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The map label for this gene is frr

Identifier: 15888703

GI number: 15888703

Start: 1370945

End: 1371502

Strand: Direct

Name: frr

Synonym: Atu1377

Alternate gene names: 15888703

Gene position: 1370945-1371502 (Clockwise)

Preceding gene: 159184738

Following gene: 15888704

Centisome position: 48.25

GC content: 56.27

Gene sequence:

>558_bases
ATGAGTGGTATTGACCTCAACGATATCAAGCGCCGCATGGATGGTGCCATCAATGCATTCAAGAGCGATATCGCATCGCT
GCGCACCGGCCGCGCTTCGGCCAATATTCTCGACCCGGTGACCATCGATGCCTACGGCTCGCGTGTTCCGCTCAACCAGG
TTGCGAACATCACCGTTCCGGAGCCGCGCATGCTCGGCGTCAACATCTGGGACAAGTCGATGGTCAATGCCGTCGACCGC
GCGATCCGCGAATCCAATCTCGGTCTCAACCCGATCGTGGACGGCCAGAACCTCAGAATTCCGCTGCCTGAACTCAACGA
AGAGCGCCGCAAATCGCTCGTCAAGGTGGCCCACGAGTATTCCGAAAAAGCAAAAGTGGCGATTCGCCATGTGCGCCGGG
ACGGCATGGACGGCCTGAAAAAAGCCGAAAAAGACGGCGATATCGGTCAGGACGAAAGCCGTGGACAGTCGGAAAAAGTG
CAGAAAATGACCGACGACACGATTTCGGAAATTGACCGCTTGCTTGCCGAGAAGGAAAAGGAAATCATGCAGGTCTGA

Upstream 100 bases:

>100_bases
CGGTGGTCGCAAGACCATCGTGCACGACAAATAATCAAAAAACGACGTCGCCTCCGGGGCGGATTCCGGCCGCCTTGGCC
GATAGAGATGGAGTATCAAG

Downstream 100 bases:

>100_bases
TATCGCTCGCGATAGACCTGTATTTTATTCGTTTTAATTCCGCGCTGCCTGTTACTGGATCGATATGCCGACGACGACAC
GTTCCTCCATACCCGAGCAC

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MSGIDLNDIKRRMDGAINAFKSDIASLRTGRASANILDPVTIDAYGSRVPLNQVANITVPEPRMLGVNIWDKSMVNAVDR
AIRESNLGLNPIVDGQNLRIPLPELNEERRKSLVKVAHEYSEKAKVAIRHVRRDGMDGLKKAEKDGDIGQDESRGQSEKV
QKMTDDTISEIDRLLAEKEKEIMQV

Sequences:

>Translated_185_residues
MSGIDLNDIKRRMDGAINAFKSDIASLRTGRASANILDPVTIDAYGSRVPLNQVANITVPEPRMLGVNIWDKSMVNAVDR
AIRESNLGLNPIVDGQNLRIPLPELNEERRKSLVKVAHEYSEKAKVAIRHVRRDGMDGLKKAEKDGDIGQDESRGQSEKV
QKMTDDTISEIDRLLAEKEKEIMQV
>Mature_184_residues
SGIDLNDIKRRMDGAINAFKSDIASLRTGRASANILDPVTIDAYGSRVPLNQVANITVPEPRMLGVNIWDKSMVNAVDRA
IRESNLGLNPIVDGQNLRIPLPELNEERRKSLVKVAHEYSEKAKVAIRHVRRDGMDGLKKAEKDGDIGQDESRGQSEKVQ
KMTDDTISEIDRLLAEKEKEIMQV

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=181, Percent_Identity=34.8066298342541, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI291042689, Length=148, Percent_Identity=37.1621621621622, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1786368, Length=178, Percent_Identity=46.6292134831461, Blast_Score=170, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24661488, Length=181, Percent_Identity=29.8342541436464, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_AGRT5 (Q8UFM0)

Other databases:

- EMBL:   AE007869
- PIR:   AI2745
- PIR:   H97526
- RefSeq:   NP_354384.1
- ProteinModelPortal:   Q8UFM0
- SMR:   Q8UFM0
- STRING:   Q8UFM0
- GeneID:   1133415
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1377
- eggNOG:   COG0233
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- PhylomeDB:   Q8UFM0
- ProtClustDB:   PRK00083
- BioCyc:   ATUM176299-1:ATU1377-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20645; Mature: 20514

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGIDLNDIKRRMDGAINAFKSDIASLRTGRASANILDPVTIDAYGSRVPLNQVANITVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCHHHHCCCCCC
EPRMLGVNIWDKSMVNAVDRAIRESNLGLNPIVDGQNLRIPLPELNEERRKSLVKVAHEY
CCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHH
SEKAKVAIRHVRRDGMDGLKKAEKDGDIGQDESRGQSEKVQKMTDDTISEIDRLLAEKEK
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EIMQV
HHHCC
>Mature Secondary Structure 
SGIDLNDIKRRMDGAINAFKSDIASLRTGRASANILDPVTIDAYGSRVPLNQVANITVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCHHHHCCCCCC
EPRMLGVNIWDKSMVNAVDRAIRESNLGLNPIVDGQNLRIPLPELNEERRKSLVKVAHEY
CCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHH
SEKAKVAIRHVRRDGMDGLKKAEKDGDIGQDESRGQSEKVQKMTDDTISEIDRLLAEKEK
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EIMQV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194