Click here to switch to the map view.

The map label for this gene is tmK-2

Identifier: 15898046

GI number: 15898046

Start: 1035783

End: 1036424

Strand: Reverse

Name: tmK-2

Synonym: SSO1192

Alternate gene names: 15898046

Gene position: 1036424-1035783 (Counterclockwise)

Preceding gene: 15898047

Following gene: 15898045

Centisome position: 34.64

GC content: 35.05

Gene sequence:

>642_bases
ATGAGAGGCTTATTAATAGCTTTTGAAGGTATTGATGGTTCTGGAAAGTCCAGTCAAGCTGTATTACTAAAAGATTGGAT
TGAAATGAGAAGAGACGTTTACCTAACTGAATGGAACTCATCTGAATGGATCCACGATATAATAAAGGAGGCAAAAAAGA
AGAATATGCTTACATCAATAACCTTTAGTCTTATTCACGCCACTGATTTCTCAGACAGATATGAAAGATATATTTTACCA
ATGCTCAAGAGCGGATTCGTTGTAATATGCGATCGATACGTATATACTGCTTACGCCAGAGATGTTGTTAGGAACGTGGA
CTTTGATTGGGTGAAGAGACTATACTCCTTCGCAATAAAGCCTAACTTTACCTTTTACATAAGGGTTACTCCAGAAATTG
CTTTGGAGAGAATTAGGAAAGCTAAGAGAAAAATAAAACCACAAGAGGCTGGAATTGATATACTGGGTGAGATACCTTTA
GAAGAGGGCTTCTTAAAATATCAGAGTAGAATTGTAGAGATTTACGATAAAATAGCTAAAGAGGAAAGCAACTTCATAAC
AATAGACGGAAATAGACCATTAAAGGACGTTCAGATTGATATAAGAAAAATTTTAGGTGAATATATTGATAATAGCCTTT
GA

Upstream 100 bases:

>100_bases
ATGTGAAACTTTTAAAGGACGATATTACAAAAAAAGAGTTATTAAGTTTCGGAAATATAGTAAAGAATAGTATAGACAAG
TACGTTGTCGGTGTAAGAGT

Downstream 100 bases:

>100_bases
GGGAATTGAAGGTTCTGGGAAAACATCTCATCTAGAGGCTACTAAAAAGTATTTGGAGAAAGAAGGATATGGAGTAGTTA
CATTTGGGTTACAGATGTCT

Product: thymidylate kinase (tmK-2)

Products: NA

Alternate protein names: dTMP kinase 2

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MRGLLIAFEGIDGSGKSSQAVLLKDWIEMRRDVYLTEWNSSEWIHDIIKEAKKKNMLTSITFSLIHATDFSDRYERYILP
MLKSGFVVICDRYVYTAYARDVVRNVDFDWVKRLYSFAIKPNFTFYIRVTPEIALERIRKAKRKIKPQEAGIDILGEIPL
EEGFLKYQSRIVEIYDKIAKEESNFITIDGNRPLKDVQIDIRKILGEYIDNSL

Sequences:

>Translated_213_residues
MRGLLIAFEGIDGSGKSSQAVLLKDWIEMRRDVYLTEWNSSEWIHDIIKEAKKKNMLTSITFSLIHATDFSDRYERYILP
MLKSGFVVICDRYVYTAYARDVVRNVDFDWVKRLYSFAIKPNFTFYIRVTPEIALERIRKAKRKIKPQEAGIDILGEIPL
EEGFLKYQSRIVEIYDKIAKEESNFITIDGNRPLKDVQIDIRKILGEYIDNSL
>Mature_213_residues
MRGLLIAFEGIDGSGKSSQAVLLKDWIEMRRDVYLTEWNSSEWIHDIIKEAKKKNMLTSITFSLIHATDFSDRYERYILP
MLKSGFVVICDRYVYTAYARDVVRNVDFDWVKRLYSFAIKPNFTFYIRVTPEIALERIRKAKRKIKPQEAGIDILGEIPL
EEGFLKYQSRIVEIYDKIAKEESNFITIDGNRPLKDVQIDIRKILGEYIDNSL

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Drosophila melanogaster, GI28573735, Length=217, Percent_Identity=25.8064516129032, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY2_SULSO (P58157)

Other databases:

- EMBL:   AE006641
- PIR:   B90273
- RefSeq:   NP_342651.1
- ProteinModelPortal:   P58157
- SMR:   P58157
- GeneID:   1454220
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO1192
- NMPDR:   fig|273057.1.peg.1074
- HOGENOM:   HBG626009
- OMA:   TAYARDS
- ProtClustDB:   CLSK803042
- BioCyc:   SSOL273057:SSO1192-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 25001; Mature: 25001

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGLLIAFEGIDGSGKSSQAVLLKDWIEMRRDVYLTEWNSSEWIHDIIKEAKKKNMLTSI
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHH
TFSLIHATDFSDRYERYILPMLKSGFVVICDRYVYTAYARDVVRNVDFDWVKRLYSFAIK
HHHHHHHCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
PNFTFYIRVTPEIALERIRKAKRKIKPQEAGIDILGEIPLEEGFLKYQSRIVEIYDKIAK
CCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHC
EESNFITIDGNRPLKDVQIDIRKILGEYIDNSL
CCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRGLLIAFEGIDGSGKSSQAVLLKDWIEMRRDVYLTEWNSSEWIHDIIKEAKKKNMLTSI
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHH
TFSLIHATDFSDRYERYILPMLKSGFVVICDRYVYTAYARDVVRNVDFDWVKRLYSFAIK
HHHHHHHCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
PNFTFYIRVTPEIALERIRKAKRKIKPQEAGIDILGEIPLEEGFLKYQSRIVEIYDKIAK
CCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHC
EESNFITIDGNRPLKDVQIDIRKILGEYIDNSL
CCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726