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The map label for this gene is hisQ [H]

Identifier: 15889638

GI number: 15889638

Start: 2339151

End: 2339873

Strand: Reverse

Name: hisQ [H]

Synonym: Atu2364

Alternate gene names: 15889638

Gene position: 2339873-2339151 (Counterclockwise)

Preceding gene: 15889639

Following gene: 15889637

Centisome position: 82.34

GC content: 64.04

Gene sequence:

>723_bases
ATGGCAAGCCTTGAAACCACGCTGCAACTGCTGTCACCCTATCCTCCGGGATGGGGCGGCACCCTTTTGAAGGGTGCGGC
GTCGACGCTTGCCATTTCCGCCGGTGCCTATCTGATTGGTATCGTTATCGGGCTTGCCGGCGCGCTCGGCAAGCTTTCCG
GCAACAGGCCGCTTGGCCTGTTGCTCAATCTCTACACGACGGCGATCCGCGCGGTTCCCGAACTGATCCTCATCGTCGGG
CTTTATTATGCCGGCACCGACGGTTTGAACCGGCTGCTGCAACTGATGGGCCTGCCGCCGCTTGAGGTGAACGGGTTCGT
TGCCGCCGTCGCGGTTCTGGGGTTCGTGCAGGGCGCCTATATGACCGAGGTGCTGCGCGGCGCGATCCTTGCCGTGCCGA
ACGGCCAGATCGAGGCGGCGCGGGCCTTCGGCATGTCGCCGTTCCTGCGTTTCCGCCGTGTGGTCCTACCAGCCCTGCTG
CCGAATGCGCTGCCGGGCCTTGCCAATCTCTGGCTTGCGGTGACCAAGGACAGCGCGCTGGTGGCCGTGGTCGGTTATCA
GGAACTGGCGCTGGCGACACGGCTGGCGGGGGCCAGCACCAAGCAATATTTCCTGTTCTTCCTTGCGGCGGCGTTTCTTT
ATCTCGCGATCACGCTCGTCTCCAACCTCGTCTTTTCACAGCTGGAACGCCGGGTGCGGCGCGGCCAGCCGGCTTTGGCC
TGA

Upstream 100 bases:

>100_bases
ATCGCTGCCGTGCGCGCCAGCGGGAAGTATGACGAGATCACCAAGAAATACTTCAGCTTCGATATCTACGGTAACTAATT
TCTCCTGACCGGTCACATCA

Downstream 100 bases:

>100_bases
GGGGGAACGGCATGGATTTTTCATGGGTCGCCAAATATTGGCCGCTGCTTCTGTCCGGCGCCTGGCAGACGCTGGCGCTG
CTCGTCATCTCCGTCAGCAT

Product: ABC transporter, membrane spanning protein

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MASLETTLQLLSPYPPGWGGTLLKGAASTLAISAGAYLIGIVIGLAGALGKLSGNRPLGLLLNLYTTAIRAVPELILIVG
LYYAGTDGLNRLLQLMGLPPLEVNGFVAAVAVLGFVQGAYMTEVLRGAILAVPNGQIEAARAFGMSPFLRFRRVVLPALL
PNALPGLANLWLAVTKDSALVAVVGYQELALATRLAGASTKQYFLFFLAAAFLYLAITLVSNLVFSQLERRVRRGQPALA

Sequences:

>Translated_240_residues
MASLETTLQLLSPYPPGWGGTLLKGAASTLAISAGAYLIGIVIGLAGALGKLSGNRPLGLLLNLYTTAIRAVPELILIVG
LYYAGTDGLNRLLQLMGLPPLEVNGFVAAVAVLGFVQGAYMTEVLRGAILAVPNGQIEAARAFGMSPFLRFRRVVLPALL
PNALPGLANLWLAVTKDSALVAVVGYQELALATRLAGASTKQYFLFFLAAAFLYLAITLVSNLVFSQLERRVRRGQPALA
>Mature_239_residues
ASLETTLQLLSPYPPGWGGTLLKGAASTLAISAGAYLIGIVIGLAGALGKLSGNRPLGLLLNLYTTAIRAVPELILIVGL
YYAGTDGLNRLLQLMGLPPLEVNGFVAAVAVLGFVQGAYMTEVLRGAILAVPNGQIEAARAFGMSPFLRFRRVVLPALLP
NALPGLANLWLAVTKDSALVAVVGYQELALATRLAGASTKQYFLFFLAAAFLYLAITLVSNLVFSQLERRVRRGQPALA

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=219, Percent_Identity=42.9223744292237, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1787087, Length=226, Percent_Identity=30.0884955752212, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1788226, Length=217, Percent_Identity=31.3364055299539, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787030, Length=216, Percent_Identity=32.4074074074074, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788645, Length=235, Percent_Identity=32.7659574468085, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1786873, Length=210, Percent_Identity=27.6190476190476, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786874, Length=217, Percent_Identity=27.1889400921659, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87082239, Length=226, Percent_Identity=28.7610619469027, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 25249; Mature: 25118

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLETTLQLLSPYPPGWGGTLLKGAASTLAISAGAYLIGIVIGLAGALGKLSGNRPLGL
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LLNLYTTAIRAVPELILIVGLYYAGTDGLNRLLQLMGLPPLEVNGFVAAVAVLGFVQGAY
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MTEVLRGAILAVPNGQIEAARAFGMSPFLRFRRVVLPALLPNALPGLANLWLAVTKDSAL
HHHHHHHHEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCEE
VAVVGYQELALATRLAGASTKQYFLFFLAAAFLYLAITLVSNLVFSQLERRVRRGQPALA
EEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ASLETTLQLLSPYPPGWGGTLLKGAASTLAISAGAYLIGIVIGLAGALGKLSGNRPLGL
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LLNLYTTAIRAVPELILIVGLYYAGTDGLNRLLQLMGLPPLEVNGFVAAVAVLGFVQGAY
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MTEVLRGAILAVPNGQIEAARAFGMSPFLRFRRVVLPALLPNALPGLANLWLAVTKDSAL
HHHHHHHHEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCEE
VAVVGYQELALATRLAGASTKQYFLFFLAAAFLYLAITLVSNLVFSQLERRVRRGQPALA
EEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]