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The map label for this gene is glpK [H]

Identifier: 15889199

GI number: 15889199

Start: 1880193

End: 1881662

Strand: Direct

Name: glpK [H]

Synonym: Atu1903

Alternate gene names: 15889199

Gene position: 1880193-1881662 (Clockwise)

Preceding gene: 159184971

Following gene: 159184972

Centisome position: 66.17

GC content: 64.01

Gene sequence:

>1470_bases
ATGCGCGCTATTCTGTCCATCGATCAGGGCACCACCAATTCCAAGGCCATACTCGTCTCGGAAAGCGGAGAGTTGCTCGC
GCGCGGCTCATCGCCGGTCGGCATTACCTATCCGCAGCCCGGCTGGGTGGAACAGGACCCGAACCGTATCTGGGCCTCGG
TCCGTGAAGCGATCTCCGCCTGCCTCGCAGCCGCACCCTCCGACGTCAGCGTCGAAGCCATCGCCATCTCAAACCAGCGC
GAATCGGTCACAATCTGGGACGGTGAAACCGGCGAGCCGCTTGGCCCGGTGCTAAGCTGGCAATGCCGCCGCACCGCACA
GGACTGCGCAGACCTGATCGCAAAGGGACAATCAGAACGCGTCATGGCCCTGACCGGCCTGCCGATCGACCCGATGTTTC
CCGGCGCTAAGATGCGCTGGCTGCTGGAACGGGCGCCGAAAGGCCGCAAGCTTCGCCTCGGCACCATAGATAGCTGGCTC
ATCCATTGCTTCACCGGCGGCAAGGTTCATGCCTGCGACGCCTCAAACGCAGCCCGCAGCCAGGTGCTCGATCTCAACCG
GCAGGTCTGGAGCGACGAGCTCTGTGACCTCTTCGGCATCGATATCAATGCCCTGCCGGACCTGCGCGACAGCAGCGGCG
ACTTCGGCGTGACATCAGGCGTTCCCGGCATCAAGGATGGCACGCCGATCCTCGCGGCCATCGGCGACAGCCACGCCGCC
CTCTTCGGCCATGGCGCTTTCAACCCCGGAGACGGTAAAGTGACCTTCGGCACCGGCTCGTCGGTCATGACGACGCTGCC
GCATTTCATCGCGCCTGAGCGCGGCATCACCACAACGGTTGCATGGCGGCTCGGCGGCAAACCGACCTTCGCCTTTGAAG
GCAATATTCTCGTTTCGGCAGCCTCCCTGCCATGGATGACGGACATTCTCGGCCTGCCGGATGTCGCCGCGCTGGTGGAA
CTCGCCGCCACGGCCGAACCGGAGGGGCCGGGGTTTGTGCCGGCCTTTGTCGGCCTTGGCGCGCCCTATTGGGATACCAA
CGCGCGCGCGCTGTTTTCGCAAATCAATTTCAGCACCACCCGCGCCCAGATGGCCCGGGCGGTCACCGATTCCATCGCCT
TTCAGGTCCACGACGTCTTCGCCGCCATGCGCGCGCAGTCGCCTTCCGGTTTCGGGCGCCTCTTCGTGGATGGCGGGCCG
AGCCAGAACCGTTTCCTGATGCAATGCGTCGCCGATATGCTGGAACACCCCGTCATTCAGCGCGATGCGCCGGAAGCCTC
CGCCCTCGGCGCTGCCTATCTCGCCGGCCTGGCCCTCGGTGTCTGGAGTGATCTTAATGCCATCGCAGCGTTGAATAGCA
ACGGGAACACCATCGCGACTTCAACCGGTGAAAGCCGTCAGCGGCTCGGCATCTGGCGCGATGCGATTGCTCGCTCGACC
TTGCCCGTAACCTCGGGTAATGGTGAATAA

Upstream 100 bases:

>100_bases
CGCGTCTTCGGATGCGCGGCGATTTCTTTTAGTACGCACGCAGCTTCTTAAACAAAGAACACCGTGTGAAAATGACCGCC
GCAGATGAGAGAACACAGAG

Downstream 100 bases:

>100_bases
AAATTCACCATGGAGGGCTTATGGGCAGGATCAACGAACTTCGGATGATATCCCGCGTGGCGCAGATGTATTTCAGCGAG
CACAAACGGCAGGCGGAAAT

Product: glycerol kinase 2

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase 2; Glycerokinase 2; GK 2 [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MRAILSIDQGTTNSKAILVSESGELLARGSSPVGITYPQPGWVEQDPNRIWASVREAISACLAAAPSDVSVEAIAISNQR
ESVTIWDGETGEPLGPVLSWQCRRTAQDCADLIAKGQSERVMALTGLPIDPMFPGAKMRWLLERAPKGRKLRLGTIDSWL
IHCFTGGKVHACDASNAARSQVLDLNRQVWSDELCDLFGIDINALPDLRDSSGDFGVTSGVPGIKDGTPILAAIGDSHAA
LFGHGAFNPGDGKVTFGTGSSVMTTLPHFIAPERGITTTVAWRLGGKPTFAFEGNILVSAASLPWMTDILGLPDVAALVE
LAATAEPEGPGFVPAFVGLGAPYWDTNARALFSQINFSTTRAQMARAVTDSIAFQVHDVFAAMRAQSPSGFGRLFVDGGP
SQNRFLMQCVADMLEHPVIQRDAPEASALGAAYLAGLALGVWSDLNAIAALNSNGNTIATSTGESRQRLGIWRDAIARST
LPVTSGNGE

Sequences:

>Translated_489_residues
MRAILSIDQGTTNSKAILVSESGELLARGSSPVGITYPQPGWVEQDPNRIWASVREAISACLAAAPSDVSVEAIAISNQR
ESVTIWDGETGEPLGPVLSWQCRRTAQDCADLIAKGQSERVMALTGLPIDPMFPGAKMRWLLERAPKGRKLRLGTIDSWL
IHCFTGGKVHACDASNAARSQVLDLNRQVWSDELCDLFGIDINALPDLRDSSGDFGVTSGVPGIKDGTPILAAIGDSHAA
LFGHGAFNPGDGKVTFGTGSSVMTTLPHFIAPERGITTTVAWRLGGKPTFAFEGNILVSAASLPWMTDILGLPDVAALVE
LAATAEPEGPGFVPAFVGLGAPYWDTNARALFSQINFSTTRAQMARAVTDSIAFQVHDVFAAMRAQSPSGFGRLFVDGGP
SQNRFLMQCVADMLEHPVIQRDAPEASALGAAYLAGLALGVWSDLNAIAALNSNGNTIATSTGESRQRLGIWRDAIARST
LPVTSGNGE
>Mature_489_residues
MRAILSIDQGTTNSKAILVSESGELLARGSSPVGITYPQPGWVEQDPNRIWASVREAISACLAAAPSDVSVEAIAISNQR
ESVTIWDGETGEPLGPVLSWQCRRTAQDCADLIAKGQSERVMALTGLPIDPMFPGAKMRWLLERAPKGRKLRLGTIDSWL
IHCFTGGKVHACDASNAARSQVLDLNRQVWSDELCDLFGIDINALPDLRDSSGDFGVTSGVPGIKDGTPILAAIGDSHAA
LFGHGAFNPGDGKVTFGTGSSVMTTLPHFIAPERGITTTVAWRLGGKPTFAFEGNILVSAASLPWMTDILGLPDVAALVE
LAATAEPEGPGFVPAFVGLGAPYWDTNARALFSQINFSTTRAQMARAVTDSIAFQVHDVFAAMRAQSPSGFGRLFVDGGP
SQNRFLMQCVADMLEHPVIQRDAPEASALGAAYLAGLALGVWSDLNAIAALNSNGNTIATSTGESRQRLGIWRDAIARST
LPVTSGNGE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=511, Percent_Identity=34.8336594911937, Blast_Score=275, Evalue=9e-74,
Organism=Homo sapiens, GI4504007, Length=511, Percent_Identity=34.8336594911937, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI42794763, Length=515, Percent_Identity=34.5631067961165, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI41393575, Length=509, Percent_Identity=35.5599214145383, Blast_Score=271, Evalue=8e-73,
Organism=Homo sapiens, GI88196792, Length=507, Percent_Identity=27.810650887574, Blast_Score=204, Evalue=2e-52,
Organism=Escherichia coli, GI1790361, Length=493, Percent_Identity=37.9310344827586, Blast_Score=318, Evalue=7e-88,
Organism=Escherichia coli, GI1789987, Length=445, Percent_Identity=26.2921348314607, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1790005, Length=470, Percent_Identity=25.531914893617, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1789168, Length=458, Percent_Identity=23.3624454148472, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1787789, Length=487, Percent_Identity=24.2299794661191, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=448, Percent_Identity=31.25, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71986140, Length=520, Percent_Identity=25.1923076923077, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71986147, Length=292, Percent_Identity=32.8767123287671, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321755, Length=497, Percent_Identity=30.5835010060362, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17864214, Length=501, Percent_Identity=32.1357285429142, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24655555, Length=495, Percent_Identity=31.9191919191919, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24655560, Length=495, Percent_Identity=31.9191919191919, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24655570, Length=495, Percent_Identity=31.9191919191919, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24655574, Length=495, Percent_Identity=31.9191919191919, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24655565, Length=495, Percent_Identity=31.9191919191919, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24654573, Length=456, Percent_Identity=32.4561403508772, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI19922058, Length=514, Percent_Identity=27.0428015564202, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24652871, Length=488, Percent_Identity=27.0491803278689, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24656367, Length=506, Percent_Identity=27.6679841897233, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21357867, Length=522, Percent_Identity=26.8199233716475, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24656372, Length=359, Percent_Identity=28.6908077994429, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45552909, Length=265, Percent_Identity=27.9245283018868, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 51666; Mature: 51666

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAILSIDQGTTNSKAILVSESGELLARGSSPVGITYPQPGWVEQDPNRIWASVREAISA
CCEEEEECCCCCCCCEEEEECCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
CLAAAPSDVSVEAIAISNQRESVTIWDGETGEPLGPVLSWQCRRTAQDCADLIAKGQSER
HHHCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
VMALTGLPIDPMFPGAKMRWLLERAPKGRKLRLGTIDSWLIHCFTGGKVHACDASNAARS
EEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCHHHHHHEEECCCEEEEECCCCHHHH
QVLDLNRQVWSDELCDLFGIDINALPDLRDSSGDFGVTSGVPGIKDGTPILAAIGDSHAA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEE
LFGHGAFNPGDGKVTFGTGSSVMTTLPHFIAPERGITTTVAWRLGGKPTFAFEGNILVSA
EEECCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEECCCEEEEE
ASLPWMTDILGLPDVAALVELAATAEPEGPGFVPAFVGLGAPYWDTNARALFSQINFSTT
CCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCHHH
RAQMARAVTDSIAFQVHDVFAAMRAQSPSGFGRLFVDGGPSQNRFLMQCVADMLEHPVIQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCC
RDAPEASALGAAYLAGLALGVWSDLNAIAALNSNGNTIATSTGESRQRLGIWRDAIARST
CCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCC
LPVTSGNGE
CCCCCCCCC
>Mature Secondary Structure
MRAILSIDQGTTNSKAILVSESGELLARGSSPVGITYPQPGWVEQDPNRIWASVREAISA
CCEEEEECCCCCCCCEEEEECCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
CLAAAPSDVSVEAIAISNQRESVTIWDGETGEPLGPVLSWQCRRTAQDCADLIAKGQSER
HHHCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
VMALTGLPIDPMFPGAKMRWLLERAPKGRKLRLGTIDSWLIHCFTGGKVHACDASNAARS
EEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCHHHHHHEEECCCEEEEECCCCHHHH
QVLDLNRQVWSDELCDLFGIDINALPDLRDSSGDFGVTSGVPGIKDGTPILAAIGDSHAA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEE
LFGHGAFNPGDGKVTFGTGSSVMTTLPHFIAPERGITTTVAWRLGGKPTFAFEGNILVSA
EEECCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEECCCEEEEE
ASLPWMTDILGLPDVAALVELAATAEPEGPGFVPAFVGLGAPYWDTNARALFSQINFSTT
CCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCHHH
RAQMARAVTDSIAFQVHDVFAAMRAQSPSGFGRLFVDGGPSQNRFLMQCVADMLEHPVIQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCC
RDAPEASALGAAYLAGLALGVWSDLNAIAALNSNGNTIATSTGESRQRLGIWRDAIARST
CCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCC
LPVTSGNGE
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]