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The map label for this gene is czcD [H]

Identifier: 159046503

GI number: 159046503

Start: 27935

End: 28900

Strand: Direct

Name: czcD [H]

Synonym: Dshi_3964

Alternate gene names: 159046503

Gene position: 27935-28900 (Clockwise)

Preceding gene: 159046502

Following gene: 159046504

Centisome position: 22.12

GC content: 59.83

Gene sequence:

>966_bases
GTGCCGCATGATCACGGCCACGCCCACATCGATCCTCAATCCGGTGATCGTCGCGTCTCCATCGCCATCTGGGCCAACGG
CCTCCTGACGGTCGCGCAGATCGTCGGCGGGATCCTTTCCGGCAGCCTCGCGCTGATCGCGGATGCCCTCCACAATTTCT
CGGACATGGCGTCGCTGGTGATCGCCTTCTTCGCGCGTAAGATCGCTCGCCGCCCGGCGGACAAGCGCATGACCTTCGGC
TATGGGCGGGTAGAAATCGTCGCAGCGCTCATCAACTACACGACACTTATCCTGATCGGCTTCTACCTGATCTACGAGGG
TGGCATGCGCATGATCGACCCACCAGAGGTACAGGGCTGGACGGTGGTGATCCTGGGCGGTGTGGCACTGGTCGTCGACA
CGTTGACGGCGCTGCTCACCTATTCGATGCAGAAAGGCAGCGTGAACATCCGTGCGCTCTTCCTGCACAACCTATCGGAC
GCTTTGGCCTCCGTGGCGGTCATCATCGGCGGCTCGCTCATCCTCCTCTACAACATGCGGTGGGTCGACCCGGCGATCAC
CATCGGCATCGCTCTCTACATCCTCTACCTCGCATTTACCGAGATCGGCGGTCCGATTCGGACGCTGATGCTCGGCAGTC
CACCGGACATCGATAATGAAACCGTCGTTCAGGCGATGCGGGGTGTGGATGGTGTCGCGGACGTTCATCACGTGCATCTG
TGGCAGATGCAGGAGCACGAGGCGGCTCTGGACTGCCACGTCGTGCTGACAGCGGACGGCTGGGGTCAAATCGAAAAGAT
CAAGGCCGCGATCAAGGACCGGCTGAAGGACGATTTCAGCATCGGTCATTCGAGTCTGGAATTTGAGCACGAAGACCGCG
CACACGAAAACGCTGACCTTTACGGTCACGGCAAACCGGAAAAAGAGGAGGAAAACCATGTTCACCGAGACACTGACAGC
TCATGA

Upstream 100 bases:

>100_bases
CGTCACTGGATGAATGCCAGGGTTCGCCGCATCCGCCGCGGAATCTTGCCGCCGGTCCCCGGATTCGATCGGCCGAACCA
CCGCCATGAGGAGACGAACC

Downstream 100 bases:

>100_bases
CGACACGATTGGCCTCGCCTGCGAGGGCAAGCTCAGCGAAAGCGACCTGAAACGGATGCACGCCCTGCTTCATGAGCGCC
TGCAAGAGACAAGTAAGCCC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MPHDHGHAHIDPQSGDRRVSIAIWANGLLTVAQIVGGILSGSLALIADALHNFSDMASLVIAFFARKIARRPADKRMTFG
YGRVEIVAALINYTTLILIGFYLIYEGGMRMIDPPEVQGWTVVILGGVALVVDTLTALLTYSMQKGSVNIRALFLHNLSD
ALASVAVIIGGSLILLYNMRWVDPAITIGIALYILYLAFTEIGGPIRTLMLGSPPDIDNETVVQAMRGVDGVADVHHVHL
WQMQEHEAALDCHVVLTADGWGQIEKIKAAIKDRLKDDFSIGHSSLEFEHEDRAHENADLYGHGKPEKEEENHVHRDTDS
S

Sequences:

