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The map label for this gene is yeiA [H]

Identifier: 15921375

GI number: 15921375

Start: 1112043

End: 1113095

Strand: Direct

Name: yeiA [H]

Synonym: ST1120

Alternate gene names: 15921375

Gene position: 1112043-1113095 (Clockwise)

Preceding gene: 15921370

Following gene: 15921376

Centisome position: 41.27

GC content: 36.94

Gene sequence:

>1053_bases
ATGATAGATCTATCAGTAACTTTCCAAGGAATAACATTTCCAAATCCTTTTTTAGTAGGCTCTGGTCCAACAACTGGGAA
TCCTCCAAAAATAATTTCGGCAATAAGAGCAGGTTGGGGAGGAGTAGTTGTTAAAACTATAGGGGACTCAATAGTTAGAA
AATCAGTAAGACCTATGTATGCTACAATTAGAAGGAATAGAGAAATAATAGCATTTGAAAACTTAGAACTGATAACAGAA
GATCCCTTAGAAGTATGGGATAAATATCTAAGAGTAATAAAATCTGAAATAGGGAAAAGTGCTCCCATTATAGTAAGTAT
AATGGGAGGTCCAGATTACTCTGAATGGATTAGGTTAGCAAGATGGGCAGAAGATAGGGGTGCTGATATGCTAGAGTTAA
ACTTTGGTTGTCCTCATGGAGAACCAGAAAAAAGAACTGGGGCATTCATAGGACAGCATGCGGATCTTGTACAAGAATAT
ACTAAAGAAGTAGTATCATCCGTAGGAATACCGGTAATAGCTAAATTAACTCCAAATATTACAGATATTAGAGAGACAGC
AAAAGCAGCTGAGAATGCGGGGGCTAAGGCAGTAACTGCAATTAATACCGTTAATGGTGTAATAGCGGTTGACATAGAGA
GAGCTCAACCACTACCAGATATTAATGGTTATTCTGGATATGGCGGAATCTCAGGCCCAGCAGTTAAACCAATAGGTTTA
GCTGCGGTATCAAAGATTTATACATCAACTTCTTTACAGATAAGTGGAGTAGGAGGAATATTTGATTGGAGAGATGCTGT
TGAATATATAATGATGGGAGCTACTACAGTTCAGTCTGTTACTTATACTATTCTTAAAGGATTTGAATTCATAAATGAGT
GGAAAAAAGAACTGGAATCCTTTATGGAGAGAAAAGGTTATAGAGCTATCGAAGATATGAGAGGGTTGGCTGCGAAGAAG
ATGACAACGTACGAAGTATTGGAGAAAGTAACAAAAAGGAGAACTAGTGTTGATGAAGAAATTAATACAGTAAGAGATGA
AACACATGGTTAA

Upstream 100 bases:

>100_bases
ATTTTTTTAAGCAAAAAAGGGAATAAAATTGTTGAATTGGAAACTATTTAAGCTAAATAATAGATAAATATTTATTTTGT
CCAATTAAATTATTTATATA

Downstream 100 bases:

>100_bases
AATTGCAATGATACAAATGGGAAGTGTAGAATCTAAGGAAGCAAATATACAGAAAGCTCTAGAGTATACAAAGGCCGCAG
TTAAAGATGGAGCAGAACTA

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MIDLSVTFQGITFPNPFLVGSGPTTGNPPKIISAIRAGWGGVVVKTIGDSIVRKSVRPMYATIRRNREIIAFENLELITE
DPLEVWDKYLRVIKSEIGKSAPIIVSIMGGPDYSEWIRLARWAEDRGADMLELNFGCPHGEPEKRTGAFIGQHADLVQEY
TKEVVSSVGIPVIAKLTPNITDIRETAKAAENAGAKAVTAINTVNGVIAVDIERAQPLPDINGYSGYGGISGPAVKPIGL
AAVSKIYTSTSLQISGVGGIFDWRDAVEYIMMGATTVQSVTYTILKGFEFINEWKKELESFMERKGYRAIEDMRGLAAKK
MTTYEVLEKVTKRRTSVDEEINTVRDETHG

Sequences:

>Translated_350_residues
MIDLSVTFQGITFPNPFLVGSGPTTGNPPKIISAIRAGWGGVVVKTIGDSIVRKSVRPMYATIRRNREIIAFENLELITE
DPLEVWDKYLRVIKSEIGKSAPIIVSIMGGPDYSEWIRLARWAEDRGADMLELNFGCPHGEPEKRTGAFIGQHADLVQEY
TKEVVSSVGIPVIAKLTPNITDIRETAKAAENAGAKAVTAINTVNGVIAVDIERAQPLPDINGYSGYGGISGPAVKPIGL
AAVSKIYTSTSLQISGVGGIFDWRDAVEYIMMGATTVQSVTYTILKGFEFINEWKKELESFMERKGYRAIEDMRGLAAKK
MTTYEVLEKVTKRRTSVDEEINTVRDETHG
>Mature_350_residues
MIDLSVTFQGITFPNPFLVGSGPTTGNPPKIISAIRAGWGGVVVKTIGDSIVRKSVRPMYATIRRNREIIAFENLELITE
DPLEVWDKYLRVIKSEIGKSAPIIVSIMGGPDYSEWIRLARWAEDRGADMLELNFGCPHGEPEKRTGAFIGQHADLVQEY
TKEVVSSVGIPVIAKLTPNITDIRETAKAAENAGAKAVTAINTVNGVIAVDIERAQPLPDINGYSGYGGISGPAVKPIGL
AAVSKIYTSTSLQISGVGGIFDWRDAVEYIMMGATTVQSVTYTILKGFEFINEWKKELESFMERKGYRAIEDMRGLAAKK
MTTYEVLEKVTKRRTSVDEEINTVRDETHG

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=329, Percent_Identity=33.434650455927, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI87082059, Length=349, Percent_Identity=36.1031518624642, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71984108, Length=327, Percent_Identity=34.2507645259939, Blast_Score=180, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6322633, Length=321, Percent_Identity=26.1682242990654, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24640763, Length=312, Percent_Identity=35.5769230769231, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI18858217, Length=312, Percent_Identity=35.5769230769231, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 38387; Mature: 38387

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLSVTFQGITFPNPFLVGSGPTTGNPPKIISAIRAGWGGVVVKTIGDSIVRKSVRPMY
CEEEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
ATIRRNREIIAFENLELITEDPLEVWDKYLRVIKSEIGKSAPIIVSIMGGPDYSEWIRLA
HHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
RWAEDRGADMLELNFGCPHGEPEKRTGAFIGQHADLVQEYTKEVVSSVGIPVIAKLTPNI
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCH
TDIRETAKAAENAGAKAVTAINTVNGVIAVDIERAQPLPDINGYSGYGGISGPAVKPIGL
HHHHHHHHHHHCCCCHHEEEHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
AAVSKIYTSTSLQISGVGGIFDWRDAVEYIMMGATTVQSVTYTILKGFEFINEWKKELES
HHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMERKGYRAIEDMRGLAAKKMTTYEVLEKVTKRRTSVDEEINTVRDETHG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIDLSVTFQGITFPNPFLVGSGPTTGNPPKIISAIRAGWGGVVVKTIGDSIVRKSVRPMY
CEEEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
ATIRRNREIIAFENLELITEDPLEVWDKYLRVIKSEIGKSAPIIVSIMGGPDYSEWIRLA
HHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
RWAEDRGADMLELNFGCPHGEPEKRTGAFIGQHADLVQEYTKEVVSSVGIPVIAKLTPNI
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCH
TDIRETAKAAENAGAKAVTAINTVNGVIAVDIERAQPLPDINGYSGYGGISGPAVKPIGL
HHHHHHHHHHHCCCCHHEEEHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
AAVSKIYTSTSLQISGVGGIFDWRDAVEYIMMGATTVQSVTYTILKGFEFINEWKKELES
HHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMERKGYRAIEDMRGLAAKKMTTYEVLEKVTKRRTSVDEEINTVRDETHG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]