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The map label for this gene is strD [H]

Identifier: 15897731

GI number: 15897731

Start: 712831

End: 713865

Strand: Reverse

Name: strD [H]

Synonym: SSO0831

Alternate gene names: 15897731

Gene position: 713865-712831 (Counterclockwise)

Preceding gene: 15897732

Following gene: 15897730

Centisome position: 23.86

GC content: 44.64

Gene sequence:

>1035_bases
ATGGAGGCAGTAATCCTACATGGAGGGCAAGGTACAAGGCTCAGGCCGTTAACCCATACTGGCCCAAAGCAGTTGATAAA
AGTCGCAGGAAAGCCGGTTTCACAGTGGGTCTTAGAACAGATCAGGGATGCAGGGATAAGGGACGTGATTATTGTACTTG
GAGACAACGCGCCAACACGTGTCGTGGAGTATTACGGAGACGGTAGCAAGTTCGGGGTTAGGATAACCTACGTTTATCAA
GGTAAGGCTAGAGGACTAGCTGACGCGGTTTATAAAGTGAAGGACGTGGTTTCGGACAAGTTCTTAGTCTACTTAGGGGA
CAACTTAGTCCCTTATGACCTTAGCAAGTTCTCCTCTTTCAAAGGCTCAGCTTCAATCCTACTAGCCAAAGTTAATAATC
CCAATAGGTTTGGCGTGGCTGTAATAAAAGACGGGAGGGTCGTAAAGCTCATCGAAAAGCCTAAAGAACAGATTTCCGAC
CTAGCCCTAGTAGGTGTTTACGGTTTCACAAGGGAGATCTTTGACGTTATTGAGTCGTTAAAGCCTAGCTGGAGAGGTGA
ACTCGAGATTACTGACGCAATACAAGGGTTAATAGACAGAGGTAGGGAAGTAAATTATGAAATAATCCAGGGTTGGTGGA
AGGACACTGGGACTCCAAAGGACATCTTAGAGGCTAACGCGTTTCTACTAGACAGATACGCTGAAAGTAGGATTGAAGGT
GTAGTAGACAACTCTACAGTTGACGGCAAAGTGATAATTGAGAAGGGGGCTGTAATAAAGAACTCTGTGGTAAGGGGACC
AACTTACATAGGGAGGGACACTAAAATTATCAATTCCTATATAGGTCCTTTCACTTCTATTGGTGACCAGAGCGAAATAA
CGGACAGTGAGATAGAATACAGCGTAATCCTTGACGGCGTTAAGATAAGGGGGGTGACACTAATGGACTCTTTAATAGGG
AATAACTCTACTGTTGAAAAAGGTGGGAGATGGCAAAAGCTAATTATAGGTGAGAACTCCTCGGTGATATTATGA

Upstream 100 bases:

>100_bases
GCTAGGAGGCCCTTTGACTCCTCTTTGGACTACTCAAAAGCTAAGAAAATCTTATCCGTCGATTTTTACAGTTTAGACCT
AGAAGGTATGGTGTTGTGAG

Downstream 100 bases:

>100_bases
AAATCATAGTAGTTGGTGGTGCTGGGTTCATAGGCTCCGCTTTCGTGAGGGAGTTGAACAAGAGGGGTATAAAGCCCATC
GTAGTAGACCTCTTAACCTA

Product: sugar phosphate nucleotydyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDAGIRDVIIVLGDNAPTRVVEYYGDGSKFGVRITYVYQ
GKARGLADAVYKVKDVVSDKFLVYLGDNLVPYDLSKFSSFKGSASILLAKVNNPNRFGVAVIKDGRVVKLIEKPKEQISD
LALVGVYGFTREIFDVIESLKPSWRGELEITDAIQGLIDRGREVNYEIIQGWWKDTGTPKDILEANAFLLDRYAESRIEG
VVDNSTVDGKVIIEKGAVIKNSVVRGPTYIGRDTKIINSYIGPFTSIGDQSEITDSEIEYSVILDGVKIRGVTLMDSLIG
NNSTVEKGGRWQKLIIGENSSVIL

Sequences:

>Translated_344_residues
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDAGIRDVIIVLGDNAPTRVVEYYGDGSKFGVRITYVYQ
GKARGLADAVYKVKDVVSDKFLVYLGDNLVPYDLSKFSSFKGSASILLAKVNNPNRFGVAVIKDGRVVKLIEKPKEQISD
LALVGVYGFTREIFDVIESLKPSWRGELEITDAIQGLIDRGREVNYEIIQGWWKDTGTPKDILEANAFLLDRYAESRIEG
VVDNSTVDGKVIIEKGAVIKNSVVRGPTYIGRDTKIINSYIGPFTSIGDQSEITDSEIEYSVILDGVKIRGVTLMDSLIG
NNSTVEKGGRWQKLIIGENSSVIL
>Mature_344_residues
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDAGIRDVIIVLGDNAPTRVVEYYGDGSKFGVRITYVYQ
GKARGLADAVYKVKDVVSDKFLVYLGDNLVPYDLSKFSSFKGSASILLAKVNNPNRFGVAVIKDGRVVKLIEKPKEQISD
LALVGVYGFTREIFDVIESLKPSWRGELEITDAIQGLIDRGREVNYEIIQGWWKDTGTPKDILEANAFLLDRYAESRIEG
VVDNSTVDGKVIIEKGAVIKNSVVRGPTYIGRDTKIINSYIGPFTSIGDQSEITDSEIEYSVILDGVKIRGVTLMDSLIG
NNSTVEKGGRWQKLIIGENSSVIL

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=361, Percent_Identity=26.3157894736842, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI11761619, Length=355, Percent_Identity=26.4788732394366, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1788351, Length=236, Percent_Identity=35.1694915254237, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1790224, Length=242, Percent_Identity=33.0578512396694, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI133931050, Length=318, Percent_Identity=27.0440251572327, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320148, Length=346, Percent_Identity=28.9017341040462, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI21355443, Length=350, Percent_Identity=29.4285714285714, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24644084, Length=350, Percent_Identity=29.4285714285714, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24653912, Length=391, Percent_Identity=26.5984654731458, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 37890; Mature: 37890

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDAGIRDVIIVLGDNAPTR
CCEEEEECCCCCEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCE
VVEYYGDGSKFGVRITYVYQGKARGLADAVYKVKDVVSDKFLVYLGDNLVPYDLSKFSSF
EEEEECCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCC
KGSASILLAKVNNPNRFGVAVIKDGRVVKLIEKPKEQISDLALVGVYGFTREIFDVIESL
CCCEEEEEEEECCCCEEEEEEEECCCEEEHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHC
KPSWRGELEITDAIQGLIDRGREVNYEIIQGWWKDTGTPKDILEANAFLLDRYAESRIEG
CCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
VVDNSTVDGKVIIEKGAVIKNSVVRGPTYIGRDTKIINSYIGPFTSIGDQSEITDSEIEY
CCCCCCCCCEEEEECCCEEECCEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEE
SVILDGVKIRGVTLMDSLIGNNSTVEKGGRWQKLIIGENSSVIL
EEEECCEEEECEEHHHHHHCCCCEECCCCCEEEEEEECCCCEEC
>Mature Secondary Structure
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDAGIRDVIIVLGDNAPTR
CCEEEEECCCCCEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCE
VVEYYGDGSKFGVRITYVYQGKARGLADAVYKVKDVVSDKFLVYLGDNLVPYDLSKFSSF
EEEEECCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCC
KGSASILLAKVNNPNRFGVAVIKDGRVVKLIEKPKEQISDLALVGVYGFTREIFDVIESL
CCCEEEEEEEECCCCEEEEEEEECCCEEEHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHC
KPSWRGELEITDAIQGLIDRGREVNYEIIQGWWKDTGTPKDILEANAFLLDRYAESRIEG
CCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
VVDNSTVDGKVIIEKGAVIKNSVVRGPTYIGRDTKIINSYIGPFTSIGDQSEITDSEIEY
CCCCCCCCCEEEEECCCEEECCEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEE
SVILDGVKIRGVTLMDSLIGNNSTVEKGGRWQKLIIGENSSVIL
EEEECCEEEECEEHHHHHHCCCCEECCCCCEEEEEEECCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]