>Translated_321_residues
MPHDHGHAHIDPQSGDRRVSIAIWANGLLTVAQIVGGILSGSLALIADALHNFSDMASLVIAFFARKIARRPADKRMTFG
YGRVEIVAALINYTTLILIGFYLIYEGGMRMIDPPEVQGWTVVILGGVALVVDTLTALLTYSMQKGSVNIRALFLHNLSD
ALASVAVIIGGSLILLYNMRWVDPAITIGIALYILYLAFTEIGGPIRTLMLGSPPDIDNETVVQAMRGVDGVADVHHVHL
WQMQEHEAALDCHVVLTADGWGQIEKIKAAIKDRLKDDFSIGHSSLEFEHEDRAHENADLYGHGKPEKEEENHVHRDTDS
S
>Mature_320_residues
PHDHGHAHIDPQSGDRRVSIAIWANGLLTVAQIVGGILSGSLALIADALHNFSDMASLVIAFFARKIARRPADKRMTFGY
GRVEIVAALINYTTLILIGFYLIYEGGMRMIDPPEVQGWTVVILGGVALVVDTLTALLTYSMQKGSVNIRALFLHNLSDA
LASVAVIIGGSLILLYNMRWVDPAITIGIALYILYLAFTEIGGPIRTLMLGSPPDIDNETVVQAMRGVDGVADVHHVHLW
QMQEHEAALDCHVVLTADGWGQIEKIKAAIKDRLKDDFSIGHSSLEFEHEDRAHENADLYGHGKPEKEEENHVHRDTDSS

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=297, Percent_Identity=27.2727272727273, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI20070323, Length=319, Percent_Identity=26.0188087774295, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI64762489, Length=304, Percent_Identity=25.9868421052632, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI289803013, Length=321, Percent_Identity=25.8566978193146, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI289803009, Length=321, Percent_Identity=25.8566978193146, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI289803007, Length=321, Percent_Identity=25.8566978193146, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI289803003, Length=321, Percent_Identity=25.8566978193146, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI21361112, Length=327, Percent_Identity=25.0764525993884, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI21359890, Length=313, Percent_Identity=21.7252396166134, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI14210520, Length=219, Percent_Identity=23.7442922374429, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI52351208, Length=112, Percent_Identity=33.9285714285714, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=30.9352517985612, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193210990, Length=321, Percent_Identity=26.1682242990654, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17555794, Length=318, Percent_Identity=25.7861635220126, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17555796, Length=306, Percent_Identity=25.8169934640523, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32564488, Length=309, Percent_Identity=25.5663430420712, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323899, Length=110, Percent_Identity=38.1818181818182, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=110, Percent_Identity=38.1818181818182, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583858, Length=320, Percent_Identity=24.375, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24584409, Length=120, Percent_Identity=35.8333333333333, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574430, Length=120, Percent_Identity=35.8333333333333, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24645863, Length=101, Percent_Identity=32.6732673267327, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24656728, Length=130, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24656724, Length=130, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24656720, Length=130, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24656715, Length=130, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357035, Length=130, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35210; Mature: 35079

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHDHGHAHIDPQSGDRRVSIAIWANGLLTVAQIVGGILSGSLALIADALHNFSDMASLV
CCCCCCCEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
IAFFARKIARRPADKRMTFGYGRVEIVAALINYTTLILIGFYLIYEGGMRMIDPPEVQGW
HHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
TVVILGGVALVVDTLTALLTYSMQKGSVNIRALFLHNLSDALASVAVIIGGSLILLYNMR
EEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECH
WVDPAITIGIALYILYLAFTEIGGPIRTLMLGSPPDIDNETVVQAMRGVDGVADVHHVHL
HCCHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHE
WQMQEHEAALDCHVVLTADGWGQIEKIKAAIKDRLKDDFSIGHSSLEFEHEDRAHENADL
EEEHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCC
YGHGKPEKEEENHVHRDTDSS
CCCCCCCCCHHCCCCCCCCCC
>Mature Secondary Structure 
PHDHGHAHIDPQSGDRRVSIAIWANGLLTVAQIVGGILSGSLALIADALHNFSDMASLV
CCCCCCEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
IAFFARKIARRPADKRMTFGYGRVEIVAALINYTTLILIGFYLIYEGGMRMIDPPEVQGW
HHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
TVVILGGVALVVDTLTALLTYSMQKGSVNIRALFLHNLSDALASVAVIIGGSLILLYNMR
EEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECH
WVDPAITIGIALYILYLAFTEIGGPIRTLMLGSPPDIDNETVVQAMRGVDGVADVHHVHL
HCCHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHE
WQMQEHEAALDCHVVLTADGWGQIEKIKAAIKDRLKDDFSIGHSSLEFEHEDRAHENADL
EEEHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCC
YGHGKPEKEEENHVHRDTDSS
CCCCCCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]