Click here to switch to the map view.

The map label for this gene is clcA [H]

Identifier: 159184485

GI number: 159184485

Start: 831362

End: 832678

Strand: Direct

Name: clcA [H]

Synonym: Atu0832

Alternate gene names: 159184485

Gene position: 831362-832678 (Clockwise)

Preceding gene: 159184484

Following gene: 159184486

Centisome position: 29.26

GC content: 64.84

Gene sequence:

>1317_bases
ATGCTCCGCCGGTCCCGCGTTGTCTGGGGGTCGTGGCGGGTGTGGAGGCCGAGGGCGGTTTTCTGGGTTGGCGCGATTGC
GGTCGGCATTATCAGCGTCGCTTTTGCCTGGGCGGCGGATCGCGCTCAGCATCTTTTCTCGGCAGTGACATCCGCAGGCG
AATGGGCGTTTCTGCTGCCGCTCCTCATCACGCCGCTCGGTTTCACGCTCTGCGCCTGGCTTGCGATCTCGGTTTTTCCC
AATGCCGGTGGCAGCGGCATTCCGCAGGCGATTGCCGCGCGGCACCTGCGCGACGACGCGGATCGTTCGCGGCTTCTGTC
GCTGAAACTCGCTTTCGGCAAGGTGGTGCTGACGGTCGCCGGCCTTCTCTCCGGCGCGTCCATCGGCCGTGAGGGGCCGA
CCGTTCAGGTCGGGGCCTCCATCATGCTGCAGGCTGCCCGCTGGGGCGGTATGGCGCAGGCCAAGGGCCTCATCCTCGCC
GGCTCGGCGGCCGGCATTGCGGCGGCCTTCAATACGCCGCTTGCAGGCATCGTCTTCGCCATCGAGGAAATGAGCAAGAC
CTACGAATCCCGCGCCAACGGCCTGGTACTGACCGCGGTCATTCTCTCCGGTCTTGCATCGCTGGCGCTGGTTGGCAGCT
ATACCTATTTCGGCACCAGTTCGGTCATGGCGAAAACGATGATGGACTGGCTGCTGGTGCTGATCTGCGGTGTCGGCGGC
GGCGCATTTGGGGCGCTGTTCAGCGCCGGCGCCCTGCGTCTGTCAGCACGCATTCGCCGTTTTGCCCAAACCATGCCGTT
GAAACGCATGCTCGCGGTCGCCGCCGCCTGCGGCCTTGCTTCCGCCGTCATCGGCATTGCGACAGGCGGAGCGACCTTCG
GAACGGGCTATGAACAGGCACGCGCCGCAATCGAAGGTGAGGCTGCGCCGGCCTTCTTCTTCATCGAAAAGCTGGCGGCG
ACGTTTCTCGCCATGATGTCGGGCATTCCCGGCGGTATCTTCGCGCCGTCGCTGTCGGTGGGTGCCGGTTTCGGCAGCAC
CATGGCCGGCCTGCTCGGCACCAGCATCGGCCTTGGCGCCATCGTCGGCATGGCGGGATATTTCGCCGGCGTCGTGCAGG
CGCCGATGACCGCCTTTGTCATCATCCTTGAAATGACCGGCAATCATGAAGGCGTCATTCCCATCATGGTTGCGGCAATG
CTCGGATATCTGACCTCGCGTCTTTTCTCGCGGGAGCCGCTTTATCACGGCCTGTCGCGGGTCTTCATTGCCCAGAGCAT
CCGCGCCCGGCGCGCCGCTCAGGCCAGCGAAACGTAA

Upstream 100 bases:

>100_bases
TGCAATCGCGGGCCTTGAGGCAGATAAACGGGCTTAACGTCTGCCGAACACCAAATCACCGATCCGGATCGCCATGCCCG
CCGATTACAAGAAGCTGAAG

Downstream 100 bases:

>100_bases
TGGCTTACGCCCGGATTCCCGCGACGCCGAAATAACCGAGCCCCGGTATCTTAATTCCCGGCTGGACGAAATCGATGCCG
GCGACGAGACCGAGGAAATT

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLRRSRVVWGSWRVWRPRAVFWVGAIAVGIISVAFAWAADRAQHLFSAVTSAGEWAFLLPLLITPLGFTLCAWLAISVFP
NAGGSGIPQAIAARHLRDDADRSRLLSLKLAFGKVVLTVAGLLSGASIGREGPTVQVGASIMLQAARWGGMAQAKGLILA
GSAAGIAAAFNTPLAGIVFAIEEMSKTYESRANGLVLTAVILSGLASLALVGSYTYFGTSSVMAKTMMDWLLVLICGVGG
GAFGALFSAGALRLSARIRRFAQTMPLKRMLAVAAACGLASAVIGIATGGATFGTGYEQARAAIEGEAAPAFFFIEKLAA
TFLAMMSGIPGGIFAPSLSVGAGFGSTMAGLLGTSIGLGAIVGMAGYFAGVVQAPMTAFVIILEMTGNHEGVIPIMVAAM
LGYLTSRLFSREPLYHGLSRVFIAQSIRARRAAQASET

Sequences:

>Translated_438_residues
MLRRSRVVWGSWRVWRPRAVFWVGAIAVGIISVAFAWAADRAQHLFSAVTSAGEWAFLLPLLITPLGFTLCAWLAISVFP
NAGGSGIPQAIAARHLRDDADRSRLLSLKLAFGKVVLTVAGLLSGASIGREGPTVQVGASIMLQAARWGGMAQAKGLILA
GSAAGIAAAFNTPLAGIVFAIEEMSKTYESRANGLVLTAVILSGLASLALVGSYTYFGTSSVMAKTMMDWLLVLICGVGG
GAFGALFSAGALRLSARIRRFAQTMPLKRMLAVAAACGLASAVIGIATGGATFGTGYEQARAAIEGEAAPAFFFIEKLAA
TFLAMMSGIPGGIFAPSLSVGAGFGSTMAGLLGTSIGLGAIVGMAGYFAGVVQAPMTAFVIILEMTGNHEGVIPIMVAAM
LGYLTSRLFSREPLYHGLSRVFIAQSIRARRAAQASET
>Mature_438_residues
MLRRSRVVWGSWRVWRPRAVFWVGAIAVGIISVAFAWAADRAQHLFSAVTSAGEWAFLLPLLITPLGFTLCAWLAISVFP
NAGGSGIPQAIAARHLRDDADRSRLLSLKLAFGKVVLTVAGLLSGASIGREGPTVQVGASIMLQAARWGGMAQAKGLILA
GSAAGIAAAFNTPLAGIVFAIEEMSKTYESRANGLVLTAVILSGLASLALVGSYTYFGTSSVMAKTMMDWLLVLICGVGG
GAFGALFSAGALRLSARIRRFAQTMPLKRMLAVAAACGLASAVIGIATGGATFGTGYEQARAAIEGEAAPAFFFIEKLAA
TFLAMMSGIPGGIFAPSLSVGAGFGSTMAGLLGTSIGLGAIVGMAGYFAGVVQAPMTAFVIILEMTGNHEGVIPIMVAAM
LGYLTSRLFSREPLYHGLSRVFIAQSIRARRAAQASET

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=463, Percent_Identity=30.2375809935205, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 45318; Mature: 45318

Theoretical pI: Translated: 10.96; Mature: 10.96

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRSRVVWGSWRVWRPRAVFWVGAIAVGIISVAFAWAADRAQHLFSAVTSAGEWAFLLP
CCCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LLITPLGFTLCAWLAISVFPNAGGSGIPQAIAARHLRDDADRSRLLSLKLAFGKVVLTVA
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
GLLSGASIGREGPTVQVGASIMLQAARWGGMAQAKGLILAGSAAGIAAAFNTPLAGIVFA
HHHHCCCCCCCCCEEEECHHHHHHHHHCCCHHHHCCEEEECCCCCHHHHHCCCHHHHHHH
IEEMSKTYESRANGLVLTAVILSGLASLALVGSYTYFGTSSVMAKTMMDWLLVLICGVGG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
GAFGALFSAGALRLSARIRRFAQTMPLKRMLAVAAACGLASAVIGIATGGATFGTGYEQA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RAAIEGEAAPAFFFIEKLAATFLAMMSGIPGGIFAPSLSVGAGFGSTMAGLLGTSIGLGA
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IVGMAGYFAGVVQAPMTAFVIILEMTGNHEGVIPIMVAAMLGYLTSRLFSREPLYHGLSR
HHHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VFIAQSIRARRAAQASET
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLRRSRVVWGSWRVWRPRAVFWVGAIAVGIISVAFAWAADRAQHLFSAVTSAGEWAFLLP
CCCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LLITPLGFTLCAWLAISVFPNAGGSGIPQAIAARHLRDDADRSRLLSLKLAFGKVVLTVA
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
GLLSGASIGREGPTVQVGASIMLQAARWGGMAQAKGLILAGSAAGIAAAFNTPLAGIVFA
HHHHCCCCCCCCCEEEECHHHHHHHHHCCCHHHHCCEEEECCCCCHHHHHCCCHHHHHHH
IEEMSKTYESRANGLVLTAVILSGLASLALVGSYTYFGTSSVMAKTMMDWLLVLICGVGG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
GAFGALFSAGALRLSARIRRFAQTMPLKRMLAVAAACGLASAVIGIATGGATFGTGYEQA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RAAIEGEAAPAFFFIEKLAATFLAMMSGIPGGIFAPSLSVGAGFGSTMAGLLGTSIGLGA
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IVGMAGYFAGVVQAPMTAFVIILEMTGNHEGVIPIMVAAMLGYLTSRLFSREPLYHGLSR
HHHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VFIAQSIRARRAAQASET
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA