Click here to switch to the map view.

The map label for this gene is mutT [C]

Identifier: 159185189

GI number: 159185189

Start: 2358011

End: 2358448

Strand: Direct

Name: mutT [C]

Synonym: Atu2387

Alternate gene names: 159185189

Gene position: 2358011-2358448 (Clockwise)

Preceding gene: 159185188

Following gene: 15889659

Centisome position: 82.98

GC content: 63.24

Gene sequence:

>438_bases
ATGAGCAGCGAGCCGAAACGCGAAATCCTCATCGCCGCCGCCATTCTCCTCAACGAACGACGGCAGATGCTTGTGGTGCG
CAAGCGCGGCACCACGCAGTTCATGCAGCCGGGCGGCAAGATCGATCCGGGCGAAACGCCGGAGCAGGCGCTGCACCGCG
AACTGGCCGAGGAAATCGGCCTGACGCTGCCGAAAAATGCCGTTCGTTATGAGGGCATCTTTCGCGAGGAAGCCGCCAAT
GAGCCCGGCGCCGATGTCGTCGCCCATGCCTTCAGCGCCAGACTTCATTCCGAGGTCGTGCCGCAGGCGGAAATCGAGGA
AGTGCGCTGGCTCGACCTCGACCACCACCCCGGCGTGATGATTGCCAGACTGACGGAAACCCAGATGCTGCCGCTGGCGC
GCGCGGCACTTACGGAAAGCGACAATCAGCCAAGATGA

Upstream 100 bases:

>100_bases
ATCCCTATCCCGCCGTCAGCCGGGCGCTTTCCACCTGGAAGGAACTCGTTTCGCCGCGCAAGGTGGAACGCACAGGCATT
CCGGCATCGGGCGTGTGACC

Downstream 100 bases:

>100_bases
ACCAGGCCTCTCCCTATTCCGTCGTTTCCGCCAGAAAACTGGGCCTCACCTTCGAAACGGGGGATGGCCCGGTCCACGCC
TTGTCGGATGTCGATCTCGA

Product: MutT family NTP pyrophosphatase

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: MutT/Nudix Family Protein; NTP Pyrophosphohydrolase Including Oxidative Damage Repair; MutT/NUDIX Family Protein; Phosphohydrolase; NTP Pyrophosphohydrolase; MutT Family NTP Pyrophosphatase; NUDIX Family Protein; Phosphatase; NUDIX Family Hydrolase; ADP-Ribose Pyrophosphatase; MutT/Nudix Family Hydrolase; Uridine Kinase; MutT/Nudix Family Phosphohydrolase; Hydrolase Nudix Family; Nudix Superfamily Hydrolase; NUDIX Protein; Hydrolase Nudix Family Protein; Hydrolase NUDIX Family; MutT Family Protein

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MSSEPKREILIAAAILLNERRQMLVVRKRGTTQFMQPGGKIDPGETPEQALHRELAEEIGLTLPKNAVRYEGIFREEAAN
EPGADVVAHAFSARLHSEVVPQAEIEEVRWLDLDHHPGVMIARLTETQMLPLARAALTESDNQPR

Sequences:

>Translated_145_residues
MSSEPKREILIAAAILLNERRQMLVVRKRGTTQFMQPGGKIDPGETPEQALHRELAEEIGLTLPKNAVRYEGIFREEAAN
EPGADVVAHAFSARLHSEVVPQAEIEEVRWLDLDHHPGVMIARLTETQMLPLARAALTESDNQPR
>Mature_144_residues
SSEPKREILIAAAILLNERRQMLVVRKRGTTQFMQPGGKIDPGETPEQALHRELAEEIGLTLPKNAVRYEGIFREEAANE
PGADVVAHAFSARLHSEVVPQAEIEEVRWLDLDHHPGVMIARLTETQMLPLARAALTESDNQPR

Specific function: Involved In The Go System Responsible For Removing An Oxidatively Damaged Form Of Guanine (7,8-Dihydro-8-Oxoguanine) From DNA And The Nucleotide Pool. 8-Oxo-Dgtp Is Inserted Opposite Da And Dc Residues Of Template DNA With Almost Equal Efficiency Thus Le

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.6.1.- [C]

Molecular weight: Translated: 16221; Mature: 16090

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEPKREILIAAAILLNERRQMLVVRKRGTTQFMQPGGKIDPGETPEQALHRELAEEIG
CCCCCHHHHHHHHHHHHHCCHHEEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHC
LTLPKNAVRYEGIFREEAANEPGADVVAHAFSARLHSEVVPQAEIEEVRWLDLDHHPGVM
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCEE
IARLTETQMLPLARAALTESDNQPR
EEECCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSEPKREILIAAAILLNERRQMLVVRKRGTTQFMQPGGKIDPGETPEQALHRELAEEIG
CCCCHHHHHHHHHHHHHCCHHEEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHC
LTLPKNAVRYEGIFREEAANEPGADVVAHAFSARLHSEVVPQAEIEEVRWLDLDHHPGVM
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCEE
IARLTETQMLPLARAALTESDNQPR
EEECCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA