Click here to switch to the map view.

The map label for this gene is betA

Identifier: 159184484

GI number: 159184484

Start: 828964

End: 830613

Strand: Direct

Name: betA

Synonym: Atu0830

Alternate gene names: 159184484

Gene position: 828964-830613 (Clockwise)

Preceding gene: 15888169

Following gene: 159184485

Centisome position: 29.17

GC content: 61.64

Gene sequence:

>1650_bases
ATGCAAGCAGATTACGTCATCGTCGGCTCCGGCTCTGCGGGCTCCGCCATCGCCTACCGCCTGTCGGAAGACGGCCGTTA
TTCTGTCATCGTCATCGAAGCTGGCGGTTCGGATTTCGGCCCCTTCATCCAGATGCCGGCGGCACTTGCCTGGCCGATGA
GCATGAAGCGCTACAATTGGGGTTATCTCTCCGAGCCCGAGCCCAATCTTGACAACCGCCGCATCACTGCGCCGCGCGGC
AAGGTCATCGGCGGCTCGTCCTCCATTAACGGCCTTGTTTACGTTCGCGGCCATGCCGAGGATTTCAACCGCTGGGAGGA
GCTTGGCGCGCAGGGCTGGGCCTATGCGGATGTGCTGCCCTATTTCAAGCGAATGGAACACAGCCACGGCGGCGAGGAAG
GCTGGCGCGGCACGGATGGGCCGCTGCATGTGCAGCGCGGGCCGGTCAGCAATCCGCTGTTCCACGCCTTCATTCAGGCG
GGCGCACAGGCGGGCTTTGAACTGACGGACGACTATAACGGCTCCAAACAGGAAGGTTTCGGCCTGATGGAGCAGACTAT
CCACAATGGCCGCCGCTGGTCCGCCGCCAATGCCTATCTTAAACCGGCGCTGAAACGCGGCAACGTCACGCTGGTCAATG
GGTTTGCCCGCAAGGTCATCATCGAGAATGGCCGTGCCGTCGGCGTCGAGATCGAGCGCAGGGGTCGGGTTGAAACCGTA
AAGGCCAATCGCGAGGTCATCGTTTCGGCCTCCTCCTTCAACTCGCCGAAACTGCTGATGCTCTCAGGCATCGGCCCCGC
CGCGCATCTGAAAGACATGGGCATCGAGGTGAAGGCGGATCGTCCCGGTGTCGGGGCCAATCTTCAGGACCATATGGAGT
TTTATTTCCAGCAAGTCTCCACCAAGCCGGTCTCGCTTTATTCATGGCTGCCATGGTTCTGGCAGGGGGTTGCCGGTGCA
CAATGGCTGCTGTCGAAAGGCGGGCTCGGTGCCTCCAACCAGTTCGAGGCCTGCGCCTTCCTGCGCTCCGCACCCGGTCT
GAAACAGCCTGACATCCAGTATCATTTCCTGCCCGTCGCCATCTCTTATGACGGCAAGGCGGCGGCGAAAAGCCATGGCT
TTCAGGCGCATGTCGGTTACAACCTGTCGAAATCGCGCGGCAACGTCACCCTGCGCTCCGCCGATCCGCATGACGACCCG
GTAATCCGCTTCAACTACATGAGCCACCCGGAAGACTGGGAAAAATTCCGCCATTGCGTGCGCCTGACGCGCGAGATTTT
CGGCCAGAAAGCCTTCGACGATTTTCGCGGGCCGGAAATCCAGCCGGGTGAAAACATCGAGACGGACGAACAGATCGACG
CCTTTTTGCGCGAGCATCTGGAAAGCGCCTATCACCCCTGCGGCACCTGCCGGATGGGAGACCGCAACGACCCCATGGCG
GTCGTCGATCCGGAATGCCGGGTGATCGGCGTGGAGGGGCTGCGGGTCGCCGACAGCTCGATCTTCCCGCATGTGACCTA
CGGCAACCTCAACGGCCCGTCGATCATGACCGGCGAAAAAGCGGCTGATCACATCCTTGGCAAAACCCCGCTGCCCCGCT
CCAATCAGGAGCCGTGGGTAAACCCGCGTGCGGCCGTCAGCGACCGCTGA

Upstream 100 bases:

>100_bases
GCCGATCTCCCTCCTTGAGGGGGAGATGTCCGGCAGGACAGAGGGGGGTGAGCCCCAATCGAATACATTCATCGGAACCG
AGCCCCCAGTGGAGCAAACA

Downstream 100 bases:

>100_bases
GGGTCAATGGTAATCATCCTCGCGCTGGTGGCGGATCGCGAGGATTGTTACTTTCTCGGCACTTTCTATCTCAAAAAGAA
CGACATAGCCTGACGAGCCA

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MQADYVIVGSGSAGSAIAYRLSEDGRYSVIVIEAGGSDFGPFIQMPAALAWPMSMKRYNWGYLSEPEPNLDNRRITAPRG
KVIGGSSSINGLVYVRGHAEDFNRWEELGAQGWAYADVLPYFKRMEHSHGGEEGWRGTDGPLHVQRGPVSNPLFHAFIQA
GAQAGFELTDDYNGSKQEGFGLMEQTIHNGRRWSAANAYLKPALKRGNVTLVNGFARKVIIENGRAVGVEIERRGRVETV
KANREVIVSASSFNSPKLLMLSGIGPAAHLKDMGIEVKADRPGVGANLQDHMEFYFQQVSTKPVSLYSWLPWFWQGVAGA
QWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVAISYDGKAAAKSHGFQAHVGYNLSKSRGNVTLRSADPHDDP
VIRFNYMSHPEDWEKFRHCVRLTREIFGQKAFDDFRGPEIQPGENIETDEQIDAFLREHLESAYHPCGTCRMGDRNDPMA
VVDPECRVIGVEGLRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKTPLPRSNQEPWVNPRAAVSDR

Sequences:

>Translated_549_residues
MQADYVIVGSGSAGSAIAYRLSEDGRYSVIVIEAGGSDFGPFIQMPAALAWPMSMKRYNWGYLSEPEPNLDNRRITAPRG
KVIGGSSSINGLVYVRGHAEDFNRWEELGAQGWAYADVLPYFKRMEHSHGGEEGWRGTDGPLHVQRGPVSNPLFHAFIQA
GAQAGFELTDDYNGSKQEGFGLMEQTIHNGRRWSAANAYLKPALKRGNVTLVNGFARKVIIENGRAVGVEIERRGRVETV
KANREVIVSASSFNSPKLLMLSGIGPAAHLKDMGIEVKADRPGVGANLQDHMEFYFQQVSTKPVSLYSWLPWFWQGVAGA
QWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVAISYDGKAAAKSHGFQAHVGYNLSKSRGNVTLRSADPHDDP
VIRFNYMSHPEDWEKFRHCVRLTREIFGQKAFDDFRGPEIQPGENIETDEQIDAFLREHLESAYHPCGTCRMGDRNDPMA
VVDPECRVIGVEGLRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKTPLPRSNQEPWVNPRAAVSDR
>Mature_549_residues
MQADYVIVGSGSAGSAIAYRLSEDGRYSVIVIEAGGSDFGPFIQMPAALAWPMSMKRYNWGYLSEPEPNLDNRRITAPRG
KVIGGSSSINGLVYVRGHAEDFNRWEELGAQGWAYADVLPYFKRMEHSHGGEEGWRGTDGPLHVQRGPVSNPLFHAFIQA
GAQAGFELTDDYNGSKQEGFGLMEQTIHNGRRWSAANAYLKPALKRGNVTLVNGFARKVIIENGRAVGVEIERRGRVETV
KANREVIVSASSFNSPKLLMLSGIGPAAHLKDMGIEVKADRPGVGANLQDHMEFYFQQVSTKPVSLYSWLPWFWQGVAGA
QWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVAISYDGKAAAKSHGFQAHVGYNLSKSRGNVTLRSADPHDDP
VIRFNYMSHPEDWEKFRHCVRLTREIFGQKAFDDFRGPEIQPGENIETDEQIDAFLREHLESAYHPCGTCRMGDRNDPMA
VVDPECRVIGVEGLRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKTPLPRSNQEPWVNPRAAVSDR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family

Homologues:

Organism=Homo sapiens, GI217272839, Length=553, Percent_Identity=49.1862567811935, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI1786503, Length=543, Percent_Identity=51.3812154696133, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17532301, Length=557, Percent_Identity=44.7037701974865, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24642042, Length=565, Percent_Identity=37.6991150442478, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI45551458, Length=569, Percent_Identity=36.7311072056239, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI45549471, Length=569, Percent_Identity=36.7311072056239, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24642048, Length=590, Percent_Identity=32.7118644067797, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24642039, Length=571, Percent_Identity=33.9754816112084, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17137792, Length=552, Percent_Identity=33.695652173913, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24642055, Length=568, Percent_Identity=34.5070422535211, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI18859995, Length=573, Percent_Identity=33.5078534031414, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI24642059, Length=562, Percent_Identity=33.0960854092527, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24650267, Length=569, Percent_Identity=33.9191564147627, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24642037, Length=570, Percent_Identity=34.5614035087719, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI18859993, Length=570, Percent_Identity=32.4561403508772, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24642035, Length=577, Percent_Identity=32.7556325823224, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24642051, Length=565, Percent_Identity=30.4424778761062, Blast_Score=245, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24645930, Length=578, Percent_Identity=27.681660899654, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24642057, Length=576, Percent_Identity=27.6041666666667, Blast_Score=143, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BETA_AGRT5 (Q8UH55)

