAATAGGTTTTAAAATCCC
AGAAGAAGAGGAGTTAAAGAAAGAGATCAGCATCAATATACCAGAAAAATTAAGGAGAAAAGAGATAGATTTGCCGGAGT
TAAGCGAACTAGAAGTTATTAGACATTTTATAAGATTATCTCAAATGAGTTTTGGTGTTGATAACGGAATGGTACCTTTA
GGTTCATGTACTATGAAGTATAACCCAAAGATAGAGGAAGAAGCTGAATTACTTACACAAAATTTGCATCCATTGCAAGA
TGATTCTACTGTTCAAGGTATTTTAGAGGTTTTATATTATATGCAGAAATGGTTAGCCGAAATAACTGGTATGGATTTAT
GTAGTTTACAAGTGCCAGCTGGAGCTGCTGGAGAATTAGCAGGGGTTTTAATGATTAAGAAATATCATGAAACTAAGGGT
AGAGGAAATAGAGATGAAATGCTTGTTGCTGATACTGCACATGGAACTAATCCTGCTAGTGCTTCTATGGAGAATTTTAA
AGTTATCTACATTAAGTCTAATAGTGAAGGTCTAGTTGATGTGGATATTCTGAAGGAGATTGTAAGTGAAAGGACTGCTG
GGTTTATGTTAACTAATCCTAATACTCTTGGTCTATTCGAGGAGAATATATTAGATATTGCAAAATATATTCACTCTGTT
GATGCAAAATTATATTATGATGGAGCAAATCTTAACGGAATTTTAGGAGTAGTTAGACCGGGAGATATGGGGTTTGATAT
TGTTCATTTAAATTTACATAAGACATTTGCTGTTCCACATGGGGGTGGAGGTCCAGGAGCTGGAGCAATATGTGCTAAGG
GAGAGATGGTTAATTTCTTACCGTATCCATTAGTAGAGAAAAAGGACGGAAAATATTCGTTGTCTTATATTCCAAAATAT
TCCATTGGAAAAATTGCCACTTTTTATGGAAATGTAGGTAATGTAGTTAGAGCATATACGTATATTCTGGGTTTAGGTGC
CGAAGGAATATCAATGATAGGAAAAATGAGTACTTTAGCTACAAATTACCTTATATCACAACTTAAAAATGTAAGAGGAC
TAGAGTTAATAGCCCCCTATAGACCTAGAAAACATGAGGTAGTTTTTTCTGCTAAAACGTTGGCTAAAGAAACTGGTGTT
ACAGCAAATGATGTTGCAAAGGCATTATTAGATAGAGGATTTTACGCGCCAACTATATATTTCCCTCCAAATGTAGAGGA
GGCTTTAATGATTGAGCCAACAGAAACCGAACCTAAAGAAGTTTTGGATAGTTTTGCAATTGCTATAAAGGAGATTATTA
ATACTGCCTATTCTAACCCTAAGGAAATTTTAGATACTCCAAAGAATACTAGTGTTAAAAGATTAGACCAAGTTATAGCA
AACCATCCGTCTAGTGTAACTCCAACTTATAGGGTTAAAAGACTAAGGGAGGAGGGAAAAATAGGTTCCTTAAAGTAG

Upstream 100 bases:

>100_bases
TAAAATTGGGTAAGACTCAAGCTTTATTTTGTGTTACTGAAGTTCATACTAAAAGTATGATTGATGAGTTAATTGAAAGC
ATTAGAGAGGTGTTTTCTGG

Downstream 100 bases:

>100_bases
GGAGAAAAGTATTGAAATATAACCTAGATAAGGTATTGAAATTACTATTCCATTAACTTCAGCTACTTTTCCTATAACTT
GTGACTGAGGAATTCCTTGA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MSWHQAVWNEPLIFEYKGKGRIGFKIPEEEELKKEISINIPEKLRRKEIDLPELSELEVIRHFIRLSQMSFGVDNGMVPL
GSCTMKYNPKIEEEAELLTQNLHPLQDDSTVQGILEVLYYMQKWLAEITGMDLCSLQVPAGAAGELAGVLMIKKYHETKG
RGNRDEMLVADTAHGTNPASASMENFKVIYIKSNSEGLVDVDILKEIVSERTAGFMLTNPNTLGLFEENILDIAKYIHSV
DAKLYYDGANLNGILGVVRPGDMGFDIVHLNLHKTFAVPHGGGGPGAGAICAKGEMVNFLPYPLVEKKDGKYSLSYIPKY
SIGKIATFYGNVGNVVRAYTYILGLGAEGISMIGKMSTLATNYLISQLKNVRGLELIAPYRPRKHEVVFSAKTLAKETGV
TANDVAKALLDRGFYAPTIYFPPNVEEALMIEPTETEPKEVLDSFAIAIKEIINTAYSNPKEILDTPKNTSVKRLDQVIA
NHPSSVTPTYRVKRLREEGKIGSLK

Sequences:

>Translated_505_residues
MSWHQAVWNEPLIFEYKGKGRIGFKIPEEEELKKEISINIPEKLRRKEIDLPELSELEVIRHFIRLSQMSFGVDNGMVPL
GSCTMKYNPKIEEEAELLTQNLHPLQDDSTVQGILEVLYYMQKWLAEITGMDLCSLQVPAGAAGELAGVLMIKKYHETKG
RGNRDEMLVADTAHGTNPASASMENFKVIYIKSNSEGLVDVDILKEIVSERTAGFMLTNPNTLGLFEENILDIAKYIHSV
DAKLYYDGANLNGILGVVRPGDMGFDIVHLNLHKTFAVPHGGGGPGAGAICAKGEMVNFLPYPLVEKKDGKYSLSYIPKY
SIGKIATFYGNVGNVVRAYTYILGLGAEGISMIGKMSTLATNYLISQLKNVRGLELIAPYRPRKHEVVFSAKTLAKETGV
TANDVAKALLDRGFYAPTIYFPPNVEEALMIEPTETEPKEVLDSFAIAIKEIINTAYSNPKEILDTPKNTSVKRLDQVIA
NHPSSVTPTYRVKRLREEGKIGSLK
>Mature_504_residues
SWHQAVWNEPLIFEYKGKGRIGFKIPEEEELKKEISINIPEKLRRKEIDLPELSELEVIRHFIRLSQMSFGVDNGMVPLG
SCTMKYNPKIEEEAELLTQNLHPLQDDSTVQGILEVLYYMQKWLAEITGMDLCSLQVPAGAAGELAGVLMIKKYHETKGR
GNRDEMLVADTAHGTNPASASMENFKVIYIKSNSEGLVDVDILKEIVSERTAGFMLTNPNTLGLFEENILDIAKYIHSVD
AKLYYDGANLNGILGVVRPGDMGFDIVHLNLHKTFAVPHGGGGPGAGAICAKGEMVNFLPYPLVEKKDGKYSLSYIPKYS
IGKIATFYGNVGNVVRAYTYILGLGAEGISMIGKMSTLATNYLISQLKNVRGLELIAPYRPRKHEVVFSAKTLAKETGVT
ANDVAKALLDRGFYAPTIYFPPNVEEALMIEPTETEPKEVLDSFAIAIKEIINTAYSNPKEILDTPKNTSVKRLDQVIAN
HPSSVTPTYRVKRLREEGKIGSLK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=405, Percent_Identity=36.7901234567901, Blast_Score=228, Evalue=7e-60,
Organism=Escherichia coli, GI1789269, Length=427, Percent_Identity=35.3629976580796, Blast_Score=238, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17535605, Length=408, Percent_Identity=37.5, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI32564013, Length=356, Percent_Identity=37.9213483146067, Blast_Score=207, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323843, Length=425, Percent_Identity=39.2941176470588, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24645648, Length=410, Percent_Identity=37.8048780487805, Blast_Score=234, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_SULTO (Q972C0)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377140.1
- ProteinModelPortal:   Q972C0
- SMR:   Q972C0
- GeneID:   1459206
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1208
- NMPDR:   fig|273063.1.peg.1308
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- BioCyc:   STOK273063:ST1208-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 55985; Mature: 55854

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWHQAVWNEPLIFEYKGKGRIGFKIPEEEELKKEISINIPEKLRRKEIDLPELSELEVI
CCHHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHH
RHFIRLSQMSFGVDNGMVPLGSCTMKYNPKIEEEAELLTQNLHPLQDDSTVQGILEVLYY
HHHHHHHHHHCCCCCCCEECCCEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MQKWLAEITGMDLCSLQVPAGAAGELAGVLMIKKYHETKGRGNRDEMLVADTAHGTNPAS
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
ASMENFKVIYIKSNSEGLVDVDILKEIVSERTAGFMLTNPNTLGLFEENILDIAKYIHSV
CCCCCEEEEEEECCCCCCEEHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHC
DAKLYYDGANLNGILGVVRPGDMGFDIVHLNLHKTFAVPHGGGGPGAGAICAKGEMVNFL
CCEEEECCCCCCEEEEEECCCCCCEEEEEEEEEEEEECCCCCCCCCCCCEEECCCEECCC
PYPLVEKKDGKYSLSYIPKYSIGKIATFYGNVGNVVRAYTYILGLGAEGISMIGKMSTLA
CCCCEECCCCCEEEEECCCCCCCHHHEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TNYLISQLKNVRGLELIAPYRPRKHEVVFSAKTLAKETGVTANDVAKALLDRGFYAPTIY
HHHHHHHHHCCCCCEEECCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHHCCCCCCEEE
FPPNVEEALMIEPTETEPKEVLDSFAIAIKEIINTAYSNPKEILDTPKNTSVKRLDQVIA
CCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHH
NHPSSVTPTYRVKRLREEGKIGSLK
CCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SWHQAVWNEPLIFEYKGKGRIGFKIPEEEELKKEISINIPEKLRRKEIDLPELSELEVI
CHHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHH
RHFIRLSQMSFGVDNGMVPLGSCTMKYNPKIEEEAELLTQNLHPLQDDSTVQGILEVLYY
HHHHHHHHHHCCCCCCCEECCCEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MQKWLAEITGMDLCSLQVPAGAAGELAGVLMIKKYHETKGRGNRDEMLVADTAHGTNPAS
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
ASMENFKVIYIKSNSEGLVDVDILKEIVSERTAGFMLTNPNTLGLFEENILDIAKYIHSV
CCCCCEEEEEEECCCCCCEEHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHC
DAKLYYDGANLNGILGVVRPGDMGFDIVHLNLHKTFAVPHGGGGPGAGAICAKGEMVNFL
CCEEEECCCCCCEEEEEECCCCCCEEEEEEEEEEEEECCCCCCCCCCCCEEECCCEECCC
PYPLVEKKDGKYSLSYIPKYSIGKIATFYGNVGNVVRAYTYILGLGAEGISMIGKMSTLA
CCCCEECCCCCEEEEECCCCCCCHHHEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TNYLISQLKNVRGLELIAPYRPRKHEVVFSAKTLAKETGVTANDVAKALLDRGFYAPTIY
HHHHHHHHHCCCCCEEECCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHHCCCCCCEEE
FPPNVEEALMIEPTETEPKEVLDSFAIAIKEIINTAYSNPKEILDTPKNTSVKRLDQVIA
CCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHH
NHPSSVTPTYRVKRLREEGKIGSLK
CCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479