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The map label for this gene is adhc1 [H]

Identifier: 159184812

GI number: 159184812

Start: 1544440

End: 1545507

Strand: Direct

Name: adhc1 [H]

Synonym: Atu1557

Alternate gene names: 159184812

Gene position: 1544440-1545507 (Clockwise)

Preceding gene: 159184811

Following gene: 159184813

Centisome position: 54.35

GC content: 61.52

Gene sequence:

>1068_bases
ATGTTCACAACGTCCGCCTATGCCTGCGATGACGGCTCTTCGCCGATGAAGCTCGCGACCATCAGGCGCCGCGATCCCGG
TCCGCGCGATGTCGAAATCGAGATAGAATTCTGTGGCGTCTGCCACTCGGACATCCATACGGCCCGCAGCGAATGGCCGG
GCTCCCTCTACCCTTGCGTCCCCGGCCACGAAATCGTCGGCCGTGTCGGTCGGGTGGGCGCGCAAGTCACCCGGTTCAAG
ACGGGTGACCGCGTCGGTGTCGGCTGTATCGTCGATAGCTGCCGCGAATGCGCAAGCTGCGCCGAAGGGCTGGAGCAATA
TTGCGAAAACGGCATGACCGGCACCTATAACTCCCCTGACAAGGCGATGGGCGGCGGCGCGCATACGCTTGGCGGCTATT
CCGCCCATGTGGTGGTGGATGACCGCTATGTGCTCAATATTCCCGAAGGGCTCGATCCGGCGGCAGCAGCACCGCTACTC
TGCGCTGGTATCACCACCTACTCGCCGCTGCGCCACTGGAATGCCGGCCCCGGCAAACGCGTCGGCGTCGTCGGTCTGGG
CGGCCTCGGCCATATGGCCGTCAAGCTCGCCAATGCCATGGGTGCGACTGTCGTGATGATCACCACCTCGCCCGGCAAGG
CGGAGGATGCCAAAAAACTCGGCGCACACGAGGTGATCATCTCCCGCGATGCGGAGCAGATGAAGAAGGCTACCTCGAGC
CTCGATCTCATCATCGATGCTGTCGCCGCCGACCACGACATCGACGCCTATCTGGCGCTGCTGAAACGCGATGGCGCGCT
GGTGCAGGTGGGCGCGCCGGAAAAGCCACTTTCGGTGATGGCCTTCAGCCTCATCCCCGGCCGCAAGACCTTTGCCGGCT
CGATGATCGGCGGTATTCCCGAGACTCAGGAAATGCTGGATTTCTGCGCCGAAAAAGGCATCGCCGGCGAAATCGAGATG
ATCGATATCGATCAGATCAATGACGCTTATGAACGCATGATAAAAAGCGATGTGCGTTATCGTTTCGTCATTGATATGAA
GAGCCTGCCGCGCCAGAAGGCCGCCTGA

Upstream 100 bases:

>100_bases
CCCGGCAGTGCCCGAAACCGGCGCAGGCGGCTGATCCCACCGCAACCGTTGTCGCAGGCCGGTGTTTGATGCATCGATCA
CCATAAGAGGAGGAACGACC

Downstream 100 bases:

>100_bases
CCTTTGGAAGGGGGCGGCCTTGCGGACGTCCCCTCCCGTTAGACCTTCTGGTCGAAAGCGTAGCCTGACCCATGACAAGC
CAGACCGGTTTCAACGACAT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MFTTSAYACDDGSSPMKLATIRRRDPGPRDVEIEIEFCGVCHSDIHTARSEWPGSLYPCVPGHEIVGRVGRVGAQVTRFK
TGDRVGVGCIVDSCRECASCAEGLEQYCENGMTGTYNSPDKAMGGGAHTLGGYSAHVVVDDRYVLNIPEGLDPAAAAPLL
CAGITTYSPLRHWNAGPGKRVGVVGLGGLGHMAVKLANAMGATVVMITTSPGKAEDAKKLGAHEVIISRDAEQMKKATSS
LDLIIDAVAADHDIDAYLALLKRDGALVQVGAPEKPLSVMAFSLIPGRKTFAGSMIGGIPETQEMLDFCAEKGIAGEIEM
IDIDQINDAYERMIKSDVRYRFVIDMKSLPRQKAA

Sequences:

>Translated_355_residues
MFTTSAYACDDGSSPMKLATIRRRDPGPRDVEIEIEFCGVCHSDIHTARSEWPGSLYPCVPGHEIVGRVGRVGAQVTRFK
TGDRVGVGCIVDSCRECASCAEGLEQYCENGMTGTYNSPDKAMGGGAHTLGGYSAHVVVDDRYVLNIPEGLDPAAAAPLL
CAGITTYSPLRHWNAGPGKRVGVVGLGGLGHMAVKLANAMGATVVMITTSPGKAEDAKKLGAHEVIISRDAEQMKKATSS
LDLIIDAVAADHDIDAYLALLKRDGALVQVGAPEKPLSVMAFSLIPGRKTFAGSMIGGIPETQEMLDFCAEKGIAGEIEM
IDIDQINDAYERMIKSDVRYRFVIDMKSLPRQKAA
>Mature_355_residues
MFTTSAYACDDGSSPMKLATIRRRDPGPRDVEIEIEFCGVCHSDIHTARSEWPGSLYPCVPGHEIVGRVGRVGAQVTRFK
TGDRVGVGCIVDSCRECASCAEGLEQYCENGMTGTYNSPDKAMGGGAHTLGGYSAHVVVDDRYVLNIPEGLDPAAAAPLL
CAGITTYSPLRHWNAGPGKRVGVVGLGGLGHMAVKLANAMGATVVMITTSPGKAEDAKKLGAHEVIISRDAEQMKKATSS
LDLIIDAVAADHDIDAYLALLKRDGALVQVGAPEKPLSVMAFSLIPGRKTFAGSMIGGIPETQEMLDFCAEKGIAGEIEM
IDIDQINDAYERMIKSDVRYRFVIDMKSLPRQKAA

