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The map label for this gene is tkt [C]

Identifier: 159184971

GI number: 159184971

Start: 1879142

End: 1880071

Strand: Direct

Name: tkt [C]

Synonym: Atu1902

Alternate gene names: 159184971

Gene position: 1879142-1880071 (Clockwise)

Preceding gene: 15889197

Following gene: 15889199

Centisome position: 66.13

GC content: 63.33

Gene sequence:

>930_bases
CTGTATGATTGCCGCGACGCCTTCGCCGAAACGCTGGAAGCGCTGGCCGCCGCCAATGACAAGGTCGTCGCCGTCTGCAA
CGATTCGGTCGGCTCCTCGAAGCTCGGCGGCTTCAAATCGAAATTCCCCGAGCGCCTCGTCAATGTCGGTATCGCCGAAC
AGAACATGGTCGGCGTCGGCGCCGGTCTCGCCAATGGCGGGCAATTGCCCTTCGTCTGCGGCGCGTCCTGCTTCCTCACC
GGCCGCGCGCTGGAGCAGATCAAGGCTGACCTTGCCTATTCCAACGCCAATGTGAAGCTGATCGGCATATCCTCAGGCAT
GGCCTATGGCGAACTCGGTCCGACGCACCATTCCATCGAGGATTTCGCCTGGACCCGCGTCCTGCCGAACCTGCCGGTCA
TCGCCCCCTGCGACCGCATCGAAACCGCTGCTGCCGTCAAATGGGCAGCGGACTATGCCGGCCCCTGCTTCCTGCGTCTG
TCACGCGTCGGCGTGCCGGACCTTCTGCCGGAAGGCCACGTCTTCGAACTCGGCCGCGCCAATCTGCTGCGTGAAGGTTC
CGACCTGACGCTGATCGCCAACGGCACGCTGACCCACCGCATCGTCAAGGCCGCCGATATTCTGTTGAGCCGCGGCATCA
AGGCGCGCGTTCTGAACATGGCGACCGTTCGCCCCATCGATGAAGCGGCCATTATCGCTGCGGCGAAGGAAACCGGCGCA
ATCCTGACGGCCGAAGAACATTCGATCTTCGGCGGCCTGGGTTCGGCCATCGCGGAAGTCGTGGTCGACCATTCGCCCGT
GCCAATGAAACGCCTCGGCGTTCCCGGTGTCTTCGCCCATACCGGCTCCGCCGAATGGCTGCTCGATGAGTTCGGCATGG
CACCCACAGCCATTGCCGACGCAGCGCAGGCGCTGATCAAGAGAAAATAA

Upstream 100 bases:

>100_bases
TCGACTGGCATCACAAGGTTCCGAGCAAGGAACAATACGAGATTGCCGTCAAAGAACTTTCGGAGGCATTGTAATGAACG
CGCCCGTAACCGCCGCCAAA

Downstream 100 bases:

>100_bases
GGTCTCCTCCCAGGGTCGTCGCGCGTCTTCGGATGCGCGGCGATTTCTTTTAGTACGCACGCAGCTTCTTAAACAAAGAA
CACCGTGTGAAAATGACCGC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MYDCRDAFAETLEALAAANDKVVAVCNDSVGSSKLGGFKSKFPERLVNVGIAEQNMVGVGAGLANGGQLPFVCGASCFLT
GRALEQIKADLAYSNANVKLIGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDRIETAAAVKWAADYAGPCFLRL
SRVGVPDLLPEGHVFELGRANLLREGSDLTLIANGTLTHRIVKAADILLSRGIKARVLNMATVRPIDEAAIIAAAKETGA
ILTAEEHSIFGGLGSAIAEVVVDHSPVPMKRLGVPGVFAHTGSAEWLLDEFGMAPTAIADAAQALIKRK

Sequences:

>Translated_309_residues
MYDCRDAFAETLEALAAANDKVVAVCNDSVGSSKLGGFKSKFPERLVNVGIAEQNMVGVGAGLANGGQLPFVCGASCFLT
GRALEQIKADLAYSNANVKLIGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDRIETAAAVKWAADYAGPCFLRL
SRVGVPDLLPEGHVFELGRANLLREGSDLTLIANGTLTHRIVKAADILLSRGIKARVLNMATVRPIDEAAIIAAAKETGA
ILTAEEHSIFGGLGSAIAEVVVDHSPVPMKRLGVPGVFAHTGSAEWLLDEFGMAPTAIADAAQALIKRK
>Mature_309_residues
MYDCRDAFAETLEALAAANDKVVAVCNDSVGSSKLGGFKSKFPERLVNVGIAEQNMVGVGAGLANGGQLPFVCGASCFLT
GRALEQIKADLAYSNANVKLIGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDRIETAAAVKWAADYAGPCFLRL
SRVGVPDLLPEGHVFELGRANLLREGSDLTLIANGTLTHRIVKAADILLSRGIKARVLNMATVRPIDEAAIIAAAKETGA
ILTAEEHSIFGGLGSAIAEVVVDHSPVPMKRLGVPGVFAHTGSAEWLLDEFGMAPTAIADAAQALIKRK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=308, Percent_Identity=34.4155844155844, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI4507521, Length=308, Percent_Identity=34.4155844155844, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI133778974, Length=297, Percent_Identity=35.016835016835, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI225637461, Length=307, Percent_Identity=33.8762214983713, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI225637463, Length=307, Percent_Identity=33.8762214983713, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI225637459, Length=307, Percent_Identity=33.8762214983713, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI4557353, Length=272, Percent_Identity=24.6323529411765, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI34101272, Length=272, Percent_Identity=24.6323529411765, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI156564403, Length=283, Percent_Identity=23.6749116607774, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI291084858, Length=272, Percent_Identity=23.8970588235294, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786622, Length=291, Percent_Identity=33.6769759450172, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI48994911, Length=285, Percent_Identity=26.6666666666667, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788808, Length=189, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=304, Percent_Identity=30.2631578947368, Blast_Score=137, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6319698, Length=315, Percent_Identity=26.3492063492064, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45551847, Length=307, Percent_Identity=32.5732899022801, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI45550715, Length=307, Percent_Identity=32.5732899022801, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24645119, Length=307, Percent_Identity=32.5732899022801, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24666278, Length=308, Percent_Identity=31.8181818181818, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI160714832, Length=263, Percent_Identity=26.2357414448669, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI160714828, Length=263, Percent_Identity=26.2357414448669, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358145, Length=285, Percent_Identity=25.6140350877193, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24650940, Length=285, Percent_Identity=25.6140350877193, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 32411; Mature: 32411

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDCRDAFAETLEALAAANDKVVAVCNDSVGSSKLGGFKSKFPERLVNVGIAEQNMVGVG
CCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEC
AGLANGGQLPFVCGASCFLTGRALEQIKADLAYSNANVKLIGISSGMAYGELGPTHHSIE
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCCCHH
DFAWTRVLPNLPVIAPCDRIETAAAVKWAADYAGPCFLRLSRVGVPDLLPEGHVFELGRA
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEHHCCCCCCCCCCCEEECCCH
NLLREGSDLTLIANGTLTHRIVKAADILLSRGIKARVLNMATVRPIDEAAIIAAAKETGA
HHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHEEEEECCCCE
ILTAEEHSIFGGLGSAIAEVVVDHSPVPMKRLGVPGVFAHTGSAEWLLDEFGMAPTAIAD
EEEECCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCHHHHHHHHCCCHHHHHH
AAQALIKRK
HHHHHHCCC
>Mature Secondary Structure
MYDCRDAFAETLEALAAANDKVVAVCNDSVGSSKLGGFKSKFPERLVNVGIAEQNMVGVG
CCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEC
AGLANGGQLPFVCGASCFLTGRALEQIKADLAYSNANVKLIGISSGMAYGELGPTHHSIE
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCCCHH
DFAWTRVLPNLPVIAPCDRIETAAAVKWAADYAGPCFLRLSRVGVPDLLPEGHVFELGRA
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEHHCCCCCCCCCCCEEECCCH
NLLREGSDLTLIANGTLTHRIVKAADILLSRGIKARVLNMATVRPIDEAAIIAAAKETGA
HHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHEEEEECCCCE
ILTAEEHSIFGGLGSAIAEVVVDHSPVPMKRLGVPGVFAHTGSAEWLLDEFGMAPTAIAD
EEEECCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCHHHHHHHHCCCHHHHHH
AAQALIKRK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]