Other databases:

- EMBL:   AE007869
- PIR:   AF2678
- PIR:   C97460
- RefSeq:   NP_353851.2
- ProteinModelPortal:   Q8UH55
- SMR:   Q8UH55
- STRING:   Q8UH55
- GeneID:   1132868
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0830
- eggNOG:   COG2303
- HOGENOM:   HBG734713
- OMA:   DNRRMHC
- PhylomeDB:   Q8UH55
- ProtClustDB:   PRK02106
- BioCyc:   ATUM176299-1:ATU0830-MONOMER
- HAMAP:   MF_00750
- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867
- PIRSF:   PIRSF000137
- TIGRFAMs:   TIGR01810

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N

EC number: =1.1.99.1

Molecular weight: Translated: 60628; Mature: 60628

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00623 GMC_OXRED_1; PS00624 GMC_OXRED_2

Important sites: ACT_SITE 465-465

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQADYVIVGSGSAGSAIAYRLSEDGRYSVIVIEAGGSDFGPFIQMPAALAWPMSMKRYNW
CCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHCCHHHHCCCHHHCCCC
GYLSEPEPNLDNRRITAPRGKVIGGSSSINGLVYVRGHAEDFNRWEELGAQGWAYADVLP
CCCCCCCCCCCCCEEECCCCCEECCCCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHH
YFKRMEHSHGGEEGWRGTDGPLHVQRGPVSNPLFHAFIQAGAQAGFELTDDYNGSKQEGF
HHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCEEECCCCCCHHHCC
GLMEQTIHNGRRWSAANAYLKPALKRGNVTLVNGFARKVIIENGRAVGVEIERRGRVETV
HHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEECCEEEEEEECCCEEEEEEECCCCEEEE
KANREVIVSASSFNSPKLLMLSGIGPAAHLKDMGIEVKADRPGVGANLQDHMEFYFQQVS
ECCCEEEEEECCCCCCCEEEEECCCCHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHC
TKPVSLYSWLPWFWQGVAGAQWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVA
CCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEE
ISYDGKAAAKSHGFQAHVGYNLSKSRGNVTLRSADPHDDPVIRFNYMSHPEDWEKFRHCV
EECCCCHHHHCCCEEEEECCCEECCCCCEEEECCCCCCCCEEEEEECCCCHHHHHHHHHH
RLTREIFGQKAFDDFRGPEIQPGENIETDEQIDAFLREHLESAYHPCGTCRMGDRNDPMA
HHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
VVDPECRVIGVEGLRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKTPLPRSNQEPWV
EECCCEEEEECCCEEEECCCCCCEEEECCCCCCCEECCCHHHHHHHCCCCCCCCCCCCCC
NPRAAVSDR
CCCCCCCCC
>Mature Secondary Structure
MQADYVIVGSGSAGSAIAYRLSEDGRYSVIVIEAGGSDFGPFIQMPAALAWPMSMKRYNW
CCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHCCHHHHCCCHHHCCCC
GYLSEPEPNLDNRRITAPRGKVIGGSSSINGLVYVRGHAEDFNRWEELGAQGWAYADVLP
CCCCCCCCCCCCCEEECCCCCEECCCCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHH
YFKRMEHSHGGEEGWRGTDGPLHVQRGPVSNPLFHAFIQAGAQAGFELTDDYNGSKQEGF
HHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCEEECCCCCCHHHCC
GLMEQTIHNGRRWSAANAYLKPALKRGNVTLVNGFARKVIIENGRAVGVEIERRGRVETV
HHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEECCEEEEEEECCCEEEEEEECCCCEEEE
KANREVIVSASSFNSPKLLMLSGIGPAAHLKDMGIEVKADRPGVGANLQDHMEFYFQQVS
ECCCEEEEEECCCCCCCEEEEECCCCHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHC
TKPVSLYSWLPWFWQGVAGAQWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVA
CCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEE
ISYDGKAAAKSHGFQAHVGYNLSKSRGNVTLRSADPHDDPVIRFNYMSHPEDWEKFRHCV
EECCCCHHHHCCCEEEEECCCEECCCCCEEEECCCCCCCCEEEEEECCCCHHHHHHHHHH
RLTREIFGQKAFDDFRGPEIQPGENIETDEQIDAFLREHLESAYHPCGTCRMGDRNDPMA
HHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
VVDPECRVIGVEGLRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKTPLPRSNQEPWV
EECCCEEEEECCCEEEECCCCCCEEEECCCCCCCEECCCHHHHHHHCCCCCCCCCCCCCC
NPRAAVSDR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194