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The map label for this gene is pyrD

Identifier: 159184334

GI number: 159184334

Start: 474266

End: 475357

Strand: Direct

Name: pyrD

Synonym: Atu0486

Alternate gene names: 159184334

Gene position: 474266-475357 (Clockwise)

Preceding gene: 159184333

Following gene: 159184336

Centisome position: 16.69

GC content: 62.73

Gene sequence:

>1092_bases
ATGAGCGGATTATTTTCCTCTGTCGGCCGCAAGGGCCTGTTTCTCATCGATCCGGAAAAGGCGCACGGGCTCTCCGTTGC
GGCGCTGAAAAGCGGCTTCCTGCCCACCTGCATGGTGCCGCATGATCCGCGCCTGCAGCAGACGGTGGCGGGCCTTGTCT
TCCCCAATCCGCTCGGCATGGCGGCGGGTTACGACAAGAATGCGGAAGTACCGGGACCGCTTCTGAGGCTCGGTTTCGGC
TTCACCGAAATCGGCACCGTCACGCCGCGGGCACAATCCGGCAATCCCAAGCCACGCATTTTCCGCCTGGTCGAGGATGA
GGGCGTCATCAACCGTCTCGGCTTCAACAATGAAGGCCATGCCGCAGCGCTGGAGCGTCTGACACAGGCGCGTCTGCGCG
GCATCGTCGGTGTCAATATCGGCGCCAACAAGGATAGCGAAGACCGCATCGCCGACTATGTGCAGGGCATCGAGGCGTTT
TATGCGGTCGCATCCTATTTCACCGTCAATATTTCTTCACCCAACACACCCGGCCTTCGTGATCTGCAGGCGCGTGAAAG
CCTTGCGGCCCTTCTCACGGCCGTGCTGGAACGCCGCAAGACGGAAGCGGAGCGCCTCGGCAAACGCATCCCGATCTTCC
TCAAGATCGCGCCCGATCTGACTGAGGAAGGACTGGACGATGTTGCCGAAGAGGCGCTCGCCCACGATCTCGATGGCCTG
ATCGTCTCGAACACCACGCTCTCACGCGAAGGCCTGCGCCCTGGTCCCCACAGGGGCGAGGCCGGCGGGCTTTCGGGCAA
GCCGCTCTTTGAGCTTTCCACCACGGTTCTCGCCAAGATGCGCCGTCGCGTTGGCGCCAATCTGCCGATCATCGGCGTTG
GTGGTGTTTCATCTGCGGAAACGGCTTTGGAAAAGGTGCGGGCAGGGGCCGATCTCGTGCAGCTCTATTCCTGCATGGTC
TATGAAGGTCCGGGCCTGCCCTCGGCCATCGTCAAGGGCATGTCGAAGCTCGTCGCCCGCGAGGGCGTGGAGACCATCCG
TGACCTGCGCGACAGCGCGGTCGACCGCTGGGCTGACCGTAAGCTCGGCTGA

Upstream 100 bases:

>100_bases
TCCCGCATCTTTACGCCCCGCTTCCCTTCAGCGCGGTCCTTTGGGAAACGCCGCTCTCGCTTGATCATGATGGCCAGCAC
CAGTTCCCGGAGATTTTGTG

Downstream 100 bases:

>100_bases
AGAGCGAAGGAGCGGGGTGATCTCCCGCCCCTGAATTCAGGCGCAAAGCACCATCGCCCAATAGGGCCGGTTGCGGCTGG
CGGCATCATAGGCAACCGCG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSGLFSSVGRKGLFLIDPEKAHGLSVAALKSGFLPTCMVPHDPRLQQTVAGLVFPNPLGMAAGYDKNAEVPGPLLRLGFG
FTEIGTVTPRAQSGNPKPRIFRLVEDEGVINRLGFNNEGHAAALERLTQARLRGIVGVNIGANKDSEDRIADYVQGIEAF
YAVASYFTVNISSPNTPGLRDLQARESLAALLTAVLERRKTEAERLGKRIPIFLKIAPDLTEEGLDDVAEEALAHDLDGL
IVSNTTLSREGLRPGPHRGEAGGLSGKPLFELSTTVLAKMRRRVGANLPIIGVGGVSSAETALEKVRAGADLVQLYSCMV
YEGPGLPSAIVKGMSKLVAREGVETIRDLRDSAVDRWADRKLG

Sequences:

>Translated_363_residues
MSGLFSSVGRKGLFLIDPEKAHGLSVAALKSGFLPTCMVPHDPRLQQTVAGLVFPNPLGMAAGYDKNAEVPGPLLRLGFG
FTEIGTVTPRAQSGNPKPRIFRLVEDEGVINRLGFNNEGHAAALERLTQARLRGIVGVNIGANKDSEDRIADYVQGIEAF
YAVASYFTVNISSPNTPGLRDLQARESLAALLTAVLERRKTEAERLGKRIPIFLKIAPDLTEEGLDDVAEEALAHDLDGL
IVSNTTLSREGLRPGPHRGEAGGLSGKPLFELSTTVLAKMRRRVGANLPIIGVGGVSSAETALEKVRAGADLVQLYSCMV
YEGPGLPSAIVKGMSKLVAREGVETIRDLRDSAVDRWADRKLG
>Mature_362_residues
SGLFSSVGRKGLFLIDPEKAHGLSVAALKSGFLPTCMVPHDPRLQQTVAGLVFPNPLGMAAGYDKNAEVPGPLLRLGFGF
TEIGTVTPRAQSGNPKPRIFRLVEDEGVINRLGFNNEGHAAALERLTQARLRGIVGVNIGANKDSEDRIADYVQGIEAFY
AVASYFTVNISSPNTPGLRDLQARESLAALLTAVLERRKTEAERLGKRIPIFLKIAPDLTEEGLDDVAEEALAHDLDGLI
VSNTTLSREGLRPGPHRGEAGGLSGKPLFELSTTVLAKMRRRVGANLPIIGVGGVSSAETALEKVRAGADLVQLYSCMVY
EGPGLPSAIVKGMSKLVAREGVETIRDLRDSAVDRWADRKLG

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=342, Percent_Identity=45.6140350877193, Blast_Score=274, Evalue=8e-74,
Organism=Escherichia coli, GI1787177, Length=337, Percent_Identity=45.1038575667656, Blast_Score=272, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17509475, Length=345, Percent_Identity=41.7391304347826, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI281361352, Length=352, Percent_Identity=45.4545454545455, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI17137316, Length=352, Percent_Identity=45.4545454545455, Blast_Score=298, Evalue=5e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_AGRT5 (A9CK85)

Other databases:

- EMBL:   AE007869
- RefSeq:   NP_353514.2
- ProteinModelPortal:   A9CK85
- SMR:   A9CK85
- STRING:   A9CK85
- GeneID:   1132524
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0486
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- PhylomeDB:   A9CK85
- ProtClustDB:   PRK05286
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 38824; Mature: 38693

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLFSSVGRKGLFLIDPEKAHGLSVAALKSGFLPTCMVPHDPRLQQTVAGLVFPNPLGM
CCCHHHHHCCCCEEEECCCCCCCCCHHHHHCCCCCEECCCCCCHHHHHHHHHCCCCCCCC
AAGYDKNAEVPGPLLRLGFGFTEIGTVTPRAQSGNPKPRIFRLVEDEGVINRLGFNNEGH
CCCCCCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCCH
AAALERLTQARLRGIVGVNIGANKDSEDRIADYVQGIEAFYAVASYFTVNISSPNTPGLR
HHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCH
DLQARESLAALLTAVLERRKTEAERLGKRIPIFLKIAPDLTEEGLDDVAEEALAHDLDGL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCE
IVSNTTLSREGLRPGPHRGEAGGLSGKPLFELSTTVLAKMRRRVGANLPIIGVGGVSSAE
EEECCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHH
TALEKVRAGADLVQLYSCMVYEGPGLPSAIVKGMSKLVAREGVETIRDLRDSAVDRWADR
HHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KLG
CCC
>Mature Secondary Structure 
SGLFSSVGRKGLFLIDPEKAHGLSVAALKSGFLPTCMVPHDPRLQQTVAGLVFPNPLGM
CCHHHHHCCCCEEEECCCCCCCCCHHHHHCCCCCEECCCCCCHHHHHHHHHCCCCCCCC
AAGYDKNAEVPGPLLRLGFGFTEIGTVTPRAQSGNPKPRIFRLVEDEGVINRLGFNNEGH
CCCCCCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCCH
AAALERLTQARLRGIVGVNIGANKDSEDRIADYVQGIEAFYAVASYFTVNISSPNTPGLR
HHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCH
DLQARESLAALLTAVLERRKTEAERLGKRIPIFLKIAPDLTEEGLDDVAEEALAHDLDGL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCE
IVSNTTLSREGLRPGPHRGEAGGLSGKPLFELSTTVLAKMRRRVGANLPIIGVGGVSSAE
EEECCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHH
TALEKVRAGADLVQLYSCMVYEGPGLPSAIVKGMSKLVAREGVETIRDLRDSAVDRWADR
HHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KLG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194