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The map label for this gene is pyrH

Identifier: 159184738

GI number: 159184738

Start: 1370156

End: 1370878

Strand: Direct

Name: pyrH

Synonym: Atu1376

Alternate gene names: 159184738

Gene position: 1370156-1370878 (Clockwise)

Preceding gene: 159184737

Following gene: 15888703

Centisome position: 48.22

GC content: 61.27

Gene sequence:

>723_bases
ATGTCTTCCAAGCCGATCTACAAACGTGTTCTTCTCAAGGCTTCCGGTGAAGCCCTCATGGGCGACCAGGGTTTCGGTAT
CGATGTGGCGGTGGCCGACCGTATCGCCTCCGATATTGCCGAGGCGAGGGCGATGGGCGTTGAAGTCGGCGTCGTCGTCG
GCGGTGGCAATATTTTCCGCGGCGTCGCCGTGGCGTCCAAGGGCGGCGACCGCGTCACCGGCGACCATATGGGCATGCTG
GCAACCGTCATCAACGCGCTAGCACTTGCAACCTCGCTGCGCAAGCTCAGCATCGACACGGTCGTTCTCTCGGCAATCGC
GATGCCGGAAATCTGTGAGAGCTTCTCGCAGCGCGCTGCCCTTCACCATCTGGCCCAGGGTCGCGTGGTGATTTTTGCCG
GCGGCACGGGCAACCCGTTCTTCACCACCGATTCTGCCGCAGCCTTGCGCGCCGCGGAAATGGGCGCCGAGGCGATCTTC
AAGGGTACCCAGGTGGATGGCATCTATTCCGCCGACCCGAAGAAGGATCCGACAGCCACCCGTTTCGACGAGCTGACCCA
TAGCGAAGTGCTCGGCAAGGGGCTGGCGGTGATGGATATCGCAGCTGTTGCTCTCGCTCGCGAAAACCACATCCCGATCA
TCGTTTTCTCGATCCACGAGAAGGGCGGTTTCGCGCAGATATTGACCGGCGGTGGTCGCAAGACCATCGTGCACGACAAA
TAA

Upstream 100 bases:

>100_bases
TGATTATATTTACCCAATCTTGGGAAAACGGGAGGGCATCGCGTGACAACGCGGTGCCCTTCGTGTATCCGCGTTTCGGT
TACATTTCCGAGGAGTCATG

Downstream 100 bases:

>100_bases
TCAAAAAACGACGTCGCCTCCGGGGCGGATTCCGGCCGCCTTGGCCGATAGAGATGGAGTATCAAGATGAGTGGTATTGA
CCTCAACGATATCAAGCGCC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSSKPIYKRVLLKASGEALMGDQGFGIDVAVADRIASDIAEARAMGVEVGVVVGGGNIFRGVAVASKGGDRVTGDHMGML
ATVINALALATSLRKLSIDTVVLSAIAMPEICESFSQRAALHHLAQGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIF
KGTQVDGIYSADPKKDPTATRFDELTHSEVLGKGLAVMDIAAVALARENHIPIIVFSIHEKGGFAQILTGGGRKTIVHDK

Sequences:

>Translated_240_residues
MSSKPIYKRVLLKASGEALMGDQGFGIDVAVADRIASDIAEARAMGVEVGVVVGGGNIFRGVAVASKGGDRVTGDHMGML
ATVINALALATSLRKLSIDTVVLSAIAMPEICESFSQRAALHHLAQGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIF
KGTQVDGIYSADPKKDPTATRFDELTHSEVLGKGLAVMDIAAVALARENHIPIIVFSIHEKGGFAQILTGGGRKTIVHDK
>Mature_239_residues
SSKPIYKRVLLKASGEALMGDQGFGIDVAVADRIASDIAEARAMGVEVGVVVGGGNIFRGVAVASKGGDRVTGDHMGMLA
TVINALALATSLRKLSIDTVVLSAIAMPEICESFSQRAALHHLAQGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIFK
GTQVDGIYSADPKKDPTATRFDELTHSEVLGKGLAVMDIAAVALARENHIPIIVFSIHEKGGFAQILTGGGRKTIVHDK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=238, Percent_Identity=50.4201680672269, Blast_Score=259, Evalue=8e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_AGRT5 (Q8UFM1)

Other databases:

- EMBL:   AE007869
- PIR:   AH2745
- PIR:   G97526
- RefSeq:   NP_354383.2
- ProteinModelPortal:   Q8UFM1
- SMR:   Q8UFM1
- STRING:   Q8UFM1
- GeneID:   1133414
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1376
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q8UFM1
- ProtClustDB:   PRK00358
- BioCyc:   ATUM176299-1:ATU1376-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 24926; Mature: 24795

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: BINDING 56-56 BINDING 57-57 BINDING 61-61 BINDING 76-76 BINDING 164-164 BINDING 165-165 BINDING 170-170 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKPIYKRVLLKASGEALMGDQGFGIDVAVADRIASDIAEARAMGVEVGVVVGGGNIFR
CCCCHHHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEE
GVAVASKGGDRVTGDHMGMLATVINALALATSLRKLSIDTVVLSAIAMPEICESFSQRAA
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHHLAQGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIFKGTQVDGIYSADPKKDPTAT
HHHHHCCCEEEEECCCCCCCEECCHHHHHHHHHHCHHHHHCCCCCCCEECCCCCCCCCHH
RFDELTHSEVLGKGLAVMDIAAVALARENHIPIIVFSIHEKGGFAQILTGGGRKTIVHDK
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCEEEEECCC
>Mature Secondary Structure 
SSKPIYKRVLLKASGEALMGDQGFGIDVAVADRIASDIAEARAMGVEVGVVVGGGNIFR
CCCHHHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEE
GVAVASKGGDRVTGDHMGMLATVINALALATSLRKLSIDTVVLSAIAMPEICESFSQRAA
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHHLAQGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIFKGTQVDGIYSADPKKDPTAT
HHHHHCCCEEEEECCCCCCCEECCHHHHHHHHHHCHHHHHCCCCCCCEECCCCCCCCCHH
RFDELTHSEVLGKGLAVMDIAAVALARENHIPIIVFSIHEKGGFAQILTGGGRKTIVHDK
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194