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=350, Percent_Identity=26.5714285714286, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4501933, Length=363, Percent_Identity=25.8953168044077, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI71565152, Length=315, Percent_Identity=26.3492063492064, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4501929, Length=350, Percent_Identity=26, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI71743840, Length=346, Percent_Identity=26.3005780346821, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI262073058, Length=345, Percent_Identity=26.3768115942029, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4501939, Length=346, Percent_Identity=23.9884393063584, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI156523966, Length=346, Percent_Identity=23.9884393063584, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI71565154, Length=355, Percent_Identity=25.0704225352113, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=340, Percent_Identity=62.3529411764706, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI87082401, Length=349, Percent_Identity=35.8166189111748, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI87081918, Length=319, Percent_Identity=28.5266457680251, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI226510992, Length=278, Percent_Identity=32.0143884892086, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788075, Length=284, Percent_Identity=26.4084507042254, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=27.3712737127371, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787863, Length=276, Percent_Identity=26.8115942028986, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790045, Length=283, Percent_Identity=27.208480565371, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788073, Length=223, Percent_Identity=26.457399103139, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87082125, Length=219, Percent_Identity=27.3972602739726, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=351, Percent_Identity=26.7806267806268, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562584, Length=354, Percent_Identity=27.9661016949153, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17562582, Length=358, Percent_Identity=25.9776536312849, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=357, Percent_Identity=27.1708683473389, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=359, Percent_Identity=27.0194986072423, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=362, Percent_Identity=27.3480662983425, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=208, Percent_Identity=30.2884615384615, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=347, Percent_Identity=26.8011527377522, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=341, Percent_Identity=37.5366568914956, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6323980, Length=346, Percent_Identity=38.728323699422, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6323961, Length=329, Percent_Identity=31.9148936170213, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324486, Length=329, Percent_Identity=30.6990881458967, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323729, Length=332, Percent_Identity=30.421686746988, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319621, Length=344, Percent_Identity=28.7790697674419, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320033, Length=365, Percent_Identity=28.4931506849315, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=266, Percent_Identity=29.6992481203008, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=266, Percent_Identity=29.6992481203008, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=332, Percent_Identity=23.7951807228916, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=379, Percent_Identity=26.1213720316623, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17737897, Length=206, Percent_Identity=28.6407766990291, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37803; Mature: 37803

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTTSAYACDDGSSPMKLATIRRRDPGPRDVEIEIEFCGVCHSDIHTARSEWPGSLYPCV
CCCCCCEECCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCC
PGHEIVGRVGRVGAQVTRFKTGDRVGVGCIVDSCRECASCAEGLEQYCENGMTGTYNSPD
CCHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KAMGGGAHTLGGYSAHVVVDDRYVLNIPEGLDPAAAAPLLCAGITTYSPLRHWNAGPGKR
HHCCCCCCCCCCEEEEEEEECEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHCCCCCCCE
VGVVGLGGLGHMAVKLANAMGATVVMITTSPGKAEDAKKLGAHEVIISRDAEQMKKATSS
EEEEEECCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCEEEECCHHHHHHHHHH
LDLIIDAVAADHDIDAYLALLKRDGALVQVGAPEKPLSVMAFSLIPGRKTFAGSMIGGIP
HHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCCHHHEEEEECCCCHHHCCHHHCCCC
ETQEMLDFCAEKGIAGEIEMIDIDQINDAYERMIKSDVRYRFVIDMKSLPRQKAA
CHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCC
>Mature Secondary Structure
MFTTSAYACDDGSSPMKLATIRRRDPGPRDVEIEIEFCGVCHSDIHTARSEWPGSLYPCV
CCCCCCEECCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCC
PGHEIVGRVGRVGAQVTRFKTGDRVGVGCIVDSCRECASCAEGLEQYCENGMTGTYNSPD
CCHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KAMGGGAHTLGGYSAHVVVDDRYVLNIPEGLDPAAAAPLLCAGITTYSPLRHWNAGPGKR
HHCCCCCCCCCCEEEEEEEECEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHCCCCCCCE
VGVVGLGGLGHMAVKLANAMGATVVMITTSPGKAEDAKKLGAHEVIISRDAEQMKKATSS
EEEEEECCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCEEEECCHHHHHHHHHH
LDLIIDAVAADHDIDAYLALLKRDGALVQVGAPEKPLSVMAFSLIPGRKTFAGSMIGGIP
HHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCCHHHEEEEECCCCHHHCCHHHCCCC
ETQEMLDFCAEKGIAGEIEMIDIDQINDAYERMIKSDVRYRFVIDMKSLPRQKAA
CHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]