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The map label for this gene is dht [H]

Identifier: 159185188

GI number: 159185188

Start: 2356551

End: 2358008

Strand: Direct

Name: dht [H]

Synonym: Atu2386

Alternate gene names: 159185188

Gene position: 2356551-2358008 (Clockwise)

Preceding gene: 159185187

Following gene: 159185189

Centisome position: 82.93

GC content: 61.18

Gene sequence:

>1458_bases
ATGATCGCCACCATCATCAAAAACGGCACCATCGTCACCGCCGACCTCACCTACAAGGCAGACATCAGGATCGAAGGCGG
CAGGATCACTGAGATCGGCCCTGATCTGACCGGCGGCACGATCCTCGATGCCACGGAATGTTACATCATGCCGGGCGGCA
TCGATCCGCATGTGCATCTGGAAATGCCCTTCATGGGCACCTATTCCGCCGACGATTTCGAGAGCGGCACGCGCGCCGCC
CTTGCCGGCGGCACCACCATGGTGGTGGATTTCTGCCTGCCCGATCCCGGCCAGTCGCTTCTCGATGCCCTGCAGAGATG
GGACAACAAGGCGACGCGCGCCAATTGCGATTATTCCTTCCACATGGCGGTTACCTGGTGGGGCGAGCGGGTCTTCAACG
AGATGAAGACGGTGGTTCAGGAAAAAGGCATCAACTCGTTCAAGCACTTCATGGCCTATAAGGGCGCGCTGATGGTAAAT
GACGACGAGATGTTCGCCTCCTTCTCGCGCTGTGCGGAACTCGGCGCCATTCCCTTCGTGCATGCGGAAAACGGCGATAT
CGTCGCGCAGATGCAGGAAAAACTGATGGCCGAGGGCAATGTCGGCCCGGAGGCGCATGCCTATTCCCGGCCTCCCTCCG
TGGAAGGCGAAGCGACCAACCGCGCCATCATCATTGCCGACATGGCCGGCGCCCCGCTTTATGTCGTCCACACATCCTGC
GAGCAGGCGCATGAAGCCATCCGCCGCGCGCGCCAGAATGGCATGCGCGTTTATGGCGAACCGCTGATCCAGCACCTGAT
CCTCGATGAAAGTGAATATGCCAATGCCGATTGGGATCATGCCGCCCGGCGGGTCATGTCGCCACCCTTCCGCAACCGGC
AACACCAGGACAGCCTCTGGGCGGGTCTTGCCTCCGGCTCGCTGCAATGCGTGGCGACCGACCATTGCGCCTTCACCACC
GAGCAGAAACGCTTCGGCCTTGGTGATTTCCGCAAGATACCGAACGGCACCGGCGGGCTGGAAGATCGCATGCCGCTGCT
CTGGACCCATGGCGTCGCGACCGGCCGGCTGACGATGAATGAATTTGTCGCCGTCACCTCCACCAATATTGCGAAGATCC
TCAACATCTATCCGAGAAAGGGCGCGATCCTCGTCGGCAGCGATGCCGATATCGTCGTCTGGGACCCGGCGCTGGAAAAG
ACCATCAGCGCCGCAAGCCAGCAATCGGCCATCGATTACAACGTGTTCGAAGGGCAGAAGGTGAAGGGCCTGCCTCGCTA
CACCCTGTCGCGCGGCCTCGTCAGTGTCGAGGAAGGCACCATCGAAACACAGGAAGGCCATGGCCAATTCGTGGCCCGCG
ATCCCTATCCCGCCGTCAGCCGGGCGCTTTCCACCTGGAAGGAACTCGTTTCGCCGCGCAAGGTGGAACGCACAGGCATT
CCGGCATCGGGCGTGTGA

Upstream 100 bases:

>100_bases
GGCTTTCCCATAACGAGGCGGAAGAAATTTCGCCGGAATGGGCCGCCGCCGGCTGCGACGTGCTGCTGCATGCGGTGCTG
GAGACTGCGGAGATCGTGCA

Downstream 100 bases:

>100_bases
CCATGAGCAGCGAGCCGAAACGCGAAATCCTCATCGCCGCCGCCATTCTCCTCAACGAACGACGGCAGATGCTTGTGGTG
CGCAAGCGCGGCACCACGCA

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MIATIIKNGTIVTADLTYKADIRIEGGRITEIGPDLTGGTILDATECYIMPGGIDPHVHLEMPFMGTYSADDFESGTRAA
LAGGTTMVVDFCLPDPGQSLLDALQRWDNKATRANCDYSFHMAVTWWGERVFNEMKTVVQEKGINSFKHFMAYKGALMVN
DDEMFASFSRCAELGAIPFVHAENGDIVAQMQEKLMAEGNVGPEAHAYSRPPSVEGEATNRAIIIADMAGAPLYVVHTSC
EQAHEAIRRARQNGMRVYGEPLIQHLILDESEYANADWDHAARRVMSPPFRNRQHQDSLWAGLASGSLQCVATDHCAFTT
EQKRFGLGDFRKIPNGTGGLEDRMPLLWTHGVATGRLTMNEFVAVTSTNIAKILNIYPRKGAILVGSDADIVVWDPALEK
TISAASQQSAIDYNVFEGQKVKGLPRYTLSRGLVSVEEGTIETQEGHGQFVARDPYPAVSRALSTWKELVSPRKVERTGI
PASGV

Sequences:

>Translated_485_residues
MIATIIKNGTIVTADLTYKADIRIEGGRITEIGPDLTGGTILDATECYIMPGGIDPHVHLEMPFMGTYSADDFESGTRAA
LAGGTTMVVDFCLPDPGQSLLDALQRWDNKATRANCDYSFHMAVTWWGERVFNEMKTVVQEKGINSFKHFMAYKGALMVN
DDEMFASFSRCAELGAIPFVHAENGDIVAQMQEKLMAEGNVGPEAHAYSRPPSVEGEATNRAIIIADMAGAPLYVVHTSC
EQAHEAIRRARQNGMRVYGEPLIQHLILDESEYANADWDHAARRVMSPPFRNRQHQDSLWAGLASGSLQCVATDHCAFTT
EQKRFGLGDFRKIPNGTGGLEDRMPLLWTHGVATGRLTMNEFVAVTSTNIAKILNIYPRKGAILVGSDADIVVWDPALEK
TISAASQQSAIDYNVFEGQKVKGLPRYTLSRGLVSVEEGTIETQEGHGQFVARDPYPAVSRALSTWKELVSPRKVERTGI
PASGV
>Mature_485_residues
MIATIIKNGTIVTADLTYKADIRIEGGRITEIGPDLTGGTILDATECYIMPGGIDPHVHLEMPFMGTYSADDFESGTRAA
LAGGTTMVVDFCLPDPGQSLLDALQRWDNKATRANCDYSFHMAVTWWGERVFNEMKTVVQEKGINSFKHFMAYKGALMVN
DDEMFASFSRCAELGAIPFVHAENGDIVAQMQEKLMAEGNVGPEAHAYSRPPSVEGEATNRAIIIADMAGAPLYVVHTSC
EQAHEAIRRARQNGMRVYGEPLIQHLILDESEYANADWDHAARRVMSPPFRNRQHQDSLWAGLASGSLQCVATDHCAFTT
EQKRFGLGDFRKIPNGTGGLEDRMPLLWTHGVATGRLTMNEFVAVTSTNIAKILNIYPRKGAILVGSDADIVVWDPALEK
TISAASQQSAIDYNVFEGQKVKGLPRYTLSRGLVSVEEGTIETQEGHGQFVARDPYPAVSRALSTWKELVSPRKVERTGI
PASGV

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=483, Percent_Identity=47.4120082815735, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI4503377, Length=479, Percent_Identity=43.4237995824635, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI190194363, Length=458, Percent_Identity=45.4148471615721, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI4503379, Length=457, Percent_Identity=43.7636761487965, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI4503051, Length=458, Percent_Identity=43.6681222707424, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI62422571, Length=458, Percent_Identity=43.6681222707424, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI19923821, Length=483, Percent_Identity=42.4430641821946, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI18105007, Length=442, Percent_Identity=26.6968325791855, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI87082175, Length=460, Percent_Identity=38.695652173913, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1786722, Length=461, Percent_Identity=27.3318872017354, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17539558, Length=483, Percent_Identity=46.9979296066253, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71989490, Length=484, Percent_Identity=43.801652892562, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI86575075, Length=460, Percent_Identity=30.2173913043478, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI193204318, Length=429, Percent_Identity=24.7086247086247, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=454, Percent_Identity=26.6519823788546, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI221377917, Length=463, Percent_Identity=45.3563714902808, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI17137462, Length=461, Percent_Identity=44.6854663774403, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24644287, Length=294, Percent_Identity=44.2176870748299, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24644289, Length=258, Percent_Identity=44.5736434108527, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24642586, Length=447, Percent_Identity=26.8456375838926, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18859883, Length=415, Percent_Identity=23.6144578313253, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 53127; Mature: 53127

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIATIIKNGTIVTADLTYKADIRIEGGRITEIGPDLTGGTILDATECYIMPGGIDPHVHL
CEEEEEECCEEEEEEEEEEEEEEECCCEEEECCCCCCCCEEEECCEEEEECCCCCCEEEE
EMPFMGTYSADDFESGTRAALAGGTTMVVDFCLPDPGQSLLDALQRWDNKATRANCDYSF
EECCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEE
HMAVTWWGERVFNEMKTVVQEKGINSFKHFMAYKGALMVNDDEMFASFSRCAELGAIPFV
EEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCCCEE
HAENGDIVAQMQEKLMAEGNVGPEAHAYSRPPSVEGEATNRAIIIADMAGAPLYVVHTSC
ECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCH
EQAHEAIRRARQNGMRVYGEPLIQHLILDESEYANADWDHAARRVMSPPFRNRQHQDSLW
HHHHHHHHHHHHCCCEEEHHHHHHHHHCCCHHCCCCCHHHHHHHHCCCCCCCCCCHHHHH
AGLASGSLQCVATDHCAFTTEQKRFGLGDFRKIPNGTGGLEDRMPLLWTHGVATGRLTMN
HHHCCCCEEEEEECCEEECCCHHHCCCCHHHHCCCCCCCCCCCCCEEEECCCEECEEEHH
EFVAVTSTNIAKILNIYPRKGAILVGSDADIVVWDPALEKTISAASQQSAIDYNVFEGQK
HEEEEECCCHHHHHHCCCCCCEEEEECCCCEEEECHHHHHHHHHHHHHCCCEEEECCCCC
VKGLPRYTLSRGLVSVEEGTIETQEGHGQFVARDPYPAVSRALSTWKELVSPRKVERTGI
CCCCCHHHHHCCCEEECCCCEEECCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHCCC
PASGV
CCCCC
>Mature Secondary Structure
MIATIIKNGTIVTADLTYKADIRIEGGRITEIGPDLTGGTILDATECYIMPGGIDPHVHL
CEEEEEECCEEEEEEEEEEEEEEECCCEEEECCCCCCCCEEEECCEEEEECCCCCCEEEE
EMPFMGTYSADDFESGTRAALAGGTTMVVDFCLPDPGQSLLDALQRWDNKATRANCDYSF
EECCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEE
HMAVTWWGERVFNEMKTVVQEKGINSFKHFMAYKGALMVNDDEMFASFSRCAELGAIPFV
EEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCCCEE
HAENGDIVAQMQEKLMAEGNVGPEAHAYSRPPSVEGEATNRAIIIADMAGAPLYVVHTSC
ECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCH
EQAHEAIRRARQNGMRVYGEPLIQHLILDESEYANADWDHAARRVMSPPFRNRQHQDSLW
HHHHHHHHHHHHCCCEEEHHHHHHHHHCCCHHCCCCCHHHHHHHHCCCCCCCCCCHHHHH
AGLASGSLQCVATDHCAFTTEQKRFGLGDFRKIPNGTGGLEDRMPLLWTHGVATGRLTMN
HHHCCCCEEEEEECCEEECCCHHHCCCCHHHHCCCCCCCCCCCCCEEEECCCEECEEEHH
EFVAVTSTNIAKILNIYPRKGAILVGSDADIVVWDPALEKTISAASQQSAIDYNVFEGQK
HEEEEECCCHHHHHHCCCCCCEEEEECCCCEEEECHHHHHHHHHHHHHCCCEEEECCCCC
VKGLPRYTLSRGLVSVEEGTIETQEGHGQFVARDPYPAVSRALSTWKELVSPRKVERTGI
CCCCCHHHHHCCCEEECCCCEEECCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHCCC
PASGV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]