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The map label for this gene is gppA [H]

Identifier: 15898047

GI number: 15898047

Start: 1036421

End: 1037674

Strand: Reverse

Name: gppA [H]

Synonym: SSO1193

Alternate gene names: 15898047

Gene position: 1037674-1036421 (Counterclockwise)

Preceding gene: 15898048

Following gene: 15898046

Centisome position: 34.68

GC content: 36.52

Gene sequence:

>1254_bases
ATGATATCGGCAGTTATAGATTGTGGCTATAATTCGTTTCGAATGGTAGTTTACCAAGTTTTTCGTAACGGAACGTTCAG
AGCGCTTGGTTCTTCTAAATCATTCGTTAGAATAGGAGAAGGATTAAAGGAAGGAGATACTATTCCAGAGGAAAAAGTCG
AAAAAGCAGAAAGGACTTTTACTATTTTTAAAAGAATATTAAATGGCATAAACGTAGATGAAGTCAAAATAGTTGCTACT
AGCGCATTTCGATATGCGTCTAACGGTAACGAGGTTAGGCTAAGGCTAAGCAAAATAATAGAAAATGAAGTTAGAGTAAT
TTCCGGAGAGGAAGAAGGGAGTTATGCCGCTTTGGGTATGTTAAACACGCTCCCAATTCCTGACGGAATATTTTTCGAAT
TAGGTGGGGGATCATTGGAAATAGCCGAAGTTACCTCGGGTAATATAATTAGAGTGCATCAATTGCCAATTGGAGCATTG
AAATTAGTTAGCCTTCCAGAAAGGGAAATTAGAAAAAAAGTATCCGATGAGCTCTCAACTATAAATATTAAGAAAGCTAA
TATCATGGTTGGCTCAGGAGGGAACGTTAGGGCACTAGCTAAGCTCGATCTCAAGCTATCTTCTTTTCCGACAAAGTCAG
TACACGGTTATTTACTATCTTCGAAACAAATTAGTAAATATGCCTCCCTTTTACCTTCACTAGATGATGAGAGTAGGAAA
TCCCTCCCTGGGATAAGTAAGGAAAGGGCTTTAACTATACATTCAGCTTCAGTAATTGTTGATGAACTTATAAAATATCT
CAATGGGAGCGACATGATTGTCTCCCTTTTCGGTATGAGAGAGGGAGTATTAACTGAAGGTAAGAAATTGGATAAGATGA
ATTGGTTGGAAGAAATATCATATTCTAATGCAATTGATCCTCCTTTCGGAATTTTTAAAGAGGTAATGAGCGAGGTTGAT
AGTAAGTACTCCTTCTATGTCGCTTCCTCTGCTCTCTTATCGTTAATCTTTAAAATGGTAGGGTATTTCAACCCATTTAG
GGCTTGCTATAGATTTATCAAGGAATCAGTTTTACCTGGTTTTACTCTAGATGAGGTATTGTTAATTGGTTTGATTTGTG
AGGCTGCTAGTGGGAAAGTTAAGAAAAAACATGTGAAACTTTTAAAGGACGATATTACAAAAAAAGAGTTATTAAGTTTC
GGAAATATAGTAAAGAATAGTATAGACAAGTACGTTGTCGGTGTAAGAGTATGA

Upstream 100 bases:

>100_bases
GATTAAGAAAGGTGGGGTTGCAGTTTTAGATTATGATCTGAAGGAAGGAAGAGGGACCCTGAAAATCCTACTCAGCCAGA
AAGTTCTTAAGCTGATTTAG

Downstream 100 bases:

>100_bases
GAGGCTTATTAATAGCTTTTGAAGGTATTGATGGTTCTGGAAAGTCCAGTCAAGCTGTATTACTAAAAGATTGGATTGAA
ATGAGAAGAGACGTTTACCT

Product: exopolyphosphatase (metaphosphatase), putative

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MISAVIDCGYNSFRMVVYQVFRNGTFRALGSSKSFVRIGEGLKEGDTIPEEKVEKAERTFTIFKRILNGINVDEVKIVAT
SAFRYASNGNEVRLRLSKIIENEVRVISGEEEGSYAALGMLNTLPIPDGIFFELGGGSLEIAEVTSGNIIRVHQLPIGAL
KLVSLPEREIRKKVSDELSTINIKKANIMVGSGGNVRALAKLDLKLSSFPTKSVHGYLLSSKQISKYASLLPSLDDESRK
SLPGISKERALTIHSASVIVDELIKYLNGSDMIVSLFGMREGVLTEGKKLDKMNWLEEISYSNAIDPPFGIFKEVMSEVD
SKYSFYVASSALLSLIFKMVGYFNPFRACYRFIKESVLPGFTLDEVLLIGLICEAASGKVKKKHVKLLKDDITKKELLSF
GNIVKNSIDKYVVGVRV

Sequences:

