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The map label for this gene is rnc

Identifier: 159184588

GI number: 159184588

Start: 1027435

End: 1028154

Strand: Direct

Name: rnc

Synonym: Atu1035

Alternate gene names: 159184588

Gene position: 1027435-1028154 (Clockwise)

Preceding gene: 15888376

Following gene: 159184589

Centisome position: 36.16

GC content: 60.97

Gene sequence:

>720_bases
ATGAGCAAGACCAAGCCGCTTTCCGCGGACGAAATTTCCCGTCTGGAAGCGTTGATCGGATATGAATTCAAGGAAAAGGC
CCGGCTCGACCGGGCCTTGACCCATGCCAGCGCCCGTTCCGCCGCCGCCGGAAATTACGAGCGGCTCGAATTTCTGGGCG
ACCGCGTTCTCGGTCTCTGCGTCGCCGAACTGCTGTTTTCCACCTTCCGTAATGCCAGCGAAGGCGAATTGTCCGTCCGG
CTGAACCAGCTTGTCAGCGCTGAATCCTGCGCCGCAATCGGCGACGAAATGGGCCTGCATAATTTCATTCGCACTGGATC
AGATGTGAAGAAGCTGACCGGCAAGGCGATGCTGAACGTGCGCGCCGATGTGGTCGAAAGCCTGATCGCCACCCTCTATC
TGGATGGCGGGCTGGAAGCGTCGCGCAAATTCATTCTGAAATATTGGCAGGGCCGCGCAACCAGCGTGGATGCCGGGCGG
CGTGACGCCAAGACCGAATTGCAGGAATGGGCGCATGCCCGATTTGCGGCGACGCCCGCTTACCGGGTTGACGATCGCTC
CGGACCGGATCACGATCCCAGCTTCACCGTGACGGTGGAAATTCCCGGCGTGAAGCCGGAAACCGGCGTTGAGCGCTCCA
AGCGCGCGGCCGAACAGGTGGCGGCAACCAGATTGCTGGAACGCGAAGGCGTCTGGCGGAAAAGCCCCACCGGAAACTGA

Upstream 100 bases:

>100_bases
CCAGCGTCATCTTCTTCTCGCTGGGCAATGACACGCCGTTCAGCCGCATTTGGGAATGGCCTGCCAACATGCGTTGGGAC
CGCCTGTTCAAGGTTGTGGG

Downstream 100 bases:

>100_bases
GCACCCGACGACAGGGTGCTGCAACCGAGCGCATGGCGGACCCTTTGGCCGCATGTTGAATACCTCTGACCTTGATGGAT
ATCATGACCGATCACGAAAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSKTKPLSADEISRLEALIGYEFKEKARLDRALTHASARSAAAGNYERLEFLGDRVLGLCVAELLFSTFRNASEGELSVR
LNQLVSAESCAAIGDEMGLHNFIRTGSDVKKLTGKAMLNVRADVVESLIATLYLDGGLEASRKFILKYWQGRATSVDAGR
RDAKTELQEWAHARFAATPAYRVDDRSGPDHDPSFTVTVEIPGVKPETGVERSKRAAEQVAATRLLEREGVWRKSPTGN

Sequences:

>Translated_239_residues
MSKTKPLSADEISRLEALIGYEFKEKARLDRALTHASARSAAAGNYERLEFLGDRVLGLCVAELLFSTFRNASEGELSVR
LNQLVSAESCAAIGDEMGLHNFIRTGSDVKKLTGKAMLNVRADVVESLIATLYLDGGLEASRKFILKYWQGRATSVDAGR
RDAKTELQEWAHARFAATPAYRVDDRSGPDHDPSFTVTVEIPGVKPETGVERSKRAAEQVAATRLLEREGVWRKSPTGN
>Mature_238_residues
SKTKPLSADEISRLEALIGYEFKEKARLDRALTHASARSAAAGNYERLEFLGDRVLGLCVAELLFSTFRNASEGELSVRL
NQLVSAESCAAIGDEMGLHNFIRTGSDVKKLTGKAMLNVRADVVESLIATLYLDGGLEASRKFILKYWQGRATSVDAGRR
DAKTELQEWAHARFAATPAYRVDDRSGPDHDPSFTVTVEIPGVKPETGVERSKRAAEQVAATRLLEREGVWRKSPTGN

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=238, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI155030234, Length=238, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1788920, Length=207, Percent_Identity=34.7826086956522, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17506883, Length=214, Percent_Identity=30.3738317757009, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=214, Percent_Identity=30.3738317757009, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17137682, Length=227, Percent_Identity=29.0748898678414, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_AGRT5 (Q8UGK2)

Other databases:

- EMBL:   AE007869
- PIR:   AB2704
- PIR:   B97486
- RefSeq:   NP_354058.2
- ProteinModelPortal:   Q8UGK2
- SMR:   Q8UGK2
- STRING:   Q8UGK2
- GeneID:   1133073
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1035
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   THASART
- PhylomeDB:   Q8UGK2
- ProtClustDB:   PRK12371
- BioCyc:   ATUM176299-1:ATU1035-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26255; Mature: 26124

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTKPLSADEISRLEALIGYEFKEKARLDRALTHASARSAAAGNYERLEFLGDRVLGLC
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VAELLFSTFRNASEGELSVRLNQLVSAESCAAIGDEMGLHNFIRTGSDVKKLTGKAMLNV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RADVVESLIATLYLDGGLEASRKFILKYWQGRATSVDAGRRDAKTELQEWAHARFAATPA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
YRVDDRSGPDHDPSFTVTVEIPGVKPETGVERSKRAAEQVAATRLLEREGVWRKSPTGN
EECCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKTKPLSADEISRLEALIGYEFKEKARLDRALTHASARSAAAGNYERLEFLGDRVLGLC
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VAELLFSTFRNASEGELSVRLNQLVSAESCAAIGDEMGLHNFIRTGSDVKKLTGKAMLNV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RADVVESLIATLYLDGGLEASRKFILKYWQGRATSVDAGRRDAKTELQEWAHARFAATPA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
YRVDDRSGPDHDPSFTVTVEIPGVKPETGVERSKRAAEQVAATRLLEREGVWRKSPTGN
EECCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194