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The map label for this gene is clpP

Identifier: 159185132

GI number: 159185132

Start: 2243071

End: 2243652

Strand: Reverse

Name: clpP

Synonym: Atu2270

Alternate gene names: 159185132

Gene position: 2243652-2243071 (Counterclockwise)

Preceding gene: 159185135

Following gene: 159185131

Centisome position: 78.96

GC content: 56.87

Gene sequence:

>582_bases
ATGAACGAAGACGAAGACGACAAGAGCAAGGAACTGCCGATCGGCAAGGAAACGGAAGCGAATCTTTTCAAGTCGCGTTC
GATCTTCATCTATGGTGGCATCACGCAGGAACTGGCGCAGAAGGTCTGCACGCAGCTCGTGGCCCTTGCCGCCGCCAGCG
ACGACGACATTCGCGTTTACGTCAATTCGCCGGGCGGTCACGTGGAATCGGGTGATTCCATCCATGACATGATCAAGTTC
ATCAAGCCGAAGGTCTATATCATCGGCACGGGCTGGGTCGCTTCCGCCGGCGCGCTGATCTATGTTTCGGTGCCGAAGGA
ACGTCGCCTTTGCCTGCCAAATACCCGCTTCCTGCTGCACCAACCCTCCGGCGGTACGCGCGGCATGGCATCCGACATCG
AAATCCAGGCCCGCGAAATCATCAAGATGAACCAGCGCCTGATCAAGATCTTCTCCAAGGCCACCGGCCAGACCGAAGAA
AAGATCGCCAAGGATATCGATCGCGATTACTGGCTGAGCGCTGATGACGCCAAGGATTATGGCCTCGTCGGCAAGATCGT
CGAAAGCCAGTCGGAACTCTGA

Upstream 100 bases:

>100_bases
TATTGTTGGCGGGCAAACCTTGCCTTTTTCTCTCATTGCCTTACGTAACAAGTCGCACTATGTCCGAAGGGCATGCATGA
ATTACGCTGGAGAGCCGTTG

Downstream 100 bases:

>100_bases
GTTTCCGATTTTCAGTTGAGAAAGCCCGCATCGGTGAGAACCGGCGCGGGCTTTTTGCGTTCAGGCCGGCGGGTGTGTTT
CGCCGCTGGTCAGCCGGGCT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 3

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MNEDEDDKSKELPIGKETEANLFKSRSIFIYGGITQELAQKVCTQLVALAAASDDDIRVYVNSPGGHVESGDSIHDMIKF
IKPKVYIIGTGWVASAGALIYVSVPKERRLCLPNTRFLLHQPSGGTRGMASDIEIQAREIIKMNQRLIKIFSKATGQTEE
KIAKDIDRDYWLSADDAKDYGLVGKIVESQSEL

Sequences:

>Translated_193_residues
MNEDEDDKSKELPIGKETEANLFKSRSIFIYGGITQELAQKVCTQLVALAAASDDDIRVYVNSPGGHVESGDSIHDMIKF
IKPKVYIIGTGWVASAGALIYVSVPKERRLCLPNTRFLLHQPSGGTRGMASDIEIQAREIIKMNQRLIKIFSKATGQTEE
KIAKDIDRDYWLSADDAKDYGLVGKIVESQSEL
>Mature_193_residues
MNEDEDDKSKELPIGKETEANLFKSRSIFIYGGITQELAQKVCTQLVALAAASDDDIRVYVNSPGGHVESGDSIHDMIKF
IKPKVYIIGTGWVASAGALIYVSVPKERRLCLPNTRFLLHQPSGGTRGMASDIEIQAREIIKMNQRLIKIFSKATGQTEE
KIAKDIDRDYWLSADDAKDYGLVGKIVESQSEL

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=169, Percent_Identity=36.094674556213, Blast_Score=120, Evalue=8e-28,
Organism=Escherichia coli, GI1786641, Length=173, Percent_Identity=42.7745664739884, Blast_Score=152, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17538017, Length=168, Percent_Identity=36.9047619047619, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129427, Length=174, Percent_Identity=35.0574712643678, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP3_AGRT5 (Q8UD57)

Other databases:

- EMBL:   AE007869
- PIR:   AE2855
- PIR:   B97632
- RefSeq:   NP_355226.2
- ProteinModelPortal:   Q8UD57
- SMR:   Q8UD57
- STRING:   Q8UD57
- GeneID:   1134308
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2270
- NMPDR:   fig|176299.3.peg.2202
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   IHDMIKF
- ProtClustDB:   PRK12553
- BioCyc:   ATUM176299-1:ATU2270-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21392; Mature: 21392

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 103-103 ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEDEDDKSKELPIGKETEANLFKSRSIFIYGGITQELAQKVCTQLVALAAASDDDIRVY
CCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEE
VNSPGGHVESGDSIHDMIKFIKPKVYIIGTGWVASAGALIYVSVPKERRLCLPNTRFLLH
EECCCCCCCCCCCHHHHHHHHCCEEEEEECCHHHCCCEEEEEECCCCCCEECCCCEEEEE
QPSGGTRGMASDIEIQAREIIKMNQRLIKIFSKATGQTEEKIAKDIDRDYWLSADDAKDY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHEECCCCCCCC
GLVGKIVESQSEL
HHHHHHHHHCCCC
>Mature Secondary Structure
MNEDEDDKSKELPIGKETEANLFKSRSIFIYGGITQELAQKVCTQLVALAAASDDDIRVY
CCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEE
VNSPGGHVESGDSIHDMIKFIKPKVYIIGTGWVASAGALIYVSVPKERRLCLPNTRFLLH
EECCCCCCCCCCCHHHHHHHHCCEEEEEECCHHHCCCEEEEEECCCCCCEECCCCEEEEE
QPSGGTRGMASDIEIQAREIIKMNQRLIKIFSKATGQTEEKIAKDIDRDYWLSADDAKDY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHEECCCCCCCC
GLVGKIVESQSEL
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194