>Translated_417_residues
MISAVIDCGYNSFRMVVYQVFRNGTFRALGSSKSFVRIGEGLKEGDTIPEEKVEKAERTFTIFKRILNGINVDEVKIVAT
SAFRYASNGNEVRLRLSKIIENEVRVISGEEEGSYAALGMLNTLPIPDGIFFELGGGSLEIAEVTSGNIIRVHQLPIGAL
KLVSLPEREIRKKVSDELSTINIKKANIMVGSGGNVRALAKLDLKLSSFPTKSVHGYLLSSKQISKYASLLPSLDDESRK
SLPGISKERALTIHSASVIVDELIKYLNGSDMIVSLFGMREGVLTEGKKLDKMNWLEEISYSNAIDPPFGIFKEVMSEVD
SKYSFYVASSALLSLIFKMVGYFNPFRACYRFIKESVLPGFTLDEVLLIGLICEAASGKVKKKHVKLLKDDITKKELLSF
GNIVKNSIDKYVVGVRV
>Mature_417_residues
MISAVIDCGYNSFRMVVYQVFRNGTFRALGSSKSFVRIGEGLKEGDTIPEEKVEKAERTFTIFKRILNGINVDEVKIVAT
SAFRYASNGNEVRLRLSKIIENEVRVISGEEEGSYAALGMLNTLPIPDGIFFELGGGSLEIAEVTSGNIIRVHQLPIGAL
KLVSLPEREIRKKVSDELSTINIKKANIMVGSGGNVRALAKLDLKLSSFPTKSVHGYLLSSKQISKYASLLPSLDDESRK
SLPGISKERALTIHSASVIVDELIKYLNGSDMIVSLFGMREGVLTEGKKLDKMNWLEEISYSNAIDPPFGIFKEVMSEVD
SKYSFYVASSALLSLIFKMVGYFNPFRACYRFIKESVLPGFTLDEVLLIGLICEAASGKVKKKHVKLLKDDITKKELLSF
GNIVKNSIDKYVVGVRV

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=299, Percent_Identity=25.752508361204, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788848, Length=424, Percent_Identity=20.9905660377358, Blast_Score=78, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 46106; Mature: 46106

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISAVIDCGYNSFRMVVYQVFRNGTFRALGSSKSFVRIGEGLKEGDTIPEEKVEKAERTF
CCCEEEECCCCHHHHHHHHHHHCCCEEECCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
TIFKRILNGINVDEVKIVATSAFRYASNGNEVRLRLSKIIENEVRVISGEEEGSYAALGM
HHHHHHHCCCCCCCEEEEEEHHHHCCCCCCCEEHHHHHHHHCCCEEEECCCCCCEEEEEH
LNTLPIPDGIFFELGGGSLEIAEVTSGNIIRVHQLPIGALKLVSLPEREIRKKVSDELST
HHCCCCCCCEEEEECCCEEEEEEECCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHE
INIKKANIMVGSGGNVRALAKLDLKLSSFPTKSVHGYLLSSKQISKYASLLPSLDDESRK
EEEEEEEEEEECCCCEEEEEEEEEECCCCCCCHHHHHEECHHHHHHHHHHCCCCCCHHHH
SLPGISKERALTIHSASVIVDELIKYLNGSDMIVSLFGMREGVLTEGKKLDKMNWLEEIS
CCCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCCHHHHHHHHHHHC
YSNAIDPPFGIFKEVMSEVDSKYSFYVASSALLSLIFKMVGYFNPFRACYRFIKESVLPG
CCCCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
FTLDEVLLIGLICEAASGKVKKKHVKLLKDDITKKELLSFGNIVKNSIDKYVVGVRV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEC
>Mature Secondary Structure
MISAVIDCGYNSFRMVVYQVFRNGTFRALGSSKSFVRIGEGLKEGDTIPEEKVEKAERTF
CCCEEEECCCCHHHHHHHHHHHCCCEEECCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
TIFKRILNGINVDEVKIVATSAFRYASNGNEVRLRLSKIIENEVRVISGEEEGSYAALGM
HHHHHHHCCCCCCCEEEEEEHHHHCCCCCCCEEHHHHHHHHCCCEEEECCCCCCEEEEEH
LNTLPIPDGIFFELGGGSLEIAEVTSGNIIRVHQLPIGALKLVSLPEREIRKKVSDELST
HHCCCCCCCEEEEECCCEEEEEEECCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHE
INIKKANIMVGSGGNVRALAKLDLKLSSFPTKSVHGYLLSSKQISKYASLLPSLDDESRK
EEEEEEEEEEECCCCEEEEEEEEEECCCCCCCHHHHHEECHHHHHHHHHHCCCCCCHHHH
SLPGISKERALTIHSASVIVDELIKYLNGSDMIVSLFGMREGVLTEGKKLDKMNWLEEIS
CCCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCCHHHHHHHHHHHC
YSNAIDPPFGIFKEVMSEVDSKYSFYVASSALLSLIFKMVGYFNPFRACYRFIKESVLPG
CCCCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
FTLDEVLLIGLICEAASGKVKKKHVKLLKDDITKKELLSFGNIVKNSIDKYVVGVRV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA