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The map label for this gene is gcvPA

Identifier: 15921470

GI number: 15921470

Start: 1208950

End: 1210299

Strand: Direct

Name: gcvPA

Synonym: ST1207

Alternate gene names: 15921470

Gene position: 1208950-1210299 (Clockwise)

Preceding gene: 15921459

Following gene: 15921471

Centisome position: 44.86

GC content: 32.3

Gene sequence:

>1350_bases
ATGGACATGCATCCATGGCTACCAAATATAAAGTATATAGAGGAGATGTTGAAAAGTATAGGAGTAAATAGCATAGACGA
TCTATTCATAGATGTGCCAGAAGAAATCAAATTAAAGAAAGAATTGGATTTAGATTATAAAAAACCTCTTTCTGAATACG
AAATTATTCTTAAATTGCAAGAATTACAAAATAAAAATAAAAGACTTAAGATGCCACCTTTTCTAGGAGGTGGACTTTGC
CCGCATTATGTTCCAGAGGTTGTAAAATTTATTATTAAACGTTCTGAATTTTATACAGCTTATACTCCTTATCAGCCAGA
AATTTCTCAAGGACTACTTCAAGCACTTTTTGAATATCAAAGTCTAATAGCTGAGCTTTTTGAAATGGAAGTAGTTAATG
CATCCCTTTATGATTGGGGTAGTGCTCTAGCTGAAGCTATAATGATGGCTAATAGAATTAATAAAAAGAAGACTGTGCTT
GTTCCTAAACTTATGAACCCATACCATAAAGAAGTTGTAAAAACGTGGACTTATGGTAAGGGTATCAAACTAGTAGAAAT
ACCTCCAAATGAAAGAGGTACTATTGACGTTAGTAAGTTAGAAAGTATGATAAATGAGGATGATGTTTCTGCAATATATA
TTCAACAACCTAATTTTTATGGAATATTTGAAGATGAGATAGAATATATTGTAGATATTGCTAAAAAGAAAAAAATTATC
ACTATTATGGGTGTTTCTCCACTAGCATTAGGCCTAATCAAGCCTCCTGGAGAATATGAAATTGATATTACAGTAGGAGA
TGGACAAGAATTAGGTTTATCTTTAAACTTTGGAGGTCCTCTTTTAGGAATTCTTGCAACCAGATGGGACGGACAATTAG
TAAGACAAATGCCTGGCAGGATTGTGGGATTAACTAAGGATTCTGAAGGAAAAAGAGGATTTACATTAATCCTTCAAACT
AGAGAACAGTTTGCTAGAAGAGAAAAAGCTACTTCAAATATAACTACTAATGAAGCATTAATGGCTATTGCAGCAGCTGT
ATATCTCTCCTTATTAGGAAGAAATGGAATAAAAGAATTGGCTAAGGAGATATACATTAGAAGTCATTATGCTAAGAAAA
GATTAGAAGAATTAGGAGTAAACACTGTATATAACGGAGATTTCTTTGAGGAGTTTGCTGTTGATTTTAGAACTGATTAT
GATATAATTCATTCTAGGTTACTTGAGAAGAATATACACGGTGGATTAAAATTGGGTAAGACTCAAGCTTTATTTTGTGT
TACTGAAGTTCATACTAAAAGTATGATTGATGAGTTAATTGAAAGCATTAGAGAGGTGTTTTCTGGATGA

Upstream 100 bases:

>100_bases
GCAAATTCGCCTATATCAGCATTAAGTTTTAATTCAATATCCAAAAGAGGCGTACTAAACATTTTTAATTCACATATTGA
ATACTAGTAGGCATATTTAT

Downstream 100 bases:

>100_bases
GCTGGCATCAAGCTGTATGGAACGAGCCTCTAATTTTTGAGTATAAAGGAAAGGGAAGAATAGGTTTTAAAATCCCAGAA
GAAGAGGAGTTAAAGAAAGA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MDMHPWLPNIKYIEEMLKSIGVNSIDDLFIDVPEEIKLKKELDLDYKKPLSEYEIILKLQELQNKNKRLKMPPFLGGGLC
PHYVPEVVKFIIKRSEFYTAYTPYQPEISQGLLQALFEYQSLIAELFEMEVVNASLYDWGSALAEAIMMANRINKKKTVL
VPKLMNPYHKEVVKTWTYGKGIKLVEIPPNERGTIDVSKLESMINEDDVSAIYIQQPNFYGIFEDEIEYIVDIAKKKKII
TIMGVSPLALGLIKPPGEYEIDITVGDGQELGLSLNFGGPLLGILATRWDGQLVRQMPGRIVGLTKDSEGKRGFTLILQT
REQFARREKATSNITTNEALMAIAAAVYLSLLGRNGIKELAKEIYIRSHYAKKRLEELGVNTVYNGDFFEEFAVDFRTDY
DIIHSRLLEKNIHGGLKLGKTQALFCVTEVHTKSMIDELIESIREVFSG

Sequences:

>Translated_449_residues
MDMHPWLPNIKYIEEMLKSIGVNSIDDLFIDVPEEIKLKKELDLDYKKPLSEYEIILKLQELQNKNKRLKMPPFLGGGLC
PHYVPEVVKFIIKRSEFYTAYTPYQPEISQGLLQALFEYQSLIAELFEMEVVNASLYDWGSALAEAIMMANRINKKKTVL
VPKLMNPYHKEVVKTWTYGKGIKLVEIPPNERGTIDVSKLESMINEDDVSAIYIQQPNFYGIFEDEIEYIVDIAKKKKII
TIMGVSPLALGLIKPPGEYEIDITVGDGQELGLSLNFGGPLLGILATRWDGQLVRQMPGRIVGLTKDSEGKRGFTLILQT
REQFARREKATSNITTNEALMAIAAAVYLSLLGRNGIKELAKEIYIRSHYAKKRLEELGVNTVYNGDFFEEFAVDFRTDY
DIIHSRLLEKNIHGGLKLGKTQALFCVTEVHTKSMIDELIESIREVFSG
>Mature_449_residues
MDMHPWLPNIKYIEEMLKSIGVNSIDDLFIDVPEEIKLKKELDLDYKKPLSEYEIILKLQELQNKNKRLKMPPFLGGGLC
PHYVPEVVKFIIKRSEFYTAYTPYQPEISQGLLQALFEYQSLIAELFEMEVVNASLYDWGSALAEAIMMANRINKKKTVL
VPKLMNPYHKEVVKTWTYGKGIKLVEIPPNERGTIDVSKLESMINEDDVSAIYIQQPNFYGIFEDEIEYIVDIAKKKKII
TIMGVSPLALGLIKPPGEYEIDITVGDGQELGLSLNFGGPLLGILATRWDGQLVRQMPGRIVGLTKDSEGKRGFTLILQT
REQFARREKATSNITTNEALMAIAAAVYLSLLGRNGIKELAKEIYIRSHYAKKRLEELGVNTVYNGDFFEEFAVDFRTDY
DIIHSRLLEKNIHGGLKLGKTQALFCVTEVHTKSMIDELIESIREVFSG

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=361, Percent_Identity=37.3961218836565, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1789269, Length=393, Percent_Identity=30.7888040712468, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17535605, Length=390, Percent_Identity=34.8717948717949, Blast_Score=206, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323843, Length=366, Percent_Identity=34.1530054644809, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24645648, Length=392, Percent_Identity=37.5, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_SULTO (Q972C1)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377139.1
- ProteinModelPortal:   Q972C1
- SMR:   Q972C1
- GeneID:   1459205
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1207
- NMPDR:   fig|273063.1.peg.1307
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   STOK273063:ST1207-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 51082; Mature: 51082

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMHPWLPNIKYIEEMLKSIGVNSIDDLFIDVPEEIKLKKELDLDYKKPLSEYEIILKLQ
CCCCCCCCCHHHHHHHHHHCCCCCCCHHEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
ELQNKNKRLKMPPFLGGGLCPHYVPEVVKFIIKRSEFYTAYTPYQPEISQGLLQALFEYQ
HHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHH
SLIAELFEMEVVNASLYDWGSALAEAIMMANRINKKKTVLVPKLMNPYHKEVVKTWTYGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHCCHHHHHHHHHHCCCC
GIKLVEIPPNERGTIDVSKLESMINEDDVSAIYIQQPNFYGIFEDEIEYIVDIAKKKKII
CEEEEECCCCCCCCEEHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEE
TIMGVSPLALGLIKPPGEYEIDITVGDGQELGLSLNFGGPLLGILATRWDGQLVRQMPGR
EEECCCHHHHHEECCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHCCCCHHHHHCCCE
IVGLTKDSEGKRGFTLILQTREQFARREKATSNITTNEALMAIAAAVYLSLLGRNGIKEL
EEEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
AKEIYIRSHYAKKRLEELGVNTVYNGDFFEEFAVDFRTDYDIIHSRLLEKNIHGGLKLGK
HHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEECC
TQALFCVTEVHTKSMIDELIESIREVFSG
CCEEEEEHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDMHPWLPNIKYIEEMLKSIGVNSIDDLFIDVPEEIKLKKELDLDYKKPLSEYEIILKLQ
CCCCCCCCCHHHHHHHHHHCCCCCCCHHEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
ELQNKNKRLKMPPFLGGGLCPHYVPEVVKFIIKRSEFYTAYTPYQPEISQGLLQALFEYQ
HHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHH
SLIAELFEMEVVNASLYDWGSALAEAIMMANRINKKKTVLVPKLMNPYHKEVVKTWTYGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHCCHHHHHHHHHHCCCC
GIKLVEIPPNERGTIDVSKLESMINEDDVSAIYIQQPNFYGIFEDEIEYIVDIAKKKKII
CEEEEECCCCCCCCEEHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEE
TIMGVSPLALGLIKPPGEYEIDITVGDGQELGLSLNFGGPLLGILATRWDGQLVRQMPGR
EEECCCHHHHHEECCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHCCCCHHHHHCCCE
IVGLTKDSEGKRGFTLILQTREQFARREKATSNITTNEALMAIAAAVYLSLLGRNGIKEL
EEEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
AKEIYIRSHYAKKRLEELGVNTVYNGDFFEEFAVDFRTDYDIIHSRLLEKNIHGGLKLGK
HHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEECC
TQALFCVTEVHTKSMIDELIESIREVFSG
CCEEEEEHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479